For example, bacterial recombination has been shown to promote the transfer of multi drug resistance genes via homologous ... Bacterial DNA is placed into the bacteriophage genome via bacterial transduction. In bacterial conjugation, DNA is transferred ... "Bacterial recombination promotes the evolution of multi-drug-resistance in functionally diverse populations". Proceedings of ... Bacterial transformation is carried out by numerous interacting bacterial gene products. Evolution in bacteria was previously ...
... drugs designed to block the mechanisms of bacterial antibiotic resistance are used. For example, bacterial resistance against ... Tolerance and Resistance Cosmetics Database HCMV drug resistance mutations tool Combating Drug Resistance - An informative ... Recently, researchers have recognized the need for new drugs that inhibit bacterial efflux pumps, which cause resistance to ... The development of antibiotic resistance in particular stems from the drugs targeting only specific bacterial molecules (almost ...
"Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics". J. Mol. Biol. ... In 2011, ASM Press published a festschrift in his honor ("The Lure of Bacterial Genetics: A Tribute to John Roth"). "Thomas ... 2011). The Lure of Bacterial Genetics: A Tribute to John Roth. Washington, DC: ASM Press. p. 362. ISBN 978-1-55581-538-7. ... Roth, J.R.; Benson, N.; Galitski, T.; Haack, K.; Lawrence, J.; Miesel, L. (1996). "Rearrangements of the bacterial chromosome: ...
"Genetic engineering in vivo using translocatable drug-resistance elements. New methods in bacterial genetics". J. Mol. Biol. ... Beckwith, J.; Silhavy, T.J. (1992). The Power of Bacterial Genetics: A Literature Based Course. NY: Cold Spring Harbor ... Alternatively insertional inactivation could be used to suppress genes that express antibiotic-resistance in bacteria., While ... Transposon-based Insertional inactivation is considered for medical research from suppression of antibiotic resistance in ...
... of the drugs across the cell surface These pumps within the cellular membrane of certain bacterial species are used to pump ... Resistance to recently developed drugs such as artemisinin has also been reported. The problem of drug resistance in malaria ... Resistance to HIV antivirals is problematic, and even multi-drug resistant strains have evolved. One source of resistance is ... The WHO defines antimicrobial resistance as a microorganism's resistance to an antimicrobial drug that was once able to treat ...
Her work on ABC transporters includes investigating their role in resistance to chemotherapy drugs; antigen presentation in ... This work applies specifically to bacterial cells, but has implications for humans. Chen's interests have recently shifted to ... This initial work has led to new insights into a mechanism by which some cancer cells mount resistance to chemotherapy. ... e9 Structural basis of substrate recognition by the multidrug resistance protein MRP1. ZL Johnson, J Chen. Cell 168 (6), 1075- ...
Infection and Drug Resistance. 11: 1959-1974. doi:10.2147/IDR.S172366. PMC 6208867. PMID 30464538. Levinson, Warren; Chin-Hong ... Perianal cellulitis, also known as perianitis or perianal streptococcal dermatitis, is a bacterial infection affecting the ... Boull C, Soutor C, Hordinsky M (2022). "Chapter 11: Bacterial Infections". Clinical Dermatology: Diagnosis and Management of ... Cellulitis describes a bacterial infection affecting the lower layers of the skin. Historically, perianal cellulitis may be ...
"Phylogenetic relationships of drug-resistance factors and other transmissible bacterial plasmids". Bacteriological Reviews. 32 ... Anderson, E S (October 1968). "The Ecology of Transferable Drug Resistance in the Enterobacteria". Annual Review of ... Jones, D; Sneath, P H (March 1970). "Genetic transfer and bacterial taxonomy". Bacteriological Reviews. 34 (1): 40-81. doi: ... Ambler, R. P. (December 1973). "Bacterial Cytochromes C and Molecular Evolution". Systematic Zoology. 22 (4): 554-565. doi: ...
"Roles of Regulatory RNAs for Antibiotic Resistance in Bacteria and Their Potential Value as Novel Drug Targets". Frontiers in ... Several bacterial sRNAs are involved in the regulation of genes that confer antibiotic resistance. For example, the sRNA DsrA ... Bacterial sRNAs affect how genes are expressed within bacterial cells via interaction with mRNA or protein, and thus can affect ... Biofilm is a type of bacterial growth pattern where multiple layers of bacterial cells adhere to a host surface. This mode of ...
"Bacterial drug resistance overcome by synthetic restructuring of antibiotics". Nature: d41586-021-02916-6. 27 October 2021. doi ... Oxepanoprolinamides function by insertion into bacterial ribosomes. They overcome a type of antibiotic resistance to ... "A synthetic antibiotic class overcoming bacterial multidrug resistance". Nature. 599 (7885): 507-599. Bibcode:2021Natur.599.. ... "A synthetic antibiotic class overcoming bacterial multidrug resistance". Nature. 599 (7885): 507-512. Bibcode:2021Natur.599.. ...
Schuster FL, Visvesvara GS (February 2004). "Opportunistic amoebae: challenges in prophylaxis and treatment". Drug Resistance ... contain diverse bacterial endosymbionts that are similar to human pathogens, so they are considered to be potential emerging ... A paper published in 2013 has shown substantial effects of some FDA-approved drugs with an in vitro kill rate above 90%. These ... Baig AM, Iqbal J, Khan NA (August 2013). "In vitro efficacies of clinically available drugs against growth and viability of an ...
She has also looked at how microbes evolve in drug gradients; finding that drug resistance is accelerated by the presence of a ... Bacterial colonies self-assemble on soft gel surfaces, and Allen has modelled how they compete for space. Allen uses algorithms ... Her research into antimicrobial resistance considers how antibiotic drugs interact with the physiology of a cell. ... "Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution of Drug-Resistant Cells". Physical Review Letters. ...
Chitsaz, Mohsen; Brown, Melissa H. (2017-03-03). "The role played by drug efflux pumps in bacterial multidrug resistance". ... Because of their importance in drug evasion such as in antibiotic resistance, there is a growing about of research on Efflux ... Laura J. V. Piddock (2006). "Multidrug-resistance efflux pumps ? not just for resistance". Nature Reviews Microbiology. 4 (8): ... Multidrug resistance pumps (MDR pumps) also known Multidrug efflux pumps are a type of efflux pump and P-glycoprotein. MDR ...
His research focuses on bacterial pathogen drug resistance, including to antibiotics. His Birmingham research group combines ...
Grynberg M, Erlandsen H, Godzik A (May 2003). "HEPN: a common domain in bacterial drug resistance and human neurodegenerative ... which includes several classes of enzymes that are responsible for some types of bacterial resistance to aminoglycosides. These ... and in many bacterial and archaea proteins. There are three classes of proteins with HEPN domains: Single-domain HEPN proteins ... enzymes deactivate various antibiotics by transferring a nucleotidyl group to the drug. A multidomain sacsin protein in genomes ...
Drug resistance Food preservation Food Irradiation Irradiation of Microbes from Spent Nuclear Fuel Storage Pool Environments ... Bacterial cell surfaces may be damaged by the acceleration forces attained in centrifuges. Laboratory centrifuges routinely ... Pulses of low intensity may result in the increased production of secondary metabolites and a build-up of resistance. PEF ... Peterson, Brandon W.; Sharma, Prashant K.; Van Der Mei, Henny C.; Busscher, Henk J. (2012). "Bacterial Cell Surface Damage Due ...
In later years she published many important studies on the occurrence and significance of drug resistance plasmids in ... Richard P. Novick et al., "Uniform Nomenclature for Bacterial Plasmids: A Proposal", Bacteriol. Rev., March 1976, pp. 168-189 ... Datta, Naomi (September 1962). "Transmissible drug resistance in an epidemic strain of Salmonella typhimurium". Journal of ... She found that some resistance genes, including those for gentamicin resistance, are located on transposons and are readily ...
"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis". "Overview". Carb-X. Retrieved 2022-01-14 ... Even the most powerful "last resort" drugs are becoming less effective due to resistance. Without an arsenal of effective ... Approximately 1.27 million people died globally in 2019 due to drug-resistant bacterial infections. CARB-X supports projects ... Jacobs, Andrew (2019-12-25). "Crisis Looms in Antibiotics as Drug Makers Go Bankrupt". The New York Times. ISSN 0362-4331. ...
However, resistance to trimethoprim and other drugs aimed at DHFR can arise due to a variety of mechanisms, limiting the ... Other classes of compounds that target DHFR in general, and bacterial DHFRs in particular, belong to the classes such as ... However, resistance has developed against some drugs, as a result of mutational changes in DHFR itself. DHFR is responsible for ... Resistance can arise from DHFR gene amplification, mutations in DHFR, decrease in the uptake of the drugs, among others. ...
... and antibacterial drug resistance. GSTs also have important roles in metabolism, such as signaling-ligand biosynthesis, ... Bacterial glutathione transferases (GSTs; EC 2.5.1.18) are part of a superfamily of enzymes that play a crucial role in ... Bacterial glutathione transferases are not detected in anaerobic bacteria or archaea. These antioxidant enzymes are a part of ... Bacterial GSTs are involved in a variety of distinct processes such as biotransformation of toxic compounds, protection against ...
Infection and Drug Resistance. 16: 125-142. doi:10.2147/IDR.S394600. PMC 9831080. PMID 36636381. S2CID 255592211. "Dual-Light ... Antibacterial Potential of Greenly Synthesized Silver Nanoparticles with Fosfomycin Against Some Nosocomial Bacterial Pathogens ... Moreover, nanoemulsions that carry drugs allow the drugs to crystallize in a controlled size with a good dissolution rate. ... In the pharmaceutical industry, oil droplets act as tiny containers that carry water-insoluble drugs, and the water provides a ...
Unlike multiple drug resistance, and antimicrobial resistance, antimicrobial tolerance is transient, and not inherited. ... 2016). "Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells". Mol Cell. 62 (2): 284-294. doi:10.1016 ... and cancer persister cells that show tolerance for cancer drugs. Recognition of bacterial persister cells dates back to 1944 ... Resistance is caused by newly acquired genetic traits (by mutation or horizontal gene transfer) that are heritable and confer ...
Drug Resistance Updates. 44: 100640. doi:10.1016/j.drup.2019.07.002. ISSN 1368-7646. PMID 31492517. S2CID 199640645. Walsh, ... She researches the evolution of bacterial interactions and the significance of bacterial traits, also known as virulence ... Joint author) "Do Bacterial "Virulence Factors" Always Increase Virulence? A Meta-analysis of Pyoverdine Production in ... doi:10.1038/s41396-018-0231-9. (Joint author) "The Evolution and Ecology of Bacterial Warfare". Current Biology. Vol. 29, Issue ...
... develop resistance to drugs by transferring genes in atypical ways and recombining with related bacterial species". Early in ... Petousis-Harris, Helen (30 September 2020). "Assessing the Safety of COVID-19 Vaccines: A Primer". Drug Safety. 43 (12): 1205- ... bacterial meningitis, bacteremia and otitis media (OM), commonly known as middle ear infection. The same paper signalled ...
The Bacterial Cell-Wall Unit Carrier at the Membrane Frontier". Microbial Drug Resistance. 20 (3): 199-214. doi:10.1089/mdr. ... is an essential molecule involved in construction of the bacterial peptidoglycan cell wall. It is a receptor found in the ...
Results showed efficacy against TB, albeit with minor toxicity and acquired bacterial resistance to the drug. Because ... It may be useful in cases where resistance to other drugs is identified.[medical citation needed] Plague (Yersinia pestis): Has ... Streptomycin controls bacterial diseases of certain fruit, vegetables, seed, and ornamental crops. A major use is in the ... They managed to do an animal study in a few guinea pigs with just 10 grams of the scarce drug, demonstrating survival.: 209-241 ...
His main research focus areas are HIV drug resistance and structure and function of bacterial cells. Goodsell has developed a ... protein-protein interactions and for computer-aided drug design. In particular he is a developer of AutoDock, the most widely- ...
Influenza viruses can show resistance to anti-viral drugs. Like the development of bacterial antibiotic resistance, this can ... Wu J, Yan P, Archibald C (2007). "Modelling the evolution of drug resistance in the presence of antiviral drugs". BMC Public ... However, virus strains have emerged that show drug resistance to some classes of drug. The United States authority on disease ... and over-use of these drugs has probably contributed to the spread of resistance. In particular, this high-level of resistance ...
The Bacterial Cell-Wall Unit Carrier at the Membrane Frontier". Microbial Drug Resistance. 20 (3): 199-214. doi:10.1089/mdr. ... On a larger scale, this is helpful when fighting, or preventing bacterial infections. Bacitracin is an example of one of these ... "Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase ...
Results obtained from this study demonstrate that drug resistance is linked to bacterial fitness as higher fitness costs are ... Antibiotic resistance: Practically all bacteria develop antibiotic resistance when exposed to antibiotics. In fact, bacterial ... Research has shown that bacteria can gain drug resistance through compensatory mutations that do not impede or having little ... 2006 has found that laboratory grown M. tuberculosis strains with rifampicin resistance have reduced fitness, however drug ...