"A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent ... May 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta ... Glycogen synthase kinase-3 beta, (GSK-3 beta), is an enzyme that in humans is encoded by the GSK3B gene. In mice, the enzyme is ... "Entrez Gene: GSK3B glycogen synthase kinase 3 beta". Iwahashi K, Nishizawa D, Narita S, Numajiri M, Murayama O, Yoshihara E, et ...

Cytosolic substrates of p90rsk include protein phosphatase 1; glycogen synthase kinase 3 (GSK3); L1 CAM, a neural cell adhesion ... In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction. There are two ... also known as S6-H1 Kinase or simply S6 Kinase. There are three variants of p90rsk in humans, rsk 1-3. Rsks are serine/ ... threonine kinases and are activated by the MAPK/ERK pathway. There are two known mammalian homologues of S6 Kinase: S6K1 and ...

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene. Glycogen synthase kinase 3-alpha EC ... "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha". Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput ... Glycogen synthase kinase 3 GRCh38: Ensembl release 89: ENSG00000105723 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical ...

Ali A, Hoeflich KP, Woodgett JR (August 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical ... Protein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene. Protein kinase C (PKC) is a family of ... "Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase". The Journal ... PRKCB1 has been shown to interact with RIPK4, beta adrenergic receptor kinase, PDLIM5 and GNB2L1. Protein kinase C GRCh38: ...

Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8 ... Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene. Protein kinase C (PKC) is a family of ... specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain ... This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been ...

Martín CP, Vázquez J, Avila J, Moreno FJ (2002). "P24, a glycogen synthase kinase 3 (GSK 3) inhibitor". Biochim. Biophys. Acta ... identification of sites targeted by different kinases". J. Biol. Chem. 282 (40): 29531-9. doi:10.1074/jbc.M703466200. hdl:2437/ ... 2006). "Interaction of TPPP/p25 protein with glyceraldehyde-3-phosphate dehydrogenase and their co-localization in Lewy bodies ...

Li X, Liu M, Cai Z, Wang G, Li X (2010). "Regulation of glycogen synthase kinase-3 during bipolar mania treatment". Bipolar ... Post-mortem examinations of bipolar disorder demonstrate increased expression of Protein Kinase C (PKC). While limited, some ... Protein kinase C and Inositol monophosphatase. Meta analysis of neuroimaging studies demonstrate increased thalamic activity, ... Decreased need for sleep (e.g., feels rested after 3 hours of sleep). More talkative than usual, or acts pressured to keep ...

Gardner, Phyllis (1997-03-28). "Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3". Science. 275 (5308): 1930- ... Now Stanford professor is star in Theranos saga". 3 June 2019. Ramsey, Lydia (March 18, 2019). "The Stanford professor who ...

"Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3". Science. 275 (5308): 1930-4. doi:10.1126/science.275.5308. ... Porter CM, Havens MA, Clipstone NA (Feb 2000). "Identification of amino acid residues and protein kinases involved in the ... Transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase". Journal of Immunology. 168 (4): 1524-7. doi:10.4049/ ... 6 (3): 235-44. doi:10.1016/S1074-7613(00)80326-X. PMID 9075924. Zhou P, Sun LJ, Dötsch V, Wagner G, Verdine GL (Mar 1998). " ...

... (NP-12, NP031112) is a potent and irreversible small molecule glycogen synthase kinase 3 (GSK-3) inhibitor. There ... "Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib". The Journal of Biological Chemistry. 287 (2 ... "Evidence for irreversible inhibition of glycogen synthase kinase-3β by tideglusib". The Journal of Biological Chemistry. 287 (2 ... which included transient increases in serum creatine kinase, ALT-or gGT-diarrhea, nausea, cough, fatigue, and headache (del Ser ...

Glycogen Synthase Kinase 3 Beta (GSK3B) GSK3B is a protein kinase that regulates transcription factors and microtubules. As ... "GSK3B - Glycogen synthase kinase-3 beta - Homo sapiens (Human) - GSK3B gene & protein". www.uniprot.org. Retrieved 2017-04-23. ... protein kinases assay, two hybrid, and confocal microscopy experiments. CRACD-L protein is also predicted to interact with ... The 3' UTR of CRACDL is predicted to be a targeted by miRNA-132, which is depicted in the conceptual translation figure. ...

Activation of the Wnt pathway inhibits glycogen synthase kinase 3 beta (GSK3B). When the Wnt pathway is not active, GSK3B is ... c-Jun N-terminal kinase (JNK) signaling is part of the mitogen-activated protein kinase (MAPK) signaling pathway essential in ... Second generation inhibitors are able to bind to the ATP-binding motif on the kinase domain of the mTOR core protein itself and ... Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G (May 2002). "Regulation of an activated S6 kinase 1 variant ...

"Regulation of human cytidine triphosphate synthetase 1 by glycogen synthase kinase 3". The Journal of Biological Chemistry. 282 ... CTP synthase 1 is an enzyme that is encoded by the CTPS1 gene in humans. CTP synthase 1 is an enzyme in the de novo pyrimidine ... "Entrez Gene: CTP synthase". Kursula P, Flodin S, Ehn M, Hammarström M, Schüler H, Nordlund P, Stenmark P (July 2006). " ... June 2014). "CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation". Nature. 510 (7504): 288 ...

This interaction appears to be regulated by glycogen synthase kinase 3 beta. Mutations in emerin cause X-linked recessive Emery ... 267 (3): 709-14. doi:10.1006/bbrc.1999.2023. PMID 10673356. Zhang Q, Skepper JN, Yang F, Davies JD, Hegyi L, Roberts RG, ... 303 (3): 764-70. doi:10.1016/s0006-291x(03)00415-7. PMID 12670476. Berk JM, Simon DN, Jenkins-Houk CR, Westerbeck JW, Grønning- ... 525 (1-3): 135-40. doi:10.1016/s0014-5793(02)03105-8. PMID 12163176. Wheeler MA, Davies JD, Zhang Q, Emerson LJ, Hunt J, ...

2006). "Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy". Hum. Mol. Genet. 14 ( ...

Kawabe, Yoshinori; Morio, Takahiro; Tanaka, Yoshimasa; Schaap, Pauline (9 May 2018). "Glycogen synthase kinase 3 promotes ... 138 (3): 387-396. doi:10.1242/dev.048934. ISSN 0950-1991. PMC 3014629. PMID 21205784. "Pauline Schaap - AcademiaNet". www. ...

2007). "Glycogen synthase kinase-3 phosphorylates CdGAP at a consensus ERK 1 regulatory site". J. Biol. Chem. 282 (6): 3624-31 ... 2010). "A human MAP kinase interactome". Nat. Methods. 7 (10): 801-5. doi:10.1038/nmeth.1506. PMC 2967489. PMID 20936779. Jenna ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 3, Wikipedia articles ... incorporating text from the United States National Library of Medicine, Proteins, All stub articles, Human chromosome 3 gene ...

"Mitochondrial hexokinase II promotes neuronal survival and acts downstream of glycogen synthase kinase-3". The Journal of ... As an isoform of hexokinase and a member of the sugar kinase family, HK2 catalyzes the rate-limiting and first obligatory step ... Activation of Akt kinase maintains HK2-VDAC coupling, which subsequently prevents cytochrome c release and apoptosis, though ... In a similar mechanism, the pro-apoptotic creatine kinase binds and opens VDAC in the absence of HK2. An alternative model ...

Gustafson MP, Welcker M, Hwang HC, Clurman BE (2006). "Zcchc8 is a glycogen synthase kinase-3 substrate that interacts with RNA ... 338 (3): 1359-67. doi:10.1016/j.bbrc.2005.10.090. PMID 16263084. Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A ...

Eldar-Finkelman is well known for her pioneering work on the protein kinase function, glycogen synthase kinase-3 (GSK-3), ... Kaidanovich-Beilin, Oksana; Eldar-Finkelman, Hagit (2006). "Long-Term Treatment with Novel Glycogen Synthase Kinase-3 Inhibitor ... "Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation". FEBS ... "Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice". Diabetes. 48 (8): 1662-1666. doi: ...

Glycogen synthase kinase 3 (GSK3) seems to be over-expressed in most cancer cells. GSK3 is involved in promoter activation ... Viral proteins like viral thymidine kinase can be used for specific targeting of a drug. By introducing a prodrug only ... kinase/Akt, heat shock protein 90, and mammalian target of rapamycin in transformed NK cells". Journal of Immunology. 174 (9): ... 10 (3): 281-7. doi:10.1016/S1074-7613(00)80028-X. PMID 10204484. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda ...

Cross, D. A.; Alessi, D. R.; Cohen, P; Andjelkovich, M; Hemmings, B. A. (1995). "Inhibition of glycogen synthase kinase-3 by ... In particular, Dario's research focusses on the leucine-rich repeat kinase LRRK2, as mutations that increase the kinase ... insulin mediated by protein kinase B". Nature. 378 (6559): 785-9. Bibcode:1995Natur.378..785C. doi:10.1038/378785a0. PMID ...

Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (December 1995). "Inhibition of glycogen synthase kinase-3 by insulin ... Discovery of the key signaling kinase PKB (Akt) and demonstration of its central role in cancer cell signaling. First use of ... Saitoh M, Pullen N, Brennan P, Cantrell D, Dennis PB, Thomas G (May 2002). "Regulation of an activated S6 kinase 1 variant ... mediated by protein kinase B.". Nature. 378 (6559): 785-789. doi:10.1038/378785a0. PMID 8524413. S2CID 4285651. Ludin B, Doll T ...

October 2001). "Presenilin 1 regulates beta-catenin-mediated transcription in a glycogen synthase kinase-3-independent fashion ... 37 (3): 254-277. doi:10.1210/er.2015-1146. PMID 27159876. Slattery ML, Folsom AR, Wolff R, Herrick J, Caan BJ, Potter JD (April ... 180 (3): 568-584.e23. doi:10.1016/j.cell.2019.12.036. PMC 7250485. PMID 31981491. Torres S, García-Palmero I, Marín-Vicente C, ... 277 (3): 1884-1891. doi:10.1074/jbc.M110248200. PMID 11711551. Graham TA, Ferkey DM, Mao F, Kimelman D, Xu W (December 2001). " ...

... in insulin-induced glycogen synthase kinase 3 inactivation. Characterization of dominant-negative mutant of PKB". J. Biol. Chem ... It was found that an enzyme, named phosphorylase kinase and Mg-ATP were required to phosphorylate glycogen phosphorylase by ... Cyclin-dependent kinases (CDKs) are serine-threonine kinases which regulate progression through the eukaryotic cell cycle. CDKs ... Most phosphorylation is carried out by a single superfamily of protein kinases that share a conserved kinase domain. Protein ...

GSK3B (Glycogen synthase kinase 3 beta) is a protein predicted to physically interact with TMEM44. TMEM44 is predicted to ... TMEM44 gene is located at the end of the long arm of chromosome 3 in humans (Homo sapiens). TMEM44 is 428 amino acids in length ... v t e (Genes on human chromosome 3, Transmembrane proteins, All stub articles, Human chromosome 3 gene stubs). ...

September 2016). "Xanthatin anti-tumor cytotoxicity is mediated via glycogen synthase kinase-3β and β-catenin". Biochemical ... "Xanthatin inhibits STAT3 and NF-κB signalling by covalently binding to JAK and IKK kinases". Journal of Cellular and Molecular ... "Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides ... 3 (3): 137-141. doi:10.1016/0305-1978(75)90017-4. Tao L, Fan F, Liu Y, Li W, Zhang L, Ruan J, et al. (2013-11-28). Afarinkia K ...

Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical ... Protein kinase C alpha (PKCα) is an enzyme that in humans is encoded by the PRKCA gene. Protein kinase C (PKC) is a family of ... Protein kinase C-alpha (PKC-α) is a specific member of the protein kinase family. These enzymes are characterized by their ... PKC-α is unique in its mode of regulation compared to other kinases within this family. In general, the protein kinase family ...

"Entrez Gene: PRKD3 protein kinase D3". Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, ... 2002). "Human serum and glucocorticoid-inducible kinase-like kinase (SGKL) phosphorylates glycogen syntheses kinase 3 beta (GSK ... 2000). "Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A". Proc. Natl. Acad. Sci. U.S.A. 97 ( ... 2002). "Convergence of Multiple Signaling Cascades at Glycogen Synthase Kinase 3: Edg Receptor-Mediated Phosphorylation and ...

Ali A, Hoeflich KP, Woodgett JR (2002). "Glycogen synthase kinase-3: properties, functions, and regulation". Chem. Rev. 101 (8 ... Protein kinase C delta type (or PKC-δ) is an enzyme that in humans is encoded by the PRKCD gene. Protein kinase C (PKC) is a ... "Entrez Gene: PRKCD protein kinase C, delta". Welman A, Griffiths JR, Whetton AD, Dive C (December 2007). "Protein kinase C ... Protein kinase C delta is also regulated by phosphorylation on various serine/threonine (e.g. T50, T141, S304, T451, T505, S506 ...