FGFR2 is a receptor for fibroblast growth factor. The protein encoded by this gene is a member of the fibroblast growth factor ... Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is ... Fibroblast growth factor receptor 2 has been shown to interact with FGF1. The spliced isoforms, however differ in binding: ... Like the other members of the fibroblast growth factor receptor family, these receptors signal by binding to their ligand and ...

Wikimedia Commons has media related to Fibroblast growth factors (FGF). Fibroblast+Growth+Factors at the U.S. National Library ... "acidic fibroblast growth factor" (FGF1) and "basic fibroblast growth factor" (FGF2). These proteins had a high degree of ... FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. Members FGF11 ... They have been alternately referred to as "pluripotent" growth factors and as "promiscuous" growth factors due to their ...

Ribatti D, Vacca A, Rusnati M, Presta M (2007). "The discovery of basic fibroblast growth factor/fibroblast growth factor-2 and ... Angiogenesis Anxiety disorders Cytokine Fibroblast growth factor Growth factor Proteases in angiogenesis Receptor (biochemistry ... also known as basic fibroblast growth factor (bFGF) and FGF-β, is a growth factor and signaling protein encoded by the FGF2 ... Basic fibroblast growth factor has been shown to interact with casein kinase 2, alpha 1, RPL6, ribosomal protein S19 and API5. ...

... and in fibroblast growth factors 1 and 2. CATH Architecture "Beta Trefoil" Murzin AG, Lesk AM, Chothia C (Jan 1992). "β-trefoil ... patterns of structure and sequence in the kunitz inhibitors interleukins-1β and 1α and fibroblast growth factors". Journal of ... 223 (2): 531-43. doi:10.1016/0022-2836(92)90668-A. PMID 1738162. Gosavi S, Whitford PC, Jennings PA, Onuchic JN (Jul 2008). " ...

... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ... Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene. FRS2 is an 80 kDa ... "Entrez Gene: FRS2 Fibroblast growth factor receptor substrate 2". Pawson T, Scott JD (December 1997). "Signaling through ...

Also Fibroblast growth factor-2 appear higher at CSF. Varicella-zoster virus particles have been found in CSF of patients ... By transcription factor The autoimmune disease-associated transcription factors EOMES and TBX21 are dysregulated in multiple ... Expression of some specific proteins in circulating CD4+ T cells is a risk factor for conversion from CIS to clinically defined ... Levels of IL-2, IL-10, and GM-CSF are lower in MS females than normal. IL6 is higher instead. These findings do not apply to ...

... targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor ... RTK targets of nintedanib include platelet-derived growth factor receptor (PDGFR) α and β; fibroblast growth factor receptor ( ... vascular endothelial growth factor receptor (VEGFR) 1, 2, and 3; and FLT3. Its use in IPF is predicated on its inhibition of ... The P-glycoprotein inhibitor ketoconazole is known to increase blood plasma levels of nintedanib by a factor of 1.8; other ...

Soulet F, Al Saati T, Roga S, Amalric F, Bouche G (2002). "Fibroblast growth factor-2 interacts with free ribosomal protein S19 ... Ribosomal protein S19 has been shown to interact with basic fibroblast growth factor. RPS19 is also secreted extracellularly ... "Fibroblast growth factor-2 interacts with free ribosomal protein S19". Biochem. Biophys. Res. Commun. 289 (2): 591-6. doi: ... "Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function"' J. ...

Rash BG, Tomasi S, Lim HD, Suh CY, Vaccarino FM (June 2013). "Cortical gyrification induced by fibroblast growth factor 2 in ... Local environmental cues such as Notch and fibroblast growth factor (FGF) signaling, developmental period, and differing ... "The receptor for granulocyte-colony stimulating factor (G-CSF) is expressed in radial glia during development of the nervous ... "Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth". Cell Stem Cell. 18 (5): 587-90. doi:10.1016/ ...

In addition, the fibroblast growth factor (FGF)- and sonic hedgehog (SHH)-signaling pathways have recently been reported to be ... Rash, BG; Tomasi, S; Lim, HD; Suh, CY; Vaccarino, FM (26 June 2013). "Cortical gyrification induced by fibroblast growth factor ... Cranial growth is thus thought to be driven by brain growth; mechanical and genetic factors intrinsic to the brain are now ... subject to the influences of many genetic cues such as fibroblast growth factors (FGF)s and Notch. RGCs generate intermediate ...

... which is regulated by molecular signals such as fibroblast growth factor FGF8 early in embryonic development. These signals ... "Cortical gyrification induced by fibroblast growth factor 2 in the mouse brain". The Journal of Neuroscience. 33 (26): 10802- ... Examples of such transcription factors include the genes EMX2 and PAX6. Together, both transcription factors form an opposing ... Other factors that can cause neurodevelopment disorders are toxicants such as drugs, and exposure to radiation as from X-rays. ...

Ueba T, Kaspar B, Zhao X, Gage FH (1999). "Repression of human fibroblast growth factor 2 by a novel transcription factor". J. ... "The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 23 (9): ... "The Methyl-CpG Binding Protein MBD1 Interacts with the p150 Subunit of Chromatin Assembly Factor 1". Mol. Cell. Biol. 23 (9): ... 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano ...

Conversely, the fibroblast growth factor pathway promotes Notch signaling to keep stem cells of the cerebral cortex in the ... "Cortical Gyrification Induced by Fibroblast Growth Factor 2 in the Mouse Brain". The Journal of Neuroscience. 33 (26): 10802- ... Fibroblast growth factor10 is thought to be important in this activity, but the details are unclear. The role of Notch ... is homologous to a set of mammalian proteins that includes epidermal growth factor". Cell. 43 (3 Pt 2): 583-90. doi:10.1016/ ...

2001). "The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production ... Sheng Z, Lewis JA, Chirico WJ (2004). "Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by ... Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 ... Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may ...

Fibroblast growth factor receptor 2 (FGFR2) plays an essential role in the regulation of osteoblast differentiation, ... "FGFR2 - Fibroblast growth factor receptor 2 precursor - Homo sapiens (Human) - FGFR2 gene & protein". UniProt. "MFAP3L - ... Immunofluorescent staining of human cell line U-2 OS shows localization to the Golgi apparatus. C19orf18 protein has been ...

"Fibroblast growth factor-2 induces Lef/Tcf-dependent transcription in human endothelial cells". The Journal of Biological ... Increasing cyclin D1 levels during the G1 phase is induced by mitogenic growth factors primarily through Ras-mediated pathways ... Musgrove EA (March 2006). "Cyclins: roles in mitogenic signaling and oncogenic transformation". Growth Factors. 24 (1): 13-9. ... Adnane J, Shao Z, Robbins PD (January 1999). "Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1- ...

... (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine ... FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, which in addition to FGFR1, includes FGFR2, FGFR3, ... There are four other members of the FGFR1 gene family: FGFR2, FGFR3, FGFR4, and Fibroblast growth factor receptor-like 1 ( ... neoplasms with eosinophil such as those caused by Platelet-derived growth factor receptor A or platelet-derived growth factor ...

... see also Fibroblast growth factor receptor 4) (= CD334) FGFRL1 (see also Fibroblast growth factor receptor-like 1) FGFR6 The ... see also Fibroblast growth factor receptor 1) (= CD331) FGFR2 (see also Fibroblast growth factor receptor 2) (= CD332) FGFR3 ( ... These receptors bind fibroblast growth factors, members of the largest family of growth factor ligands, comprising 22 members. ... The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast ...

"Biochemical analysis of the arginine methylation of high molecular weight fibroblast growth factor-2". J. Biol. Chem. 275 (5): ... "Structural and functional conservation of human and yeast HCP1 genes which can suppress the growth defect of the Saccharomyces ... interacts with and is regulated by interleukin enhancer-binding factor 3". J. Biol. Chem. 275 (26): 19866-76. doi:10.1074/jbc. ... interacts with and is regulated by interleukin enhancer-binding factor 3". J. Biol. Chem. 275 (26): 19866-76. doi:10.1074/jbc. ...

"Human ryudocan from endothelium-like cells binds basic fibroblast growth factor, midkine, and tissue factor pathway inhibitor ... Syndecan-4 is also a regulator of fibroblast growth factor-2 (FGF-2) signaling. Syndecan-4 binds to FGF and mediates ... "Heparan sulfate proteoglycans function as receptors for fibroblast growth factor-2 activation of extracellular signal-regulated ... "Syndecan-4 proteoliposomes enhance fibroblast growth factor-2 (FGF-2)-induced proliferation, migration, and neovascularization ...

... (FGF23) is a protein and member of the fibroblast growth factor (FGF) family which participates in ... Fibroblast growth factor 23 (FGF23) is a protein which in humans is encoded by the FGF23 gene. FGF23 is a member of the ... "Entrez Gene: FGF23 fibroblast growth factor 23". Zadik Y, Nitzan DW (February 2012). "Tumor induced osteomalacia: a forgotten ... January 2003). "Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25- ...

"Dermatan sulfate released after injury is a potent promoter of fibroblast growth factor-2 function". The Journal of Biological ... Mutation of CHST14 results in a deficiency of dermatan sulfate, which disrupts glycosaminoglycan constituents in fibroblasts ... 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K (September ... 58 (2): 88-99. doi:10.1111/ped.12878. PMID 26646600. S2CID 5289682. Bian S, Akyüz N, Bernreuther C, Loers G, Laczynska E, ...

"Fibroblast growth factor 2 internal ribosome entry site (IRES) activity ex vivo and in transgenic mice reveals a stringent ... When expressed the fibroblast growth factor 2 FGF-2 protein plays a pivotal role in cell proliferation, differentiation and ... UTR of the mRNA of fibroblast growth factor-2. It has been found that the FGF-2 internal ribosome entry site (IRES) activity is ... "Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes". Molecular and Cellular ...

She discovered that similar mutations in the same gene, fibroblast growth factor receptor 2 or FGFR2, cause both Jackson-Weiss ... "Jackson-Weiss and Crouzon syndromes are allelic with mutations in fibroblast growth factor receptor 2". Nature Genetics. 8 (3 ... a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndrome". Nature Genetics. 15 (1): 36-41. doi:10.1038/ng0197 ...

2005). "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier ... 1999). "Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman- ... Schoorlemmer J, Goldfarb M (2003). "Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate ... Munoz-Sanjuan I, Smallwood PM, Nathans J (2000). "Isoform diversity among fibroblast growth factor homologous factors is ...

... ubiquitination mediated by HUWE1 is triggered by growth factor activation of the ERK1/2 pathway and is a prerequisite for ... 281 (2): 927-33. doi:10.1074/jbc.M507360200. PMID 16301319. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, ... Leucine-rich repeat (LRR) protein SHOC-2 is a protein that in humans is encoded by the SHOC2 gene. The best-studied role of ... "Entrez Gene: SHOC2 soc-2 suppressor of clear homolog (C. elegans)". Jang, Eun Ryoung; Shi, Ping; Bryant, Jamal; Chen, Jing; ...

... has been shown to interact with FGF8 and FGF9. Cluster of differentiation Fibroblast growth ... Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as ... The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is ... Hernández S, Toll A, Baselga E, Ribé A, Azua-Romeo J, Pujol RM, Real FX (July 2007). "Fibroblast growth factor receptor 3 ...

1993). "Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but ... 1996). "Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer ... 1992). "A radiation hybrid map of 18 growth factor, growth factor receptor, hormone receptor, or neurotransmitter receptor ... Fibroblast growth factor receptor 4 is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as ...

"Prolotherapy agent P2G is associated with upregulation of fibroblast growth factor-2 genetic expression in vitro". Journal of ... 66 (2): 140-52. doi:10.1016/j.crad.2010.09.006. PMID 21216330. Johannes, Laura (October 19, 2010). "A Pinch of Sugar for Pain ... 31 (2): 35. ProQuest 88980623. Rice, Carl O. (March 1937). "The Injection Treatment of Hernia". Annals of Surgery. 105 (3): 343 ... 72 (2): 220-233. doi:10.1002/art.41142. hdl:2027.42/153546. PMID 31908163. S2CID 210041163. Rabago, D; Slattengren, A; Zgierska ...

The production of these factors is regulated by fibroblast growth factor 2, TGF-β1, and PDGF. In addition to cytokine-mediated ... Connective tissue growth factor is involved in the pathogenesis of fibrotic diseases and is predominantly found in PaSCs ... Protein kinases such as MAPKs are primary mediators of activating signals initiated by the growth factors, angiotensin II and ... Hypoxia also stimulates nuclear expression of HIF-1α followed by the production of vascular endothelial growth factor (VEGF) in ...