Deoxycytidine monophosphate
... (dCMP), also known as deoxycytidylic acid or deoxycytidylate in its conjugate acid and conjugate ... In a DNA double helix, it will base pair with deoxyguanosine monophosphate. Cytidine monophosphate v t e (Articles without KEGG ...
Cytidine monophosphate
Deoxycytidine monophosphate Nucleoside Oligonucleotide Pascal JM (February 2008). "DNA and RNA ligases: structural variations ... Cytidine monophosphate, also known as 5'-cytidylic acid or simply cytidylate, and abbreviated CMP, is a nucleotide that is used ... a ribonucleoside monophosphate. As a substituent it takes the form of the prefix cytidylyl-. CMP can be phosphorylated to ...
DCMP deaminase
... deoxycytidine monophosphate deaminase, deoxycytidine-5'-phosphate deaminase, deoxycytidine-5'-monophosphate aminohydrolase) is ... Deoxycytidine monophosphate Deoxyuridine monophosphate Scarano E (March 1960). "The enzymatic deamination of 6-aminopyrimidine ... I. The enzymatic deamination of deoxycytidine 5'-phosphate and of 5-methyldeoxycytidine 5-methyldeoxycytidine 5'-phosphate". ...
Deoxycytidine kinase
dCK predominantly phosphorylates deoxycytidine (dC) and converts dC into deoxycytidine monophosphate. dCK catalyzes one of the ... gemcitabine's original form as a deoxycytidine analog) to convert it into dFdCMP, its monophosphate form. Cytidylate kinase or ... conformation may assist in the initial nucleoside binding and the release of the monophosphate product Deoxycytidine kinase ( ... "Entrez Gene: DCK deoxycytidine kinase". Nathanson DA, Armijo AL, Tom M, Li Z, Dimitrova E, Austin WR, Nomme J, Campbell DO, Ta ...
Nucleotide salvage
Alternatively, uridine-cytidine kinase can phosphorylate them into cytidine monophosphate (CMP) or deoxycytidine monophosphate ... The nucleosides cytidine and deoxycytidine can be salvaged along the uracil pathway by cytidine deaminase, which converts them ... Thymidine kinase can then phosphorylate the 5'-carbon of this compound into thymidine monophosphate (TMP). Thymidylate kinase ... carbon of this nucleoside into uridine monophosphate (UMP). UMP/CMP kinase (EC 2.7.4.14) can phosphorylate UMP into uridine ...
CMP kinase
Hsu CH, Liou JY, Dutschman GE, Cheng YC (2004). "Phosphorylation of Cytidine, Deoxycytidine, and Their Analog Monophosphates by ... Van Rompay AR, Johansson M, Karlsson A (1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP kinase: ... Uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) catalyzes the phosphoryl transfer from ATP to UMP ... and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624-31. PMID 11912132. Pasti C, Gallois-Montbrun S ...
UCK2
Van Rompay AR, Johansson M, Karlsson A (September 1999). "Phosphorylation of deoxycytidine analog monophosphates by UMP-CMP ... and L-form deoxycytidine analogue monophosphates". Cancer Research. 62 (6): 1624-31. PMID 11912132. Kashuba E, Kashuba V, ... The protein encoded by this gene catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (UMP) and ... Satlin A, Kucherlapati R, Ruddle FH (1976). "Assignment of the gene for human uridine monophosphate kinase to chromosome 1 ...
Deoxycytidine
... of the deoxyribose by deoxycytidine kinase, converting it to deoxycytidine monophosphate (dCMP), a DNA precursor. dCMP can be ... 5-(Hydroxymethyl)-2′-deoxycytidine (5-hmdC), 5-(formyl)-2′-deoxycytidine (5-fodC), and 5-(carboxyl)-2′-deoxycytidine (5-cadC) ... deoxycytidine, 5-(Formyl)-2′-deoxycytidine, and 5-(Carboxyl)-2′-deoxycytidine in Human Urine of Breast Cancer Patients by ... Deoxycytidine can also serve as a biomarker for tumor diagnosis. Deoxycytidine can be used as a biomarker for breast cancer ...
Clofarabine
Embedded clofarabine-5´-monophosphate in the DNA promotes polymerase arrest at the replication fork, triggering DNA repair ... Nagai S, Takenaka K, Nachagari D, Rose C, Domoney K, Sun D, Sparreboom A, Schuetz JD (Mar 2011). "Deoxycytidine kinase ... ABC transporter ABCG2 promotes export of clofarabine-5´-monophosphate and thus limits the cytotoxic effects of this analog in ... Clofarabine enters cells via hENT1, hENT2, and hCNT2, where upon it is phosphorylated by deoxycytidine kinase to generate ...
DCMP
... a football club of the Democratic Republic of the Congo Described and Captioned Media Program Deoxycytidine monophosphate ...
List of MeSH codes (D13)
... deoxycytidine monophosphate MeSH D13.695.740.600 - pyrimidine dimers MeSH D13.695.740.706 - thymine nucleotides MeSH D13.695. ... deoxycytidine monophosphate MeSH D13.695.201.175 - deoxyguanine nucleotides MeSH D13.695.201.200 - deoxyuracil nucleotides MeSH ... thymidine monophosphate MeSH D13.695.462.200 - cyclic amp MeSH D13.695.462.200.225 - 8-bromo cyclic adenosine monophosphate ... cytidine monophosphate MeSH D13.695.740.246.370.250 - cytidine monophosphate n-acetylneuraminic acid MeSH D13.695.740.246.400 ...
Gemcitabine
Similarly, the genes that express proteins that lead to its inactivation (deoxycytidine deaminase, cytidine deaminase, and NT5C ... and so it becomes gemcitabine monophosphate (dFdCMP). This is the rate-determining step that is catalyzed by the enzyme ... carbon of deoxycytidine are replaced by fluorine atoms. The synthesis described and pictured below is the original synthesis ... gemcitabine can masquerade as deoxycytidine triphosphate and is incorporated into new DNA strands being synthesized as the cell ...
Cytidylate kinase
... deoxycytidine monophosphokinase, UMP-CMP kinase, ATP:UMP-CMP phosphotransferase, and pyrimidine nucleoside monophosphate kinase ... Ruffner BW, Anderson EP (November 1969). "Adenosine triphosphate: uridine monophosphate-cytidine monophosphate ...
Glossary of genetics (0-L)
deoxycytidine One of the four standard deoxyribonucleosides used in DNA molecules, consisting of a cytosine base with its N9 ... cyclic adenosine monophosphate (cAMP) cyclosis See cytoplasmic streaming. cytidine (C, Cyd) One of the four standard ... Cytosine bonded to deoxyribose is known as deoxycytidine, which is the version used in DNA. cytogenetics The branch of genetics ... adenosine diphosphate (ADP) adenosine monophosphate (AMP) adenosine triphosphate (ATP) An organic compound derived from adenine ...
d)CMP kinase
... (EC 2.7.4.25, prokaryotic cytidylate kinase, deoxycytidylate kinase, dCMP kinase, deoxycytidine monophosphokinase ... CDP The prokaryotic cytidine monophosphate kinase specifically phosphorylates CMP (or dCMP). Bertrand T, Briozzo P, Assairi L, ...
Cytarabine
... -5´-monophosphate is deaminated by deoxycytidylate deaminase, leading to the inactive uridine-5´-monophosphate analog ... Cytarabine is transported into the cell primarily by hENT-1. It is then monophosphorylated by deoxycytidine kinase and ...
Purine nucleoside phosphorylase
Deoxycytidine can be phosphorylated by deoxycytidine kinase (DCK). Adenosine uses the enzyme adenosine kinase, which is a very ... These pathways allow the cell to produce nucleotide monophosphates when the de novo synthesis pathway has been interrupted or ...
Discovery and development of nucleoside and nucleotide reverse-transcriptase inhibitors
Addition of the second phosphate group to nucleoside monophosphate analogues is completed by the nucleoside monophosphate ... Apricitabine is a deoxycytidine analogue. It is structurally related to lamivudine where the positions of the oxygen and the ... The 3' carbon of the ribose ring of 2'-deoxycytidine has been replaced by a sulfur atom because it had greater anti-HIV ... Elvucitabine is a deoxycytidine analogue with activity against HIV resistant to several other nucleoside analogues, including ...
Thymidine kinase in clinical chemistry
ATP ---> + ADP Thymidine reacts with ATP to give thymidine monophosphate and ADP. Thymidine monophosphate, the product of the ... Arnér ES, Spasokoukotskaja T, Eriksson S (1992). "Selective assays for thymidine kinase 1 and 2 and deoxycytidine kinase and ... The monophosphate of iodo deoxyuridine is adsorbed on aluminum oxide that is suspended in the incubation medium. After ... In this technique 3'-azido-2',3'-deoxythymidine (Zidovudine, AZT) is first phosphorylated to AZT 5'-monophosphate (AZTMP) by ...
Epigenetics in stem-cell differentiation
One example of such an application is the use of decitabine (a deoxycytidine analog) to deplete DNA methyl transferase 1 (DNMT1 ... which function to catalyze the hydrolysis of monophosphate esters. McKenna et al. (1979) found that there are at least three ...
List of EC numbers (EC 3)
... monophosphate deformylase EC 3.5.1.103: N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-α-D-glucopyranoside deacetylase EC 3.5.1.104 ... deoxy)cytidine deaminase EC 3.5.4.15: guanosine deaminase EC 3.5.4.16: GTP cyclohydrolase I EC 3.5.4.17: adenosine-phosphate ...
Thymidine kinase
ATP ---> + ADP Thymidine reacts with ATP to give thymidine monophosphate and ADP. Thymidine monophosphate, the product of the ... Arnér ES, Spasokoukotskaja T, Eriksson S (October 1992). "Selective assays for thymidine kinase 1 and 2 and deoxycytidine ... As analogs of thymidine, this type of drugs are readily phosphorylated to 5'-monophosphates. The monophosphate is further ... Thymidine monophosphate is also produced by the cell in a different reaction by methylation of deoxyuridine monophosphate, a ...