The glutamate transporter 1 (GLT1)/ excitatory amino acid transporter 2 (EAAT2) is responsible for the reuptake of more than 90 ... "Designing Novel Nanoformulations Targeting Glutamate Transporter Excitatory Amino Acid Transporter 2: Implications in Treating ... Excitatory amino acid transporter 2 (EAAT2) also known as solute carrier family 1 member 2 (SLC1A2) and glutamate transporter 1 ... The major glial glutamate transporter is referred to as GLT1 in the rodent literature and excitatory amino acid transporter 2 ( ...

... is a member of the high-affinity glutamate transporters which plays an essential role in ... Excitatory amino acid transporter Glutamate transporter Solute carrier family GRCh38: Ensembl release 89: ENSG00000106688 - ... "The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?". ... Excitatory amino acid transporter 3 (EAAT3), is a protein that in humans is encoded by the SLC1A1 gene. EAAT3 is expressed on ...

"Aberrant expression of the glutamate transporter excitatory amino acid transporter 1 (EAAT1) in Alzheimer's disease". The ... Excitatory amino acid transporter 1 (EAAT1) is a protein that, in humans, is encoded by the SLC1A3 gene. EAAT1 is also often ... DL-threo-beta-benzyloxyaspartate (TBOA) is an inhibitor of the excitatory amino acid transporters. Selective inhibitors for ... Excitatory amino acid transporter 1) at the PDBe-KB. (CS1 maint: DOI inactive as of August 2023, Articles with short ...

"Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci ... Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene. EAAT5 is expressed ... has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions. ... 2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and ...

Astrocytes use excitatory amino acid transporter 2 (EAAT2, aka GLT-1) to remove glutamate from the synapse. EAAT2 knockout mice ... In TM1, an aspartate distinguishes monoamine NSS transporters from amino acid transporters which contain a glycine at the same ... At a molecular level, Na+ ions stabilize amino acid binding at the substrate site and also hold the transporter in an outward- ... and dopamine transporters. This effect requires the transporter and TAAR1 to be co-localized (occur together) within the same ...

... seems to increase excitatory amino acid transporter-2 pump expression and activity in the central nervous system, ... May 2008). "Mechanism of ceftriaxone induction of excitatory amino acid transporter-2 expression and glutamate uptake in ... Verma R, Mishra V, Sasmal D, Raghubir R (July 2010). "Pharmacological evaluation of glutamate transporter 1 (GLT-1) mediated ... January 2005). "Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression". Nature. 433 ( ...

... synthesis of urea and essential amino acids), activate vitamin D, utilization of vitamin K, transporter expression of vitamin A ... Examples: PIP3, DAG, phosphatidic acid, arachidonic acid and ceramide. They are involved in regulation of kinases and ... These include genes associated with bile acid metabolism, glycolysis metabolism and fatty acid metabolism pathways, supporting ... LXRE Expression of CYP7A1 and ABC transporters Degradate of toxic substances Via LXR /LXRE Expression of ABC transporters ...

The glutamate transporter 1 (GLT1)/ excitatory amino acid transporter 2 (EAAT2) is responsible for the reuptake of more than 90 ... The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family ... The major glial glutamate transporter is referred to as GLT1 in the rodent literature and excitatory amino acid transporter 2 ( ... "Developmental expression of excitatory amino acid transporter 5: a photoreceptor and bipolar cell glutamate transporter in rat ...

... in part by upregulating the expression of excitatory amino acid transporter 2 (EAAT2), a.k.a. glutamate transporter 1 (GLT1), ... Amino acid derivatives, Alpha-Amino acids, Antidotes, Antioxidants, Excipients, Excitatory amino acid receptor ligands, ... The sulfur-containing amino acids cysteine and methionine are more easily oxidized than the other amino acids. Intravenous and ... is correlated with a persistent reduction in the expression of excitatory amino acid transporter 2 (EAAT2) in the nucleus ...

Excitatory amino acid transporter 3 (EAAT3) Excitatory amino acid transporter 4 (EAAT4) Excitatory amino acid transporter 5 ( ... Glutamate/aspartate transporters, including: Excitatory amino acid transporter 1 (EAAT1) Excitatory amino acid transporter 2 ( ... Vesicular glutamate transporter 3 (VGLUT3) GABA transporters, including: GABA transporter type 1 (GAT1) GABA transporter type 2 ... GAT2) GABA transporter type 3 (GAT3) Betaine transporter (BGT1) Vesicular GABA transporter (VGAT) Glycine transporters, ...

... these being transporters for monoamines, the amino acids proline and glycine, GABA, and a group of orphan transporters. ... which are responsible for excitatory amino acid transport (see TC# 2.A.23). The latter couple glutamate and aspartate uptake to ... Malandro MS, Kilberg MS (1996). "Molecular biology of mammalian amino acid transporters". Annu. Rev. Biochem. 65: 305-336. doi: ... is type of neurotransmitter transporter that catalyzes the uptake of a variety of neurotransmitters, amino acids, osmolytes and ...

... excitatory amino acid transporter 1 MeSH D12.776.157.530.200.249.500.500.750 - excitatory amino acid transporter 2 MeSH D12.776 ... excitatory amino acid transporter 3 MeSH D12.776.157.530.200.249.500.500.937 - excitatory amino acid transporter 4 MeSH D12.776 ... excitatory amino acid transporter 1 MeSH D12.776.157.530.450.625.147.750 - excitatory amino acid transporter 2 MeSH D12.776. ... excitatory amino acid transporter 3 MeSH D12.776.157.530.450.625.147.937 - excitatory amino acid transporter 4 MeSH D12.776. ...

... excitatory amino acid transporter 1 MeSH D12.776.543.585.200.249.500.500.750 - excitatory amino acid transporter 2 MeSH D12.776 ... excitatory amino acid transporter 3 MeSH D12.776.543.585.200.249.500.500.937 - excitatory amino acid transporter 4 MeSH D12.776 ... excitatory amino acid transporter 1 MeSH D12.776.543.585.450.625.147.750 - excitatory amino acid transporter 2 MeSH D12.776. ... excitatory amino acid transporter 3 MeSH D12.776.543.585.450.625.147.937 - excitatory amino acid transporter 4 MeSH D12.776. ...

Excitatory amino acid transporter GABA transporter Glycine receptor Glycine reuptake inhibitor Harvey RJ, Yee BK (November 2013 ... There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2). ... Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine ... v t e (Articles with short description, Short description matches Wikidata, Membrane proteins, Neurotransmitter transporters, ...

Excitatory amino acid transporters (EAATs) EAAT1 EAAT2 EAAT3 EAAT4 EAAT5 Glucose transporter Monoamine transporters, including ... Dopamine transporter (DAT) Norepinephrine transporter (NET) Serotonin transporter (SERT) Vesicular monoamine transporters (VMAT ... Methyltransfer-driven transporters 3.D: Oxidoreduction-driven transporters 3.E: Light absorption-driven transporters, such as ... P-P-bond-hydrolysis-driven transporters : ATP-binding cassette transporter (ABC transporter), such as MDR, CFTR V-type ATPase ...

... to the central nervous system because they transport GABA and its analogues which can induce and inhibitory and excitatory ... Unlike most amino acid transporters in the exchange of Na+ with amino acid symporters, proton-coupled amino acid transporters ... The activity of transporters, such as Proton-coupled amino acid transporter 1 and Proton-coupled amino acid transporter 2 can ... Unlike typical mammalian amino acid transporters which function in exchanging Na+/amino acid symporters, these- transporters ...

Once the vesicle is released, glutamate is removed from the synaptic cleft by excitatory amino-acid transporters (EAATs). This ... The amino acid moves in the opposite direction of glutamine. In the opposite direction of the amino acid, a corresponding ... amino acids) might be employed. Certainly, ammonia can diffuse across lipid membranes, and it has been shown that ammonia can ... A Review and Strategies for Future Studies of Amino Acids in Autism". Disease Markers. 35 (5): 281-286. doi:10.1155/2013/536521 ...

... inhibits excitatory amino acid release mediated by glutamate transporter reversal". European Journal of Pharmacology. 643 (1): ... Bromocriptine has additionally been found to inhibit the release of glutamate by reversing the GLT1 glutamate transporter. As ... Bromocriptine is a semisynthetic derivative of a natural ergot alkaloid, ergocryptine (a derivative of lysergic acid), which is ... When administered within 2 hours of awakening, it increases hypothalamic dopamine level and as a result decreases hepatic ...

Members of the family include: several mammalian excitatory amino acid transporters, and a number of bacterial transporters. ... The structure of these transporter proteins has been variously reported to contain from 8 to 10 transmembrane (TM) regions, ... dependent glutamate/aspartate transporter from rat brain". Proc. Natl. Acad. Sci. U.S.A. 89 (22): 10955-9. Bibcode:1992PNAS... ... "Cloning and expression of a rat brain L-glutamate transporter". Nature. 360 (6403): 464-7. Bibcode:1992Natur.360..464P. doi: ...

This gene encodes the excitatory amino acid transporter 1 (EAAT1) protein, which is responsible for glutamate uptake. In cell ... Jen J, Wan J, Palos T, Howard B, Baloh R (2005). "Mutation in the glutamate transporter EAAT1 causes episodic ataxia, ... 3.0.CO;2-4. PMID 11013453. S2CID 35501355. Lee H, Wang H, Jen J, Sabatti C, Baloh R, Nelson S (2004). "A novel mutation in ... 3.0.CO;2-J. PMID 9600739. Guida S, Trettel F, Pagnutti S, Mantuano E, Tottene A, Veneziano L, Fellin T, Spadaro M, Stauderman K ...

... of the excitatory neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters ( ... Glutamatergic GABA reuptake inhibitor Glycine reuptake inhibitor Excitatory amino acid receptor agonist Excitatory amino acid ... Media related to Excitatory amino acid reuptake inhibitors at Wikimedia Commons v t e (Commons category link is on Wikidata, ... An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake ...

Reuptake inhibitor Glycinergic GABA reuptake inhibitor Excitatory amino acid reuptake inhibitor Harsing LG, Juranyi Z, Gacsalyi ... Harvey RJ, Yee BK (November 2013). "Glycine transporters as novel therapeutic targets in schizophrenia, alcohol dependence and ... Neurotransmitter Transporters. Springer Science & Business Media. pp. 472-. ISBN 978-3-540-29784-0. v t e (Glycine reuptake ... a type of drug which inhibits the reuptake of the neurotransmitter glycine by blocking one or more of the glycine transporters ...

Greer JJ, Smith JC, Feldman JL (June 1991). "Role of excitatory amino acids in the generation and transmission of respiratory ... November 2006). "Vesicular glutamate transporter 2 is required for central respiratory rhythm generation but not for locomotor ... role of excitatory amino acids". Journal of Neurophysiology. 70 (4): 1497-1515. doi:10.1152/jn.1993.70.4.1497. PMID 8283211. ... This is due to the reduction of excitatory synaptic transmission in a nucleus and increased excitability in motor neurons ...

Synthesis and Pharmacological Characterization of Functionalized Aspartate Analogues As Novel Excitatory Amino Acid Transporter ... amino acids undergo transamination/deamination in the liver. Thus amino acids are converted into ammonia and keto acids, which ... Quisqualic acid is an excitatory amino acid (EAA) and a potent agonist of metabotropic glutamate receptors, where evidence ... There is evidence to suggest that excitatory amino acids like quisqualic acid play a significant role in the induction of cell ...

"LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes". ... Jentsch TJ (May 2016). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature ... 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M ... 41 (5): 561-2. doi:10.1016/j.molimm.2004.04.001. PMID 15183935. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, ...

... kinetics Ephraim Katzir Eric Kandel Erich Sackmann Erwin Neher Escheriosome Eva Nogales Excitatory amino-acid transporter ... Top 0-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 5-HT3 receptor ACCN1 ANO1 AP2 adaptor complex Aaron Klug Acid- ... Cafiso David States Davydov soliton Dendrosome Denny's paradox Depolarization Detlev Bronk Dopamine transporter Douglas Warrick ... Locomotor effects of shoes Luca Turin Lymphocyte homing receptor M1 protein M2 proton channel MHC class I Magnesium transporter ...

"LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes". ... Jentsch TJ (May 2016). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature ... 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M ... 41 (5): 561-2. doi:10.1016/j.molimm.2004.04.001. PMID 15183935. Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, ...

... α-Ketoglutarate is one of the most important nitrogen transporters in metabolic pathways. The amino groups of amino acids are ... to form the excitatory neurotransmitter glutamate. Glutamate can then be decarboxylated (requiring vitamin B6) into the ... Proline, arginine, and lysine (in some organisms) are other amino acids synthesized as well. These three amino acids derive ... Dicarboxylic acids, Alpha-keto acids, Citric acid cycle compounds). ...

"LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes". ... Jentsch, Thomas J. (2016-05-17). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". ... Jentsch Thomas J (2016). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature ... 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and ...

"LRRC8A protein is indispensable for swelling-activated and ATP-induced release of excitatory amino acids in rat astrocytes". ... Jentsch, Thomas J. (2016-05-17). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". ... Jentsch Thomas J (2016). "VRACs and other ion channels and transporters in the regulation of cell volume and beyond". Nature ... 12 (2): 117-26. doi:10.1093/dnares/12.2.117. PMID 16303743. Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and ...