Erythropoietin
"Erythropoietin". Dictionary.com Unabridged (Online). n.d. "erythropoietin - definition of erythropoietin in English from the ... Erythropoietin production can be induced by HIF-2α as well as by PGC-1α. Erythropoietin also activates these factors, resulting ... Erythropoietin has been shown to exert its effects by binding to the erythropoietin receptor (EpoR). EPO binds to the ... Exogenous erythropoietin, recombinant human erythropoietin (rhEPO), is produced by recombinant DNA technology in cell culture ...
Erythropoietin receptor
... has been shown to interact with: CRKL, Erythropoietin, Grb2, Janus kinase 2, LYN, PIK3R1, PTPN6, SOCS2 ... Zhu Y, D'Andrea AD (Mar 1994). "The molecular physiology of erythropoietin and the erythropoietin receptor". Current Opinion in ... "Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor". ... The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a ...
Erythropoietin in neuroprotection
Erythropoietin mutants R103-E and S100-E (though S100 in Epo doesn't exist) has been reported to be non-erythropoietin but ... Erythropoietin in neuroprotection is the use of the glycoprotein erythropoietin (Epo) for neuroprotection. Epo controls ... Campana WM, Myers RR (August 2001). "Erythropoietin and erythropoietin receptors in the peripheral nervous system: changes ... "Erythropoietin and erythropoietin receptor in the developing human central nervous system". Pediatr. Res. 43 (1): 40-9. doi: ...
Continuous erythropoietin receptor activator
... (CERA) is the generic term for drugs in a new class of third-generation ... Lasne, F; Martin, L; Martin, J. A; De Ceaurriz, J (2009). "Detection of continuous erythropoietin receptor activator in blood ... CERAs have an extended half-life and a mechanism of action that promotes increased stimulation of erythropoietin receptors ... "Continuous Erythropoietin Receptor Activator (C.E.R.A.) administered at extended administration intervals corrects anaemia in ...
Epileptogenesis
... the hormone erythropoietin; and, paradoxically, drugs such as the α2 adrenergic receptor antagonist atipamezole and the CB1 ...
Eugene Goldwasser
After providing a sample of the purified erythropoietin to researchers at Amgen, a team there led by Fu-Kuen Lin was able to ... In subsequent years erythropoietin has faced controversy for its use as a performance-enhancing drug, particularly in long- ... His memoir, A Bloody Long Journey: Erythropoietin (Epo) and the Person Who Isolated It, (ISBN 978-1-4568-5736-3) was published ... Goldwasser, E.; Kung, C. K. H. (1971). "Purification of erythropoietin". Proc. Natl. Acad. Sci. USA. 68 (4): 697-698. Bibcode: ...
Rejuvenation
... erythropoietin (EPO); 4. insulin; 5. DHEA; 6. melatonin; 7. thyroid; 8. pregnenolone. In theory, if all or some of these ...
Doping at the 1999 Tour de France
13 June 2006). "Detection of recombinant human erythropoietin in urine for doping analysis - Interpretation of isoelectric ... Françoise Lasne & Jacques de Ceaurriz (8 June 2000). "Recombinant erythropoietin in urine". Nature. 405 (6787): 635. Bibcode: ...
Doping at the 1998 Tour de France
13 June 2006). "Detection of recombinant human erythropoietin in urine for doping analysis - Interpretation of isoelectric ... Françoise Lasne & Jacques de Ceaurriz (8 June 2000). "Recombinant erythropoietin in urine". Nature. 405 (6787): 635. Bibcode: ... erythropoietin (EPO), growth hormones, testosterone and amphetamines. When raiding the Festina headquarters in France, the ...
Daprodustat
... increases erythropoietin levels. The effectiveness of daprodustat was established in a randomized study of 2,964 ... In this study, participants received either oral daprodustat or injected recombinant human erythropoietin (a standard of care ... similar to that of the recombinant human erythropoietin. The US Food and Drug Administration (FDA) granted the approval of ...
List of stripped Olympic medals
Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. pp. 187-. ISBN 978-3-527-60543-9. ...
Zidovudine
Fisher JW (December 1997). "Erythropoietin: physiologic and pharmacologic aspects". Proceedings of the Society for Experimental ... Fisher JW (January 2003). "Erythropoietin: physiology and pharmacology update". Experimental Biology and Medicine. 228 (1): 1- ...
Amgen
Also around this time, Amgen researcher Steve Elliott and his team added more sugar molecules to erythropoietin, causing it to ... an Amgen research team led by Fu-Kuen Lin had a breakthrough in finding and cloning the erythropoietin gene, a protein created ... erythropoietin) for anemia Evenity (romosozumab-aqqg) for osteoporosis Imlygic (talimogene laherparepvec) for local treatment ... ". "Amgen and its erythropoietin drugs". The Washington Post. 19 July 2012. Retrieved 20 September 2022. "Drugs@FDA: FDA ...
Epitestosterone
Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. pp. 187-. ISBN 978-3-527-60543-9. ...
Tan Chorh Chuan
Tan completed his PhD in 1992 with a dissertation entitled "Regulation of erythropoietin messenger RNA". Upon graduation in ... Tan, Chorh Chuan (1992). Regulation of Erythropoietin Messenger RNA. National University of Singapore. Archived from the ...
List of Olympic Games scandals and controversies
Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. p. 187. ISBN 978-3-527-60543-9. " ...
Soviet Union
Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. pp. 187-. ISBN 978-3-527-60543-9. ...
1980 Summer Olympics
Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. pp. 187-. ISBN 978-3-527-60543-9. ...
Doping in sport
Erythropoietin (EPO) is largely taken by endurance athletes who seek a higher level of red blood cells, which leads to more ... The Juventus team has been accused of using erythropoietin (EPO) and the matter went to trial in 2004. In November 2004, club ... Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. pp. 187-. ISBN 978-3-527-60543-9. ... that the purchase of erythropoietin or its administration to the athletes of the club does not emerge from any act of the trial ...
Polycythemia
In many families, PFCP is due to an autosomal dominant mutation in the EPOR erythropoietin receptor gene. PFCP can cause an ... The production of red blood cells (or erythropoeisis) in the body is regulated by erythropoietin, which is a protein produced ... Ebert BL, Bunn HF (September 1999). "Regulation of the erythropoietin gene". Blood. 94 (6): 1864-1877. doi:10.1182/blood.V94.6. ... Secondary polycythemia is caused by either natural or artificial increases in the production of erythropoietin, hence an ...
Endocrine gland
... erythropoietin and renin); the thymus; skin (cholecalciferol); and adipose tissue (leptin and resistin). Endocrine glands ...
Doping at the Olympic Games
Sytkowski, Arthur J. (May 2006). Erythropoietin: Blood, Brain and Beyond. John Wiley & Sons. pp. 187-. ISBN 978-3-527-60543-9. ...
Altitude
Ismailov, RM (July-September 2013). "Erythropoietin and epidemiology of Alzheimer disease". Alzheimer Dis. Assoc. Disord. 27 (3 ... the recent hypothesis suggests that high altitude could be protective against Alzheimer's disease via action of erythropoietin ...
Megakaryocyte
It has high homology with erythropoietin. It is essential for the formation of an adequate quantity of platelets. After budding ... Certain cytokines such as IL-3, IL-6, IL-11, LIF, erythropoietin, and thrombopoietin all stimulate the maturation of ... Jelkmann W (2001). "The role of the liver in the production of thrombopoietin compared with erythropoietin". Eur. J. ... and erythropoietin. The megakaryocyte develops through the following lineage: CFU-Me (pluripotential hemopoietic stem cell or ...
Renal cell carcinoma
... due to increased erythropoietin secretion; varicocele, which is seen in males as an enlargement of the pampiniform plexus of ... anaemia resulting from depression of erythropoietin; erythrocytosis (increased production of red blood cells) ...
Hereditary haemochromatosis
"The interaction of iron and erythropoietin". sickle.bwh.harvard.edu. Ofojekwu, Mary-Jane N.; Nnanna, Ogbonnaya U.; Okolie, ...
UFC 174
Ali Bagautinov tested positive for erythropoietin. The following fighters were awarded $50,000 bonuses: Fight of the Night: Tae ... announced that Bagautinov tested positive for erythropoietin (EPO) prior to the title fight. In response, the BCAC has ...
UFC Fight Night: Cejudo vs. Dillashaw
Dillashaw tested positive for erythropoietin (EPO). The following fighters were awarded $50,000 bonuses: Fight of the Night: ... as it was revealed he tested positive to erythropoietin in a fight night test. martial arts portal New York City portal New ...
List of recombinant proteins
Erythropoietin (EPO): Epogen from Amgen Granulocyte colony-stimulating factor (G-CSF): filgrastim sold as Neupogen from Amgen; ... Inoue N, Takeuchi M, Ohashi H, Suzuki T (1995). "The production of recombinant human erythropoietin". Biotechnology Annual ...
Assessment of kidney function
... such as erythropoietin; and activation of vitamin D. The GFR is regarded as the best overall measure of the kidney's ability to ... such as erythropoietin; and activation of vitamin D.[citation needed] The functions of the kidney include maintenance of acid- ...