"Mapping and characterization of visna/maedi virus cytotoxic T-lymphocyte epitopes". J. Gen. Virol. 89 (Pt 10): 2586-96. doi: ... This causal lentivirus can be found in monocytes, lymphocytes and macrophages of infected sheep in the presence of humoral and ... Infected differentiated monocytes, also known as macrophages, will continuously present VMV antigens inducing T-lymphocytes to ... visna virus does not infect T-lymphocytes. The relationship of visna and HIV as lentiviruses was first published in 1985 by ...

In RHD, molecular mimicry results in incorrect T cell activation, and these T lymphocytes can go on to activate B cells, which ... Molecular mimicry occurs when epitopes are shared between host antigens and Streptococcus antigens. This causes an autoimmune ... The valvular endothelium is a prominent site of lymphocyte-induced damage. CD4+ T cells are the major effectors of heart tissue ... The dominant contributors are a component of MHC class II molecules, found on lymphocytes and antigen-presenting cells, ...

The TCRs of T lymphocytes recognise only sequential epitopes, also called linear epitopes, of only peptides and only if coupled ... It presents epitopes to killer T cells, also called cytotoxic T lymphocytes (CTLs). A CTL expresses CD8 receptors, in addition ... T lymphocytes can detect a peptide displayed at 0.1-1% of the MHC molecules. In their development in the thymus, T lymphocytes ... Classical MHC molecules present epitopes to the TCRs of CD8+ T lymphocytes. Nonclassical molecules (MHC class IB) exhibit ...

2006). "A molecular approach to the identification of cytotoxic T-lymphocyte epitopes with Equine Herpes-1". Journal of General ...

It targets CD20 marker on B lymphocytes and is an immunosuppressive drug. Ocrelizumab binds to an epitope that overlaps with ... Ocrelizumab is a humanized monoclonal antibody that binds to a CD20 epitope that overlaps partially with the epitope to which ... the epitope to which rituximab binds. It was approved by the US Food and Drug Administration (FDA) in March 2017, and the first ...

"IFN-gamma exposes a cryptic cytotoxic T lymphocyte epitope in HIV-1 reverse transcriptase". Journal of Immunology. 162 (12): ... Madani N, Kabat D (Dec 1998). "An endogenous inhibitor of human immunodeficiency virus in human lymphocytes is overcome by the ... is the processing of numerous MHC class-I restricted T cell epitopes. This gene encodes a member of the proteasome B-type ... is the major degradation machinery that degrades the antigen and present the resulting peptides to cytotoxic T lymphocytes. The ...

GP2 consisting of 9 amino acids is the subdominant epitope. Both E75 and GP2 stimulate the CD8+ lymphocytes but GP2 has a lower ... Some IgE-inducing epitopes cause hypersensitivity reactions after vaccination in humans due to the overlap with IgG epitopes in ... The whole peptide vaccine is to mimic the epitope of an antigen, so epitope design is the most important stage of vaccine ... The followings are the points to consider when designing the epitope: The non-dominant epitope could generate a stronger immune ...

... cytotoxic T-lymphocyte responses against dominant and recessive epitopes of influenza virus nucleoprotein induced by DNA ... CTL responses can be raised against immunodominant and immunorecessive CTL epitopes, as well as subdominant CTL epitopes,[ ... One of the advantages of DNA vaccines is that they are able to induce cytotoxic T lymphocytes (CTL) without the inherent risk ... This may prove to be a useful tool in assessing CTL epitopes and their role in providing immunity. Cytotoxic T-cells recognise ...

"Amphipathic segment of the nicotinic receptor alpha subunit contains epitopes recognized by T lymphocytes in myasthenia gravis ...

"The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides". ... Bowness, Paul (1993). Recognition of antigen and superantigen by cytotoxic lymphocytes (Thesis). Thesis DPhil--University of ... "Vertical T cell immunodominance and epitope entropy determine HIV-1 escape". The Journal of Clinical Investigation. 123 (1): ... "Phenotypic analysis of antigen-specific T lymphocytes". Science. 274 (5284): 94-96. Bibcode:1996Sci...274...94A. doi:10.1126/ ...

The parts of an antigen that interact with an antibody molecule or a lymphocyte receptor, are called epitopes, or antigenic ... T and B lymphocytes are the cells of the adaptive immune system. The human body has about 2 trillion lymphocytes, which are 20- ... In jawless fishes, two subsets of lymphocytes use variable lymphocyte receptors (VLRs) for antigen binding. Diversity is ... Lymphocyte receptors, Ig and TCR, are found in all jawed vertebrates. The most ancient Ig class, IgM, is membrane-bound and ...

3 HLA-A2 restricted epitopes in CTAG1B were identified as the recognition sites for CD8+ cytotoxic T lymphocytes. Integrated ... A2-binding peptide epitopes". The Journal of Experimental Medicine. 187 (2): 265-70. doi:10.1084/jem.187.2.265. PMC 2212106. ... "NY-ESO-1 119-143 is a promiscuous major histocompatibility complex class II T-helper epitope recognized by Th1- and Th2-type ... "Efficient simultaneous presentation of NY-ESO-1/LAGE-1 primary and nonprimary open reading frame-derived CTL epitopes in ...

... containing a mutated epitope recognized by autologous tumor-infiltrating T lymphocytes". J. Immunol. 166 (4): 2871-7. doi: ...

The SART1(259) protein possesses tumor epitopes capable of inducing HLA-A2402-restricted cytotoxic T lymphocytes in cancer ... "A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes". J Exp Med. 187 (3 ... "Identification of a SART-1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes". ... required for induction of histocompatibility leukocyte antigen-class I-restricted and tumor-specific cytotoxic T lymphocytes by ...

"The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". Immunol ... Sewell WA, Brown MH, Dunne J, Owen MJ, Crumpton MJ (1986). "Molecular cloning of the human T-lymphocyte surface CD2 (T11) ... It interacts with other adhesion molecules, such as lymphocyte function-associated antigen-3 (LFA-3/CD58) in humans, or CD48 in ... Schraven B, Samstag Y, Altevogt P, Meuer SC (1990). "Association of CD2 and CD45 on human T lymphocytes". Nature. 345 (6270): ...

... the differentiated DCs present the allergenic epitope associated with the allergen to T lymphocytes. These T cells then divide ... In a similar fashion, cytotoxic T lymphocytes patrol an area of skin and play an important role in controlling both the ... Their immunology centres on the interaction of immunoregulatory cytokines and discrete subpopulations of T lymphocytes. The ... and present the antigen to T-lymphocytes. This process is controlled by cytokines and chemokines - with tumor necrosis factor ...

"The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". ... Implications for the relationship of NK and T lymphocytes". Journal of Immunology. 149 (6): 1876-80. PMID 1387664. Wong S, ... "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation ... "Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120". European Journal of Immunology ...

1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". ... 1996). "Composition of TCR-CD3 complex in human intestinal intraepithelial lymphocytes: lack of Fc epsilon RI gamma chain". Int ... 1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55-65. doi:10.1111/j.1432-1033.1989 ... "A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation ...

Vaccination with cytotoxic T lymphocyte epitope‐containing peptide protects against a tumor induced by human papillomavirus ... In addition, it is likely that protein vaccination leads to presentation of epitopes in the context of various HLA alleles, and ... Cooperation between helper T cells and cytotoxic T lymphocyte precursors. Annals of the New York Academy of Sciences, 532(1), ... The inclusion of CD4+ epitopes into MAGE-3 vaccination studies has recently been facilitated by the identification of several ...

... encoding the interleukin 1 receptor antagonist and six epitopes recognized by human cytolytic T lymphocytes". Cancer Res. 60 ( ...

2006). "Profiling lymphocyte subpopulations in peripheral blood under efalizumab treatment of psoriasis by multi epitope ligand ... The Toponome Imaging Systems (TIS) and multi-epitope-ligand cartographs (MELC) represent different stages of the ICM ... Ademmer; Ebert; Müller-Ostermeyer; Friess; Büchler; Schubert; Malfertheiner (April 1998). "Effector T lymphocyte subsets in ... "Comparative Multi-Epitope-Ligand-Cartography reveals essential immunological alterations in Barrett's metaplasia and esophageal ...

Epitope spreading or epitope drift - when the immune reaction changes from targeting the primary epitope to also targeting ... In this form of the disease, the absence of lymphocytes can accelerate organ damage, and intravenous IgG administration can be ... Epitope modification or Cryptic epitope exposure - this mechanism of autoimmune disease is unique in that it does not result ... Pike B, Boyd A, Nossal G (1982). "Clonal anergy: the universally anergic B lymphocyte". Proceedings of the National Academy of ...

1992). "The antigen-specific induction of normal human lymphocytes in vitro is down-regulated by a conserved HIV p24 epitope". ... 1987). "The human T3 gamma chain is phosphorylated at serine 126 in response to T lymphocyte activation". J. Biol. Chem. 262 ( ... Implications for the relationship of NK and T lymphocytes". J. Immunol. 149 (6): 1876-80. PMID 1387664. Letourneur F, Klausner ... 1989). "Dephosphorylation of the human T lymphocyte CD3 antigen". Eur. J. Biochem. 181 (1): 55-65. doi:10.1111/j.1432-1033.1989 ...

Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, ... and lymphocyte aggregation". Journal of Immunology. 153 (9): 3847-61. PMID 7523506. as referenced in paragraph 146 of the PCT ... "Distinct but overlapping epitopes are involved in alpha 4 beta 7-mediated adhesion to vascular cell adhesion molecule-1, ... mucosal addressin-1, fibronectin, and lymphocyte aggregation. Andrew DP, Berlin C, Honda S, Yoshino T, Hamann A, Holzmann B, ...

Lymphocyte anergy pathways involve induction of some, but not all of the signaling pathways used during lymphocyte activation. ... demonstrated that epitope-mapping tools could accurately identify the epitopes responsible for 95% of the murine T-cell ... It may have been expected that B lymphocytes and T lymphocytes would cluster separately from each other, or that natural killer ... T-cell and B-cell epitope mapping algorithms can computationally predict epitopes based on the genomic sequence of pathogens, ...

... cytotoxic T lymphocyte epitope in a human glioma-associated antigen, interleukin 13 receptor alpha2 chain". Clinical Cancer ...

This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in ... of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes ...

... ic escape Antitoxin Conformational epitope Epitope Linear epitope Magnetic immunoassay Neutralizing antibody Original ... Upon exposure to an antigen, only the lymphocytes that recognize that antigen are activated and expanded, a process known as ... Using the "lock and key" metaphor, the antigen can be seen as a string of keys (epitopes) each of which matches a different ... Any such feature constitutes an epitope. Most antigens have the potential to be bound by multiple antibodies, each of which is ...

There is a large diversity of epitopes recognized and, as a result, it is possible for some B and T lymphocytes to develop with ... Each of these lymphocytes express specificity to a particular epitope, or the part of an antigen to which B cell and T cell ... this allows microorganisms with epitopes similar to host antigen to escape recognition and detection by T and B lymphocytes. ... B and T lymphocytes are tested for their affinity for self MHC/peptide complexes before leaving the primary lymphoid organs and ...

This activity is required to generate signal sequence-derived human lymphocyte antigen-E epitopes that are recognized by the ... 2002). "Intramembrane proteolysis of signal peptides: an essential step in the generation of HLA-E epitopes". J. Immunol. 167 ( ...