... is a Human immunodeficiency virus gene and protein product. Vpr stands for "Viral Protein R". Vpr, a 96 amino acid 14-kDa ... Vpr+Gene+Products,+Human+Immunodeficiency+Virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Genes ... Two functions of Vpr in HIV-1 are split between Vpr and Vpx in HIV-2, with the HIV-2 Vpr protein inducing cell cycle arrest and ... When bound to Vpr, VprBP allows Vpr to modulate the catalytic activity of the CUL4-DDB1 complex, inducing G2 cell cycle arrest ...

Gene. 263 (1-2): 131-40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251. "Entrez Gene: VPRBP Vpr (HIV-1) binding protein". ... Protein VPRBP is a protein that in humans is encoded by the VPRBP gene. VPRBP has been shown to interact with Merlin. GRCh38: ... Wen X, Duus KM, Friedrich TD, de Noronha CM (September 2007). "The HIV1 protein Vpr acts to promote G2 cell cycle arrest by ... Le Rouzic E, Belaïdouni N, Estrabaud E, Morel M, Rain JC, Transy C, Margottin-Goguet F (January 2007). "HIV1 Vpr arrests the ...

Stark LA, Hay RT (Apr 1998). "Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) interacts with Lys-tRNA ... "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) ... "Entrez Gene: KARS lysyl-tRNA synthetase". Yannay-Cohen N, Carmi-Levy I, Kay G, Yang CM, Han JM, Kemeny DM, Kim S, Nechushtan H ... Lysyl-tRNA synthetase is an enzyme that in humans is encoded by the KARS gene. Aminoacyl-tRNA synthetases are a class of ...

Importin-5 is a protein that in humans is encoded by the IPO5 gene. The protein encoded by this gene is a member of the ... Vodicka MA, Koepp DM, Silver PA, Emerman M (January 1998). "HIV-1 Vpr interacts with the nuclear transport pathway to promote ... "Entrez Gene: RANBP5 RAN binding protein 5". Chao HW, Lai YT, Lu YL, Lin CL, Mai W, Huang YS (September 2012). "NMDAR signaling ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 13, All stub articles, ...

Lamin-B1 is a protein that in humans is encoded by the LMNB1 gene. The nuclear lamina consists of a two-dimensional matrix of ... Vodicka MA, Koepp DM, Silver PA, Emerman M (1998). "HIV-1 Vpr interacts with the nuclear transport pathway to promote ... Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Lamin B, along with ... "Entrez Gene: LMNB1 lamin B1". Furukawa, K; Kondo T (Feb 1998). "Identification of the lamina-associated-polypeptide-2-binding ...

"Entrez Gene: TNPO1 transportin 1". R.A. Fridell (1997). Nuclear import of hnRNP A1 is mediated by a novel cellular cofactor ... Bukrinsky MI, Haffar OK (1998). "HIV-1 nuclear import: matrix protein is back on center stage, this time together with Vpr". ... Transportin-1 (or Importin-β 2) is a protein that in humans is encoded by the TNPO1 gene. This protein is a karyopherin which ... The classical karyopherin receptor complex, such as the complex that uses Importin-β1 (encoded by gene KPNB1), is a heterodimer ...

... gene which is essential for viability of Saccharomyces cerevisiae cells". Gene. 171 (1): 27-32. doi:10.1016/0378-1119(96)00024- ... 2006). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism". Cell Death Differ. 12 ... "Entrez Gene: KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)". Muthumani K, Choo AY, Premkumar A, et al. ( ... KRR1 small subunit processome component homolog is a protein that in humans is encoded by the KRR1 gene. GRCh38: Ensembl ...

The CYC1 gene produces a 13.5 kDa protein composed of 130 amino acids. CYC1 belongs to the cytochrome c family. CYC1 is a ... Moon HS, Yang JS (February 2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Molecules ... Mutations in this gene may cause mitochondrial complex III deficiency, nuclear, type 6. CYC1 is located on the q arm of ... "Entrez Gene: CYC1 cytochrome c-1". "CYC1 - Cytochrome c1, heme protein, mitochondrial precursor - Homo sapiens (Human) - CYC1 ...

iCasp9 can be added to the CAR T cells as an inducible suicide gene. If therapy with CAR T cells results in severe side effects ... Moon HS, Yang JS (February 2006). "Role of HIV Vpr as a regulator of apoptosis and an effector on bystander cells". Molecules ... Caspase-9 is an enzyme that in humans is encoded by the CASP9 gene. It is an initiator caspase, critical to the apoptotic ... "CASP9 caspase 9 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-11-30. Li P, Zhou L, Zhao T, Liu X ...

"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) ... Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast ( ... "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) ... "Entrez Gene: PPP2R5C protein phosphatase 2, regulatory subunit B', gamma isoform". McCright B, Rivers AM, Audlin S, Virshup DM ...

Janket ML, Manickam P, Majumder B (2004). "Differential regulation of host cellular genes by HIV-1 viral protein R (Vpr): cDNA ... "Entrez Gene: DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and ... DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene. GRCh38: Ensembl release 89: ... v t e (CS1: long volume value, Articles with short description, Short description matches Wikidata, Genes on human chromosome 2 ...

Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS (1995). "The human immunodeficiency virus type 1 vpr gene arrests ... Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS (1997). "Human immunodeficiency virus type 1 vpr gene induces ... "Entrez Gene: CCNB2 cyclin B2". Liu JH, Wei S, Burnette PK, Gamero AM, Hutton M, Djeu JY (Jan 1999). "Functional association of ... G2/mitotic-specific cyclin-B2 is a protein that in humans is encoded by the CCNB2 gene. Cyclin B2 is a member of the cyclin ...

The dCAs9-VPR system is used as an activator by targeting it to the promoter of a gene upstream of the coding region. A study ... Thus, the dCas9-SAM system can further be employed to activate latent genes, develop gene therapies, and discover new genes. ... When different genes were targeted by dCas9, they all showed significantly greater expression with dCas9-VPR than with dCas9- ... dCas9-VPR has been used to activate the neurogenin 2 (link) and neurogenic differentiation 1 (link) genes, resulting in ...

WEE1 homolog (S. pombe), also known as WEE1, is a protein which in humans is encoded by the WEE1 gene. This gene encodes a ... 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast (Schizosaccharomyces pombe) through a pathway involving ... Genes on human chromosome 11, EC 2.7.11, All stub articles, Human chromosome 11 gene stubs). ... "Entrez Gene: WEE1 WEE1 homolog (S. pombe)". Wang, Y; Jacobs C; Hook K E; Duan H; Booher R N; Sun Y (April 2000). "Binding of 14 ...

Chemokine (C-C motif) ligand 5 (also CCL5) is a protein which in humans is encoded by the CCL5 gene. The gene has been ... Zhao RY, Bukrinsky M, Elder RT (April 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of ... Zeng Z, Lan T, Wei Y, Wei X (January 2022). "CCL5/CCR5 axis in human diseases and related treatments". Genes & Diseases. 9 (1 ... RANTES expression is regulated in T lymphocytes by Kruppel like factor 13 (KLF13). The CCL5 gene is activated after 3-5 days ...

"Entrez Gene: NUPL2 nucleoporin like 2". Fouchier RA, Meyer BE, Simon JH, et al. (1998). "Interaction of the human ... 2003). "Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1". J. Biol. Chem. ... Nucleoporin-like 2 is a protein that in humans is encoded by the NUPL2 gene. GRCh38: Ensembl release 89: ENSG00000136243 - ... 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome ...

Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS (1995). "The human immunodeficiency virus type 1 vpr gene arrests ... "Entrez Gene: CCNB1 cyclin B1". Kimura K, Hirano M, Kobayashi R, Hirano T (October 1998). "Phosphorylation and activation of 13S ... The gene product complexes with p34 (Cdk1) to form the maturation-promoting factor (MPF). Two alternative transcripts have been ... G2/mitotic-specific cyclin-B1 is a protein that in humans is encoded by the CCNB1 gene. Cyclin B1 is a regulatory protein ...

"Specific G2 arrest of caprine cells infected with a caprine arthritis encephalitis virus expressing vpr and vpx genes from ... Although Vpr and Vpx are similar in size (both are ~100 amino acids with 20-25% sequence similarity) and structure (both are ... Vpx targets a host restriction factor for proteasomal degradation, while Vpr arrests the host cell cycle in the G2 phase. ... It is similar in structure to the protein Vpr that is carried by SIV and HIV-2 as well as HIV-1. Vpx is one of five accessory ...

It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr. COPS6 ... Jowett JB, Planelles V, Poon B, Shah NP, Chen ML, Chen IS (1995). "The human immunodeficiency virus type 1 vpr gene arrests ... Poon B, Jowett JB, Stewart SA, Armstrong RW, Rishton GM, Chen IS (1997). "Human immunodeficiency virus type 1 vpr gene induces ... COP9 signalosome complex subunit 6 is a protein that in humans is encoded by the COPS6 gene. The protein encoded by this gene ...

The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which ... Zhao RY, Bukrinsky M, Elder RT (2005). "HIV-1 viral protein R (Vpr) & host cellular responses". Indian J. Med. Res. 121 (4): ... the transcription factor that regulates heat shock gene expression". Genes Dev. 6 (7): 1153-64. doi:10.1101/gad.6.7.1153. PMID ... This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 (Hsp70) family. As a ...

Accordingly, gene expression by degradation of transcription factors, such as p53, c-jun, c-Fos, NF-κB, c-Myc, HIF-1α, MATα2, ... Mahalingam S, Ayyavoo V, Patel M, Kieber-Emmons T, Kao GD, Muschel RJ, Weiner DB (Mar 1998). "HIV-1 Vpr interacts with a human ... The gene PSMD7 encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 17. The human ... Sheehy AM, Gaddis NC, Choi JD, Malim MH (Aug 2002). "Isolation of a human gene that inhibits HIV-1 infection and is suppressed ...

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene. This gene is highly conserved during ... Re F, Braaten D, Franke EK, Luban J (1995). "Human immunodeficiency virus type 1 Vpr arrests the cell cycle in G2 by inhibiting ... "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)". Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V ... Amini S, Khalili K, Sawaya BE (2004). "Effect of HIV-1 Vpr on cell cycle regulators". DNA Cell Biol. 23 (4): 249-60. doi: ...

This gene encodes one of four subunits of the splicing factor 3B. The protein encoded by this gene cross-links to a region in ... Terada Y, Yasuda Y (Nov 2006). "Human immunodeficiency virus type 1 Vpr induces G2 checkpoint activation by interacting with ... SF3B4 human gene location in the UCSC Genome Browser. SF3B4 human gene details in the UCSC Genome Browser. v t e (Articles with ... Genes & Development. 8 (16): 1974-83. doi:10.1101/gad.8.16.1974. PMID 7958871. "Entrez Gene: SF3B4 splicing factor 3b, subunit ...

... synergy with GR for full transcriptional increase of the alpha 2-macroglobulin gene". Genes & Development. 17 (20): 2564-2577. ... Le Rouzic E, Benichou S (February 2005). "The Vpr protein from HIV-1: distinct roles along the viral life cycle". Retrovirology ... Because the receptor gene is expressed in several forms, it has many different (pleiotropic) effects in different parts of the ... The GR is expressed in almost every cell in the body and regulates genes controlling the development, metabolism, and immune ...

This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. PPP2R5A has been shown to interact with: AXIN1, ... Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (Sep 2001). "HIV-1 Vpr induces cell cycle G2 arrest in fission yeast ( ... "Entrez Gene: PPP2R5A protein phosphatase 2, regulatory subunit B', alpha isoform". Yamamoto H, Hinoi T, Michiue T, Fukui A, ... The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four ...

Cohen, E.A., Terwilliger, E.F. and Haseltine, W.A. The Vpr protein of HIV-1 is a virion associated positive regulatory protein ... Göttlinger, H. and Cohen, E.A. The Vpu gene product of HIV. HIV: a practical approach. Volume 2. Biochemistry, Molecular ... Richard, J.; Sindhu, S.; Pham, T. N.; Belzile, J. P.; Cohen, E. A. (2010). "HIV-1 VPR up-regulates expression of ligands for ... His work was also involved in defining Vpr as a viral factor with immune-modulatory functions. Cohen has investigated the role ...

"Entrez Gene: PCNT pericentrin (kendrin)". Chen H, Gos A, Morris MA, Antonarakis SE (Aug 1996). "Localization of a human homolog ... Chang F, Re F, Sebastian S, Sazer S, Luban J (Apr 2004). "HIV-1 Vpr induces defects in mitosis, cytokinesis, nuclear structure ... Pericentrin (kendrin), also known as PCNT and pericentrin-B (PCNTB), is a protein which in humans is encoded by the PCNT gene ... The protein encoded by this gene is expressed in the cytoplasm and centrosome throughout the cell cycle, and to a lesser extent ...

Vpr acts via distinct mechanisms to cooperate with Nef in NFAT-directed gene expression and to promote transactivation by CREB ... The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of ... "Entrez Gene: NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4". Yang T, Davis RJ, Chow CW (Oct ... Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene. The product of ...

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene. This gene encodes subunit 2 of the ... "Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr". ... Genes & Development. 10 (2): 233-43. doi:10.1101/gad.10.2.233. PMID 8566756. "Entrez Gene: SF3B2 splicing factor 3b, subunit 2 ... Articles with short description, Short description matches Wikidata, Genes on human chromosome 11). ...

tev: This gene is only present in a few HIV-1 isolates. It is a fusion of parts of the tat, env, and rev genes, and codes for a ... HIV-2 and SIV encode an additional Vpr related protein called Vpx which functions in association with Vpr. vif - Vif is a ... genes unique to HIV. The HIV genome contains nine genes that encode fifteen viral proteins. These are synthesized as ... vpr (lentivirus protein R): Vpr is a virion-associated, nucleocytoplasmic shuttling regulatory protein. It is believed to play ...