The protein encoded by this gene is a type I membrane receptor for group B coxsackie viruses and subgroup C adenoviruses. CAR ... "Adenovirus serotype 30 fiber does not mediate transduction via the coxsackie-adenovirus receptor". Journal of Virology. 76 (2 ... CAR is a receptor for both Coxsackie B virus and adenovirus 2 and 5, which are structurally distinct. In patients with ... Coxsackievirus and adenovirus receptor (CAR) is a protein that in humans is encoded by the CXADR gene. ...

... by Adhesive Interactions between Epithelial Coxsackie and Adenovirus Receptor and a Junctional Adhesion Molecule-like Protein ... It is composed of two extracellular immunoglobulin-like domains, a membrane-spanning region, and a cytoplasmic tail involved in ... A known ligand of JAML is Coxsackie virus and Adenovirus Receptor (CXADR in humans and CAR in mice) which has been shown to ... by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein ...

CAR (coxsackie and adenovirus receptor) also belongs to the immunoglobulin superfamily, same like JAM proteins. CAR is ... Plaque proteins are molecules, that are required for the coordination of signals coming from the plasma membrane. In recent ... This domain contains PDZ-binding motif, that facilitate to bind them to the PDZ membrane proteins, like a ZO-1, ZO-2, ZO-3, ... The tetraspan membrane protein is established by two extracellular loops, two extracellular domains and one short intracellular ...

Coxsackie virus and adenovirus receptor (CAR), VSIG, ESAM Nectins and related proteins, including CADM1 and other Synaptic Cell ... The Ig domains are then followed by Fibronectin type III domain repeats and IgSFs are anchored to the membrane by a GPI moiety ... Articles with short description, Short description matches Wikidata, Protein pages needing a picture, Cell adhesion molecules) ... protein), CHL1, Neurofascin and NrCAM SIGLEC family including Myelin-associated glycoprotein (MAG, SIGLEC-4), CD22 and CD83 CTX ...

"Study of Coxsackie B viruses interactions with Coxsackie Adenovirus receptor and Decay-Accelerating Factor using Human CaCo-2 ... The ER membrane moves to surround the genome and proteins, at which point the procapsid attaches to the exterior of the vesicle ... Riabi, 2014) When VP1 binds to the Coxsackie-Adenovirus receptor (CAR), which can be found on heart muscle cells as well as ... Coxsackie B4 virus is able to infect the brain and spinal cord and cause inflammation. Infection due to Coxsackie B viruses can ...

September 2009). "Combination of soluble coxsackievirus-adenovirus receptor and anti-coxsackievirus siRNAs exerts synergistic ... Coxsackie A virus causes paralysis and death of the mice, with extensive skeletal muscle necrosis; Coxsackie B causes less ... Other researchers found this interference can be mediated by a substance produced by the host animal, a protein now known as ... In general, group A coxsackieviruses tend to infect the skin and mucous membranes, causing herpangina; acute hemorrhagic ...

... sCAR-Fc prevents the virus entering the cell by competitively binding to coxsackie virus and adenovirus receptors (CAR) on the ... internal capsid protein, VP4. This irreversible reaction prevents the virus from interacting with cellular receptors (CAR) on ... located in tight junctions on cell membranes. Once inside the cytoplasm, the virus can use the host's ribosomal machinery to ... September 2005). "Inhibition of coxsackie B virus infection by soluble forms of its receptors: binding affinities, altered ...

"Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells". ... This amphipathic helix enables the binding of protein VI to the endsomal membrane leading to a severe membrane curvature that ... It is the co-receptor interaction that stimulates entry of the adenovirus. This co-receptor molecule is αV integrin. Binding to ... The two currently established receptors are: CD46 for the group B human adenovirus serotypes and the coxsackievirus/adenovirus ...

Coxsackie B, specifically B3 and B5, has been found to interact with coxsackievirus-adenovirus receptor (CAR) and decay- ... Myocardial inflammation can be suspected on the basis of elevated inflammatory markers including C-reactive protein (CRP), ... In people with myocarditis severe enough to cause cardiac arrest, extracorporeal membrane oxygenation (ECMO) is used to ... Viral: adenovirus, parvovirus B19, coxsackie virus, rubella virus, polio virus, Epstein-Barr virus, hepatitis C virus, ...

... whose binding to host cells is initiated by interactions between the cellular coxsackie virus and adenovirus receptor (CAR), ... and the knob domain of the adenovirus coat protein trimer. CAR is necessary for adenovirus infection. Although expressed widely ... "Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of ... For adenovirus replication to occur, the host cell must be induced into S phase by viral proteins interfering with cell cycle ...