... is a protein that in humans is encoded by the EFNA5 gene. Ephrin A5 is a glycosylphosphatidylinositol (GPI)-anchored ... This finding that ephrin A5 promotes growth cone survival that is opposite of EphA signaling and mediated directly by ephrin A5 ... Ephrin A5 has also been shown to bind to the EphB2 receptor. "Reverse" signaling is one unique property of ephrin ligands that ... Nonetheless, certain ephrin-A ligands are known to initiate reverse signaling cascades like ephrin A5, which has been shown to ...
... is a protein that in humans is encoded by the EFNA3 gene. This gene encodes a member of the ephrin (EPH) family. The ... "Entrez Gene: EFNA3 ephrin-A3". Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu ... 1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885-93. doi: ... Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to ...
... is a protein that in humans is encoded by the EFNA4 gene. This gene encodes a member of the ephrin (EPH) family. The ... "Entrez Gene: EFNA4 ephrin-A4". Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu ... Choi S, Jeong J, Kim T, Park S (2000). "Characterization of ephrin-A1 and ephrin-A4 as ligands for the EphA8 receptor protein ... 2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". ...
... (ephrin type-A receptor 3) is a protein that in humans is encoded by the EPHA3 gene. This gene belongs to the ... The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their ... affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Two ... EPH receptor A3 has been shown to interact with EFNB2 and EFNA5. GRCh38: Ensembl release 89: ENSG00000044524 - Ensembl, May ...
... (ephrin type-A receptor 4) is a protein that in humans is encoded by the EPHA4 gene. This gene belongs to the ... "Entrez Gene: EPHA4 EPH receptor A4". Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development ... Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly; Chapter: Eph receptors and ephrins: ... 1998). "Ephrin-B3, a ligand for the receptor EphB3, expressed at the midline of the developing neural tube". Oncogene. 16 (4): ...
Carmona MA, Murai KK, Wang L, Roberts AJ, Pasquale EB (2009). "Glial ephrin-A3 regulates hippocampal dendritic spine morphology ... Once localized, the enzyme alternates between two conformations, E1 and E2, to transport ions across the membrane. The E1 ... It is a member of the P-type ATPases, also known as E1-E2 ATPases due to its two states. The gastric hydrogen potassium ATPase ... The E2 conformation binds potassium, and reverts to the E1 conformation to release phosphate and K+ into the cytoplasm where ...
ephrin-A2 and ephrin-A3 have been showed to negatively regulate adult neurogenesis. Early neuroanatomists, including Santiago ... Eph receptors and ephrin signaling have been shown to regulate adult neurogenesis in the hippocampus and have been studied as ... Jiao, J. W.; Feldheim, D. A.; Chen, D. F. (2008). "Ephrins as negative regulators of adult neurogenesis in diverse regions of ... 156 (5): 1114-1114.e1. doi:10.1016/j.cell.2014.02.029. PMID 24581504. Duan, Xin; Kang, Eunchai; Liu, Cindy Y; Ming, Guo-li; ...
Ephrin-A3 (Efna3) is a gene that is involved in the inhibition of angiogenesis. Although it is known that Efna3 inhibits the ... "Hypoxia induces microRNA miR-210 in vitro and in vivo ephrin-A3 and neuronal pentraxin 1 are potentially regulated by miR-210 ... "MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3". The ... "MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3". The ...
Although several members of Ephs and ephrins contribute to motor neuron guidance, ephrin-A5 reverse signaling has been shown to ... as it has recently been shown that ephrin-B3 can bind to and activate EphA4 and that ephrin-A5 can bind to and activate EphB2. ... The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal ... The ability of Eph/ephrin signaling to direct migrating axons along Eph/ephrin expression gradients is evidenced in the ...
Specifically, ephrin-A5 was shown to stimulate growth cone spreading in spinal motor neurons and ephrin-B1 was shown to promote ... Ephrin ligands are divided into two subclasses of ephrin-A and ephrin-B based on their structure and linkage to the cell ... Of the eight ephrins that have been identified in humans there are five known ephrin-A ligands (ephrin-A1-5) that interact with ... binding specificity as it has recently been shown that ephrin-B3 is able to bind to and activate EPH receptor A4 and ephrin-A5 ...
This interaction, mediated by ephrin A3/EphA4 signaling, induces the recruitment and activation of cyclin-dependent kinase 5 ( ... Astrocytes and their processes express ephrin A3, whereas the EphA4 receptor is enriched in hippocampal neurons. ... For example, Ephrin B3 interacts with the adaptor protein glutamate-receptor-interacting protein 1 (GRIP-1) to regulate the ... Ephrin B/EphB signaling is also involved in synaptic stabilization through different mechanisms. These molecules contain ...
... the family of ephrins include ephrin A1, A2, A3, A4, A5, B1, B2, and B3. The EGF and TGF families of neurotrophic factors are ... The ephrins are a family of neurotrophic factors that signal through eph receptors, a class of receptor tyrosine kinases; ...
Aasheim HC, Munthe E, Funderud S, Smeland EB, Beiske K, Logtenberg T (January 2000). "A splice variant of human ephrin-A4 ... Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene. EphA6 may serve an important role in breast ... Overview of all the structural information available in the PDB for UniProt: Q62413 (Mouse Ephrin type-A receptor 6) at the ... cite book}}: ,journal= ignored (help) Xu Q, Mellitzer G, Wilkinson DG (July 2000). "Roles of Eph receptors and ephrins in ...
... ephrin-A2 and ephrin-A3) from the astrocytes. The astrocytes are able to activate the stem cells to transform into working ... neurons by dampening the release of ephrin-A2 and ephrin-A3. In a study published in a 2011 issue of Nature Biotechnology a ... Jiao JW, Feldheim DA, Chen DF (June 2008). "Ephrins as negative regulators of adult neurogenesis in diverse regions of the ...
The ephrins EPH receptor A2 and A3 are shed by ADAM10, creating cleaved soluble Eph receptors, which inhibit tumor angiogenesis ...
"Characterization of the genes for mouse LERK-3/Ephrin-A3 (Epl3), mouse LERK-4/Ephrin-A4 (Epl4), and human LERK-6/Ephrin-A2 ( ... Ephrin-A2 is a protein that in humans is encoded by the EFNA2 gene. This gene encodes a member of the ephrin family. The ... "Entrez Gene: EFNA2 ephrin-A2". Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu ... Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to ...
More specifically in the mouse, Ephrin A5 is expressed along the rostral-caudal axis of the optic tectum whereas the EphB ... Later, it was identified that receptor tyrosine kinases family EphA and a related EphA binding molecule referred to as ephrin-A ...
The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact- ... Ephrin type-A receptor 8 is a protein that in humans is encoded by the EPHA8 gene. This gene encodes a member of the ephrin ... The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their ... cite book}}: ,journal= ignored (help) Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental ...
... ephrin A4 and ezrin. It is also suggested that angiogenin and FGF18 may be potential transcriptional targets of the H19 RNA. As ...
This subsequently lead to extensive research and the discovery of two repulsive factors, Ephrin-A5 and Ephrin-A2, by observing ... Reverse signaling can also occur when Ephrin-A is activated by Eph-A3 binding; this is regulated by metalloprotease-dependent ... Ephrins are divided into 2 classes: Ephrin-As are bound to the membrane through GPI (glycosylphosphatidylinositol) linkage and ... Eph/Ephrin binding induces conformational changes in the Ephrin transmembrane and cytoplasmic domains, activating the signaling ...
Ephrins Ephrin A1 Ephrin A2 Ephrin A3 Ephrin A4 Ephrin A5 Ephrin B1 Ephrin B2 Ephrin B3 Erythropoietin (EPO) Fibroblast growth ...
... ephrin-a2 MeSH D23.348.479.500.300 - ephrin-a3 MeSH D23.348.479.500.400 - ephrin-a4 MeSH D23.348.479.500.500 - ephrin-a5 MeSH ... D23.348.479.500.600 - ephrin-b1 MeSH D23.348.479.500.700 - ephrin-b2 MeSH D23.348.479.500.800 - ephrin-b3 MeSH D23.348.479.750 ... adenovirus e1 proteins MeSH D23.050.327.045.060 - adenovirus e2 proteins MeSH D23.050.327.045.070 - adenovirus e3 proteins MeSH ... ephrins MeSH D23.348.479.500.100 - ephrin-a1 MeSH D23.348.479.500.200 - ...
... ephrin-A2 MeSH D12.644.276.500.300 - ephrin-A3 MeSH D12.644.276.500.400 - ephrin-A4 MeSH D12.644.276.500.500 - ephrin-A5 MeSH ... D12.644.276.500.600 - ephrin-b1 MeSH D12.644.276.500.700 - ephrin-b2 MeSH D12.644.276.500.800 - ephrin-b3 MeSH D12.644.276.625 ... ephrins MeSH D12.644.276.500.100 - ephrin-A1 MeSH D12.644.276.500.200 - ...
... (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene. This gene belongs to the ... 1999). "A role for the Eph ligand ephrin-A3 in entorhino-hippocampal axon targeting". J. Neurosci. 19 (20): 8885-93. doi: ... The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their ... axon guidance and axon fasciculation suggested by studies of the tyrosine kinase receptor EphA5/REK7 and its ligand ephrin-A5/ ...
Ephrin and the ephrin receptors, Eph, have been found to regulate and direct retinal axon branches. Forward signaling between ... Pruning of axons along the visual corticospinal tract (CST) is defective in neuropilin-2 mutants and plexin-A3 and plexin-A4 ... Ensuing binding of ephrin-B3 to the cytoplasmic adaptor protein, Grb4, leads to the recruitment and binding of Dock180 and p21 ... Reverse signaling between ephrin-B proteins and their Eph receptor tyrosine kinases have been found to initiate the retraction ...
207 (5): 405.e1-7. doi:10.1016/j.ajog.2012.07.008. PMC 3484193. PMID 22917484. Hill, Denise S; Wlodarczyk, Bogdan J; Palacios, ... Davy, A; Bush, J. O; Soriano, P (2006). "Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies ... 32 (18): 2282-91, 2291.e1-7. doi:10.1038/onc.2012.251. PMID 22797075. S2CID 21255355. Sirnes, S; Bruun, J; Kolberg, M; Kjenseth ...
June 2012). "The ephrin receptor tyrosine kinase A2 is a cellular receptor for Kaposi's sarcoma-associated herpesvirus". Nature ... ubiquitin E3 ligases - regulates antigen presentation K4 - vCCL2 - chemokine K4.1 - vCCL3 - chemokine K8 - transcriptional ...