Protoporphyrin ferrochelatase (EC 4.98.1.1, formerly EC 4.99.1.1, or ferrochelatase; systematic name protoheme ferro-lyase ( ... Frataxin acts as the Fe+2 chaperone and complexes with ferrochelatase on its mitochondrial matrix side. Ferrochelatase can also ... In cases of lead poisoning, lead inhibits ferrochelatase activity, in part resulting in porphyria. Ferrochelatase interacts ... Lyases Erythropoietic protoporphyria Sirohydrochlorin ferrochelatase Zinc protoporphyrin "FECH - Ferrochelatase, mitochondrial ...

... with the last step carried out by sirohydrochlorin ferrochelatase. Sirohydrochlorin ferrochelatase is a class II chelatase, i.e ... Sirohydrochlorin ferrochelatase in all land plants and certain green algae, but not bacteria or other algae, consists of an ... The enzyme sirohydrochlorin ferrochelatase (EC 4.99.1.4) catalyzes the following reaction: siroheme + 2H+ ⇌ {\displaystyle \ ... a bifunctional dehydrogenase and ferrochelatase". EMBO J. 21 (9): 2068-75. doi:10.1093/emboj/21.9.2068. PMC 125995. PMID ...

"Pfam entry: Ferrochelatase". Archived from the original on 2007-09-29. Retrieved 2007-01-25. "Pfam entry:Myotubularin-related ...

... has been shown to interact with Ferrochelatase. ATP-binding cassette transporter GRCh38: Ensembl release 89: ... interaction of ABC7 with ferrochelatase". Blood. 101 (8): 3274-80. doi:10.1182/blood-2002-04-1212. PMID 12480705. S2CID ... interaction of ABC7 with ferrochelatase". Blood. 101 (8): 3274-80. doi:10.1182/blood-2002-04-1212. PMID 12480705. S2CID ...

"Mitochondrial localization of functional ferrochelatase from Plasmodium falciparum". Molecular and Biochemical Parasitology. ...

... a bifunctional dehydrogenase and ferrochelatase". EMBO J. 21 (9): 2068-75. doi:10.1093/emboj/21.9.2068. PMC 125995. PMID ...

Ferrochelatase (FECH) catalyzes the insertion of ferrous iron into the protoporphyrin IX ring to form heme. EPP exhibits both ... Mutation of the gene that encodes for ferrochelatase in the long arm of chromosome 18 is found in majority of the cases. ... It arises from a deficiency in the enzyme ferrochelatase, leading to abnormally high levels of protoporphyrin in the red blood ... B. subtilis (a gram-positive soil probiotic) produces ferrochelatase, which may be able to convert some of the protoporphyrin ...

... a bifunctional dehydrogenase and ferrochelatase". The EMBO Journal. 21 (9): 2068-75. doi:10.1093/emboj/21.9.2068. PMC 125995. ...

For example, ferrochelatase converts the compound into heme B (i.e. Fe-protoporphyrin IX or protoheme IX). In chlorophyll ...

A ferrochelatase then inserts iron into the macrocycle to give siroheme. Ferredoxin-nitrite reductase Hydrogensulfite reductase ...

Lead also inhibits the enzyme ferrochelatase, another enzyme involved in the formation of heme. Ferrochelatase catalyzes the ...

... ferrochelatase an enzyme that catalyzes insertion of iron to form siroheme. Sirohydrochlorin cobaltochelatase ...

Iron is then enzymatically inserted into protoporphyrin via ferrochelatase to produce heme. Globin synthesis takes place in the ...

In the case of ferrochelatases, the reaction that chelatases catalyze is: Fe2+ + H2P → FeP + 2 H+ In the above equation H2P ... Several families of chelatase are known including cobalt chelatase, magnesium chelatase, and ferrochelatase. Nickel insertion ...

Chen W, Dailey HA, Paw BH (July 2010). "Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid ... a porphyrin disease linked to mutations in the Ferrochelatase enzyme. Selective deletion of Mfrn1 in adult mice led to severe ... or protoporphyrin ferrochelatase). Furthermore, ABC10 binding enhances the stability and functionality of Mfrn1, suggesting ... Mitoferrin-1 has been shown to form oligomeric complexes with the ATP-binding cassette transporter ABCB10 and Ferrochelatase ( ...

Cancer cells lack or have reduced ferrochelatase activity and this results in accumulation of Protoporphyrin IX, a fluorescent ... This protoporphyrin molecule chelates with iron in presence of enzyme ferrochelatase to produce Heme. Heme increases the ...

... a common wild-type ferrochelatase allelic variant with low expression accounts for clinical manifestation". Am J Hum Genet. 93 ...

The other 20% is present in ferritin, hemosiderin, iron-sulfur (Fe/S) proteins, such as ferrochelatase, and more. A relatively ...

Zoller H, Decristoforo C, Weiss G (August 2002). "Erythroid 5-aminolevulinate synthase, ferrochelatase and DMT1 expression in ...

The cells respond by producing PPIX (photosensitiser) at a faster rate than the ferrochelatase enzyme can convert it to haem. ...

... may refer to: Ferrochelatase Student Federation of the University of Chile Fech This disambiguation page lists articles ...

... an autosomal dominant porphyria resulting from a reduced activity of ferrochelatase.[citation needed] In contrast to PCT, EPP ...

... ferrochelatase) enzyme; the very last enzyme in the pathway. All individuals studied presented symptoms without mutations in ...

... dehydrogenase and ferrochelatase activities. Bacterial sulphur metabolism depends on the iron-containing porphinoid sirohaem. ...

In the human body, lead inhibits porphobilinogen synthase and ferrochelatase, preventing both porphobilinogen formation and the ...

... and less heme synthesis occurs due to the enzymes δ-aminolevulinic acid dehydratase and ferrochelatase becoming impaired. The ...

... sirohydrochlorin ferrochelatase EC 4.99.1.5: Now EC 4.8.1.2, aliphatic aldoxime dehydratase EC 4.99.1.6: Now EC 4.8.1.3, ... protoporphyrin ferrochelatase EC 4.99.1.1: Now EC 4.98.1.1 EC 4.99.1.2: alkylmercury lyase EC 4.99.1.3: sirohydrochlorin ... coproporphyrin ferrochelatase * EC 4.99.1.10: magnesium dechelatase * EC 4.99.1.11: sirohydrochlorin nickelchelatase * EC 4.99. ...

... ferrochelatase (deficiency causes erythropoietic protoporphyria) HMBS: hydroxymethylbilane synthase (deficiency causes acute ...

HtrA serine peptidase 2 Adrenodoxin reductase Heme biosynthesis Protoporphyrinogen oxidase Ferrochelatase Uncoupling protein ...

... such as ferrochelatase Some lyases associate with biological membranes as peripheral membrane proteins or anchored through a ...