EIF5 is a GTPase-activating protein. Furthermore, YopE is a protein domain that is a Rho GTPase-activating protein (GAP), which ... GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to ... With a nonfunctional G protein enzyme, GAPs cannot activate the GTPase activity, and the G protein is constitutively on. This ... These G proteins acquire missense mutations that disrupt the inherent GTPase activity of the proteins. The mutant G proteins ...

... is a protein that in humans is encoded by the ARHGAP21 gene. ARHGAP21 functions preferentially ... "Entrez Gene: Rho GTPase activating protein 21". Retrieved 2017-01-30. Rosa LRO; Soares, G. M.; Silveira, L. R.; Boschero, A. C ... a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein". Biochem. Biophys. Res. Commun. 294 (3 ... "β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II ...

... (IQGAP) is a carrier protein. It is associated with the Rho GTP-binding protein. ... IQGAP1, IQGAP2, IQGAP3 IQ calmodulin-binding motif v t e (All stub articles, Protein stubs, GTP-binding protein regulators). ...

... is a protein that in humans is encoded by the ABR gene. The ABR activator of RhoGEF ... Additionally, the protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the ... "Entrez Gene: ABR, RhoGEF and GTPase activating protein". Retrieved 2018-05-23. "Gene: Abr (ENSMUSG00000017631) - Summary - Mus ... two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages". Molecular and ...

Rho GTPase activating protein 18 is a protein that in humans is encoded by the ARHGAP18 gene. The gene is also known as MacGAP ... "Rho GTPase activating protein 18". Retrieved 2011-12-05. Potkin, S. G.; Turner, J. A.; Fallon, J. A.; Lakatos, A.; Keator, D. B ... ARHGAP18 belongs to a family of Rho GTPase-activating proteins that modulate cell signaling. Model organisms have been used in ... v t e (Articles with short description, Short description matches Wikidata, Human proteins, Genes mutated in mice, All stub ...

Rho GTPase activating protein 25 is a protein that in humans is encoded by the ARHGAP25 gene. The gene is also known as ... "Rho GTPase activating protein 25". Retrieved 2011-12-05. Katoh M, Katoh M (August 2004). "Identification and characterization ... ARHGAP25 belongs to a family of Rho GTPase-modulating proteins that are implicated in actin remodeling, cell polarity, and cell ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 2, Human proteins, Genes ...

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene. EIF5 is a GTPase-activating ... Das S, Ghosh R, Maitra U (2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol ... "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720-6. doi: ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...

Rho GTPase activating protein 44 is a protein in humans that is encoded by the ARHGAP44 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: Rho GTPase activating protein 44". Retrieved 2013-05-13. Human ARHGAP44 genome location and ARHGAP44 gene details ... "Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein RICH2". Molecular Brain. 9 (28). (Articles ...

RAB GTPase activating protein 1 is a protein in humans that is encoded by the RABGAP1 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: RAB GTPase activating protein 1". Caratù G, Allegra D, Bimonte M, Schiattarella GG, D'Ambrosio C, Scaloni A, ... a GTPase activating protein for Rab6, part of which associates with the centrosome". The EMBO Journal. 18 (7): 1772-82. doi: ... "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus ...

The Rho GTPase activating protein 31 is encoded in humans by the ARHGAP31 gene. It is a Cdc42/Rac1 GTPase regulator. ARHGAP31 ... 2002). "The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin". J. Biol. Chem. ... Lamarche-Vane N, Hall A (1998). "CdGAP, a novel proline-rich GTPase-activating protein for Cdc42 and Rac". J. Biol. Chem. 273 ( ... 2006). "The human orthologue of CdGAP is a phosphoprotein and a GTPase-activating protein for Cdc42 and Rac1 but not RhoA". ...

"Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1". Cell. 65 (6): 1033-42. doi:10.1016/ ... Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene. RAP1GAP has been shown to interact ... "Entrez Gene: RAP1GAP RAP1 GTPase activating protein". Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N ( ... "Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. ...

... is a GTPase-activating protein (GAP). It accelerates the GTP hydrolysis on G proteins determining their fast inactivation ... Regulator of G-protein signaling 7 is a protein that in humans is encoded by the RGS7 gene. RGS7 is highly enriched in the ... Snow BE, Betts L, Mangion J, Sondek J, Siderovski DP (1999). "Fidelity of G protein β-subunit association by the G protein γ- ... "The R7 RGS Protein Family: Multi-Subunit Regulators of Neuronal G Protein Signaling". Cell Biochemistry and Biophysics. 54 (1-3 ...

Rho GTPase activating protein 27 is a protein that in humans is encoded by the ARHGAP27 gene. This gene encodes a member of a ... "Entrez Gene: Rho GTPase activating protein 27". Retrieved 2018-05-30. PDBe-KB provides an overview of all the structure ... information available in the PDB for Human Rho GTPase-activating protein 27 (ARHGAP27) This article incorporates text from the ... large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may play ...

Roychowdhury S, Panda D, Wilson L, Rasenick MM (May 1999). "G protein alpha subunits activate tubulin GTPase and modulate ... Tian G, Bhamidipati A, Cowan NJ, Lewis SA (August 1999). "Tubulin folding cofactors as GTPase-activating proteins. GTP ... Tubulin+GTPase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Articles with short ... Tubulin GTPase (EC 3.6.5.6) is an enzyme with systematic name GTP phosphohydrolase (microtubule-releasing). This enzyme ...

Rho GTPase-activating protein 19 is an enzyme that in humans is encoded by the ARHGAP19 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARHGAP19 Rho GTPase activating protein 19". Human ARHGAP19 genome location and ARHGAP19 gene details page in the ...

... and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903-45914. ... Rho GTPase-activating protein 8 is a protein that in humans is encoded by the ARHGAP8 gene. This gene encodes a member of the ... GAP (GTPase-activating) family proteins participate in signaling pathways that regulate cell processes involved in cytoskeletal ... "Entrez Gene: ARHGAP8 Rho GTPase activating protein 8". Human ARHGAP8 genome location and ARHGAP8 gene details page in the UCSC ...

... and GTPase-activating protein domains of a novel Rho GTPase-activating protein, BPGAP1". J. Biol. Chem. 278 (46): 45903-14. doi ... "Crystal structure of a small G protein in complex with the GTPase-activating protein rhoGAP". Nature. 388 (6643): 693-7. doi: ... "Characterization of the interactions between the small GTPase Cdc42 and its GTPase-activating proteins and putative effectors. ... "Magnesium fluoride-dependent binding of small G proteins to their GTPase-activating proteins". Biochemistry. 38 (45): 14981-7. ...

Rho GTPase-activating protein 4 is an enzyme that in humans is encoded by the ARHGAP4 gene. It has been shown to regulate cell ... 2002). "p115 Rho GTPase activating protein interacts with MEKK1". J. Cell. Physiol. 192 (2): 200-8. doi:10.1002/jcp.10125. PMID ... "Entrez Gene: ARHGAP4 Rho GTPase activating protein 4". Vogt, DL; Gray, CD; Young Ws, 3rd; Orellana, SA; Malouf, AT (2007). " ... Katoh M, Katoh M (2004). "FNBP2 gene on human chromosome 1q32.1 encodes ARHGAP family protein with FCH, FBH, RhoGAP and SH3 ...

August 2002). "p115 Rho GTPase activating protein interacts with MEKK1". Journal of Cellular Physiology. 192 (2): 200-208. doi: ... Mitogen-activated protein kinase kinases (MAP2Ks) are substrates for direct phosphorylation by the MAP3K1 protein kinase. The ... "Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein ... "Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein ...

Rho GTPase-activating protein 5 is an enzyme that in humans is encoded by the ARHGAP5 gene. Rho GTPase activating protein 5 ... Chakravarty G, Roy D, Gonzales M, Gay J, Contreras A, Rosen JM (2000). "P190-B, a Rho-GTPase-activating protein, is ... Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM (2006). "P190-B Rho GTPase-activating protein overexpression ... "Entrez Gene: ARHGAP5 Rho GTPase activating protein 5". Wennerberg K, Forget MA, Ellerbroek SM, Arthur WT, Burridge K, Settleman ...

Ran GTPase-activating protein 1 is an enzyme that in humans is encoded by the RANGAP1 gene. RanGAP1, is a homodimeric 65-kD ... Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A (May 1995). "RNA1 encodes a GTPase-activating protein ... Becker J, Melchior F, Gerke V, Bischoff FR, Ponstingl H, Wittinghofer A (1995). "RNA1 encodes a GTPase-activating protein ... "Entrez Gene: RANGAP1 Ran GTPase activating protein 1". Hochstrasser M (2000). "Biochemistry. All in the ubiquitin family". ...

GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic ... Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene. Rho GTPases control a variety of ... "Entrez Gene: RACGAP1 Rac GTPase activating protein 1". Ren K, Zhou D, Wang M, Li E, Hou C, Su Y, et al. (March 2021). "RACGAP1 ... June 2000). "CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis". The ...

The CDC42 GTPase, which is controlled by nucleotide exchange factors (GEFs; see MIM 606057) and GTPase-activating proteins ( ... Joberty G, Petersen C, Gao L, Macara IG (Oct 2000). "The cell-polarity protein Par6 links Par3 and atypical protein kinase C to ... Partitioning defective 3 homolog is a protein that in humans is encoded by the PARD3 gene. PARD proteins, which were first ... "Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in ...

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity ... Rho GTPase-activating protein 9 is an enzyme that in humans is encoded by the ARHGAP9 gene. ... "Entrez Gene: ARHGAP9 Rho GTPase activating protein 9". Human ARHGAP9 genome location and ARHGAP9 gene details page in the UCSC ... encoding a rho-GTPase activating protein". Biochemical and Biophysical Research Communications. 284 (3): 643-9. doi:10.1006/ ...

July 2003). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d- ... Zhang B, Zheng Y (April 1998). "Regulation of RhoA GTP hydrolysis by the GTPase-activating proteins p190, p50RhoGAP, Bcr, and ... Transforming protein RhoA, also known as Ras homolog family member A (RhoA), is a small GTPase protein in the Rho family of ... Zhang B, Chernoff J, Zheng Y (April 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A ...

The HRG ligand activates a GTPase activating protein. Cowden Syndrome is a genetic disorder that makes an individual more ... They differ with the GCDFP-15 protein, HER-2/neu status, EGFR status, KRAS gene status, p16lnk4a protein, cyclin d1 protein, ...

Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARHGAP24 Rho GTPase activating protein 24". Human ARHGAP24 genome location and ARHGAP24 gene details page in the ... Lavelin I, Geiger B (Feb 2005). "Characterization of a novel GTPase-activating protein associated with focal adhesions and the ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ...

Rho GTPase activating protein 26 (ARHGAP26) also known as GTPase Regulator Associated with Focal Adhesion Kinase (GRAF) is a ... ARHGAP26 Rho GTPase activating protein 26". Hildebrand JD, Taylor JM, Parsons JT (June 1996). "An SH3 domain-containing GTPase- ... "PKNbeta interacts with the SH3 domains of Graf and a novel Graf related protein, Graf2, which are GTPase activating proteins ... Lundmark R, Doherty GJ, Howes MT, Cortese K, Vallis Y, Parton RG, McMahon HT (November 2008). "The GTPase-activating protein ...

This particular protein domain can be referred to as a Rho GTPase-activating protein (GAP). YopE is an effector protein of the ... It functions as a Rho GTPase-activating protein (GAP). YopE acts as both a virulence factor and a protective antigen. In order ... This bundle acts as the GAP domain, because arginine from an alpha helix is inserted into a GTP-ase which catalyses GTP ... Rosqvist R, Forsberg A, Rimpiläinen M, Bergman T, Wolf-Watz H (April 1990). "The cytotoxic protein YopE of Yersinia obstructs ...

SLIT-ROBO Rho GTPase activating protein 2C is a protein in humans that is encoded by the SRGAP2C gene. Cortical development ... "Entrez Gene: SLIT-ROBO Rho GTPase activating protein 2C". Charrier C, Joshi K, Coutinho-Budd J, Kim JE, Lambert N, de Marchena ... gene Slit-Robo Rho GTPase-activating protein 2 (SRGAP2) has been highly conserved over mammalian evolution, and human is the ... SRGAP2C is the most likely duplicate to encode a functional protein and is among the most fixed human-specific duplicate genes ...