"Recombinant Factor XIII". 2010. "Factor XIII". 2014-03-05. Muszbek, Laszlo; et al. (1999). "Blood coagulation factor XIII: ... Factor XIII Dorgalaleh A, Naderi M, Hosseini MS, Alizadeh S, Hosseini S, Tabibian S, et al. (2015). "Factor XIII Deficiency in ... "Safety and pharmacokinetics of recombinant factor XIII-A2 administration in patients with congenital factor XIII deficiency". ... Factor XIII deficiency occurs exceedingly rarely, causing a severe bleeding tendency. The incidence is one in a million to one ...

Deficiency of factor XIII (a rare genetic condition) predisposes to hemorrhage; concentrated enzyme can be used to correct the ... Examples are blood clots (coagulation factor XIII), skin, and hair. The catalytic reaction is generally viewed as being ... The exact biochemical activity of transglutaminases was discovered in blood coagulation protein factor XIII in 1968. Nine ... doi:10.1016/0003-9861(59)90413-8. Pisano JJ, Finlayson JS, Peyton MP (May 1968). "[Cross-link in fibrin polymerized by factor ...

Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B ... the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. ... Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a ... Adány R (1997). "Intracellular factor XIII: cellular distribution of factor XIII subunit a in humans". Semin. Thromb. Hemost. ...

... Deficiency is also known as Laki-Lorand factor, after Kalman Laki and Laszlo Lorand, the scientists who first ... Factor XIII is a transglutaminase that circulates in human blood as a heterotetramer of two A and two B subunits. Factor XIII ... Factor XIIIa is an enzyme of the blood coagulation system that crosslinks fibrin. Deficiency of XIII worsens clot stability and ... Deficiency of Factor XIII (FXIIID), while generally rare, does occur, with Iran having the highest global incidence of the ...

... congenital factor XIII A-subunit deficiency, which is a kind of Factor XIII deficiency. The medication prevents bleeding in ... a breakthrough in the treatment of congenital factor XIII A-subunit deficiency?". J Blood Med. 5: 107-13. doi:10.2147/JBM. ... "Blood-coagulation factor XIII". Drug Information Portal. U.S. National Library of Medicine. Portal: Medicine v t e (Webarchive ... Catridecacog, sold under the brand name Tretten in the US and NovoThirteen in the EU) is a class of recombinant factor XIII A- ...

However, on 25 April, he abruptly announced his retirement, citing Factor XIII deficiency, a rare blood disorder. He was ... 13 June 2014. Retrieved 19 January 2015. "UFC Fight Night 46 results: Paddy Holohan submits Josh Sampo". Cage Pages. 19 July ...

"Effect of Social Factors on the Highest Global Incidence of Factor XIII Deficiency in Southeast of Iran". Archives of Iranian ... Khash also is the point of origin for the abnormally high incidence of Factor XIII deficiency, an extremely serious genetic ...

Notably, deficiencies in factors VII or XIII will not be detected with the PTT test.[citation needed] Prolonged aPTT may ... Deficiencies of factors VIII, IX, XI and XII and rarely von Willebrand factor (if causing a low factor VIII level) may lead to ... coagulation factor deficiency (e.g., hemophilia) sepsis - coagulation factor consumption presence of antibodies against ... antiphospholipid antibodies or coagulation factor specific inhibitors), while if it does disappear a factor deficiency is more ...

... with Factor XIII deficiencies display impairment in wound healing as fibroblasts don't grow well in fibrin lacking Factor XIII ... covalently cross-linked to fibrin with the help of Factor XIII (fibrin-stabilizing factor). Fibroblasts play a major role in ... Martin JA, Miller BA, Scherb MB, Lembke LA, Buckwalter JA (July 2002). "Co-localization of insulin-like growth factor binding ... Gui Y, Murphy LJ (May 2001). "Insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) binds to fibronectin (FN): ...

Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B ... the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. ... Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a ... 1990). "A familial factor XIII subunit B deficiency". Br. J. Haematol. 74 (3): 290-4. doi:10.1111/j.1365-2141.1990.tb02585.x. ...

... of ROTEM clot stabilization kinetics in a patient with severe factor XIII deficiency after administration of factor XIII ... In contrast to standard clotting tests, the fibrin-stabilizing effect of factor XIII contributes to the result. The rapid ... Prolongation of CT may be a result of coagulation deficiencies, primarily coagulation factors, or heparin (dependent on the ... The sensitivity for coagulation factor deficiencies, including those induced by oral anticoagulation, is less pronounced as ...

Hemophilia A 286.1 Hemophilia B 286.2 Hemophilia C 286.3 Congenital deficiency of other clotting factors Factor XIII deficiency ... 280 Iron deficiency anemias 280.0 Iron deficiency anemia secondary to blood loss (chronic) 280.1 Iron deficiency anemia ... unspecified 281 Other deficiency anemias 281.0 pernicious anemia 281.2 Anemia, folate deficiency 281.3 Other specified ... Hemorrhagic disorder due to intrinsic anticoagulants 286.6 Defibrination syndrome 286.7 Acquired coagulation factor deficiency ...

... factor, which is involved in platelet activation. Deficiencies in other factors, such as factor XIII or factor VII are ... For instance, deficiency of Factor VIII causes classic hemophilia A while deficiencies of Factor IX cause "Christmas disease"( ... Deficiencies of platelet function may require platelet transfusion while deficiencies of clotting factors may require ... Deficiencies of coagulation factors are associated with clinical bleeding. ...

For example, factor X deficiency may be seen in amyloidosis, where factor X is adsorbed to the amyloid fibrils in the ... Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as ... The result is a Factor VIIa/TF complex, which catalyzes the activation of Factor X and Factor IX. Factor Xa formed on the ... Factor XIa activates free Factor IX on the surface of activated platelets. The activated Factor IXa with Factor VIIIa forms the ...

... with Factor VIII or IX deficiency) who have developed antibodies against replacement coagulation factor. It has also been used ... the interface between factor Xa and tissue factor in the quaternary complex tissue factor-factor VIIa-factor Xa-tissue factor ... The complex of factor VIIa with TF catalyzes the conversion of factor IX and factor X into the active proteases, factor IXa and ... or blood-coagulation factor VIIa, activated blood coagulation factor VII), which in turn activates factor IX and factor X. ...

It is majorly associated with a complex I deficiency, a deficiency in the first complex of the mitochondrial respiratory chain ... "Complex I assembly factor TMEM126B, mitochondrial". www.uniprot.org. Retrieved 2018-07-27. Rhein VF, Carroll J, Ding S, ... A complex I deficiency involving the dysfunction of the mitochondrial respiratory chain may cause a wide range of clinical ... The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It ...

"The biochemical pathways of central nervous system neural degeneration in niacin deficiency". Neural Regeneration Research. 9 ( ... BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a ... Binder DK, Scharfman HE (September 2004). "Brain-derived neurotrophic factor". Growth Factors. 22 (3): 123-31. doi:10.1080/ ... "trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor". Cell ...

Deficiency of VWF can then lead to a reduction in factor VIII levels, which explains the elevation in PTT. Normal levels do not ... Factor VIII levels are also performed because factor VIII is bound to VWF which protects the factor VIII from rapid breakdown ... This is a deficiency of the binding of VWF to coagulation factor VIII. The VWF antigen test is normal, indicating normal ... It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required ...

"Nutritional Factors in Tooth Development". ADHA. Retrieved 2008-12-30. "Effect of Inorganic Fluoride on Living Organisms of ... Fluoride or fluorine deficiency is a disorder[dubious - discuss] which may cause increased dental caries and possibly ... Symptoms such as fractured hips in the elderly or brittle and weak bones may be caused by fluorine deficiency in the body.[ ... Mamelle, N; Meunier, PJ; Dusan, R; Guillaume, M; Martin, JL; Gaucher, A; Prost, A; Zeigler, G; Netter, P (13 August 1988). " ...

"Deficiency of fibroblast growth factor 21 (FGF21) promotes hepatocellular carcinoma (HCC) in mice on a long term obesogenic ... Badman, MK; Pissios, P; Kennedy, AR; Koukos, G; Flier, JS; Maratos-Flier, E (2007). "Hepatic fibroblast growth factor 21 is ... "Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic ... "Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury ...

... allowing factor XI's protease activity on it. Deficiency of factor XI causes the rare hemophilia C; this mainly occurs in ... factor XII, factor XI, and factor IX). Factor XIa activates factor IX by selectively cleaving arg-ala and arg-val peptide bonds ... Factor IXa, in turn, forms a complex with Factor VIIIa (FIXa-FVIIIa) and activates factor X. Physiological inhibitors of factor ... "Activation of human blood coagulation factor XI independent of factor XII. Factor XI is activated by thrombin and factor XIa in ...

... congenital Factor X deficiency Factor XI deficiency, congenital Factor XIII deficiency, congenital Factor XIII deficiency ... II deficiency Factor V deficiency Factor V Leiden mutation Factor VII deficiency Factor VIII deficiency Factor X deficiency, ... 6-bisphosphatase deficiency Fructose-1-phosphate aldolase deficiency, heredita Fructosemia, hereditary Fructosuria Frydman- ... with nephrocalcinosis and renal stones Fanconi anemia Fara-Chlupackova syndrome Farber's disease Farmer's lung Fas deficiency ...

Marlar RA, Griffin JH (1980). "Deficiency of protein C inhibitor in combined factor V/VIII deficiency disease". The Journal of ... Deficiency of protein C inhibitor in the human body may cause male infertility. Protein C inhibitor has a role in reproduction ... Either deficiency or the presence of inactive protein C inhibitor can lead to male caused infertility. Protein C inhibitor has ... inhibiting several blood coagulation enzymes counting thrombin and factor Xa. In the beginning, protein C inhibitor(PCI) was ...

"Accumulation of apoplastic iron in plant roots: a factor in the resistance of soybeans to iron-deficiency induced chlorosis?." ... Her 1980 MSc titled 'Factors affecting iron uptake by iron-efficient and inefficient soybean varieties' and a 1986 PhD titled ' ... She and her research group examine factors that affect peoples' attitudes towards science-related issues. They also examine how ... "Factors affecting iron uptake by iron-efficient and inefficient soybean varieties" - via Open WorldCat. Longnecker, Nancy Ellen ...

... deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell ... and a Factor VIII cofactor, it hydrolyses one arginine-isoleucine bond in factor X to form factor Xa. Factor IX is inhibited by ... Deficiency of factor IX causes Christmas disease (hemophilia B). Over 3000 variants of factor IX have been described, affecting ... Zhong D, Bajaj MS, Schmidt AE, Bajaj SP (Feb 2002). "The N-terminal epidermal growth factor-like domain in factor IX and factor ...

... but deficiency remains a serious public health problem in the developing world. Iodine deficiency is also a problem in certain ... It is unknown if the thyroid gland is the rate-limiting factor in generating thyroid hormone from iodine and tyrosine, but ... A deficiency of thyroid hormones can reduce basal metabolic rate up to 50%, while an excessive production of thyroid hormones ... In turn, an excess of selenium increases demand for iodine, and deficiency will result when a diet is high in selenium and low ...

In the next two years, the same two groups showed that the congenital deficiency of a vWF-cleaving protease was associated with ... Fujimura Y, Matsumoto M, Yagi H, Yoshioka A, Matsui T, Titani K (January 2002). "Von Willebrand factor-cleaving protease and ... Deficiency of ADAMTS13 was originally discovered in Upshaw Schulman Syndrome, the recurring familial form of thrombotic ... Kremer Hovinga JA, Studt JD, Lämmle B (2005). "The von Willebrand factor-cleaving protease (ADAMTS-13) and the diagnosis of ...

According to the Journal Citation Reports, the journal has a 2014 impact factor of 4.556, ranking it twelfth out of 78 journals ... Journal of acquired immune deficiency syndromes (accessed 24 October 2007) NLM Catalog: Journal of acquired immune deficiency ... The Journal of Acquired Immune Deficiency Syndromes is a peer-reviewed medical journal covering all aspects of research in HIV/ ... The journal was established in 1988 (ISSN 0894-9255). It was retitled Journal of Acquired Immune Deficiency Syndromes and Human ...

All these factors are currently believed to contribute to global reserve. Cognitive reserve is commonly used to refer to both ... Journal of Acquired Immune Deficiency Syndromes. 6 (5): 503-11. doi:10.1097/00126334-199305000-00011. PMID 8483113. Wilson RS, ... Studies use factors like education, occupation, and lifestyle as proxies for cognitive reserve because they tend to positively ... Due to the variety of the four lifestyle factors, a lot of different self-report-scales are used to specify the severity of ...

Another disease associated with deficiencies in the COP II pathway is combined factor V and factor VIII deficiency. In this ... Spreafico, Marta; Peyvandi, Flora (June 2009). "Combined Factor V and Factor VIII Deficiency". Seminars in Thrombosis and ... The mutation of the MCFD2 gene is what causes combined factor V and VIII deficiency. Treatment for the disease includes ... the person produces Factor V and VIII but they can not transport factor V or VIII into the bloodstream. This is an autosomal ...