Fucose
... is released from fucose-containing polymers by an enzyme called α-fucosidase found in lysosomes. l-Fucose has several ... In the fucose-containing glycan structures, fucosylated glycans, fucose can exist as a terminal modification or serve as an ... In human N-linked glycans, fucose is most commonly linked α-1,6 to the reducing terminal β-N-acetylglucosamine. However, fucose ... Fucose is a hexose deoxy sugar with the chemical formula C6H12O5. It is found on N-linked glycans on the mammalian, insect and ...
L-fucose isomerase
In enzymology, a L-fucose isomerase (EC 5.3.1.25) is an enzyme that catalyzes the chemical reaction L-fucose ⇌ {\displaystyle \ ... The systematic name of this enzyme class is L-fucose aldose-ketose-isomerase. This enzyme participates in fructose and mannose ... Lu Z, Lin EC (1989). "The nucleotide sequence of Escherichia coli genes for L-fucose dissimilation". Nucleic Acids Res. 17 (12 ... Seemann JE, Schulz GE (October 1997). "Structure and mechanism of L-fucose isomerase from Escherichia coli". J. Mol. Biol. 273 ...
Fucose (data page)
This box: view edit Except where noted otherwise, data relate to Standard temperature and pressure. Reliability of data general note. ^a 219-452-7 ^a CID 17106 from PubChem (Articles with short description, Short description matches Wikidata, PubChem ID (CID) not in Wikidata, Chemical data pages, Chemical data pages cleanup ...
GDP-L-fucose synthase
In enzymology, a GDP-L-fucose synthase (EC 1.1.1.271) is an enzyme that catalyzes the chemical reaction GDP-4-dehydro-6-deoxy-D ... Retrieved October 11, 2018 R. Planas et al, GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients ... The systematic name of this enzyme class is GDP-L-fucose:NADP+ 4-oxidoreductase (3,5-epimerizing). This enzyme is also called ... Somers WS, Stahl ML, Sullivan FX (1998). "GDP-fucose synthetase from Escherichia coli: structure of a unique member of the ...
Fucose-1-phosphate guanylyltransferase
Other names in common use include GDP fucose pyrophosphorylase, guanosine diphosphate L-fucose pyrophosphorylase, GDP-L-fucose ... Ishihara H, Heath EC (1968). "The metabolism of L-fucose. IV. The biosynthesis of guanosine diphosphate L-fucose in porcine ... GDP-L-fucose Thus, the two substrates of this enzyme are GTP and beta-L-fucose 1-phosphate, whereas its two products are ... In enzymology, a fucose-1-phosphate guanylyltransferase (EC 2.7.7.30) is an enzyme that catalyzes the chemical reaction GTP + ...
GDP-fucose transporter 1
... is a protein that in humans is encoded by the SLC35C1 gene. Defects can be associated with Congenital ... 2003). "Insights into leukocyte adhesion deficiency type 2 from a novel mutation in the GDP-fucose transporter gene". Blood. ... 2006). "Leukocyte adhesion deficiency II patients with a dual defect of the GDP-fucose transporter". Blood. 107 (10): 3959-66. ... as a GDP-fucose transporter deficiency". Nat Genet. 28 (1): 73-6. doi:10.1038/88299. PMID 11326280. "Entrez Gene: SLC35C1 ...
Fungal fucose-specific lectin
In molecular biology, the fungal fucose-specific lectin family is a family of lectins. Lectins are proteins which are involved ... The beta-propeller fold is important in fucose recognition; five binding pockets are found between the propeller blades. The ... six-bladed beta-propeller fold and novel fucose recognition mode for Aleuria aurantia lectin". J. Biol. Chem. 278 (29): 27059- ...
GDP-fucose protein O-fucosyltransferase 2
... (POFUT2) is an enzyme responsible for adding fucose sugars in O linkage to serine or ... that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose- ... GDP-fucose protein O-fucosyltransferase 2, The Universal Protein Resource Lopaticki S, Yang AS, John A, Scott NE, Lingford JP, ...
GDP-fucose protein O-fucosyltransferase 1
in the endoplasmic reticulum POFUT-1 utilizes its sub-strait GDP-β-L-fucose as a donor for the five carbon sugar Fucose. fucose ... POFUT-1 belongs to the O-Fuc family of proteins all which is involved in the transferring of o-fucose from GDP-β-L-fucose to ... that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose- ... GDP-fucose protein O-fucosyltransferase 1 is also known as Protein O-fucosyltransferase O-FucT-1 FUT12 OFUCT1 O-FUT POFUT-1 is ...
Rosalind Kornfeld
Fucose is an important determinant". Journal of Biological Chemistry. 256 (13): 6633-6640. doi:10.1016/s0021-9258(19)69037-x. ... Fucose is an important determinant". Journal of Biological Chemistry. 256 (13): 6633-6640. doi:10.1016/S0021-9258(19)69037-X. ...
L-fuconate dehydratase
Yuen R, Schachter H (1972). "L-Fucose metabolism in mammals. I. Port liver L-fuconate hydro-lyase". Can. J. Biochem. 50 (7): ...
Agromyces
1992, ; Neo-Latin noun fucosum, fucose; Neo-Latin masculine gender adjective fucosus (sic), containing fucose in the cell wall ...
Paucimannosylation
The paucimannosidic glycans may also be modified with other types of monosaccharides including fucose (Fuc) and xylose (Xyl) ... 3-linked fucose". FEBS Letters. 561 (1-3): 132-136. doi:10.1016/s0014-5793(04)00150-4. ISSN 0014-5793. PMID 15013764. S2CID ... 3-linked fucose and xylose substitutions". Glycobiology. 11 (4): 261-274. doi:10.1093/glycob/11.4.261. ISSN 0959-6658. PMID ... "Galactosylated Fucose Epitopes in Nematodes". Journal of Biological Chemistry. 287 (34): 28276-28290. doi:10.1074/jbc. ...
L-Fuculokinase
Heath EC, Ghalambor MA (1962). "The metabolism of L-fucose. I. The purification and properties of L-fuculose kinase". J. Biol. ...
O-linked glycosylation
Addition of a fucose alone creates the H-antigen, present in people with blood type O. By adding a galactose onto this ... Addition of fucose sugars to serine and threonine residues is an unusual form of O-glycosylation that occurs in the endoplasmic ... Once the core O-fucose has been added, it is often elongated by addition of GlcNAc, galactose and sialic acid. Notch is an ... Addition of fucose sugars by fucosyltransferases forms Lewis epitopes and the scaffold for blood group determinants. ...
D-fuconate dehydratase
Dahms AS, Anderson RL (1972). "D-Fucose metabolism in a pseudomonad. 3. Conversion of D-fuconate to 2-keto-3-deoxy-D-fuconate ...
Purple shore crab
Hemigrapsus nudus can digest glucose, galactose, fucose. maltose, maltotriose, and maltotetraose, making its metabolism similar ...
Congenital disorder of glycosylation
Fucose supplementation has had a partial effect on some SLC35C1-CDG patients. The first CDG patients (twin sisters) were ... caused by a GDP-fucose (Fuc) transporter deficiency. All N-linked oligosaccharides originate from a common lipid-linked ... a generalized defect in fucose metabolism". The Journal of Pediatrics. 134 (6): 681-688. doi:10.1016/S0022-3476(99)70281-7. PMC ...
Arabinose isomerase
Other names in common use include D-arabinose(L-fucose) isomerase, D-arabinose isomerase, L-fucose isomerase, and D-arabinose ... Green M, Cohen SS (1956). "Enzymatic conversion of L-fucose to L-fuculose". J. Biol. Chem. 219 (2): 557-568. PMID 13319278. ...
Galactoside 2-alpha-L-fucosyltransferase
GDP fucose-lactose fucosyltransferase, guanosine diphospho-L-fucose-lactose fucosyltransferase, guanosine diphosphofucose-beta- ... The systematic name of this enzyme class is GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase. Other names in ... Grollman AP (1966). "GDP-L-fucose:lactose fucosyltransferase from mammary gland". Methods Enzymol. 8: 351-353. doi:10.1016/0076 ... the two substrates of this enzyme are GDP-beta-L-fucose and beta-D-galactosyl-R, whereas its two products are GDP and alpha-L- ...
Pathophysiology of multiple sclerosis
It is the enzyme GDP-L-fucose synthase. This theory in part could also explain why some patients report amelioration under ... "GDP-l-fucose synthase is a CD4+ T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis" (PDF). Science ...
Arabinogalactan protein
In Arabidopsis, terminal sugars such as fucose are proposed to be added by AtFUT4 (a fucosyl transferase) and AtFUT6 in the ... Two α-fucosyltransferase genes, FUT4 and FUT6, both belonging to GT37 family, encode enzymes which add α-1,2-fucose residues to ... L-fucose (Fuc), D-glucopyranose (Glcp), D-glucuronic acid (GlcA) and its 4-O-methyl derivative, and D-galacturonic acid (GalA) ... fucose (Fuc), and glucuronic acid (GlcA). These AG glycan moieties are assembled by glycosyltransferases (GTs). O-glycosylation ...
Heparinoid
Fucoidan is a polymer composed of sulfated L-fucose. Carrageenans are isolated from algae. Hyaluronan functions as a heparinoid ...
Digitalose
Chemically, it is a methyl ether of D-fucose. Sarmentose, a related deoxy sugar Digitalose, Merck Index, 12th Edition, 3202 ...
Fucosidase
Alpha-Fucosidase is an enzyme that breaks down fucose. Fucosidosis is an autosomal recessive lysosomal storage disease caused ... by defective alpha-L-fucosidase with accumulation of fucose in the tissues. Different phenotypes include clinical features such ...
EGF-like domain
O-fucose modifications have only been detected in hEGF-like domains and they are important for the proper folding of the hEGF- ... Factor VII exhibits an O-linked fucose at Ser60. Multiple cbEGF domains are often connected by one or two amino acids to form ... These post-translational modifications include O-glycosylations, mostly O-fucose modifications, and β-hydroxylation of ...
Pattern recognition receptor
... similarly fucose presents the same for certain bacteria and helminths; and glucans are present on mycobacteria and fungi. In ...
Biology and sexual orientation
Park D, Choi D, Lee J, Lim DS, Park C (July 2010). "Male-like sexual behavior of female mouse lacking fucose mutarotase". BMC ... Those mice who retained the gene fucose mutarotase (FucM) were attracted to male mice. In interviews to the press, researchers ...
Major facilitator superfamily
Dang S, Sun L, Huang Y, Lu F, Liu Y, Gong H, Wang J, Yan N (October 2010). "Structure of a fucose transporter in an outward- ...