Diazoxide
... interferes with insulin release through its action on potassium channels. Diazoxide is one of the most potent openers ... Diazoxide is used as a vasodilator in the treatment of acute hypertension or malignant hypertension. Diazoxide also inhibits ... diazoxide)" (Press release). Food and Drug Administration. July 16, 2015. Retrieved 2015-07-19. "Diazoxide". Drug Information ... Diazoxide, sold under the brand name Proglycem and others, is a medication used to treat low blood sugar due to a number of ...
Lofepramine
Diazoxide. Enhanced hypotensive (blood pressure-lowering) effect. Digoxin. May increase risk of irregular heart rate. ...
Glucose-elevating agent
Diazoxide, which is used to counter hypoglycemia in disease states such as insulinoma (a tumor producing insulin) or congenital ... Glucose (dextrose) Glucagon Diazoxide Huang, Qin; Bu, Shizhong; Yu, Yongwei; Guo, Zhiyong; Ghatnekar, Gautam; Bu, Min; Yang, ... Linhui; Lu, Bin; Feng, Zhengkang (January 2007). "Diazoxide Prevents Diabetes through Inhibiting Pancreatic β-Cells from ...
Cyclothiazide
Related drugs include diazoxide, hydrochlorothiazide, and chlorothiazide. In 1993, it was discovered that cyclothiazide is a ... "Modulation of AMPA/kainate receptors by analogues of diazoxide and cyclothiazide in thin slices of rat hippocampus". Receptors ...
Glutamate dehydrogenase 1
FHI-GCK, caused by mutations in GCK, may be much milder than FHI-KATP; however, some persons have severe, diazoxide- ... FHI-UCP2, caused by mutations in UCP2, is a rare cause of diazoxide-responsive FH1. Hyperammonemia/hyperinsulinism (HA/HI) is ... Long-term medical management includes the use of diazoxide, somatostatin analogs, nifedipine, glucagon, recombinant IGF-I, ... diazoxide therapy) and thus may require pancreatic resection. Individuals with autosomal dominant FHI-KATP tend to be ...
IDRA-21
Yamada KA, Covey DF, Hsu CY, Hu R, Hu Y, He YY (May 1998). "The diazoxide derivative IDRA 21 enhances ischemic hippocampal ...
Congenital hyperinsulinism
Dominant HI may be mild and respond to diazoxide or severe and diazoxide unresponsive. Some changes in the ABCC8 and KCNJ11 ... Children and adults with GDH-CHI often respond to diazoxide. An excess of proteins in the diet can bring about low sugars, so a ... Responsiveness to diazoxide is defined by the demonstration that the cardinal feature of HI, hypoketotic hypoglycemia, is ... More commonly, many on diazoxide develop excess body hair or a change in facial features over a long time. Children with focal ...
Hypoglycemia
Medications like diazoxide and octreotide decrease insulin levels, increasing blood glucose levels. Dasiglucagon was approved ... In patients who cannot undergo surgery for removal of the insulinoma, diazoxide or octreotide may be used. Hypoglycemia is ... diazoxide, or octreotide. Some causes of hypoglycemia require treatment of the underlying cause to best prevent hypoglycemia. ...
GLUT1 deficiency
Hyperkalemia
Calcineurin inhibitors such as cyclosporine, tacrolimus, diazoxide, and minoxidil can cause hyperkalemia. Box jellyfish venom ...
Hyperinsulinemic hypoglycemia
... can often be treated with diazoxide or a somatostatin analog called octreotide. Diazoxide is given by mouth, octreotide by ...
Metastatic insulinoma
In order to counteract this, Diazoxide is commonly used in combination with thiazide diuretics. Although Diazoxide has been ... Diazoxide is a medication used to primarily reduce the excess insulin secreted from the insulinoma cells. Insulin is suppressed ... Cytoreductive surgery Diazoxide & Thiazide Diuretics Beta-Blockers Cytoreductive surgery, alongside other anti-tumor therapies ...
ATP-binding cassette transporter
SUR is also the binding site for drugs such as sulfonylureas and potassium-channel openers activators such as diazoxide. The ...
Mianserin
There is a risk of dangerously low blood pressure if people take mianserin along with diazoxide, hydralazine, or nitroprusside ...
ATP-sensitive potassium channel
Suzuki M, Saito T, Sato T, Tamagawa M, Miki T, Seino S, Nakaya H (February 2003). "Cardioprotective effect of diazoxide is ...
ABCC8
"The essential role of the Walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide". The EMBO Journal. 16 (6 ...
Benzothiadiazine
... bendroflumethiazide chlorothiazide cyclothiazide hydrochlorothiazide diazoxide Hu Z, Martí J, Lu H (October 2021). "Structure ...
Ion channel hypothesis of Alzheimer's disease
"The KATP Channel Activator Diazoxide Ameliorates Aβ and Tau Pathologies and Improves Memory in the 3xTgAD Mouse Model of ...
Insulinoma
Medications such as diazoxide and somatostatin can be used to block the release of insulin for patients who are not surgical ...
Prepubertal hypertrichosis
Minoxidil Cyclosporine Diazoxide Danazol Phenothiazine Hydantoin Omeprazole - possibly via modulation of prostaglandin pathways ...
Oculogyric crisis
... diazoxide, levodopa, lithium, metoclopramide, lurasidone, domperidone, nifedipine, pemoline,[citation needed] phencyclidine (" ...
List of MeSH codes (D03)
... diazoxide MeSH D03.438.174.475 - hydroflumethiazide MeSH D03.438.174.620 - methyclothiazide MeSH D03.438.174.781 - polythiazide ...
Potassium channel opener
Some examples include: Diazoxide vasodilator used for hypertension, smooth muscle relaxing activity Minoxidil vasodilator used ...
Hydroxyacyl-Coenzyme A dehydrogenase
Most documented cases thus far have shown that individuals are responsive to diazoxide treatment, and highlight the need for ...
Jennifer S. Lawton
"Exploitation of the KATP Channel Opener Diazoxide during Cardiac Surgery." During her tenure at the Washington University ...
WHO Model List of Essential Medicines
Diazoxideα Levothyroxine Potassium iodide Methimazole Propylthiouracil Complementary: Lugol's solutionα Methimazoleα Potassium ...
List of MeSH codes (D02)
... diazoxide MeSH D02.886.655.500.475 - hydroflumethiazide MeSH D02.886.655.500.620 - methyclothiazide MeSH D02.886.655.500.781 - ... diazoxide MeSH D02.886.590.700.135.475 - hydroflumethiazide MeSH D02.886.590.700.135.620 - methyclothiazide MeSH D02.886. ...
WHO Model List of Essential Medicines for Children
ATC code V03
V03AF11 Arginine and lysine V03AF12 Trilaciclib V03AG01 Sodium cellulose phosphate V03AG05 Sodium phosphate V03AH01 Diazoxide ...
List of drugs: Df-Di
... diazoxide (INN) dibekacin (INN) dibemethine (INN) Dibenil dibenzepin (INN) Dibenzyline dibotermin alfa (USAN) dibrompropamidine ...