Enteropathy-associated T-cell lymphoma
... (EATL), previously termed enteropathy-associated T-cell lymphoma, type I and at one time ... Lymphoma Working Party of the EBMT (2013). "Autologous stem cell transplantation for enteropathy-associated T-cell lymphoma: A ... termed enteropathy-type T-cell lymphoma (ETTL), is a complication of coeliac disease in which a malignant T-cell lymphoma ... Autologous Stem-cell Transplantation as Frontline Treatment of Patients with Enteropathy-associated T-cell Lymphoma Type 1". 9 ...
Monomorphic epitheliotropic intestinal T cell lymphoma
... (MEITL) (formerly termed enteropathy-associated T cell lymphoma, type II ... terming the celiac disease-associated lymphoma as enteropathy-associted T cell lymphoma (EATL) and the lymphoma not associated ... In 2008, the World Health Organization defined a specific type of lymphoma, enteropathy-associated T cell lymphoma (EATL), as ... Peripheral T-cell lymphoma not otherwise specified (PTCL-NOS): PTCL-NOS is a heterogenous group of T cell lymphomas that ...
Indolent T cell lymphoproliferative disorder of the gastrointestinal tract
... formerly termed Type II enteropathy-associate T-cell lymphoma): Unlike ITCLD-GT, MEITL a) is a highly aggressive lymphoma of ... Peripheral T-cell lymphoma subtype peripheral T-cell lymphoma not otherwise specified (PTCL-NOS): Unlike ITCLD-GT, PTCL-NOS a) ... Unlike certain types of T cell lymphomas for which it has been mistaken, the T cells in ITCLD-GT do not express the neutral ... Ondrejka S, Jagadeesh D (December 2016). "Enteropathy-Associated T-Cell Lymphoma". Current Hematologic Malignancy Reports. 11 ( ...
Intraepithelial lymphocyte
... or become the malignant cells in enteropathy-associated T-cell lymphoma, a lymphoma that is a complication of celiac sprue. ... Chander U, Leeman-Neill RJ, Bhagat G (August 2018). "Pathogenesis of Enteropathy-Associated T Cell Lymphoma". Current ... Ondrejka S, Jagadeesh D (December 2016). "Enteropathy-Associated T-Cell Lymphoma". Current Hematologic Malignancy Reports. 11 ( ... These cells are very similar to iCD8α population and it is unclear if this is a different subset of cells or only precursors of ...
Natural killer cell enteropathy
... peripheral T-cell lymphoma not otherwise specified, T cell lymphomas that consist of mature T cells and occur in the GI tact, ... Natural killer cell enteropathy, also termed NK cell enteropathy (NKCE), and a closely related disorder, lymphomatoid ... Chander U, Leeman-Neill RJ, Bhagat G (August 2018). "Pathogenesis of Enteropathy-Associated T Cell Lymphoma". Current ... The two NK cell proliferation diseases have been termed NK cell enteropathy and lymphomatoid gastropathy with NKCE being seen ...
T-cell lymphoma
Primary intestinal T-cell lymphomas Enteropathy-associated T-cell lymphoma (EATL) Monomorphic epitheliotropic intestinal T cell ... Extranodal NK/T-cell lymphoma, nasal type, Cutaneous T-cell lymphoma (CTCL), etc. T-cell lymphoma which develops from the lymph ... angioimmunoblastic T-cell lymphoma (AITL), extranodal NK/T-cell lymphoma, nasal type, and Peripheral T-cell lymphoma not ... Angioimmunoblastic T-cell lymphoma (AITL): Aggressive form of T-cell lymphoma.[citation needed] Anaplastic large cell lymphoma ...
HLA DR3-DQ2
This increased risk is most prominent in a rare cancer, enteropathy associated T-cell lymphoma. HLA-DR3-DQ2 is found in HLA A1- ... HLA DR3-DQ2 is double serotype that specifically recognizes cells from individuals who carry a multigene HLA DR, DQ haplotype. ... The DQA1*0501:DQB1*0201 (DQ2.5) locus confers susceptibility to Gluten Sensitive Enteropathy (GSE)and (Type 1 Diabetes) but has ... implications for unrelated hematopoietic stem cell donor selection". Hum Immunol. 66 (6): 721-31. doi:10.1016/j.humimm.2005.02. ...
HLA-DQ
... for disease and some specific complications of coeliac disease such as Gluten-sensitive enteropathy associated T-cell lymphoma ... These T-cells, called T-helper cells, can promote the amplification of B-cells which, in turn recognize a different portion of ... As a variable cell surface receptor on immune cells, these D antigens, originally HL-A4 antigens, are involved in graft-versus- ... HLA-DQ (DQ) is a cell surface receptor protein found on antigen-presenting cells. It is an αβ heterodimer of type MHC class II ...
Dennis H. Wright
... he and his coworkers were among the first to describe T-cell lymphomas associated with enteropathy and to describe lymphomas of ... "Enteropathy-Type Intestinal T-Cell Lymphoma: Clinical Features and Treatment of 31 Patients in a Single Center". Journal of ... A distinctive type of B-cell lymphoma". Cancer. 52 (8): 1410-1416. doi:10.1002/1097-0142(19831015)52:8. 3.0.CO;2-3. PMID ... He was the first to suggest that Reed-Sternberg cells are derived from B-cells - a controversial proposal that was not ...
HLA-DQ2
... leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma ... When DQA1*0505 or DQA1*0501 gene products are processed to the cell surface they become α5. The gene products of DQB1*0202 and ... Qiao SW, Bergseng E, Molberg O, Jung G, Fleckenstein B, Sollid LM (July 2005). "Refining the rules of gliadin T cell epitope ... This creates very strong binding of T-cells for DQ2.5-33mer complexes. DQ2.5 binds gliadin, but the binding is sensitive to ...
Gluten-sensitive enteropathy-associated conditions
... cancer of the esophagus and lymphoproliferative diseases such as gluten-sensitive enteropathy-associated T-cell lymphoma (EATL ... leukocyte antigen-DQ2 homozygosity and the development of refractory celiac disease and enteropathy-associated T-cell lymphoma ... Mäkelä M, Oling V, Marttila J, Waris M, Knip M, Simell O, Ilonen J (2006). "Rotavirus-specific T cell responses and cytokine ... 2006). "Autoimmune enteropathy and rheumatoid arthritis: a new association in the field of autoimmunity". Digestive and Liver ...
Gastric lymphoma
... lymphomas involving the stomach include mantle cell lymphoma and T-cell lymphomas which may be associated with enteropathy; the ... large-cell lymphomas. Sometimes, it's hard to differentiate poorly differentiated high grade B-cell gastric lymphoma from ... An elevated LDH level may be suggestive of lymphoma. Diffuse large B-cell lymphomas of the stomach are primarily treated with ... of all lymphomas. However, the stomach is a very common extranodal site for lymphomas (lymphomas originate elsewhere and ...
Coeliac disease
... enteropathy-associated T-cell lymphoma (EATL) or other non-Hodgkin lymphomas). This risk is also higher in first-degree ... However, CE can be used for diagnosing T-cell lymphoma, ulcerative jejunoileitis, and adenocarcinoma in refractory or ... Fleckenstein B, Molberg Ø, Qiao SW, Schmid DG, von der Mülbe F, Elgstøen K, Jung G, Sollid LM (2002). "Gliadin T cell epitope ... This increases the likelihood that the DQ2 isoform will bind, and stay bound to, peptide when recognised by T-cells. Gliadin in ...
Steven Wells
After being in remission for a short time, he was diagnosed with enteropathy-associated T-cell lymphoma in January 2009 and ... Wells, Steven (31 March 2009). "Cell Out". Philadelphia Weekly. Archived from the original on 1 February 2013. Retrieved 25 ... In June 2006, he wrote in the Philadelphia Weekly about his treatment for Hodgkin's lymphoma. ... Deaths from non-Hodgkin lymphoma, English bloggers, English music journalists, English radio writers, English television ...
Enteropathy
Specific types of enteropathy include: Enteropathy-associated T-cell lymphoma Environmental enteropathy, also known as tropical ... Protein losing enteropathy Radiation enteropathy Chronic enteropathy associated with SLCO2A1 gene If the condition also ... Eosinophilic enteropathy A condition in which eosinophils (a type of white blood cell) accumulate in the gastrointestinal tract ... "HIV Enteropathy - MeSH - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-07-09. "eMedicine - Protein-Losing Enteropathy : Article ...
Mature T-cell lymphoma
... adult T-cell leukaemia/lymphoma, enteropathy-type T-cell lymphoma, nasal NK/T-cell lymphoma, hepatosplenic gamma-delta T-cell ... Anaplastic large cell lymphoma (ALCL) is a subtype of mature T-cell lymphoma involving T-cells or natural killer (NK) cells, ... The common subtypes are angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma and peripheral T-cell lymphoma not ... Its common subtypes include angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma and peripheral T-cell lymphoma ...
Peripheral T-cell lymphoma
... nasal type Enteropathy type T-cell lymphoma Subcutaneous panniculitis-like T-cell lymphoma Anaplastic large cell lymphoma ... Examples include: Cutaneous T-cell lymphomas Angioimmunoblastic T-cell lymphoma Extranodal natural killer/T-cell lymphoma, ... cutaneous T-cell lymphomas are classified separately. "Peripheral T-Cell Lymphoma". Lymphoma Research Foundation. Retrieved ... Peripheral T-cell lymphoma refers to a group of T-cell lymphomas that develop away from the thymus[citation needed] or bone ...
HLA-A1
The A1-B8-DR3-DQ2 haplotype has a known association with Enteropathy-associated T-cell lymphoma, approximately 70% of patients ... For example, A*01:02 was found linked to a type of stroke seen frequently in children with sickle cell anemia. There is a ... In Hodgkin's lymphoma HLA-A1, but DR3 was not found higher. ... "The genetic control of HLA-A and B antigens in somatic cell ... "Distinct HLA associations by stroke subtype in children with sickle cell anemia". Blood. 101 (7): 2865-9. doi:10.1182/blood- ...
Lymphoma
... nasal type Enteropathy-associated T-cell lymphoma Hepatosplenic T-cell lymphoma Blastic NK cell lymphoma Mycosis fungoides/ ... large B-cell lymphoma ALK+ large B-cell lymphoma Plasmablastic lymphoma Primary effusion lymphoma Large B-cell lymphoma arising ... "popcorn cells". (H&E) Certain lymphomas (extranodal NK/T-cell lymphoma, nasal type and type II enteropathy-associated T-cell ... primary effusion lymphoma; plasmablastic lymphoma; extranodal NK/T cell lymphoma, nasal type; peripheral T cell lymphoma, not ...
List of MeSH codes (C20)
... lymphoma, small-cell MeSH C20.683.515.761.480.300 - lymphoma, diffuse MeSH C20.683.515.761.480.300.300 - lymphoma, large-cell, ... hiv enteropathy MeSH C20.673.480.500 - hiv seropositivity MeSH C20.673.480.520 - hiv wasting syndrome MeSH C20.673.483.260 - ... lymphoma, mantle-cell MeSH C20.683.515.761.480.475 - lymphoma, large-cell MeSH C20.683.515.761.480.475.300 - lymphoma, large- ... lymphoma, small noncleaved-cell MeSH C20.683.515.761.480.750 - lymphoma, t-cell MeSH C20.683.515.761.480.750.475 - lymphoma, ...
Human leukocyte antigen
Gluten-sensitive enteropathy is associated with increased prevalence of enteropathy-associated T-cell lymphoma, and DR3-DQ2 ... it can stimulate B-cells that also recognize the same molecule in their B-cell receptors. Thus, T-cells help B-cells make ... T-cells have receptors that are similar to B-cell receptors, and each T-cell recognizes only a few MHC class II-peptide ... Major MHC class II proteins only occur on antigen-presenting cells, B cells, and T cells. HLA-DP α-chain encoded by HLA-DPA1 ...
ITGAE
... a fraction of splenic marginal zone lymphomas, and enteropathy-associated T cell lymphoma. The chief ligand for αEβ7 is E- ... T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells (Tregs). It has also been reported on lamina ... A subset of dendritic cells in the gut mucosa and mesenteric lymph nodes, known as CD103 dendritic cells, also expresses this ... Tregs are defined as CD4+/CD25+/Foxp3+ cells. Some CD4+/FoxP3− cells also express CD103 and have been attributed regulatory ...
Radiation enteropathy
Early radiation enteropathy is very common during or immediately after the course of radiotherapy. This involves cell death, ... This is used in standard therapeutic regimens for cervical cancer, prostate cancer, rectal cancer, anal cancer, lymphoma and ... Radiation enteropathy represents the longer-term, chronic effects that may be found after a latent period most commonly of 6 ... Radiation enteropathy is a syndrome that may develop following abdominal or pelvic radiation therapy for cancer. Many affected ...
Hypogammaglobulinemia
Patients with WHIM syndrome have severely reduced peripheral blood B cells and some reduction in peripheral blood T cells and ... These include blood cancers such as chronic lymphocytic leukemia (CLL), lymphoma, or myeloma, HIV, nephrotic syndrome, poor ... nutrition, protein-losing enteropathy, getting an organ transplant, or radiation therapy. This also includes medications which ... 2015). "Chromothriptic Cure of WHIM Syndrome". Cell. 160 (4): 686-699. doi:10.1016/j.cell.2015.01.014. PMC 4329071. PMID ...
List of MeSH codes (C02)
... leukemia-lymphoma, t-cell, acute, htlv-i-associated MeSH C02.782.815.200.470.710 - paraparesis, tropical spastic MeSH C02.782. ... hiv enteropathy MeSH C02.782.815.616.400.500 - hiv seropositivity MeSH C02.782.815.616.400.520 - hiv wasting syndrome MeSH ... hiv enteropathy MeSH C02.800.801.400.500 - hiv seropositivity MeSH C02.800.801.400.520 - hiv wasting syndrome MeSH C02.825. ... burkitt lymphoma MeSH C02.256.466.313.400 - infectious mononucleosis MeSH C02.256.466.313.500 - leukoplakia, hairy MeSH C02.256 ...
IL2RA
... protein can be expressed in many types of neoplastic cells, such as in most B-cell neoplasms, T-cell lymphomas, some ... Enteropathy, X-linked (IPEX) syndrome, caused by mutations in FOXP3 gene. Levels of CD25 soluble form, called sIL-2Rα, has been ... It can also be found on activated B cells, NK (natural killer) cells, thymocytes, and some myeloid lineage cells (e.g. ... Jones D, Ibrahim S, Patel K, Luthra R, Duvic M, Medeiros LJ (August 2004). "Degree of CD25 expression in T-cell lymphoma is ...
CTLA-4
... and have low CTLA-4 protein expression in T regulatory cells, hyperactivation of effector T cells, low switched memory B cells ... Most patients have diarrhea or enteropathy. Lymphadenopathy and hepatosplenomegaly are also common, as is autoimmunity. The ... and may slightly increase one's risk of lymphoma. CTLA-4 mutations have first been described by a collaboration between the ... T cell activation through the T cell receptor and CD28 leads to increased expression of CTLA-4. The mechanism by which CTLA-4 ...
Common variable immunodeficiency
Malignancies, particularly non-Hodgkin's lymphoma and gastric carcinoma. Enteropathy, which manifests with a blunting of ... A likely cause is deletions in genes that encode cell surface proteins and cytokine receptors, such as CD19, CD20, CD21, and ... The symptoms of CVID enteropathy are similar to those of celiac disease but do not respond to a gluten-free diet. Infectious ... Due to changes in B cell development, some individuals with CVID have accumulations of lymphocytes in lymphoid tissues. This ...
Gliadin
CD8+ T cells then enter the epithelium and express NK receptors specific for gliadin and transglutaminase causing ... People with celiac disease (also known as gluten-sensitive enteropathy) are sensitive to α, β, and γ gliadins. Those with wheat ... an increased risk of intestinal lymphomas and greater mortality. It is associated with some autoimmune diseases, such as ... However, the gliadins are unable to form polymers in the cell since its cysteines form intra-chain disulphide bonds at ...
Protein losing enteropathy
Gastrointestinal lymphoma and intestinal lymphangiectasia are other diseases that can cause protein losing enteropathy in dogs ... In pediatric protein losing enteropathy there are several changes in epithelial cells causing PLE by augmenting the rate of ... causing protein loss and protein loosing enteropathy. The widespread hypoproteinemia seen in protein loosing enteropathy may ... Chronic enteropathy is one of the possible reasons for PLE and it has been shown in a study that hypoalbuminaemia is a risk ...