DNA adducts are researched in laboratory settings. A typical experimental design for studying DNA adducts is to induce them ... forming DNA adducts, and inducing double-strand breaks (DSBs). In regards to DNA adduct formation, this analysis was conducted ... Ongoing research on DNA adducts seeks to overcome these complications. It is the hope that in future medical practices DNA ... In molecular genetics, a DNA adduct is a segment of DNA bound to a cancer-causing chemical. This process could lead to the ...
"Mitosene-DNA Adducts. Characterization of Two Major DNA Monoadducts Formed by 1,10-Bis(acetoxy)-7-methoxymitosene upon ...
... ions are often formed in a mass spectrometer ion source. Adductomics DNA adduct IUPAC, Compendium of Chemical ... Adducts often form between Lewis acids and Lewis bases. A good example is the formation of adducts between the Lewis acid ... Adducts are not necessarily molecular in nature. A good example from solid-state chemistry is the adducts of ethylene or carbon ... An adduct ion is formed from a precursor ion and contains all of the constituent atoms of that ion as well as additional atoms ...
These adducts may then produce DNA crosslinks. Glycation of DNA may also lead to mutation, breaks in DNA and cytotoxicity. In ... Formation mechanism of glyoxal-DNA adduct, a DNA cross-link precursor. Int J Biol Macromol. 2017 May;98:664-675. doi: 10.1016/j ... Guanine bases in DNA can undergo non-enzymatic glycation by glyoxal to form glyoxal-guanine adducts. ...
... reacts with DNA to form adducts. It is more reactive toward DNA than acrylamide. Several glycidamide-DNA adducts ... The main DNA adducts are N7-(2-carbamoyl-2-hydroxyethyl)-guanine (or N7-GA-Gua) and N3-(2-carbamoyl-2-hydroxyethyl)adenine (or ... Mice and rats show mutations and DNA adducts consistent with those arising from glycidamide. Another study found tumors in the ... ISBN 978-1-4419-3672-1. Bergmark, E., Calleman, C. J., & Costa, L. G. (1991). Formation of hemoglobin adducts of acrylamide and ...
LTA4 can form adducts with tissue DNA. Other reactions of lipoxygenases generate cellular damage; murine models implicate 15- ... PGs and LTs may signal or regulate DNA-transcription there; LTB4 is ligand for PPARĪ±.(See diagram at PPAR). Both COX1 and COX2 ...
Liu XY, Zhu MX, Xie JP (2010). "Mutagenicity of acrolein and acrolein-induced DNA adducts". Toxicol. Mech. Methods. 20 (1): 36- ... Tompkins EM, McLuckie KI, Jones DJ, Farmer PB, Brown K (2009). "Mutagenicity of DNA adducts derived from ethylene oxide ... Kastan MB (2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Mol ... The most important chemicals causing cancer are those that produce DNA damage, since such damage appears to be the primary ...
Liu XY, Zhu MX, Xie JP (2010). "Mutagenicity of acrolein and acrolein-induced DNA adducts". Toxicol. Mech. Methods. 20 (1): 36- ... Tompkins EM, McLuckie KI, Jones DJ, Farmer PB, Brown K (2009). "Mutagenicity of DNA adducts derived from ethylene oxide ... Kastan MB (2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Mol ... The most important chemicals causing cancer are those that produce DNA damage since such damage appears to be the primary ...
... s can also form adducts with DNA by a single covalent bond through an aminal linkage from the 3'-amino of ... Cutts SM, Nudelman A, Rephaeli A, Phillips DR (February 2005). "The power and potential of doxorubicin-DNA adducts". IUBMB Life ... The supply of extracellular formaldehyde using formaldehyde-releasing prodrugs can promote covalent DNA adduct formation. Such ... Anthracyclines intercalated into DNA, form a stable anthracycline-DNA-topoisomerase II ternary complex thus "poisoning" the ...
Liu XY, Zhu MX, Xie JP (2010). "Mutagenicity of acrolein and acrolein-induced DNA adducts". Toxicol. Mech. Methods. 20 (1): 36- ... Tompkins EM, McLuckie KI, Jones DJ, Farmer PB, Brown K (2009). "Mutagenicity of DNA adducts derived from ethylene oxide ... Kastan MB (2008). "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture". Mol ... The most important chemical compounds causing cancer are those that produce DNA damage since such damage appears to be the ...
CG adduct destabilizes the helix and induces a bend and twist in the DNA. DNA crosslinking lesions can also be formed when ... intrastrand DNA crosslinks, interstrand DNA crosslinks, and DNA-protein crosslinks. When cisplatin generates DNA crosslinks, it ... Cancer treatments have been engineered using DNA cross-linking agents to interact with nitrogenous bases of DNA to block DNA ... These adducts result in local distortions to DNA at the site of intercalation. Psoralens are used in the medical treatment of ...
... causes DNA damage, which is thought to be mediated by formation of DNA adducts. In this process, 4- ... A linear correlation was found between adduct levels and the occurrence of liver tumors in female mice by comparing DNA adducts ... The compound can be metabolized by humans which the product may form adducts with DNA in human urothelial mucosa and bladder ... The final products of this metabolism are aryl nitrenium ions which form DNA adducts. During this process reactive oxygen ...
... forms monofunctional adducts with guanosine residues in the DNA. The large and hydrophobic nature of the ... "Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis ... a major protein used by the cell to transcribe DNA. Since transcription is essential for DNA synthesis and gene expression, ... A study examining the effects of monofunctional adducts on bacterial growth reported a significant decrease in Escherichia coli ...
These groups can ultimately form an adduct with the base of a nucleotide in the DNA. DNA adducts with PAHs can disrupt the DNA ... Baird, W. M.; Hooven, L. A.; Mahadevan, B. (2015). "Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and mechanism of ... replication or modify the DNA, by removing bases like adenine and guanine from the nucleotides. This can in the end lead to ...
A DNA adduct is a segment of DNA that binds to a chemical carcinogen. Some adducts that cause lesions to DNA included ... MDA reacts with DNA to form the M1dG adduct which causes DNA lesions. Many systems are in place to repair DNA and RNA lesions ... ROS is one of the major endogenous sources of DNA damage and the most studied oxidative DNA adduct is 8-oxo-dG. Other adducts ... These epoxy aldehydes can damage DNA by producing etheno adducts. An increase in this type of DNA lesion exhibits conditions ...
DNA Adducts by the Mammalian Excision Nuclease". Biochemistry. 35 (31): 10004-10013. doi:10.1021/bi960453+. ISSN 0006-2960. ... "HMG-domain proteins specifically inhibit the repair of the major DNA adduct of the anticancer drug cisplatin by human excision ... "Cisplatin and DNA repair in cancer chemotherapy". Trends in Biochemical Sciences. 20 (10): 435-439. doi:10.1016/S0968-0004(00) ...
Stable adducts may lead to DNA replication errors, while unstable adducts react with the DNA strand, removing a purine base ( ... These metabolites can bind to DNA at specific sites, forming bulky complexes called DNA adducts that can be stable or unstable ... This enzyme then metabolically processes the PAHs to quinone metabolites that bind to DNA in reactive adducts that remove ... Baird, W. M.; Hooven, L. A.; Mahadevan, B. (2015-02-01). "Carcinogenic polycyclic aromatic hydrocarbon-DNA adducts and ...
... reacts with DNA in vitro. The major DNA adduct formed in this reaction is identified as the 8-(phenylazo)guanine adduct, which ... Guanosine DNA adducts derived from peroxidase metabolites of Sudan 1 were also found in vivo in the bladder of rats. The ... As a consequence DNA, RNA and protein adducts are formed. (See figure 2). Therefore, peroxidase-catalyzed activation of Sudan I ... Hence, formation of adducts of Sudan I reactive species with nucleophilic species, such as DNA, tRNA, proteins, polynucleotides ...
... which can damage DNA). The level of oxidative stress and acetaldehyde-induced DNA adducts due to alcohol consumption does not ... Oxidative DNA damage is mutagenic and also causes epigenetic alterations at the sites of DNA repair. Epigenetic alterations and ... "Formation of acetaldehyde-derived DNA adducts due to alcohol exposure". Chemico-Biological Interactions. 188 (3): 367-75. doi: ... The excess deoxycholic acid causes DNA damage and inflammation in the liver, which, in turn, can lead to liver cancer. Several ...
PhIP has been shown to induce DNA adducts and mutations. These adducts have been found in a wide variety of sensitive tissues ... DNA and protein adducts were formed in the colon and blood. However, the adducts were unstable and declined over a 24-hour ... 1999). DNA and protein adduct formation in the colon and blood of humans after exposure to a dietary-relevant dose of 2-amino-1 ... PhIP has also formed DNA adducts in vivo in both rats and monkeys. PhIP has been tested for carcinogenicity in both mice and ...
In rats gavaged with riddelliine, a set of DNA adducts of dehydroretronecine (DHS) in liver DNA can serve as biomarkers for the ... the resulting carbocation can bind to two DNA bases, producing another cross-linked DNA adduct. In both cases, the covalently ... To date, 8 DHP-derived DNA adducts have been observed, all of which contribute to the tumorigenicity of riddelliine. ... Two possible pathways emerge from this cytotoxic intermediate, both of which produce similar tumorigenic DNA adducts. Neither ...
... which can form DNA-base adducts, thus giving aristolochic acid I its mutagenic properties. Aristolactam I adducts that are ... Nephropathy caused by aristolochic acid consumption is not mechanistically understood, but DNA adducts characteristic of ... "Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients ... have AAN can be confirmed through phytochemical analysis of plant products consumed and detection of aristolactam DNA adducts ...
Acetaldehyde can react with DNA to create DNA adducts including the Cr-Pdg adduct. This Cr-PdG adduct "is likely to play a ... Brooks P, Theruvathu J, Cho CH, Purohit V (2006). "Acetaldehyde-DNA Adducts: Implications for the Molecular Mechanism of ... owing to its multiple mutagenic effects on DNA." ...
M1dG is the major endogenous DNA adduct in humans. M1dG adducts have been detected in cell DNA in liver, leucocytes, pancreas ... of a specific type of DNA adduct called M1dG. The M1dG adduct in turn is formed by a condensation reaction between guanosine ... Detection and quantification of M1dG adducts in the body as measured by free M1G is a tool for detecting DNA damage that may ... "Metabolism in vitro and in vivo of the DNA base adduct, M1G". Chem. Res. Toxicol. 20 (3): 550-7. doi:10.1021/tx600334x. PMID ...
"bulky adduct formation" (e.g., benzo[a]pyrene diol epoxide-dG adduct, aristolactam I-dA adduct) mismatch of bases, due to ... Reduced expression of DNA repair genes causes deficient DNA repair. When DNA repair is deficient DNA damages remain in cells at ... Biology portal Accelerated aging disease Aging DNA Cell cycle DNA damage (naturally occurring) DNA damage theory of aging DNA ... Human DNA Repair Genes 3D structures of some DNA repair enzymes Human DNA repair diseases DNA repair special interest group DNA ...
"Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment". Toxicological ... the majority of formaldehyde-DNA adducts found in non-respiratory tissues are derived from endogenously produced formaldehyde. ... Formaldehyde and its adducts are ubiquitous in living organisms because they are produced naturally. Food may contain ... In yeast, formaldehyde is found to perturb pathways for DNA repair and cell cycle. In the residential environment, formaldehyde ...
Metabolites of aristolochic acid enter the cell nucleus and form adducts on DNA. While adducts on the transcribed DNA strand ... the adducts on the non-transcribed strand remain and eventually cause DNA replication errors. These adducts have a preference ... "Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs ... "Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with Chinese herbs ...
These diol-epoxides covalently bind with DNA base pairs, most often with guanine and adenine to form stable adducts within the ... One mechanism of action for genotoxic carcinogens includes the formation of DNA adducts. Once the PAH compound enters an ... A biological target, also known as the site of action, can be binding proteins, ion channels, DNA, or a variety of other ... Since these toxicants do not directly act on DNA, little is known about the mechanistic pathway. It has been proposed that ...
"Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment". Toxicological ... Singer, B. (1996). "DNA Damage: Chemistry, Repair, and Mutagenic Potential". Regulatory Toxicology and Pharmacology. 23 (1 Pt 1 ...
Ageing Aging brain AP site Direct DNA damage DNA DNA adduct DNA damage theory of aging DNA repair DNA replication Free radical ... estimated that there were 24,000 steady state oxidative DNA adducts per cell in young rats and 66,000 adducts per cell in old ... DNA damage is an alteration in the chemical structure of DNA, such as a break in a strand of DNA, a nucleobase missing from the ... DNA damage is an abnormal chemical structure in DNA, while a mutation is a change in the sequence of base pairs. DNA damages ...