There are three subsets of selectins: E-selectin (in endothelial cells) L-selectin (in leukocytes) P-selectin (in platelets and ... In addition to E-selectin, the role of P-selectin (expressed on platelets) and L-selectin (on leukocytes) in cancer ... E-selectin to the plasma membrane, and L-selectin to the tips of microfolds on leukocytes. The name selectin comes from the ... "Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin ...

In human, P-selectin has nine repeats while E-selectin contains six and L-selectin has only two. P-selectin is anchored in ... P-selectin has a functional role in tumour metastasis similar to E-selectin. P-selectin is expressed on the surface of both ... However, PSGL-1 is not specific for P-selectin, as it can also function as a ligand for both E- and L-selectin. P-selectin ... "Comparison of human eosinophil and neutrophil ligands for P-selectin: ligands for P-selectin differ from those for E-selectin ...

... is expressed on naive T cells and is rapidly shed following T cell priming. L-selectin expression is re-activated in ... L-selectin is also expressed by naive B cells, with the loss of L-selectin distinguishing activated B cells destined to ... L-selectin expressed on CD4 T lymphocytes has been implicated in mediating adhesion and entry of HIV. L-selectin binds gp120, ... L-selectin expression decreases by the 17th week of pregnancy, and remains low or non-existent until term (2017). L-selectin ...

Like other selectins, it plays an important part in inflammation. In humans, E-selectin is encoded by the SELE gene. E selectin ... The E-selectin locus flanks the L-selectin locus on chromosome 1. Different from P-selectin, which is stored in vesicles called ... "Identification of leukocyte E-selectin ligands, P-selectin glycoprotein ligand-1 and E-selectin ligand-1, on human metastatic ... E-selectin is found to mediate the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands on the tumor ...

... which is one of a family of selectins that includes E-selectin (endothelial) and L-selectin (leukocyte). Selectins are part of ... 1997). "Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin". J. Cell Biol. 137 (2): 509-19. doi: ... 1996). "P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation". Blood. 88 (7): 2415-21 ... The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on ...

There are three types of selectins found in humans; L-selectin, P-selectin and E-selectin. L-selectin deals with lymphocytes, ... There are four main types: selectins, cadherins, integrins, and the immunoglobulin superfamily. Selectins are cell adhesion ... monocytes and neutrophils, P-selectin deals with platelets and endothelium and E-selectin deals only with endothelium. They ... Tedder TF, Steeber DA, Chen A, Engel P (July 1995). "The selectins: vascular adhesion molecules". FASEB Journal. 9 (10): 866-73 ...

... and E-selectin); stimulates apoptosis (i.e. cell death) of CD4+ and CD8+ lymphocytes; causes the chemokinesis (i.e. cell ...

The selectin-selectin ligand axis in tumor progression. Cancer Metastasis Rev, 27:19-30. 2008. Witz IP. Yin-yang activities and ...

It is expressed on lymph node endothelia, whereas the L-selectin to which it binds is on the T cell. Conversely, under other ... It also interacts with L-selectin, important in inflammation. CD34- has been related to hair follicles' melanocyte regeneration ... "Sulfotransferases of two specificities function in the reconstitution of high endothelial cell ligands for L-selectin". The ... "Complexity and differential expression of carbohydrate epitopes associated with L-selectin recognition of high endothelial ...

This has indeed been observed for interactions of P-selectin with PSGL-1 or anti-P-selectin antibody, L-selectin with PSGL-1, ... Because one leukocyte has many selectins around the surface, these selectin binding/ unbinding cause a rolling motion on the ... January 2004). "Low force decelerates L-selectin dissociation from P-selectin glycoprotein ligand-1 and endoglycan". The ... Similar to selectin binding, FimH binding also have a threshold where it only starts binding to the host cells above this ...

September 1994). "C5a-induced expression of P-selectin in endothelial cells". The Journal of Clinical Investigation. 94 (3): ...

"P-selectin targeting polysaccharide-based nanogels for miRNA delivery". International Journal of Pharmaceutics. 597: 120302. ...

Barthel, Steven R; Gavino, Jacyln D; Descheny, Leyla; Dimitroff, Charles J (2007). "Targeting selectins and selectin ligands in ... Selectins are a family of specialised CAMs involved in transient cell-cell adhesion occurring in the circulatory system. They ... Selectins undergo heterophilic bindings, as its extracellular domain binds to carbohydrates on adjacent cells instead of other ... Other CAMs, like selectins and integrins, can facilitate metastasis by mediating cell-cell interactions between migrating ...

E-selectins: E-selectin is expressed on activated endothelial cells. Synthesis of E-selectin follows shortly after P-selectin ... Selectins (E-selectin, L-selectin, and P-selectin) were found to be involved in this phenomenon. The shear threshold ... E-selectins bind PSGL-1 and ESL-1. L-selectins: L-selectins are constitutively expressed on some leukocytes, and are known to ... P-selectins: P-selectin is expressed on activated endothelial cells and platelets. Synthesis of P-selectin can be induced by ...

Endothelial involvement is indicated by levels of Soluble E-Selectin. Fu C, Bardhan S, Cetateanu ND, Wamil BD, Wang Y, Yan HP, ... Wamil BD, Thurman GB, Sundell HW, DeVore RF, Wakefield G, Johnson DH, Wang YF, Hellerqvist CG (1997). "Soluble E-selectin in ...

The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]. Acts as a ligand for vascular selectins ... Fieger CB, Sassetti CM, Rosen SD (2003). "Endoglycan, a member of the CD34 family, functions as an L-selectin ligand through ... and L-selectins GRCh38: Ensembl release 89: ENSG00000114631 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000033152 ...

This glycoprotein provides selectins with carbohydrate ligands. It may play a role in tumor cell metastasis. It may also ... LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM. The ...

Additional examples are the proteolytic shedding of soluble E-selectin, shedding of urokinase receptor (uPAR) by MMP-12 ... "Src and phosphatidylinositol 3-kinase mediate soluble E-selectin induced angiogenesis". Blood. 101 (10): 3960-3968. doi:10.1182 ...

"Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): ...

These proteins collectively bind to L-selectin to guide lymphocytes such as mature naïve B and T cells into the lymph node. ... They carry carbohydrates in order to be recognized by L-selectin. Addressins physically bind to mobile lymphocytes to guide ... L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member ...

A common example of this is selectin-expressing cells in animals. Selectin is a receptor protein found on the membranes of ... Platelet cells, which are involved in tissue repair, use their selectins to associate with leukocytes on the way to the ... Leukocytes then use their own selectins to recognize potential pathogens at the site of the injury. In this manner, the ... In response to an injury, endothelial cells will express selectin, which binds to glycans present on the leukocyte cell surface ...

The alpha granules express the adhesion molecule P-selectin and CD63. These are transferred to the membrane after synthesis. ...

Carson DD, Julian J, Lessey BA, Prakobphol A, Fisher SJ (September 2006). "MUC1 is a scaffold for selectin ligands in the human ... MUC1 displays carbohydrate moieties on its extracellular domain that are ligands of L-selectin, a cell adhesion molecule on the ... An in vitro model of implantation gave evidence to support the hypothesis that L-selectin mediates apposition of the blastocyst ... February 2021). "Highly glycosylated MUC1 mediates high affinity L-selectin binding at the human endometrial surface". Journal ...

The adhesin expressed by the naïve T cells is L-selectin (1). once the T cells are activated they repress the expression of L ... An example of this is the interaction between L-selectin and the PNAD (peripheral node addressin) ligand. Arrest of the ' ... This 'rolling interaction' occurs in three stages: Initial binding of a lymphocyte selectin and its ligand. This creates an ... These integrins interact with E-selectin molecules found on inflamed skin. Breast specific homing- Involved in the redirection ...

July 2021). "ESDN inhibits melanoma progression by blocking E-selectin expression in endothelial cells via STAT3". Cancer ... Used in cancer metastasis research as a blocker of E-selectin. Numerous other drug interactions. The mechanism of action of ...

This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P- ... selectin. SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8 GRCh38: Ensembl release 89: ... "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): ... "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813-25. doi: ...

The binding of versican with leukocyte adhesion molecules L-selectin, P-selectin, and CD44 is also mediated by the interaction ... Both CD44 and L-selectin have been implicated in leukocyte trafficking. The ability of versican to bind a large panel of ...

... for Hematopoietic Cell E-selectin/L-selectin Ligand). (see below) Transcripts for this gene undergo complex alternative ... Burdick MM, Chu JT, Godar S, Sackstein R (May 2006). "HCELL is the major E- and L-selectin ligand expressed on LS174T colon ... Alves CS, Burdick MM, Thomas SN, Pawar P, Konstantopoulos K (Apr 2008). "The dual role of CD44 as a functional P-selectin ... Dimitroff CJ, Lee JY, Rafii S, Fuhlbrigge RC, Sackstein R (Jun 2001). "CD44 is a major E-selectin ligand on human hematopoietic ...

Noguchi M, Sato N, Sugimori H, Mori K, Oshimi K (October 2001). "A minor E-selectin ligand, CD65, is critical for extravascular ... Noguchi M, Sato N, Sugimori H, Mori K, Oshimi K (October 2001). "A minor E-selectin ligand, CD65, is critical for extravascular ... Trinchera M, Aronica A, Dall'Olio F (February 2017). "Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal ... Trinchera M, Aronica A, Dall'Olio F (February 2017). "Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal ...

Meanwhile Wnt is activated during the early outgrowth phase by E-selectin. The link between PGE2 and Wnt suggests that a ... "Bone vascular niche E-selectin induces mesenchymal-epithelial transition and Wnt activation in cancer cells to promote bone ...