"Mutant library construction in directed molecular evolution". Molecular Biotechnology. 34 (1): 55-68. doi:10.1385/MB:34:1:55. ... This can be repeated in cycles of creating gene variants and screening the expression products in a directed evolution process ... "DNA shuffling of a family of genes from diverse species accelerates directed evolution". Nature. 391 (6664): 288-91. Bibcode: ... In molecular biology, a library is a collection of DNA fragments that is stored and propagated in a population of micro- ...

Iffland A, Tafelmeyer P, Saudan C, Johnsson K (September 2000). "Directed molecular evolution of cytochrome c peroxidase". ... The yeast enzyme is a monomer of molecular weight 34,000, containing 293 amino acids, and contains as well a single non- ... Advances in Enzymology and Related Areas of Molecular Biology. Vol. 33. pp. 309-35. doi:10.1002/9780470122785.ch6. ISBN ...

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Alt URL Penny, David (November 2014). "Cooperation and selfishness both occur during molecular evolution". Biology Direct. 10 ( ... His research has focused on theoretical biology, molecular evolution, human evolution, and the history of science. In the 1970s ... "Recovering evolutionary trees under a more realistic model of sequence evolution". Molecular Biology and Evolution. 11 (4): 605 ... 2009). "Toward Resolving Deep Neoaves Phylogeny: Data, Signal Enhancement, and Priors". Molecular Biology and Evolution. 26 (2 ...

Neylon, David Cameron (1999). Towards the directed molecular evolution of DNA-binding specificity (PhD thesis). Australian ... University where they were awarded a Doctor of Philosophy degree in Biophysics in 1999 for work on directed molecular evolution ... Neylon, C.; Wu, S. (2009). "Article-Level Metrics and the Evolution of Scientific Impact". PLOS Biology. 7 (11): e1000242. doi: ...

October 2022). "NMR-guided directed evolution". Nature. 610 (7931): 389-393. Bibcode:2022Natur.610..389B. doi:10.1038/s41586- ... Other journals dedicated to molecular evolution include Journal of Molecular Evolution and Molecular Phylogenetics and ... Genome evolution Heterotachy History of molecular evolution Horizontal gene transfer Human evolution Molecular clock Molecular ... Hence the evolution of protein function is critical to understand molecular evolution. Evolution of proteins is studied by ...

Romero, PA; Arnold, FH (Dec 2009). "Exploring protein fitness landscapes by directed evolution". Nature Reviews Molecular Cell ... Protein Sequence space Directed evolution Protein engineering High-dimensional space DePristo, Mark A.; Weinreich, Daniel M.; ... Evolution by natural selection can be visualised as the process of sampling nearby sequences in sequence space and moving to ... it provides a useful abstract model to think about the range of proteins and evolution from one sequence to another. These ...

... and its improvement by directed evolution". Molecular Cancer Therapeutics. 5 (1): 97-103. doi:10.1158/1535-7163.MCT-05-0365. ... Molecular and functional characterization of a carbon starvation gene of Escherichia coli. Journal of Molecular Biology, 218: ... Matin, A. (1991). "The molecular basis of carbon-starvation-induced general resistance in Escherichia coli". Molecular ... "Analysis of novel soluble chromate and uranyl reductases and generation of an improved enzyme by directed evolution". Applied ...

Biology Direct. 7 (1): 35. doi:10.1186/1745-6150-7-35. ISSN 1745-6150. PMC 3534586. PMID 23062217. Gray, Michael W.; Lukeš, ... Adaptive evolution in the human genome Coalescent theory Evolution of biological complexity Masatoshi Nei Molecular evolution ... Nei, Masatoshi (December 2005). "Selectionism and neutralism in molecular evolution". Molecular Biology and Evolution. 22 (12 ... "Toward a selection theory of molecular evolution". Evolution; International Journal of Organic Evolution. 62 (2): 255-65. doi: ...

The Maxygen legacy was revived in 2018 with a focus on Directed Evolution of Proteins using Molecular Breeding. Maxygen LLC is ... Applied Molecular Evolution and Genencor International. Another company, Enchira Biotechnology, was also as direct competitor. ... known as its Molecular Breeding directed evolution platform. These technologies allow the generation of millions of variant ... Maxygen has demonstrated that the MolecularBreeding directed evolution platform has commercial potential in a number of areas, ...

"Improvement of cold adaptation of Bacillus alcalophilus alkaline protease by directed evolution". Journal of Molecular ... Ntougias, S; Zervakis, GI; Ehaliotis, C; Kavroulakis, N; Papadopoulou, KK (May 2006). "Ecophysiology and molecular phylogeny of ...

... methyltransferase by directed evolution". Journal of Molecular Biology. 395 (1): 79-88. doi:10.1016/j.jmb.2009.09.027. PMID ... Lauster R (March 1989). "Evolution of type II DNA methyltransferases. A gene duplication model". Journal of Molecular Biology. ... Smith SS, Kaplan BE, Sowers LC, Newman EM (May 1992). "Mechanism of human methyl-directed DNA methyltransferase and the ... Progress in Nucleic Acid Research and Molecular Biology. Vol. 49. pp. 65-111. doi:10.1016/s0079-6603(08)60048-3. ISBN ...

Molecular Biology and Evolution. 20 (3): 307-14. doi:10.1093/molbev/msg013. PMID 12644552. Malnic B, Hirono J, Sato T, Buck LB ... Matsui A, Go Y, Niimura Y (May 2010). "Degeneration of olfactory receptor gene repertories in primates: no direct link to full ... Methods in Molecular Biology. Vol. 1003. Olfactory Receptors Methods in Molecular Biology: Humana Press. pp. 203-209. doi: ... Molecular Phylogenetics and Evolution. 66 (2): 558-64. doi:10.1016/j.ympev.2012.07.032. PMID 22906809. Buck L, Axel R (April ...

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Site-directed mutagenesis Restriction digest DNA footprinting Kamvysselis, M. (2003). Computational molecular genomics: genes, ... regulation, evolution. (Doctoral Dissertation). Retrieved from http://web.mit.edu/manoli/www/thesis/Intro.html Chalfie, M., & ... Non-directed PCR-based mutagenesis can also be used; the parameters of the mutagenic PCR reaction can be adjusted to introduce ... Promoter bashing is a technique used in molecular biology to identify how certain regions of a DNA strand, commonly promoters, ...

Directed Evolution Library Creation. Methods in Molecular Biology. Vol. 231. Totowa, NJ: Humana Press. pp. 99-104. doi:10.1385/ ... Directed Evolution Library Creation. Methods in Molecular Biology. Vol. 231. Totowa, NJ: Humana Press. pp. 105-110. doi:10.1385 ... Zhao H, Giver L, Shao Z, Affholter JA, Arnold FH (March 1998). "Molecular evolution by staggered extension process (StEP) in ... Crameri A, Dawes G, Rodriguez E, Silver S, Stemmer WP (May 1997). "Molecular evolution of an arsenate detoxification pathway by ...

... of the Department of Biology at the University of Oslo in 1998 and directed the laboratory of molecular ecology and evolution. ... Molecular Biology and Evolution 27(7) 1710-1733. Caetano-Anollés G, Wang M, Mittenthal JE (2009) The origin, evolution and ... genomics and molecular evolution. He is particularly interested in evolution of macromolecular structure. His research group ... He received the Emile Zuckerkandl Prize in molecular evolution in 2002 and became University Scholar of the University of ...

Pauplin Y (2000). "Direct calculation of a tree length using a distance matrix". Journal of Molecular Evolution. 51 (1): 41-47 ... Molecular Biology and Evolution. 10: 21073-1095. Desper R, Gascuel O (2005). The minimum evolution distance-based approach to ... Molecular Biology and Evolution. 10: 21073-1095. Rzhetsky A, Nei M (1993). "Theoretical foundations of the minimum evolution ... Gascuel O, Steel M (2006). "Neighbor-joining Revealed". Molecular Biology and Evolution. 23 (11): 1997-2000. doi:10.1093/molbev ...

"Live blog: directed evolution takes chemistry Nobel prize". Chemistry World. Retrieved 23 February 2022. "PELHAM, Sir Hugh ( ... The emphasis on classical molecular biology shifted towards cell biology and development, so that the Molecular Genetics ... During the 1960s, molecular biology the world over flourished, the outline bones of the 1950s now having flesh put on them. The ... Finally, the molecular mechanisms elucidated by Neuberger may be of great importance in understanding the mutational pattern of ...

Reetz, M. T.; Carballeira J. D. (2007). "Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional ... Genetic engineering Oncomouse Saturated mutagenesis Directed evolution Hsu PD, Lander ES, Zhang F (June 2014). "Development and ... a novel method for directed evolution". Nucleic Acids Research. 32 (3): 26e-26. doi:10.1093/nar/gnh028. PMC 373423. PMID ... "SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4): ...

... combinatorial libraries in which portions of the FN3 scaffold are diversified using molecular display and directed evolution ... "Directed evolution of high-affinity antibody mimics using mRNA display". Chem. Biol. 9 (8): 933-42. doi:10.1016/s1074-5521(02) ... The native FN3 scaffold consists of 94 amino acids and has a molecular mass of about 10 kDa, fifteen times smaller than an IgG ... Monobodies are synthetic binding proteins constructed using a fibronectin type III domain (FN3) as a molecular scaffold. ...

... directed molecular evolution MeSH E05.393.420.238 - dna shuffling MeSH E05.393.420.301 - gene therapy MeSH E05.393.420.451 - ... direct MeSH E05.200.750.551.512.240.310 - fluorescent antibody technique, indirect MeSH E05.200.750.551.790 - periodic acid- ... site-directed MeSH E05.393.420.890 - sex preselection MeSH E05.393.525.085 - biotinylation MeSH E05.393.525.100 - blotting, ... direct MeSH E05.478.588.375.310 - fluorescent antibody technique, indirect MeSH E05.478.588.375.341 - fluoroimmunoassay MeSH ...

Mindell's paper explains that there was no direct correlation found between these and molecular evolution in the test taxa of ... Bromham, Lindell (1 March 2002). "Molecular Clocks in Reptiles: Life History Influences Rate of Molecular Evolution". Molecular ... Easteal, S. (1 January 1991). "The relative rate of DNA evolution in primates". Molecular Biology and Evolution. 8 (1): 115-127 ... Easteal, S. (January 1990). "The Pattern of Mammalian Evolution and the Relative Rate of Molecular Evolution". Genetics. 124 (1 ...

Biocontainment Bioorthogonal chemistry Biosafety Biosecurity Biosignature Central dogma of molecular biology Directed evolution ... "Molecular Biotechnology". Max Planck Institute. Archived from the original on June 10, 2007. Retrieved August 10, 2017. "List ... In 2015, the team led by Ned Budisa reported the successful completion of a long-term evolution experiment that resulted in ... This is a solid basis for the evolution of life with alternative building blocks, foldamers or biochemistries. At the same time ...

Cirino, Patrick C.; Arnold, Frances H. (2002), Directed Molecular Evolution of Proteins, Wiley-VCH Verlag GmbH & Co. KGaA, pp. ... One advantage of directed evolution is that the mutations do not have to be completely random; instead, they can be random ... In 2018 she was awarded the Nobel Prize in Chemistry for her work in directed evolution, making her the fifth woman to receive ... The directed evolution strategy involves iterative rounds of mutagenesis and screening for proteins with improved functions and ...

... "for her pioneering directed molecular evolution strategies, used worldwide to optimize the functions of enzymes and to engineer ... molecular biology, and biomedicine in the development of spherical nucleic acids and new types of nanostructures that are ...

... with comparison of direct and indirect surveys of mitochondrial DNA variation. Molecular Phylogenetics and Evolution, 39(2), ... Molecular Phylogenetics and Evolution, 47(2), 870-876. Wilson, D. E. and D. M. Reeder, Editors. Vampyressa. Mammal Species of ... Hoofer, S. R. & Baker, R. J. (2006). Molecular systematics of Vampyressine bats (Phyllostomidae: Stenodermatinae) ...

... with comparison of direct and indirect surveys of mitochondrial DNA variation. Molecular Phylogenetics and Evolution, 39(2), ... Molecular Phylogenetics and Evolution, 47(2), 870-876. Lee, T.E. Jr.; Scott, J.B. & Marcum, M.M. (2001). "Vampyressa bidens". ... Hoofer, S. R. & Baker, R. J. (2006). Molecular systematics of Vampyressine bats (Phyllostomidae: Stenodermatinae) ...

"Molecular breeding", a form of "Directed evolution". His contributions to malaria research over an 18-year period began in ... During this time, Molecular breeding or DNA shuffling Technology was conceived and the nascent company Maxygen Inc. incubated ... He was a pioneer in the fields of molecular parasitology, especially malaria, and in leading the commercialisation of one of ... From 1988 to 1992, he worked at the Laboratory of Infectious Diseases of the DNAX Research Institute of Molecular and Cellular ...

Dihybrid Dihybrid cross Dimerization Dimorphism Dioecious plant Diploid Directed evolution Directed mutagenesis Directed ... Modifier gene Molecular biology Molecular chaperone Molecular farming Molecular genetics Molecular imprinting Molecular ... Phe Phenocopy Phenotype Phenotypic variance Phenylketonuria Pheromone Phosphodiester bond Photoreactivation Phyletic evolution ... sequencing Directionality (molecular biology) Discrete generations Disease Disruptive selection Distribution DMD DNA DNA bank ...