Martínez RD (1992). "[Characterization of the desmoglein in renal cells in culture]" [Characterization of the desmoglein in ... Desmoglein-1 is a protein that in humans is encoded by the DSG1 gene. Desmoglein-1 is expressed everywhere in the skin ... These desmoglein gene family members are located in a cluster on chromosome 18. The protein encoded by this gene has been ... Desmoglein-1 has been shown to interact with PKP3, PKP2, and PTPRT (PTPrho) Desmoglein List of target antigens in pemphigus ...
... is a protein that in humans is encoded by the DSG3 gene. In the skin epidermis Desmoglein-3 is expressed in the ... Desmoglein 3 has been shown to interact with PKP3. Desmoglein List of target antigens in pemphigus List of conditions caused by ... These desmoglein gene family members are located in a cluster on chromosome 18. This protein, along with Desmoglein-1, has been ... Hartlieb E, Kempf B, Partilla M, Vigh B, Spindler V, Waschke J (2013-01-11). "Desmoglein 2 is less important than desmoglein 3 ...
Desmogleins are targeted in the autoimmune disease pemphigus. Desmoglein proteins are a type of cadherin, which is a ... These desmoglein proteins thus hold cells together, but, when the body starts producing antibodies against desmoglein, these ... The desmogleins are a family of desmosomal cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the ... April 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and ...
... is the only desmoglein isoform expressed in cardiomyocytes. Desmoglein-2 is an integral component of desmosomes, ... Desmoglein-2 is a protein that in humans is encoded by the DSG2 gene. Desmoglein-2 is highly expressed in epithelial cells and ... Desmoglein-2 has been shown to interact with: DSC1 PKP3 Plakoglobin and SCN5A Desmoglein List of conditions caused by problems ... These desmoglein gene family members are located in a cluster on chromosome 18. This second family member, desmoglein-2 is ...
Swine desmoglein 1 (Dsg1) is a desmosomal intracellular adhesion molecule that is cleaved by the exfoliative toxins produced by ... Exfoliative toxins will cleave swine desmoglein-1 (Dsg1); therefore, creating an opportunity for epidermal bacterial invasion ... With bacterial invasion, 1 to 2 cm (diameter) brown lesions will begin to appear within the 24 to 48 hour range; and lesions ... 89 (1): 83-94. doi:10.1016/S0378-1135(02)00177-3. PMID 12223165. Park J, Friendship RM, Weese JS, Poljak Z, Dewey CE (October ...
... is a protein that in humans is encoded by the DSG4 gene. List of conditions caused by problems with junctional ... "Entrez Gene: DSG4 desmoglein 4". Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more ... 2006). "Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle ... 2003). "Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and ...
Pemphigus is an autoimmune disease caused by antibodies directed against both desmoglein 1 and desmoglein 3 present in ... are more anti-desmoglein 1 heavy. The disease arises most often in middle-aged or older people, usually starting with a blister ... human T cells are genetically engineered to recognize only those B cells that produce antibodies to desmoglein. In PV, ... is believed to be directly proportional to the levels of desmoglein 3. Milder forms of pemphigus (like foliacious and ...
Toxins are produced by S. aureus and target desmoglein, which is a desmosomal cell-cell adhesion molecule found in the upper ... Exfoliating toxins are serine proteases that specifically bind to and cleave desmoglein 1 (Dsg1). Previous studies suggested ... 1. New York City: Lippincott Williams & Wilkins, 2004. 17f "Impetigo: antimicrobial prescribing". NICE. Retrieved 8 July 2021 ... Insect bites bullous erythema multiforme fungal infections/bullous fungal Herpes simplex 1/2 Since the common pathogens ...
"The GEF Bcr activates RhoA/MAL signaling to promote keratinocyte differentiation via desmoglein-1". The Journal of Cell Biology ... 89 (1): 297-306. doi:10.1182/blood.V89.1.297. PMID 8978305. Kolibaba KS, Bhat A, Heaney C, Oda T, Druker BJ (March 1999). "CRKL ... 94 (1): 5-16. doi:10.1046/j.1365-2141.1996.6102053.x. PMID 8757502. S2CID 30033345. Bai RY, Jahn T, Schrem S, Munzert G, ... 96 (1): 203-207. Bibcode:1999PNAS...96..203T. doi:10.1073/pnas.96.1.203. PMC 15117. PMID 9874796. Wang L, Seale J, Woodcock BE ...
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nat ... 37 (1): 56-65. doi:10.1038/ng1493. PMID 15619623. S2CID 11404025. Renner E, Hartle D, Rylaarsdam S, Young M, Monaco-Shawver L, ... 152 (1): 159-165. doi:10.1111/j.1365-2133.2005.06337.x. PMID 15656819. S2CID 22760789. Chavanas S, Bodemer C, Rochat A (June ...
January 2005). "Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease ... 124 (1): 198-203. doi:10.1111/j.0022-202X.2004.23547.x. PMID 15654974. Caubet C, Jonca N, Brattsand M, Guerrin M, Bernard D, ... 254 (1-2): 119-128. doi:10.1016/S0378-1119(00)00280-8. PMID 10974542. Sales KU, Masedunskas A, Bey AL, Rasmussen AL, Weigert R ... 91 (1): 180-186. doi:10.1160/TH03-05-0261. PMID 14691584. Johnson SK, Ramani VC, Hennings L, Haun RS (May 2007). "Kallikrein 7 ...
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nature ... 44 (1): 1-6. doi:10.1007/s00795-010-0513-4. PMID 21424930. S2CID 320940. Tortora and Derrickson, Gerard J. and Bryan H. (2011 ... 37 (1): 56-65. doi:10.1038/ng1493. PMID 15619623. S2CID 11404025. Ishida-Yamamoto, Akemi; Simon, Michel; Kishibe, Mari; ... Fartasch, Manigé; Williams, Mary L.; Elias, Peter M. (1 July 1999). "Altered Lamellar Body Secretion and Stratum Corneum ...
"Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity". Nat ... ISBN 978-1-284-02568-2. Ovaere P; Lippens S; Vandenabeele P; Declercq W. (2009). "The emerging roles of serine protease ... 37 (1): 56-65. doi:10.1038/ng1493. PMID 15619623. S2CID 11404025. MedEd at Loyola medicine/dermatology/melton/skinlsn/stcorn. ...
Desmoglein and desmocollin have a single pass transmembrane region plus an intracellular anchor to secure its position in the ... Desmogleins and the desmocollin isoform "Dsc-a" contain an intracellular cadherin domain, which binds to plakoglobin. The outer ... Loss of desmoglein 4 leads to defective hair-follicle differentiation. Epidermolysis bullosa simplex is an epidermal blistering ... Desmoglein 1 haploinsufficiency leads to striate palmoplantar keratoderma, a disease which causes extreme thickening of the ...
Desmoglein 1, the protein that is targeted by the autoantibodies, is enriched in the upper skin layers. PF is characterized by ... When autoantibodies attack desmogleins, the cells become separated from each other and the epidermis becomes detached, a ... Pemphigus vulgaris (PV - ICD-10 L10.0) is the most common form of the disorder and occurs when antibodies attack desmoglein 3. ... The name is derived from the Greek root pemphix, meaning "pustule". In pemphigus, autoantibodies form against desmoglein, which ...
When desmogleins are attacked, skin cells separate from each other and fluid can collect between the layers of skin, forming ... If there is an autoimmune IgG buildup in the epidermis, then nearly all of the antibodies are aimed against desmoglein 1. The ... Disruption of function: In this case, the antibody blocks the desmoglein 1 from being formed into a desmosome. This in turn ... The immune system produces antibodies against proteins in the skin known as desmogleins. These proteins form the glue that ...
Abnormal distribution of plakoglobin due to mutations in genes encoding for Desmoglein 1 and 3 have also been implicated in ... Plakoglobin binds to conserved regions of desmoglein and desmocollin at intracellular catenin-binding sites to assemble ... desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): ... where it can bind to the cadherin family member desmoglein I. Plakoglobin also associates with classical cadherins such as E- ...
Three adhesive proteins desmoglein-1, desmocollin-1 and corneodesmosin compose the corneodesmosomes and provide the cohesive ... 17 (Suppl 1): 6-15. doi:10.1111/j.1396-0296.2004.04s1001.x. PMID 14728694. S2CID 41277807. Proksch E, Brandner JM, Jensen JM ( ... Size of a corneocyte is approximately 30-50 µm in diameter and 1 µm thick, and the average area of corneocytes at the surface ... ISBN 978-1-85775-775-0. Archived from the original (PDF) on 14 December 2010. "The epidermis". L'Oreal. Archived from the ...
... desmoglein 1, desmoglein 2, desmoplakin, connexin 43, plakoglobin, Kir6.2, and SCN5A. Skin fragility syndrome GRCh38: Ensembl ... 76 (1): 189-94. doi:10.1253/circj.cj-11-0747. PMID 22019812. van der Zwaag PA, Cox MG, van der Werf C, Wiesfeld AC, Jongbloed ... 6 (7): 450-1. doi:10.1038/nrcardio.2009.97. PMID 19554004. S2CID 20454940. Cox MG, van der Zwaag PA, van der Werf C, van der ... 7 (1): 22-9. doi:10.1016/j.hrthm.2009.09.070. PMID 20129281. Fressart V, Duthoit G, Donal E, Probst V, Deharo JC, Chevalier P, ...
These exotoxins are proteases that cleave desmoglein-1, which normally holds the granulosum and spinosum layers together, ... Retrieved 1 March 2023. "exfoliatin" at Dorland's Medical Dictionary Mockenhaupt M, Idzko M, Grosber M, Schöpf E, Norgauer J ( ... 133 (1): 88-91. doi:10.1001/archpedi.1979.02130010094020. PMID 367152. Melish, ME; Glasgow, LA (June 1971). "Staphylococcal ... ISBN 978-1-4160-2999-1. "Staphylococcal Scalded Skin Syndrome". Johns Hopkins Medicine. 19 November 2019. ...
... -2 and desmoglein-2 are found in all desmosome-containing tissues such as colon and cardiac muscle tissues, while ... Desmoglein, a subfamily of desmosomal cadherins Armadillo protein family, instrumental in the cytoplasmic anchoring of ... The '2' and '3' isoforms of desmocollin and desmoglein are expressed in the lower epidermal layers, and the '1' proteins and ... They are co-expressed with desmogleins to link adjacent cells by extracellular adhesion. There are seven desmosomal cadherins ...
... is one of the three major subtypes that affects IgG autoantibodies that are characteristically raised against desmoglein 1 and ... desmoglein 3 (which are cell-cell adhesion molecules found in desmosomes). Underlying cancer or irreversible system impairment ... 15 (1): 13-18. doi:10.1097/cnd.0b013e3182a04538. PMID 23965404. S2CID 37917515. Lancaster E, Huijbers MG, Bar V, Boronat A, ... ISBN 978-1-4160-2973-1. 8th edition. Goldner W (May 2016). "Cancer-Related Hypercalcemia". Journal of Oncology Practice. 12 (5 ...
Through immunoprecipitation, target antigens have been found to include desmoglein-3, desmoglein-1, envoplakin, periplakin, ... This piece labeled PNP as a "multiorgan disease characterized by antibodies against plakins, desmogleins and the α2- ... 410 (1-2): 13-8. doi:10.1016/j.cca.2009.08.022. PMID 19737550. Huang, Yongchu; Li, Jing; Zhu, Xuejun (2009). "Detection of anti ... However, alpha2-macroglobulin-like-1 can also be detected in patients with toxic epidermal necrosis. Bullous Pemphigoid, ...
... desmogleins MeSH D12.776.395.550.200.200.500.500.500 - desmoglein 1 MeSH D12.776.395.550.200.200.500.500.625 - desmoglein 2 ... MeSH D12.776.395.550.200.200.500.500.750 - desmoglein 3 MeSH D12.776.395.550.200.210 - carcinoembryonic antigen MeSH D12.776. ... par-1 MeSH D12.776.395.550.625.800.800 - thrombomodulin MeSH D12.776.395.550.625.905 - p-selectin MeSH D12.776.395.550.895.800 ... thrombospondin 1 MeSH D12.776.395.560.631.115 - ca-15-3 antigen MeSH D12.776.395.560.631.300 - gastric mucin MeSH D12.776. ...
... desmogleins MeSH D23.050.301.350.200.500.500.500 - desmoglein 1 MeSH D23.050.301.350.200.500.500.625 - desmoglein 2 MeSH ... desmoglein 3 MeSH D23.050.422.500 - heymann nephritis antigenic complex MeSH D23.050.422.500.500 - ldl-receptor related protein ... D23.050.301.350.200.500.500.750 - desmoglein 3 MeSH D23.050.301.350.210 - carcinoembryonic antigen MeSH D23.050.301.350.230 - ... neuregulin-1 MeSH D23.348.740.650 - proto-oncogene proteins c-sis MeSH D23.348.862.505 - insulin-like growth factor i MeSH ...
... desmogleins MeSH D12.776.543.550.200.200.500.500.500 - desmoglein 1 MeSH D12.776.543.550.200.200.500.500.625 - desmoglein 2 ... MeSH D12.776.543.550.200.200.500.500.750 - desmoglein 3 MeSH D12.776.543.550.200.210 - carcinoembryonic antigen MeSH D12.776. ... toll-like receptor 1 MeSH D12.776.543.750.705.910.500.200 - toll-like receptor 2 MeSH D12.776.543.750.705.910.500.300 - toll- ... syntaxin 1 MeSH D12.776.543.512.249.500.500.750 - syntaxin 16 MeSH D12.776.543.512.249.500.750 - qb-snare proteins MeSH D12.776 ...
... desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP)". Genomics. 10 (3): ... 8 (1): 143-8. doi:10.1093/hmg/8.1.143. PMID 9887343. Whittock NV, Ashton GH, Dopping-Hepenstal PJ, Gratian MJ, Keane FM, Eady ... 28 (1): 131-5. doi:10.1016/j.det.2009.10.015. PMID 19945626. S2CID 36535041. Anhalt GJ, Kim SC, Stanley JR, Korman NJ, Jabs DA ... 366 (1): 244-57. doi:10.1016/j.jmb.2006.11.036. PMC 1850962. PMID 17161423. Choi HJ, Weis WI (2011). "Crystal structure of a ...
1997). "A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes ... These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the ... DSC1 has been shown to interact with Desmoglein 2. GRCh38: Ensembl release 89: ENSG00000134765 - Ensembl, May 2017 GRCm38: ... Chitaev NA, Troyanovsky SM (1997). "Direct Ca2+-dependent Heterophilic Interaction between Desmosomal Cadherins, Desmoglein and ...
June 1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". ... Desmocollin-2 binds to desmoglein family members through a calcium-dependent interaction with its extracellular domains, and to ... Desmosomal cadherins, including the desmocollin family members and desmogleins, are found at desmosome cell-cell junctions and ... cadherins than to desmogleins". Genomics. 44 (3): 330-5. doi:10.1006/geno.1997.4894. PMID 9325054. Syed SE, Trinnaman B, Martin ...
These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the ... 1991). "Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG ... 1994). "Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18". ... 2000). "Different effects of dominant negative mutants of desmocollin and desmoglein on the cell-cell adhesion of keratinocytes ...