Ether cleavage
Ranu, B. C.; Bhar, S. (1996). "Dealkylation of Ethers. A Review". Org. Prep. Proc. Int. 28 (4): 371-409. doi:10.1080/ ... Weissman, Steven A.; Zewge, Daniel (2005). "Recent Advances in Ether Dealkylation". Tetrahedron. 61 (33): 7833-7863. doi: ...
Alkylation
Complementing alkylation reactions are the reverse, dealkylations. Prevalent are ether dealkylations. Hydrodealkylation ... Alkyl groups can also be removed in a process known as dealkylation. Alkylating agents are often classified according to their ... Weissman, Steven A.; Zewge, Daniel (2005). "Recent advances in ether dealkylation". Tetrahedron. 61 (33): 7833-7863. doi: ...
Domperidone
CYP3A4 is the major enzyme involved in the N-dealkylation of domperidone, while CYP3A4, CYP1A2, and CYP2E1 are involved in its ... This occurs via hydroxylation and N-dealkylation. Domperidone is almost exclusively metabolized by CYP3A4/5, though minor ...
Trimethylsilyl iodide
"Quantitative dealkylation of alkyl ethers via treatment with trimethylsilyl iodide. A new method for ether hydrolysis". J. Org ...
Oxybenzone
To form DHB the methoxy functional group undergoes O-dealkylation; to form THB the same ring is hydroxylated. Ring B in ...
Alpidem
... dealkylation, and conjugation. Many metabolites of alpidem have been identified, and some of these metabolites may contribute ...
Meta-Chlorophenylpiperazine
It is formed by dealkylation via CYP3A4. Caution should be exercised in concomitant administration of CYP2D6 inhibitors such as ...
Butylone
The third pathway is a N-dealkylation into N-dealkyl metabolites. The first two pathways occur more than pathway three. The ...
Lofepramine
Other routes of metabolism include hydroxylation, glucuronidation, N-dealkylation and N-oxidation. Lofepramine is a tricyclic ...
DABCO
Ho, T. L. (1972). "Dealkylation of Quaternary Ammonium Salts with 1,4-Diazabicyclo[2.2.2]octane". Synthesis. 1972 (12): 702. ...
Thiol
... s are prepared by reductive dealkylation of sulfides, especially benzyl derivatives and thioacetals. Thiophenols are ...
Boron trichloride
Williard, Paul G.; Fryhle, Craig B. (1980). "Boron trihalide-methyl sulfide complexes as convenient reagents for dealkylation ...
Iproniazid
... can also be metabolised by O-dealkylation from iproniazid to acetone and isoniazid. Isoniazid can undergo further ...
AM-2201
... N-dealkylation produces fluoropentane instead of pentane (or plain alkanes in general).[citation needed] A forensic ...
2,3-Dichlorophenylpiperazine
Caccia S (August 2007). "N-dealkylation of arylpiperazine derivatives: disposition and metabolism of the 1-aryl-piperazines ...
Trimethyldiborane
doi:10.1016/s0022-328x(00)93089-4. Marsella, John A.; Caulton, Kenneth G. (May 1982). "Dealkylation of zirconium(IV) by borane ...
Methyldiborane
doi:10.1016/s0022-328x(00)93089-4. Marsella, John A.; Caulton, Kenneth G. (May 1982). "Dealkylation of zirconium(IV) by borane ...
1,2-Dimethyldiborane
doi:10.1016/s0022-328x(00)93089-4. Marsella, John A.; Caulton, Kenneth G. (May 1982). "Dealkylation of Zirconium(IV) by Borane ...
1,1-Dimethyldiborane
doi:10.1016/s0022-328x(00)93089-4. Marsella, John A.; Caulton, Kenneth G. (May 1982). "Dealkylation of zirconium(IV) by borane ...
AM-1235
... N-dealkylation produces fluoropentane instead of pentane (or plain alkanes in general). It has been speculated that the ...
Refractory metals
It is used as a catalyst in reactions such as alkylation, dealkylation, hydrogenation and oxidation. However its rarity makes ...
Methamphetamine
The primary site of metabolism is in the liver by aromatic hydroxylation, N-dealkylation and deamination. At least seven ... N-dealkylation, and deamination. The known metabolic pathways include: Methamphetamine and amphetamine are often measured in ...
UV filter
4-methoxy benzaldehyde (MOBA) and 4-methoxy cinnamic acid are two transformation products of EHMC via dealkylation. The ...
Ada regulon
Recent observations suggest that AidB may bind to double-stranded DNA and take part in its dealkylation. However, to determine ...
Angelicin
Mechanism and Stereochemistry of the Oxidative Dealkylation of Columbianetin to Angelicin in Heracleum mantegazzianum (Apiaceae ...
Dextroamphetamine
N-dealkylation, and deamination. The known metabolic pathways, detectable metabolites, and metabolizing enzymes in humans ...
Amphetamine
N-dealkylation, and deamination. The known metabolic pathways, detectable metabolites, and metabolizing enzymes in humans ...
Lisdexamfetamine
N-dealkylation, and deamination. The known metabolic pathways, detectable metabolites, and metabolizing enzymes in humans ...
Adderall
N-dealkylation, and deamination. The known metabolic pathways, detectable metabolites, and metabolizing enzymes in humans ...
MMACHC
The MMACHC gene product catalyzes the decyanation of cyanocobalamin as well as the dealkylation of alkylcobalamins including ...