"Early stimulation of RNA synthesis by erythropoietin in cultures of erythroid precursor cells". Proceedings of the National ... Mao, Zhijuan; Zhang, Suming; Chen, Hong (2015-11-19). "Stem cell therapy for amyotrophic lateral sclerosis". Cell Regeneration ... Tom Maniatis: Gene Expression, Cloning and Beyond Harvard Molecular and Cell Biology Lab Website (Columbia) (Articles with ... proteins in mammalian cells in culture, a central process in the biotechnology industry. Maniatis joined the Department of ...
Primary role of EpoR is to promote proliferation of erythroid progenitor cells and rescue erythroid progenitors from cell death ... "Macrocytosis Resulting from Early Denucleation of Erythroid Precursors". Blood. 24 (5): 582-93. doi:10.1182/blood.V24.5.582.582 ... various non-erythroid cells, and cancer cells. So far, there is no sufficient evidence that in vivo, EpoR signaling can induce ... erythroid progenitors to undergo cell division, or whether Epo levels can modulate the cell cycle. EpoR signaling may still ...
Silva M, Richard C, Benito A, Sanz C, Olalla I, Fernández-Luna JL (February 1998). "Expression of Bcl-x in erythroid precursors ... Studies of cell cultures of senescent human umbilical vein endothelial cells have shown that both fisetin and quercetin induce ... and anti-survival Bcl-2 family of proteins determine whether the cell will undergo cell death; if more Bcl-xL is present, then ... B-cell lymphoma-extra large (Bcl-xL), encoded by the BCL2-like 1 gene, is a transmembrane molecule in the mitochondria. It is a ...
Types of T-cell acute lymphoblastic leukemia include adult T-cell leukemia/lymphoma and (precursor) T-lymphoblastic leukemia/ ... T-lymphoblastic cells of acute leukemia in the bone marrow Acute erythroid leukemia, a rare form of acute myeloid leukemia ... In most cases, these can be classified according to the lineage, myeloid or lymphoid, of the malignant cells that grow ... Yodoi, J; Takatsuki, K; Masuda, T (1974). "Letter: Two cases of T-cell chronic lymphocytic leukemia in Japan". New England ...
... identified in erythroid precursor cells". Br. J. Haematol. 112 (4): 1016-24. doi:10.1046/j.1365-2141.2001.02644.x. PMID ... The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and ... Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. GRCh38: Ensembl release 89 ... 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. ...
The bone marrow of patients with RCC contains islands of erythroid precursors and spare granulocytes. In some scenarios, ... Symptoms result from underproduction of red blood cells (weakness, pallor, failure to thrive, pica), white blood cells ( ...
"MicroRNA-223 reversibly regulates erythroid and megakaryocytic differentiation of K562 cells". J Cell Mol Med. 13 (11-12): 4551 ... Page for mir-223 microRNA precursor family at Rfam (Articles with short description, Short description with empty Wikidata ... Analysis of expression profiles indicate that miR-223 expression decreases as cells mature during monocytic, erythroid, and ... Cell. 129 (3): 617-31. doi:10.1016/j.cell.2007.02.048. PMID 17482553. Sun G, Li H, Rossi JJ (2010). "Sequence context outside ...
On bone marrow examination, people with the disease exhibit abnormal vacuoles in precursor cells of the myeloid and erythroid ... In 2022 the National Cancer Institute announced a three-year clinical trial to evaluate stem cell transplant as a possible ... "A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, ... caused by a somatic mutation of the UBA1 gene in hematopoietic progenitor cells. The name VEXAS is an acronym deriving from the ...
Cell 53:857-867 (1988) In vitro derived leukaemic erythroid cell lines induced by a raf/myc retrovirus differentiate in ... Effect of inhibitors of Ornithine decarboxylase on retrovirus induced transformation of murine erythroid precursors in vitro. ... Leukemia 9:900-907 (1995) Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. ... EMBO Journal 18:5559-5566 (1999) Maturation of erythroid cells and erythroleukemia development are affected by the kinase ...
In vivo the switch of fetal to adult hemoglobin was observed after infusion of nucleated erythroid precursors derived from ... May 2013). "TAP-deficient human iPS cell-derived myeloid cell lines as unlimited cell source for dendritic cell-like antigen- ... June 2014). "Human somatic cell nuclear transfer using adult cells". Cell Stem Cell. 14 (6): 777-80. doi:10.1016/j.stem.2014.03 ... June 2013). "Human embryonic stem cells derived by somatic cell nuclear transfer". Cell. 153 (6): 1228-38. doi:10.1016/j.cell. ...
... involved in the development of erythroid lineage from multipotent progenitors. The burst-forming unit-erythroid (BFU-E) cells ... Erythropoietin has its primary effect on red blood cell progenitors and precursors (which are found in the bone marrow in ... Precursors of red cells, the proerythroblasts and basophilic erythroblasts also express erythropoietin receptor and are ... This results in differentiation, survival and proliferation of the erythroid cell. SOCS1, SOCS3 and CIS are also expressed ...
HbF are termed F cells. These cells are progeny of a small pool of immature committed erythroid precursors (BFU-e) that retain ... thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by ... which does not polymerize and deform red blood cells like the mutated HbS, responsible for sickle cell disease). Adult red ... In sickle-cell disease it increases fetal hemoglobin and decreases the number of attacks. It is taken by mouth. Common side ...
A diagnosis of DBA is made on the basis of anemia, low reticulocyte (immature red blood cells) counts, and diminished erythroid ... precursors in bone marrow. Features that support a diagnosis of DBA include the presence of congenital abnormalities, ... Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia that usually presents in infancy. DBA causes low red blood cell ... The phenotype of DBA patients suggests a hematological stem cell defect specifically affecting the erythroid progenitor ...
As they mature, a number of erythrocyte characteristics change: The overall size of the erythroid precursor cell decreases, ... These cells still contain RNA and are also called "immature red blood cells") The cell is released from the bone marrow after ... There are colony forming units that the cells follow during their formation. These cells are referred to as the committed cells ... Erythropoiesis is the development of mature red blood cells from erythropoietic stem cells. The first cell that is ...
A decrease in Thromboxane-A synthase leads to an increase in prostaglandin E2 levels which may affect erythroid precursor cells ... The TBXAS1 gene mainly transcribes in cells involved with the skeletal system and muscular system. The increased bone density ... with a range between 0.1 mg/kg/day to 1.5 mg/kg/day to maintain hemoglobin and white blood cells at normal levels in the blood ...
... an increase in megakaryocytes and erythroid precursors may be observed, but dyspoiesis in not seen in any cell lineage. Also, ... The postulated cell of origin is a limited-potential, marrow-derived stem cell. The majority (90%) of cases have not had ... so the bone marrow biopsy may show evidence of a plasma cell dyscrasia with increased numbers of atypical plasma cells. Splenic ... On both the bone marrow aspirate and the core biopsy, a hypercellular marrow with an increased myeloid:erythroid ratio of 20:1 ...
... granulocyte precursor cells MeSH A11.148.378.590 - myeloid progenitor cells MeSH A11.148.378.590.249 - erythroid progenitor ... cho cells MeSH A11.251.210.505 - l cells (cell line) MeSH A11.251.210.520 - llc-pk1 cells MeSH A11.251.210.700 - 3t3 cells MeSH ... granulocyte precursor cells MeSH A11.251.210.172 - cell line, transformed MeSH A11.251.210.172.500 - cos cells MeSH A11.251. ... u937 cells MeSH A11.627.635.350 - granulocyte precursor cells MeSH A11.635.500.700 - satellite cells, skeletal muscle MeSH ...
... defined as cytoplasmic and nuclear morphologic changes in erythroid, granulocytic, and megakaryocytic precursors, than what is ... First, the percentage of undifferentiated progenitor cells, blast cells, is always less than 20%, with considerably more ... Cell. 165 (4): 867-881. doi:10.1016/j.cell.2016.04.006. ISSN 1097-4172. PMC 4881391. PMID 27133164. Sumpter, Rhea; Levine, Beth ... "Role of Fanconi DNA repair pathway in neural stem cell homeostasis". Cell Cycle. 7 (13): 1911-5. doi:10.4161/cc.7.13.6235. PMID ...
Decreased reticulocyte count due to destruction of fragile and abnormal megaloblastic erythroid precursor. The platelet count ... unbalanced cell proliferation and impaired cell division occur as a result of arrested nuclear maturation so the cells show ... Anemia is a condition in which the body does not have enough healthy red blood cells. Red blood cells provide oxygen to body ... There is a defect in DNA synthesis in the rapidly dividing cells and to a lesser extent, RNA and protein synthesis are also ...
"Interplay of pu.1 and gata1 determines myelo-erythroid progenitor cell fate in zebrafish". Dev. Cell. 8 (1): 97-108. doi: ... Choi K, Kennedy M, Kazarov A, Papadimitriou JC, Keller G (1998). "A common precursor for hematopoietic and endothelial cells" ( ... immune cells, and even platelets all originate from the same progenitor cell, the hematopoietic stem cell (HSC). As these cells ... PAX5 and Notch mutations can result in B-cell and T-cell leukemias, respectively. Dysregulation of stromal cells can in some ...
Bone marrow produces both white blood cells and red blood cells from the same precursor stem cells. Therefore, the upregulation ... Inflammatory cytokines suppress the proliferation of erythroid precursors in the bone marrow.; (ii) inflammatory cytokines ... of white blood cells causes fewer stem cells to differentiate into red blood cells. This effect may be an important additional ... the effect of locking up iron stores is to reduce the ability of the bone marrow to produce red blood cells. These cells ...
Chen Y, McPhie DL, Hirschberg J, Neve RL (2000). "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle ... Gubin AN, Njoroge JM, Bouffard GG, Miller JL (1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2 ... "The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in ... Cell. 17 (3): 341-50. doi:10.1016/j.molcel.2004.12.020. PMID 15694336. Gong, L; Yeh E T (April 1999). "Identification of the ...
It is classified as an erythrovirus because of its capability to invade red blood cell precursors in the bone marrow. Three ... This infection is sometimes complicated by severe aplastic anemia caused by lysis of early erythroid precursors.[citation ... as well as the virus directly negatively affecting the red blood cell precursors in the bone marrow. The risk of fetal loss is ... Although most patients have a decrease of erythropoiesis (production of red blood cells) during parvovirus infection, it is ...
... erythroid precursors in the bone marrow, it binds to it and is transported into the cell in a vesicle by receptor-mediated ... The retained iron in Hereditary hemochromatosis is primarily deposited in parenchymal cells, with reticuloendothelial cell ... The main role of transferrin is to deliver iron from absorption centers in the duodenum and white blood cell macrophages to all ... The receptor with its ligand bound transferrin is then transported through the endocytic cycle back to the cell surface, ready ...
However, infection with parvoviruses (such as human parvovirus B19) can affect erythroid precursors while they still have DNA, ... Lipid rafts that have been implicated in cell signaling events in nonerythroid cells have been shown in erythroid cells to ... Red blood cells in mammals are anucleate when mature, meaning that they lack a cell nucleus. In comparison, the red blood cells ... Red blood cells are deformable, flexible, are able to adhere to other cells, and are able to interface with immune cells. Their ...
... is possible to use negative exclusion markers to deplete a cell population of other precursors and differentiated cells by cell ... Early erythroid progenitors are found at a quite low frequency relative to later stages of erythroid differentiation, such as ... CFU-E cells express Epo receptor, c-Kit (Stem cell factor receptor), transferrin receptor (CD71+), and are Ter119(glycophorin-A ... CFU-E stands for Colony Forming Unit-Erythroid. It arises from CFU-GEMM (via BFU-E, which stands for "erythroid burst-forming ...
Among white blood cells and precursors, CD71 is expressed only by erythroid precursors within the normal hematopoietic marrow ... the adult T cell leukemia (ATLL) caused by HTLV-1 and the Mantle cell lymphoma (MCL).[citation needed] TfR1 expressed on the ... "Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin". Proceedings of the ... Each monomer binds one holo-transferrin molecule creating an iron-Tf-TfR complex which enters the cell by endocytosis. TfR1 as ...
... a condition where macrophages phagocytose myeloid and erythroid precursors (similar to hemophagocytic lymphohistiocytosis in ... Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and ... and it is mediated by infiltration of CD8-expressing T cells followed by expression of Type 1 T helper cell cytokines (such as ... Cytology reveals cells with clear to lightly basophilic cytoplasm and round or indented nuclei with fine chromatin and ...
... a condition where macrophages phagocytose myeloid and erythroid precursors (similar to hemophagocytic lymphohistiocytosis in ... Langerhans cells are dendritic cells found in the skin and function by internalizing antigens (foreign particles) and ... A histiocyte is a differentiated tissue cell that has its origin in the bone marrow. The source for histiocytes is the monocyte ... Ginhoux F, Tacke F, Angeli V, Bogunovic M, Loubeau M, Dai XM, Stanley ER, Randolph GJ, Merad M (2006). "Langerhans cells arise ...
... and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development. It is associated with ... placenta and chorio-carcinoma cells. Splicing products on the 5´end were found in primary haematopoietic cells and acute ... stem cells the β chain is expressed at very low levels and the amount increases along initial differentiation of erythroid, ... Kinetics of the receptor in immature and mature myeloid cells in response to GM-CSF is readily regulated by internalization or ...