... (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to ... Diacylglycerol+Kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 2.7.1.107 Portal: Biology ( ... Mérida I, Avila-Flores A, Merino E (January 2008). "Diacylglycerol kinases: at the hub of cell signalling". The Biochemical ... Some Gram-positive bacteria also encode a soluble diacylglycerol kinase capable of reintroducing DAG into the phospholipid ...

... (EC 2.7.1.174, DAG kinase, CTP-dependent diacylglycerol kinase, diglyceride kinase) is an ... Diacylglycerol kinase Han GS, O'Hara L, Carman GM, Siniossoglou S (July 2008). "An unconventional diacylglycerol kinase that ... "Characterization of the yeast DGK1-encoded CTP-dependent diacylglycerol kinase". The Journal of Biological Chemistry. 283 (29 ... Diacylglycerol+kinase+(CTP+dependent) at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology ...

2006). "Phosphorylation and up-regulation of diacylglycerol kinase gamma via its interaction with protein kinase C gamma". J. ... Diacylglycerol kinase gamma is an enzyme that in humans is encoded by the DGKG gene. This gene encodes an enzyme that is a ... "Entrez Gene: DGKG diacylglycerol kinase, gamma 90kDa". Brose N, Betz A, Wegmeyer H (2004). "Divergent and convergent signaling ... Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage ...

Diacylglycerol kinase beta is an enzyme that in humans is encoded by the DGKB gene. Diacylglycerol kinases (DGKs) are ... "Entrez Gene: DGKB diacylglycerol kinase, beta 90kDa". Caricasole A, Bettini E, Sala C, Roncarati R, Kobayashi N, Caldara F, ... Goto K, Kondo H (August 1993). "Molecular cloning and expression of a 90-kDa diacylglycerol kinase that predominantly localizes ... The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Two alternatively spliced transcript variants have ...

Diacylglycerol kinase theta is an enzyme that in humans is encoded by the DGKQ gene. The protein encoded by this gene contains ... "Entrez Gene: DGKQ diacylglycerol kinase, theta 110kDa". Houssa, B; de Widt J; Kranenburg O; Moolenaar W H; van Blitterswijk W J ... 2003). "Diacylglycerol kinase-theta is localized in the speckle domains of the nucleus". Exp. Cell Res. 287 (1): 143-54. doi: ... 1999). "Diacylglycerol kinase theta binds to and is negatively regulated by active RhoA". J. Biol. Chem. 274 (11): 6820-2. doi: ...

"The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C- ... Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene. This gene encodes a cytoplasmic enzyme ... "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa". Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding ... 2007). "Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice". Am. J. Hum. Genet. 80 (4 ...

"Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. ... Hasegawa M, Cuenda A, Spillantini MG, Thomas GM, Buée-Scherrer V, Cohen P, Goedert M (1999). "Stress-activated protein kinase-3 ... "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci. 2 (7): ...

"Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. ... "Interactions between beta 2-syntrophin and a family of microtubule-associated serine/threonine kinases". Nat. Neurosci. 2 (7): ...

"Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". J. ... Hasegawa M, Cuenda A, Spillantini MG, Thomas GM, Buée-Scherrer V, Cohen P, Goedert M (1999). "Stress-activated protein kinase-3 ...

"Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions". The ... a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering ... "Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases". Nature. 378 (6552 ... two related membrane-associated putative guanylate kinases". Neuropharmacology. 35 (7): 993-1000. doi:10.1016/0028-3908(96) ...

By the phosphorylation of diacylglycerol (DAG) by DAG kinase (DAGK). By the acylation of lysophosphatidic acid by lysoPA- ... October 2004). "Sphingosine kinase 1 is an intracellular effector of phosphatidic acid". J. Biol. Chem. 279 (43): 44763-74. doi ... This will show whether the phosphate group is newly derived from the kinase activity or whether it originates from the PC. ... The conversion of PA into diacylglycerol (DAG) by LPPs is the commitment step for the production of phosphatidylcholine (PC), ...

2001). "Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ ...

2004). "Diacylglycerols containing Omega 3 and Omega 6 fatty acids bind to RasGRP and modulate MAP kinase activation". J. Biol ... Topham MK, Prescott SM (2001). "Diacylglycerol kinase zeta regulates Ras activation by a novel mechanism". J. Cell Biol. 152 (6 ... It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. ... It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of ...

1998). "Protein kinase C regulates the nuclear localization of diacylglycerol kinase-zeta". Nature. 394 (6694): 697-700. ... The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C ... Luo B, Prescott SM, Topham MK (2003). "Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase ... Luo B, Prescott SM, Topham MK (2005). "Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by ...

Houssa B, de Widt J, Kranenburg O, Moolenaar WH, van Blitterswijk WJ (March 1999). "Diacylglycerol kinase theta binds to and is ... Leung T, Chen XQ, Manser E, Lim L (October 1996). "The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is ... RhoA activates ROCK (RhoA kinase) which stimulates LIM kinase, which then inhibits cofilin, which effectively reorganizes the ... Due to pathophysiological overlap of RhoA and Rho-kinase in asthma, both RhoA and Rho-kinase have become promising new target ...

"Entrez Gene: DGKA diacylglycerol kinase, alpha 80kDa". *Topham MK, Prescott SM (1999). "Mammalian diacylglycerol kinases, a ... 2005). "Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase". ... Diacylglycerol kinase alpha is an enzyme that in humans is encoded by the DGKA gene. The protein encoded by this gene belongs ... Hart TC, Zhou J, Champagne C, Van Dyke TE, Rao PN, Pettenati MJ (Dec 1994). "Assignment of the human diacylglycerol kinase gene ...

Specifically, ritanserin acts as a potent inhibitor of diacylglycerol kinase alpha (DGKα). As such, it may be used to treat ... January 2018). "Targeting the mesenchymal subtype in glioblastoma and other cancers via inhibition of diacylglycerol kinase ... "Chemoproteomic Discovery of a Ritanserin-Targeted Kinase Network Mediating Apoptotic Cell Death of Lung Tumor Cells". Molecular ...

It is similar to the diacylglycerol-binding C1 domains of protein kinase C (PKC) enzymes. But unlike PKC, the C1 domains of Raf ... The only kinases currently known to perform this act are the Raf family kinases themselves. But some other kinases, such as ... Raf kinases A-Raf kinase B-Raf kinase KSR1 protein KSR2 protein GRCm38: Ensembl release 89: ENSMUSG00000000441 - Ensembl, May ... C-Raf is a member of the Raf kinase family of serine/threonine-specific protein kinases, from the TKL (Tyrosine-kinase-like) ...

"Phosphatidyl-L-serine is necessary for protein kinase C's high-affinity interaction with diacylglycerol-containing membranes". ... These include the Akt, protein kinase C (PKC) and Raf-1 signaling that is known to stimulate neuronal survival, neurite growth ... CMP is formed from CDP-diacylglycerol by PS synthase. Phosphatidylserine can eventually become phosphatidylethanolamine by the ...

The esters bind to PKC in a similar way to its natural ligand, diacylglycerol, and activate the kinase. Diacylglycerol is ... Moscat, Jorge; Diaz-Meco, María T; Rennert, Paul (January 2003). "NF-κB activation by protein kinase C isoforms and B-cell ... Blumberg PM (1988). "Protein Kinase C as the Receptor for the Phorbol Ester Tumor Promoters: Sixth Rhoads Memorial Award ... Phorbol derivatives work primarily by interacting with protein kinase C (PKC), although they can interact with other ...

... phospholipase C/IP3/cell Ca2+ mobilization/diacylglycerol/protein kinase Cs; calmodulin-modulated myosin light chain kinase; ... RAF/MEK/Mitogen-activated protein kinases; PKC/Ca2+/Calcineurin/Nuclear factor of activated T-cells; and the EGF cellular ... regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase ... to activate the Rho family of GTPases signaling proteins and Gi-Gβγ G proteins to activateRaf/MEK/mitogen-activated kinase ...

"Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase ...

"A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar ... BDNF receptor tyrosine kinase) inside neurons in the hippocampal region of the brain to modulate synapse depression and ...

The other product of phospholipase C, diacylglycerol, activates protein kinase C, which assists in the activation of cAMP ( ... For example, RasGTP signals link with the mitogen activated protein kinase (MAPK) cascade to amplify the allosteric activation ... These small molecules bind and activate protein kinases, ion channels, and other proteins, thus continuing the signaling ... Examples of second messenger molecules include cyclic AMP, cyclic GMP, inositol triphosphate, diacylglycerol, and calcium. ...

... domain and a diacylglycerol kinase domain. BLAST searches of expressed sequence tag (ESTs) by Sugiura and colleagues have ... Sugiura M, Kono K, Liu H, Shimizugawa T, Minekura H, Spiegel S, Kohama T (June 2002). "Ceramide kinase, a novel lipid kinase. ... Bajjalieh SM, Martin TF, Floor E (August 1989). "Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co- ... As a lipid kinase CERK is responsible for the phosphorylation of ceramides. CERK is capable of phosphorylating multiple ...

Then, Bazan's laboratory in collaboration with the Stephen Prescott lab showed that neuronal diacylglycerol kinase epsilon is ... Diacylglycerol kinase ε regulates seizure susceptibility and long-term potentiation through arachidonoyl-inositol lipid ... This finding has been referred to as the "Bazan Effect". In the early 70's, his laboratory isolated a diacylglycerol containing ... Rodriguez de Turco EB, Morelli de Liberti S, Bazan NG: Stimulation of free fatty acid and diacylglycerol accumulation in ...

... induced alpha-diacylglycerol kinase activation is an essential step in IL-2-mediated lymphocyte proliferation". The Journal of ...

Diacylglycerol can be phosphorylated to phosphatidic acid by diacylglycerol kinase. Activation of PKC-θ by diacylglycerol may ... Diacylglycerol can be mimicked by the tumor-promoting compounds phorbol esters. In addition to activating PKC, diacylglycerol ... Two possible forms exist, 1,2-diacylglycerols and 1,3-diacylglycerols. Diglycerides are natural components of food fats, though ... diacylglycerol, or free fatty acids. Diacylglycerol is a precursor to triacylglycerol (triglyceride), which is formed in the ...

... may refer to: Diacylglycerol kinase (CTP dependent), an enzyme Diacylglycerol kinase, an enzyme This set ...

"Protein kinase C alpha phosphorylates and negatively regulates diacylglycerol kinase zeta". The Journal of Biological Chemistry ... 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase". ... Phosphoinositide 3-kinase Phosphoinositide 3-kinase inhibitor PIK3CA-related overgrowth spectrum P110α has been shown to ... All PI 3-kinases are inhibited by the drugs wortmannin and LY294002 but wortmannin shows better efficiency than LY294002 on the ...