Dyneins can be divided into two groups: cytoplasmic dyneins and axonemal dyneins, which are also called ciliary or flagellar ... Yeast dynein can walk along microtubules without detaching, however in metazoans, cytoplasmic dynein must be activated by the ... This suggests that proline-rich sequences may be a major binding site that co-opts dynein. Each molecule of the dynein motor is ... One major form of motor regulation within cells for dynein is dynactin. It may be required for almost all cytoplasmic dynein ...

... (EC 3.6.4.2, dynein adenosine 5'-triphosphatase) is an enzyme with systematic name ATP phosphohydrolase (tubulin- ... Dynein+ATPase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (Articles with ... Dynein Summers KE, Gibbons IR (December 1971). "Adenosine triphosphate-induced sliding of tubules in trypsin-treated flagella ... Gee M, Vallee R (1998). "The role of the dynein stalk in cytoplasmic and flagellar motility". European Biophysics Journal. 27 ( ...

... is a protein that in humans is encoded by the DNAH14 gene. Dyneins are microtubule-associated ... Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) ( ... "Entrez Gene: Dynein, axonemal, heavy chain 14". Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore ... KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (August 1996). "Multiple mouse chromosomal loci for dynein-based motility". ...

... , (LC1) is a protein that in humans is encoded by the DNAL1 gene. LC1 is a component of outer ... "Entrez Gene: dynein". Horváth J, Fliegauf M, Olbrich H, Kispert A, King SM, Mitchison H, Zariwala MA, Knowles MR, Sudbrak R, ... Fekete G, Neesen J, Reinhardt R, Omran H (July 2005). "Identification and analysis of axonemal dynein light chain 1 in primary ... dynein arms, which contain the molecular motors for ATP-dependent cilia movement. Mutations in the DNAL1 gene are associated ...

Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene. This gene is a member of the ... Jiang J, Yu L, Huang X, Chen X, Li D, Zhang Y, Tang L, Zhao S (Dec 2001). "Identification of two novel human dynein light chain ... "Entrez Gene: DYNLRB1 dynein, light chain, roadblock-type 1". Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional ... Overview of all the structural information available in the PDB for UniProt: Q9NP97 (Dynein light chain roadblock-type 1) at ...

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene. DYNLL2 has been shown to interact ... "Entrez Gene: DYNLL2 dynein, light chain, LC8-type 2". Naisbitt, S; Valtschanoff J; Allison D W; Sala C; Kim E; Craig A M; ... 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3): 597-605. doi: ... Overview of all the structural information available in the PDB for UniProt: Q96FJ2 (Dynein light chain 2, cytoplasmic) at the ...

The dynein in the axoneme - axonemal dynein forms bridges between neighbouring microtubule doublets. When ATP activates the ... The axoneme in a motile cilium acts as a scaffold for the inner and outer dynein arms that move the cilium, and provides tracks ... They possess the 9+2 axoneme of the motile cilia but lack the inner dynein arms that give movement. They do move passively ... While lacking the central apparatus there are dynein arms present that allow the nodal cilia to move in a spinning fashion. The ...

2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. ... Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene. In melanocytic cells ... "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1". Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel ... 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059-66. ...

Dynein axonemal intermediate chain 2 also known as axonemal dynein intermediate chain 2, is a protein that in humans is encoded ... The protein encoded by this gene belongs to the dynein intermediate chain family, and is part of the dynein complex of ... "Entrez Gene: dynein". Pennarun G, Chapelin C, Escudier E, Bridoux AM, Dastot F, Cacheux V, Goossens M, Amselem S, Duriez B ( ... "DNAI2 mutations cause primary ciliary dyskinesia with defects in the outer dynein arm". Am. J. Hum. Genet. 83 (5): 547-58. doi: ...

Cytoplasmic dynein 1 light intermediate chain 2 is a protein that in humans is encoded by the DYNC1LI2 gene. GRCh38: Ensembl ... "Entrez Gene: DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2". Hughes SM, Vaughan KT, Herskovits JS, Vallee RB (1995 ... "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411-3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. " ... "Molecular analysis of a cytoplasmic dynein light intermediate chain reveals homology to a family of ATPases". J. Cell Sci. 108 ...

Cytoplasmic dynein 1 intermediate chain 2 is a protein that in humans is encoded by the DYNC1I2 gene. GRCh38: Ensembl release ... "Entrez Gene: DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method ... Vaughan KT, Vallee RB (1996). "Cytoplasmic dynein binds dynactin through a direct interaction between the intermediate chains ... "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411-3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. " ...

Dynein light chain Tctex-type 1 is a protein that in humans is encoded by the DYNLT1 gene. Cytoplasmic dynein is the major ... 2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. ... 1998). "Interaction of Doc2 with tctex-1, a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle ... TCTEX1 is a dynein light chain involved in cargo binding (Chuang et al., 2005).[supplied by OMIM] GRCh38: Ensembl release 89: ...

Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene. Cytoplasmic dyneins are large ... "Entrez Gene: DYNLL1 dynein, light chain, LC8-type 1". Day CL, Puthalakath H, Skea G, Strasser A, Barsukov I, Lian LY, Huang DC ... Lo KW, Kan HM, Chan LN, Xu WG, Wang KP, Wu Z, Sheng M, Zhang M (Mar 2005). "The 8-kDa dynein light chain binds to p53-binding ... Lo KW, Naisbitt S, Fan JS, Sheng M, Zhang M (Apr 2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R ...

Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene. DYNC1H1 has been shown to ... "Entrez Gene: DYNC1H1 dynein, cytoplasmic 1, heavy chain 1". Tai, Chin-Yin; Dujardin Denis L; Faulkner Nicole E; Vallee Richard ... 1997). "Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal ... 2004). "Preferentially localized dynein and perinuclear dynactin associate with nuclear pore complex proteins to mediate ...

Cytoplasmic dynein 1 light intermediate chain 1 is a protein that in humans is encoded by the DYNC1LI1 gene. GRCh38: Ensembl ... "Entrez Gene: DYNC1LI1 dynein, cytoplasmic 1, light intermediate chain 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple ... 2001). "The small GTPase Rab4A interacts with the central region of cytoplasmic dynein light intermediate chain-1". Biochem. ... "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411-3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502. " ...

These include CENPE; MCAK; KID; cytoplasmic dynein (e.g., DYNC1H1); CliPs (e.g. CLIP1); and CENPF/mitosin (CENPF). The inner ...

He discovered and named dynein, and demonstrated energy source as ATP is sufficient for dynein to walk on microtubules. In 2017 ... Dyneins: The Biology of Dynein Motors (2nd ed.). Academic Press. pp. 3-87. ISBN 978-0-12-809471-6. Sanders, Robert (14 February ... Two years later, he purified two regions of the protein, known as its two "arms", naming the protein "dynein". During his last ... After these findings, Gibbons switched his focus to the molecular biology of dyneins, and determined the DNA sequence of the ...

Dynein is minus-end directed. There are many forms of kinesin and dynein motor proteins, and each is thought to carry a ... Outgoing transport is provided by kinesin, and ingoing return traffic is provided by dynein. ...

In contrast, dyneins are motor proteins that move toward the minus end of a microtubule in retrograde transport. The first ... Another type of motor protein, known as dyneins, move towards the minus end of the microtubule. Thus, they transport cargo from ... Lodish H, Berk A, Zipursky SL, Matsudaira P, Baltimore D, Darnell J (2000). "Kinesin, Dynein, and Intracellular Transport". {{ ... "Kinesin and Dynein Move Along Microtubules". Biochemistry. 5th Edition. Vale RD (February 2003). "The molecular motor toolbox ...

Dynactin binds to cytoplasmic dynein, dynein cargo adaptors, and microtubules. It is involved in a diverse array of cellular ... Holzbaur EL, Hammarback JA, Paschal BM, Kravit NG, Pfister KK, Vallee RB (June 1991). "Homology of a 150K cytoplasmic dynein- ... Cianfrocco MA, DeSantis ME, Leschziner AE, Reck-Peterson SL (2015). "Mechanism and regulation of cytoplasmic dynein". Annual ... Karki S, Holzbaur EL (December 1995). "Affinity chromatography demonstrates a direct binding between cytoplasmic dynein and the ...

The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein. PAFAH1B1 was ... Tai CY, Dujardin DL, Faulkner NE, Vallee RB (Mar 2002). "Role of dynein, dynactin, and CLIP-170 interactions in LIS1 ... "NUDEL is a novel Cdk5 substrate that associates with LIS1 and cytoplasmic dynein". Neuron. 28 (3): 697-711. doi:10.1016/S0896- ... CLIP-170's key to the dynein/dynactin pathway". Molecular and Cellular Biology. 22 (9): 3089-102. doi:10.1128/MCB.22.9.3089- ...

... a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065-8. doi: ...

... a light chain of cytoplasmic dynein. Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065-8. doi: ...

Dynein motors and kinesin motors, on the other hand, use microtubules to transport vesicles across the cell. The mechanism ... These motor proteins are classified as myosins, kinesins, or dyneins. Myosin motors are responsible for muscle contractions and ...

Dynein motors and kinesin motors, on the other hand, use microtubules to transport vesicles across the cell. The mechanism ... These motor proteins are classified as myosins, kinesins, or dyneins. Myosin motors are responsible for muscle contractions and ...

Her doctoral research at the University of Pennsylvania involved studies of the ATPase pathway of axonemal dynein. She worked ... She found that targeted disruption of the dynein-dynctin interaction can result in the degeneration of motor neurons. Holzbaur ... During her postdoctoral research, Holzbaur studied cytoplasmic dynein. She was the first person to clone the p150Glued, the ... Holzbaur studies various motor proteins, including dyneins, myosins and kinesins. In the axons of neurons, these motor proteins ...

Dynein transports vesicles and organelles throughout the cytoplasm. In order to do this, dynein molecules bind organelle ... and dynein, which moves toward the (−) end. Dynein is composed of two identical heavy chains, which make up two large globular ... Dynein-mediated transport takes place from the (+) end towards the (-) end of the microtubule. ATP hydrolysis occurs in the ... The action of the dynein motor proteins on the various microtubule strands that run along a cilium or flagellum allows the ...

His team also solved the structure of the dynein motor domain. Vale has extended his research to other fields, including T-cell ... Since 2003, Vale has focused on dynein, a motor protein discovered by Ian R. Gibbons in 1965. Although its discovery occurred ... Carter, Andrew P.; Cho, Carol; Jin, Lan; Vale, Ronald D. (March 4, 2011). "Crystal Structure of the Dynein Motor Domain". ... His research is focused on motor proteins, particularly kinesin and dynein. He was awarded the Canada Gairdner International ...

Davis L, Smith GR (2005). "Dynein promotes achiasmate segregation in Schizosaccharomyces pombe". Genetics. 170 (2): 581-90. doi ... This ability depends on the microtubule motor dynein that regulates the movement of chromosomes to the poles of the meiotic ...

Dynein, axonemal, heavy chain 7 is a protein in humans that is encoded by the DNAH7 gene. DNAH7 is a component of the inner ... "Entrez Gene: Dynein, axonemal, heavy chain 7". Retrieved 2013-02-12. v t e (Articles with short description, Short description ... dynein arm of ciliary axonemes (Zhang et al., 2002 [PubMed 11877439]).[supplied by OMIM, Mar 2008]. ##RefSeq-Attributes-START# ...