The globin fold is found in its namesake globin families as well as in phycocyanins. The globin fold was thus the first protein ... Globin E: a globin responsible for storing and delivering oxygen to the retina in birds Globin-coupled sensors: chimeric, with ... Eight globins are known to occur in vertebrates: androglobin (Adgb), cytoglobin (Cygb), globin E (GbE, from bird eye), globin X ... IPR011406 Globin, nematode InterPro: IPR012085 Globin, lamprey/hagfish type InterPro: IPR013314 Globin, annelid-type InterPro: ...

This locus contains not only the beta globin gene but also delta, gamma-A, gamma-G, and epsilon globin. Expression of all of ... The human β-globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of ... The order of the genes in the beta-globin cluster is: 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. The arrangement of ... Many CRMs have been mapped within the cluster of genes encoding β-like globins expressed in embryonic (HBE1), fetal (HBG1 and ...

... flanking region of the beta-globin gene. The CoTC core is highly conserved in the 3' UTR of other primate beta-globin genes. ... Page for Beta-globin co-transcriptional cleavage ribozyme at Rfam v t e v t e (Orphaned articles from May 2016, All orphaned ... The Beta-globin co-transcriptional cleavage ribozyme (CotC ribozyme) was proposed to be an RNA enzyme known as a ribozyme. ... This process is also referred to as co-transcriptional cleavage (CoTC). The CoTC process in the human beta-globin gene was ...

... belongs to the globin superfamily of proteins, and as with other globins, consists of eight alpha helices connected ... Wu G, Wainwright LM, Poole RK (2003). Microbial globins. Advances in Microbial Physiology. Vol. 47. pp. 255-310. doi:10.1016/ ...

Usually there are four genes that code for alpha globin and two genes that code for beta globin. If the genes for alpha chains ... With most of these variants are mutations in the alpha globin gene that result in an abnormally long alpha chain and an ... Hb H usually occurs in some alpha thalassemia and is composed of four beta globin (protein) chains. This variant is usually ... or globins, that cause changes or alterations in the amino acid. They could affect the structure, behavior, the production rate ...

... heme/globin-containing molecules (even monomeric globin ones) that deal with gas-binding are referred to as oxyhemoglobins. In ... Nitric oxide can also be transported by hemoglobin; it is bound to specific thiol groups in the globin protein to form an S- ... NO binds reversibly to a specific cysteine residue in globin; the binding depends on the state (R or T) of the hemoglobin. The ... Such a name is given because this arrangement is the same folding motif used in other heme/globin proteins such as myoglobin. ...

"N-Baltimore.html". globin.bx.psu.edu. Retrieved 2017-03-30. "Medical Archives - Personal Paper Collections: The C. Lockard ... Disorders of globin and globulin proteins, Mutation). ...

These globin genes in the globin family are all well conserved and only differ by a small portion of the gene, indicating that ... The globin gene family is an elaborate network of genes consisting of alpha and beta globin genes including genes that are ... An example of a gene family that may have been created due to copy number variations is the globin gene family. ... Goodman M, Koop BF, Czelusniak J, Weiss ML (December 1984). "The eta-globin gene. Its long evolutionary history in the beta- ...

Table 1: α represents the presence of α-globin gene and- represents the deletion of α-globin gene. The chance of a fetus ... As a result, gamma chains will accumulate and form four gamma globins. These gamma globins bind to form hemoglobin Barts. It is ... three alpha globin gene deletions). Deletion of four alpha globin genes was previously felt to be incompatible with life, but ... As an embryo develops, it begins to produce alpha-globins at weeks 5-6 of development. When both of the HBA1 and HBA2 genes ...

... is a globin molecule ubiquitously expressed in all tissues and most notably utilized in marine mammals. It was ... Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans JP, Moens L (Aug 2003). "A globin in the nucleus!". The Journal of ... Burmester T, Ebner B, Weich B, Hankeln T (Apr 2002). "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate ... Burmester T, Ebner B, Weich B, Hankeln T (Apr 2002). "Cytoglobin: a novel globin type ubiquitously expressed in vertebrate ...

"Regulation of Globin Gene Expression". {{cite journal}}: Cite journal requires ,journal= (help) "World Renowned Geneticist ... His team sought to understand globin gene expression, studying both cis- and trans-acting components that regulate ...

Banerji J, Rusconi S, Schaffner W (December 1981). "Expression of a beta-globin gene is enhanced by remote SV40 DNA sequences ... Evans T, Felsenfeld G, Reitman M (1990). "Control of globin gene transcription". Annual Review of Cell Biology. 6: 95-124. doi: ... high-level expression of the human beta-globin gene in transgenic mice". Cell. 51 (6): 975-85. doi:10.1016/0092-8674(87)90584-8 ...

I. Helical regions of human alpha and beta globins". Biochemical and Biophysical Research Communications. 97 (3): 868-874. doi: ...

These globins reside inside a cell, much like the vertebrate Hb. Multi-subunit Hbs. These globins form complexes and work ... These globins form complexes, work outside a cell, and have multiple globin domains per peptide chain. Erythrocruorin and ... The isolation of the globin gene from plant root cells has suggested that the globin genes that were inherited from a common ... Globin enjoys a large biological distribution, not only occurring among more than 9 different phyla of animals but occurring in ...

Weatherall, D. J. (2015). "The Thalassemias: Disorders of Globin Synthesis". Williams Hematology (9e ed.). McGraw Hill ...

The epsilon globin gene (HBE) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains ... Tuan D, Solomon W, Li Q, London IM (1985). "The "beta-like-globin" gene domain in human erythroid cells". Proc. Natl. Acad. Sci ... The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilon - gamma- ... 1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019 ...

Non-legume symbiotic globins (SymPhytogbs) are scattered among Phytogb1 and Phytogb2. Symbiotic globins generally provide ... Hill R.; Hargrove M. S.; Arredondo-Peter R (2016). "Phytoglobin: a novel nomenclature for plant globins accepted by the globin ... Furthermore, the structure of the globin domain from Phytogbs3 is highly similar to that of bacterial truncated globins ... known as the globin fold which forms a hydrophobic pocket where heme is located. Two types of the globin fold have been ...

Villeponteau, B., Landes, G.M., Pankratz, M.J., and Martinson, H.G. (1982). The chicken beta globin gene region. Delineation of ... Lois, R., Freeman, L., Villeponteau, B., and Martinson, H.G. (1990). Active beta-globin gene transcription occurs in methylated ... Villeponteau, B., and Martinson, H.G. (1981). Isolation and characterization of the complete chicken beta-globin gene region: ... where he carried out genomic cloning of the B-globin gene cluster in Chickens.... He continued in the same department for six ...

The technology is based on delivery of a lentiviral vector carrying both the human β-globin gene and an ankyrin insulator to ... This test is used to investigate deletions and mutations in the alpha- and beta-globin-producing genes. Family studies can be ... Mutations are characterized as (βo) if they prevent any formation of β globin chains, mutations are characterized as (β+) if ... Most often, mutations occur in the promoter regions preceding the beta-globin genes. Less often, abnormal splice variants are ...

... zeta globins) and two ε globins (epsilon globins) (ζ2ε2) Hb Gower-2, composed of two alpha globins and two epsilon globins ( ... The severity of alpha and beta thalassemia depends on how many of the four genes for alpha globin or two genes for beta globin ... HbF induction is an attempt to reactivate fetal globin gene transcription. Efforts involve trying to disrupt the fetal globin ... α2ε2) Hb Portland, composed of two zeta globins and two gamma globins (ζ2γ2) Fetal Hb (Hb F) is produced from approximately ...

Freitas, Tracey Allen K.; Saito, Jennifer A.; Wan, Xuehua; Hou, Shaobin; Alam, Maqsudul (2008), "Protoglobin and Globin-coupled ... Synteny and Collinearity in Plant Genomes (2008). Protoglobin and globin-coupled sensors (2008). "About Professor Maqsudul Alam ...

The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains ... 1979). "Human T gamma globin chain is a variant of A gamma chain (A gamma Sardinia)". Proc. Natl. Acad. Sci. U.S.A. 76 (7): ... Fucharoen S, Shimizu K, Fukumaki Y (1990). "A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in ... 1977). "Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA". J. Biol. Chem. 252 (14): 5019 ...

Expression of beta globin and the neighbouring globins in the β-globin locus is controlled by single locus control region (LCR ... Hemoglobin subunit beta (beta globin, β-globin, haemoglobin beta, hemoglobin beta) is a globin protein, coded for by the HBB ... The mutant alleles are subdivided into two groups: β0, in which no functional β-globin is made, and β+, in which a small amount ... The order of the genes in the beta-globin cluster is 5' - epsilon - gamma-G - gamma-A - delta - beta - 3'. HBB interacts with ...

... while alpha-globin is produced throughout fetal and adult life. The zeta-globin gene is a member of the human alpha-globin gene ... Zeta-globin is an alpha-like hemoglobin. The zeta-globin polypeptide is synthesized in the yolk sac of the early embryo, ... Lau ET, Kwok YK, Chui DH, Wong HS, Luo HY, Tang MH (July 2001). "Embryonic and fetal globins are expressed in adult erythroid ... Proudfoot NJ, Gil A, Maniatis T (December 1982). "The structure of the human zeta-globin gene and a closely linked, nearly ...

... is a member of the vertebrate globin family involved in cellular oxygen homeostasis and reactive oxygen/nitrogen ... It is of ancient evolutionary origin, and is homologous to nerve globins of invertebrates. Recent research confirmed the ... Burmester T, Weich B, Reinhardt S, Hankeln T (September 2000). "A vertebrate globin expressed in the brain". Nature. 407 (6803 ... science.gov, Neuroglobins, Pivotal Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity ...

In 1979, his research group isolated the gene for epsilon-globin (HBE1), a component of human embryonic hemoglobin. He was one ... Proudfoot, NJ; Baralle, FE (November 1979). "Molecular cloning of human epsilon-globin gene". Proceedings of the National ... Tito published the sequence of the messenger RNA coding for beta-globin, the first complete primary structure of a eukaryotic ... "The Structure and evolution of the human b-globin gene family" "TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral ...

Flavell, R. A. (1983). "The globin genes of rabbit and man. The eighteenth Colworth medal lecture". Biochemical Society ...

Cocca, E (1997). "Do the hemoglobinless icefishes have globin genes?". Comp. Biochem. Physiol. A. 118 (4): 1027-1030. doi: ...

The β-globin LCR in mice and humans is found 6-22 kb upstream of the first globin gene (epsilon). It controls the following ... The β-globin LCR was identified over 20 years ago in studies of transgenic mice. These studies determined that the LCR was ... Although the name implies that the LCR is limited to a single region, this implication only applies to the β-globin LCR (HBB- ... It functions in a copy number-dependent manner and is tissue-specific, as seen in the selective expression of β-globin genes in ...

... and his inquisitive and mischievous friend Globin. They carry oxygen bubbles or carbon dioxide bubbles in a back pouch, ... Plasmus and Globina for Hemo and Globin, Corpo for Jumbo; Toxicus, Germus and Infectius for the bacterium characters; Virulus ...