... and they are thought to be under the influence of the GATA4 transcription factor. GATA4 inactivation, with GATA4-null mice, ... Transcription factor GATA-4 is a protein that in humans is encoded by the GATA4 gene. This gene encodes a member of the GATA ... GATA4 works in combination with other essential cardiac transcription factors as well, such as Nkx2-5 and Tbx5. GATA4 is ... Tremblay JJ, Viger RS (1999). "Transcription factor GATA-4 enhances Müllerian inhibiting substance gene transcription through a ...

Wakana K, Akiyama Y, Aso T, Yuasa Y (September 2006). "Involvement of GATA-4/-5 transcription factors in ovarian carcinogenesis ... "GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in ... Transcription factor GATA-5 is a protein that in humans is encoded by the GATA5 gene. The protein encoded by this gene is a ... Gata5 is a transcription factor. Gata5 regulates the proper development of the heart. Early in embryo development, Gata5 helps ...

GATA-4, a transcription factor, also may be useful in the diagnosis of EST. Diagnosis of EST in pregnant women and in infants ... "Transcription Factor GATA-4 Is Expressed in Pediatric Yolk Sac Tumors". American Journal of Pathology. 155 (6): 1823-9. doi: ...

This was done using three transcription factors: GATA4, Mef2c, and Tbx5. Cardiac fibroblasts make up more than half of all ... Blackburn, CC (April 2014). "Regeneration of the aged thymus by a single transcription factor". Development. 141 (8): 1627-1637 ... 2010). "Direct Reprogramming of Fibroblasts into Functional Cardiomyocytes by Defined Factors". Cell. 142 (3): 375-386. doi: ...

NKX2-5 has been shown to interact with GATA4 and TBX5. NKX2-5 is a transcription factor that regulates heart development from ... Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M (September 1997). "The cardiac transcription factors Nkx2-5 and GATA-4 ... Durocher D, Charron F, Warren R, Schwartz RJ, Nemer M (September 1997). "The cardiac transcription factors Nkx2-5 and GATA-4 ... NKX2-5 NK2 transcription factor related, locus 5 (Drosophila)". Akazawa H, Komuro I (May 2003). "Roles of cardiac transcription ...

Viger, R. S.; Mertineit, C.; Trasler, J. M.; Nemer, M. (1998-07-15). "Transcription factor GATA-4 is expressed in a sexually ... "Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor". Development. 124 (12): 2387- ... "The cardiac transcription factors Nkx2‐5 and GATA‐4 are mutual cofactors". The EMBO Journal. 16 (18): 5687-5696. doi:10.1093/ ... "A Murine Model of Holt-Oram Syndrome Defines Roles of the T-box Transcription Factor Tbx5 in Cardiogenesis and Disease". Cell. ...

In order to elucidate the mechanism of myogenesis in P19 cells, several cardiac specific transcription factors including GATA-4 ... "Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor". Development. 124 (12): 2387-95 ... through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx-2.5 and GATA-4". ... "Increased levels of FoxA1 transcription factor in pluripotent P19 embryonal carcinoma cells stimulate neural differentiation". ...

The transcription factor GATA4 forms a complex with the TBX5 which interacts with MYH6. Another factor, the homeobox ( ... Risk factors include certain infections during pregnancy such as rubella, use of certain medications or drugs such as alcohol ... Having a parent with a congenital heart defect is also a risk factor. A number of genetic conditions are associated with heart ... The Wnt signaling co-factors BCL9, BCL9L and PYGO might be part of these molecular pathways, as when their genes are mutated, ...

"Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4". Molecular Cell. 9 (2): 279 ... Forkhead box protein A2 (FOXA2), also known as hepatocyte nuclear factor 3-beta (HNF-3B), is a transcription factor that plays ... The proteins were therefore originally named hepatocyte nuclear factor 3 alpha, beta and gamma. These transcription factors ... restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3 beta involves a cell-specific factor ...

"Opening of Compacted Chromatin by Early Developmental Transcription Factors HNF3 (FoxA) and GATA-4". Molecular Cell. 9 (2): 279 ... His laboratory discovered and named pioneer transcription factors that can bind to compacted chromosome domains harboring ... Zaret, Kenneth S. (September 4, 2020). "Pioneer Transcription Factors Initiating Gene Network Changes". Annual Review of ... The mechanism of targeting of silent, compacted chromosome domains by pioneer factors has since been found by many laboratories ...

Blocking Nodal and BMP also induces lineage-specific transcription factors Gata4 and Tbx5, which interact with Baf60c. ... Bouwmeester T, Kim S, Sasai Y, Lu B, De Robertis EM (August 1996). "Cerberus is a head-inducing secreted factor expressed in ... This induces Brahma-associated factor 60c (Baf60c), one of three Baf60 variants (a, b, and c) that are mutually exclusively ... For the heart, Cerberus is one of several factors that inhibits Nodal to initiate cardiomyogenic differentiation The Cerberus ...

For example, it has been shown to bind directly with the N-terminal zinc finger of the GATA4 transcription factor to inhibit ... Svensson EC, Tufts RL, Polk CE, Leiden JM (March 1999). "Molecular cloning of FOG-2: a modulator of transcription factor GATA-4 ... The ZFPM2 protein interacts primarily with the GATA4 but also with GATA2, GATA5, and GATA6 transcription factors. ZFPM2 ... Its members may act as coactivators and/or corepressors to modulate the activity of GATA transcription factors. That is, the ...

NF-κB is expressed as a result of inhibition of autophagy-mediated degradation of the transcription factor GATA4. GATA4 is ... SASP expression is induced by a number of transcription factors, including C/EBPβ, of which the most important is NF-κB. NF-κB ... SASP factors IL-6 and TNFα enhance T-cell apoptosis, thereby impairing the capacity of the adaptive immune system. SASP factors ... SASP factors cause non-senescent cells to become senescent. SASP factors induce insulin resistance. SASP disrupts normal tissue ...

Transcription factors GATA4 and NKX2-5 have been shown to physically interact with TBX20 and enhance gene expression. Tbx2 was ... Tbx20 is a transcription factor that is essential for proper heart development in a growing fetus. Any mutations in this gene ... Liu C, Shen A, Li X, Jiao W, Zhang X, Li Z (1 November 2008). "T-box transcription factor TBX20 mutations in Chinese patients ... Song MR, Shirasaki R, Cai CL, Ruiz EC, Evans SM, Lee SK, Pfaff SL (Dec 2006). "T-Box transcription factor Tbx20 regulates a ...

Dai YS, Cserjesi P, Markham BE, Molkentin JD (July 2002). "The transcription factors GATA4 and dHAND physically interact to ... Dai YS, Cserjesi P, Markham BE, Molkentin JD (July 2002). "The transcription factors GATA4 and dHAND physically interact to ... In addition, this transcription factor plays an important role in limb and branchial arch development. In one study, it was ... Shen L, Li XF, Shen AD, Wang Q, Liu CX, Guo YJ, Song ZJ, Li ZZ (July 2010). "Transcription factor HAND2 mutations in sporadic ...

"Opening of compacted chromatin by early developmental transcription factors HNF3 (FoxA) and GATA-4". Molecular Cell. 9 (2): 279 ... Pioneer factors can function passively, by acting as a bookmark for the cell to recruit other transcription factors to specific ... Pioneer factors can exhibit their greatest range of effects on transcription through the modulation of epigenetic factors by ... Pioneer factors are transcription factors that can directly bind condensed chromatin. They can have positive and negative ...

... in part via the transcription factor GATA4. An additional study showed that beta-adrenergic signaling via protein kinase A and ... CARP is highly expressed in cardiac and skeletal muscle, and is a transcription factor involved in development and under ... "Transforming growth factor-beta/Smads signaling induces transcription of the cell type-restricted ankyrin repeat protein CARP ... Chen B, Zhong L, Roush SF, Pentassuglia L, Peng X, Samaras S, Davidson JM, Sawyer DB, Lim CC (2012). "Disruption of a GATA4/ ...

Mutation of HAND1 has been shown to hinder the effect of GATA4, another vital cardiac transcription factor, and is associated ... Mutation of HAND1 has been shown to hinder the effect of GATA4, another vital cardiac transcription factor, and is associated ... The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is ... Scott IC, Anson-Cartwright L, Riley P, Reda D, Cross JC (January 2000). "The HAND1 basic helix-loop-helix transcription factor ...

Kiiveri S, Liu J, Heikkilä P, Arola J, Lehtonen E, Voutilainen R, Heikinheimo M (2005). "Transcription factors GATA-4 and GATA- ... Kiiveri S, Liu J, Westerholm-Ormio M, Narita N, Wilson DB, Voutilainen R, Heikinheimo M (2003). "Transcription factors GATA-4 ... Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 ... Keijzer R, van Tuyl M, Meijers C, Post M, Tibboel D, Grosveld F, Koutsourakis M (February 2001). "The transcription factor ...

Viger RS, Mertineit C, Trasler JM, Nemer M (July 1998). "Transcription factor GATA-4 is expressed in a sexually dimorphic ... transcription GATA factors, sex-reversal gene DAX1, and follicle-stimulating hormone (FSH). Mutations in both the AMH gene and ... Shen WH, Moore CC, Ikeda Y, Parker KL, Ingraham HA (June 1994). "Nuclear receptor steroidogenic factor 1 regulates the ... Seifer DB, Maclaughlin DT (September 2007). "Mullerian Inhibiting Substance is an ovarian growth factor of emerging clinical ...

... which is a part of the T-box family of transcription factors. It also interacts with other genes, such as GATA4 and NKX2-5, and ... TBX5 is a transcription factor that codes for the protein called T-box 5. The transcription factors it encodes are necessary ... T-box transcription factor TBX5, (T-box protein 5) is a protein that in humans is encoded by the TBX5 gene. Abnormalities in ... "TBX5 t-Box Transcription Factor 5 [Homo Sapiens (Human)] - Gene - NCBI."". National Center for Biotechnology Information. U.S. ...

Phosphorylation of the transcription factor may activate it and that activated transcription factor may then activate the ... The endoderm is specified early in development by Gata4 expression, and Gata4 goes on to direct gut morphogenesis later. Gata4 ... Several cell function specific transcription factors (there are about 1,600 transcription factors in a human cell) generally ... when bound to its proper transcription factors called repressors, repress the transcription of the gene. Silencers and ...

Genetic changes that disable the transcription factors CNOT1, GATA4, GATA6, PDX1, PTF1A, or RFX6 - all involved in the ... Similarly, variations in the transcription factors GLIS3, NEUROD1, NEUROG3, NKX2-2, or MNX1 can result in malformed or absent β ... Other contributing factors are umbilical hernia and enlarged tongue, which are present in 9 and 30% of patients with chromosome ... The diagnostic evaluations are based upon the following evaluation factors: patients with TNDM are more likely to have ...

SRY acts as a transcription factor that causes upregulation of other transcription factors, most importantly SOX9. Its ... How these proteins regulate SRY transcription is not clear, but FOG2 and GATA4 mutants have significantly lower levels of SRY ... It's been shown that binding of three transcription factors, steroidogenic factor 1 (SF1), specificity protein 1 (Sp1 ... Sp1 is a transcription factor that binds GC-rich consensus sequences, and mutation of the SRY binding sites leads to a 90% ...

One gene Onecut1/Hnf6 (onecut domain family member 1 transcription factor) is also responsible for the timely expression of ... Similarly, another set of genes Gata4 (GATA binding protein 4) and Hnf1b/Tcf2 (HNF homobox B gene) is required for the ... This transcription factor has been shown to give rise to the multipotent stem cell lineages contributing to the endocrine, ... Sry-related HMB box transcription factor 9) and suppression of Notch signaling. Pancreatic Progenitor cells are hence Ngn3+/ ...

... between human and rat is related to the differential response of the Dio2 genes to Nkx-2.5 and GATA-4 transcription factors". ... Molnár I, Balázs C, Szegedi G, Sipka S (2002). "Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin- ...

The transcription factor c-Myc can also be used as the fourth factor and was the original fourth factor used by Shinya Yamanaka ... GATA4, NKX2-5, as well as the other three factors used for reprogramming. Glis1 also up-regulates expression of the protein ... The three transcription factors Oct3/4, Sox2 and Klf4 are essential for reprogramming but are extremely inefficient on their ... These pathways are activated due to the up regulation of the transcription factors N-Myc, Mycl1, c-Myc, Nanog, ESRRB, FOXA2, ...

Mice exposed in vivo, to three cardiac transcription factors GMT (Gata4, Mef2c, Tbx5) and the small-molecules: SB-431542 (the ... However, brief expression of a single transcription factor, the ELT-7 GATA factor, can convert the identity of fully ... Najm FJ, Lager AM, Zaremba A, Wyatt K, Caprariello AV, Factor DC, et al. (May 2013). "Transcription factor-mediated ... by lineage-instructive approach Injury induced stem cell niches Transcription factors Growth factors Pioneer factors Cellular ...

... which leads to a decrease in the expression of genes regulated by the GATA4 transcription factor and linked to the development ... When the guanosine at the -6 position in the Kozak sequence of GATA4 is mutated to a cytosine, a reduction in GATA4 protein ... The GATA4 gene is responsible for gene expression in a wide variety of tissues including the heart. ... Assisted by several other initiation factors (eIF1 and eIF1A, eIF5, eIF3, polyA binding protein) it is recruited to the 5′ end ...

Afterwards, different membrane markers (Sca-1, Abcg-2, Flk-1) and transcription factors (Isl-1, Nkx2.5, GATA4) have been ... "Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection ... "Endogenous cardiac stem cell activation by insulin-like growth factor-1/hepatocyte growth factor intracoronary injection ... Briefly, eCSCs have been first identified through the expression of c-kit, the receptor of the stem cell factor and the absence ...