The Core binding factor (CBF) is a group of heterodimeric transcription factors. Core binding factors are composed of: a non- ... DNA-binding CBFβ chain (CBFB) a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3) de Bruijn M, Speck N (2004). "Core-binding factors ... Core+Binding+Factors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ... description, Short description is different from Wikidata, Transcription factors, All stub articles, Genetics stubs). ...

Core-binding factor subunit beta is a protein that in humans is encoded by the CBFB gene. The protein encoded by this gene is ... Core binding factor acute myeloid leukaemia is a cancer related to genetic changes in the CBF gene. It is most commonly caused ... "Entrez Gene: CBFB core-binding factor, beta subunit". The Cancer Genome Atlas Network (2012). "Comprehensive molecular ... Hart SM, Foroni L (2003). "Core binding factor genes and human leukemia". Haematologica. 87 (12): 1307-23. PMID 12495904. Bae ...

... a DNA binding CBFα chain (RUNX1 or RUNX2) and a non-DNA-binding subunit called core binding factor β (CBFβ); the binding ... Wang, S, Speck, NA (January 1992). "Purification of core-binding factor, a protein that binds the conserved core site in murine ... Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor ... It belongs to the Runt-related transcription factor (RUNX) family of genes which are also called core binding factor-α (CBFα). ...

Protein CBFA2T3 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3) is a protein that in humans is encoded ... "Entrez Gene: CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3". Hoogeveen AT, Rossetti S, ... Calabi F, Cilli V (Dec 1998). "CBFA2T1 (core-binding factor, runt domain, alpha subunit 2; translocated to, 3), a gene ... Transcription factors, Oncogenes, All stub articles, Human chromosome 16 gene stubs). ...

May 2016). "Comprehensive mutational profiling of core binding factor acute myeloid leukemia". Blood. 127 (20): 2451-9. doi: ... June 2011). "CCCTC-binding factor (CTCF) and cohesin influence the genomic architecture of the Igh locus and antisense ... August 2013). "Transcription factor binding in human cells occurs in dense clusters formed around cohesin anchor sites". Cell. ... February 2008). "Cohesin mediates transcriptional insulation by CCCTC-binding factor". Nature. 451 (7180): 796-801. Bibcode: ...

"Entrez Gene: CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2". Rual JF, Venkatesan K, Hao T, ... The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several ... Transcription factors, All stub articles, Human chromosome 20 gene stubs). ...

... is a nuclear protein that binds to DNA and acts as an architectural chromatin-binding factor. It can also be released ... Bernués J, Espel E, Querol E (May 1986). "Identification of the core-histone-binding domains of HMG1 and HMG2". Biochimica et ... After binding, HMGB1 bends DNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in ... Contact with core histones changes the structure of nucleosomes. The presence of HMGB1 in the nucleus depends on ...

Due to the higher expression, the factor will bind with a high probability to the polymerase-core-enzyme. Doing so, other ... Instead, it changes its binding with the core during initiation and elongation. Therefore, the sigma factor cycles between a ... Different sigma factors are utilized under different environmental conditions. These specialized sigma factors bind the ... A sigma factor (σ factor or specificity factor) is a protein needed for initiation of transcription in bacteria. It is a ...

Pellegrini, Luca; Tan, Song; Richmond, Timothy J. (1995). "Structure of serum response factor core bound to DNA". Nature. 376 ( ... His laboratory has elucidated the structures of the nucleosome core particle and various transcription factor complexes. Their ... Luger, Karolin; Richmond, Timothy J. (1998). "DNA binding within the nucleosome core". Current Opinion in Structural Biology. 8 ... Richmond, T. J.; Finch, J. T.; Rushton, B.; Rhodes, D.; Klug, A. (1984). "Structure of the nucleosome core particle at 7 Å ...

The core domain, which mediates this binding to DNA, shows 95% identity between TBP and TBPL2. The N-terminal domain of TBPL2 ... Similar to TBP, TBPL2 can bind to the TATA box. It interacts with other general transcription factors such as TFIIA and TFIIB ... The TBPL2 protein is also known as TBP-related factor 3 (TRF3) and TATA binding protein 2 (TBP2). The protein was independently ... a TATA-box-binding protein-related factor, is vertebrate-specific and widely expressed". Proceedings of the National Academy of ...

"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J. Biol. Chem. 276 (13): 10263-71. doi: ... The heparan sulfate chains of perlecan bind growth factors in the ECM, and serve as co-ligands or ligand enhancers when bound ... Transcriptional activation by transforming growth factor-beta via a nuclear factor 1-binding element". J. Biol. Chem. 272 (8): ... "The protein core of the proteoglycan perlecan binds specifically to fibroblast growth factor-7". J. Biol. Chem. 275 (10): 7095- ...

"Fibroblast growth factor-binding protein is a novel partner for perlecan protein core". J Biol Chem. 276 (13): 10263-71. doi: ... Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene. FGFBP1, or HBP17, binds ... 2000). "Induction of the angiogenic modulator fibroblast growth factor-binding protein by epidermal growth factor is mediated ... "Characterization and molecular cloning of a putative binding protein for heparin-binding growth factors". J Biol Chem. 266 (25 ...

The binding of the σ-factor to the promoter is the first step in initiation. Once the σ-factor releases from the polymerase, ... When the σ-factor detaches, it is in core polymerase form. The σ-factor recognizes promoter sequences at -35 and -10 regions ... Bacteria have a σ-factor that detects and binds to promoter sites but eukaryotes do not need a σ-factor. Instead, eukaryotes ... The σ-factor binds to the -35 promoter region. At this point, the holoenzyme is referred to as the closed complex because the ...

"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... Additionally, transcription factors, including STAT4 and RUNX family transcription factors play a role in the introduction of ...

"Core-binding factor β and Runx transcription factors promote adaptive natural killer cell responses". Science Immunology. 2 (18 ... association with regulatory factors; 3. central DNA-binding domain - binding to the enhancer region of IFN-γ activated sequence ... Binding of IL-12 to IL-12R, which is composed of two different subunits (IL12Rβ1 and IL12Rβ2), leads to the interaction of ... STAT4+Transcription+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) (CS1: long volume value, ...

The dimeric eukaryotic upstream binding factor (UBF) binds the UCE and the core element. UBF recruits and binds a protein ... allowing the UCE and the core elements to come into contact. RRN3/TIF-IA is phosphorylated and binds Pol I. Pol I binds to the ... When rRNA synthesis is stimulated, SL1 (selectivity factor 1) will bind to the promoters of rDNA genes that were previously ... Clos, Joachim; Buttgereit, Detlev; Grummt, Ingrid (February 1986). "A purified transcription factor (TIF-IB) binds to essential ...

... factor binds to the core, forming the holoenzyme. After transcription starts, the factor can unbind and let the core enzyme ... In order to bind promoters, RNAP core associates with the transcription initiation factor sigma (σ) to form RNA polymerase ... RNA polymerase binding in bacteria involves the sigma factor recognizing the core promoter region containing the −35 and −10 ... A transcription factor and its associated transcription mediator complex must be attached to a DNA binding site called a ...

... core protein binds to the growth factors BMP-4 and influences its bioactivity. It has also been reported that the ... There is also evidence that biglycan binds to TGF-beta 1. Biglycan interacts with collagen, both via the core protein and GAG ... Bidanset DJ, Guidry C, Rosenberg LC, Choi HU, Timpl R, Hook M (March 1992). "Binding of the proteoglycan decorin to collagen ... The structure of biglycan core protein is highly conserved across species; over 90% homology has been reported for rat, mouse, ...

The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position ... In molecular biology, TAFII28 refers to the TATA box binding protein associated factor. Together with the TATA-binding protein ... "Entrez Gene: TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa". Birck C, Poch O, Romier C ... TAF11 has been shown to interact with: GTF2F1, POLR2A and TAF13, TAF15, TATA binding protein, and Transcription Factor II B. ...

However this is only a Newtonian approximation and in relativistic conditions other factors must be taken into account as well ... Planets and stars have radial density gradients from their lower density surfaces to their much denser compressed cores. ... binding} }=-{\frac {3GM^{2}}{5Rc^{2}}}} For example, the fact that Earth is a gravitationally-bound sphere of its current size ... The gravitational binding energy of a system is the minimum energy which must be added to it in order for the system to cease ...

"DNA Binding and Phosphorylation Regulate the Core Structure of the NF-κB p50 Transcription Factor". Journal of the American ... phosphorylation represents a reversible switch that transmits intracellular signals in response to extracellular factors. In ...

2008). "Histone deacetylase inhibitor romidepsin has differential activity in core binding factor acute myeloid leukemia". ... AML1 or RUNX1 is a DNA-binding transcription factor located at the 21q22. ETO is a protein with transcriptional repressing ...

The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the ... nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this ... RNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene. ... Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). "Novel nuclear autoantigen with splicing factor motifs identified with ...

Makde R, England J, Yennawar H, Tan S (2010). "Structure of the RCC1 chromatin factor bound to the nucleosome core particle". ... is attached to nucleosomes via core histones H2A and H2B. Thus, a gradient of GTP-bound Ran is generated around the vicinity of ... which directly binds the growing ends of microtubules and coordinates the binding of other +TIPs. Opposing the action of these ... Once they bind a kinetochore, they are stabilized and their dynamics are reduced. The newly mono-oriented chromosome oscillates ...

These complexes directly bind to and inhibit the core circadian transcription factor, CLOCK:BMAL1. As PERIOD proteins are ... Lower concentrations of SasA allow for KaiB to bind to the KaiC hexamer solely; it does not need to compete for KaiC binding ... It was found that SasA uses structural mimicry to help fold-switched KaiB bind to the KaiC hexamer so that the nighttime ... Conversely, SasA proteins compete with KaiB proteins for the binding of the KaiC hexamer when the concentration of SasA exceeds ...

"Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding ... A novel Sp1-binding site occurs close to the major transcription start site (position - 65); a GC-rich core region including ... ALOX5 binds with the F actin-binding protein, coactin-like protein. Based on in vitro studies, this protein binding serves to ... The upstream promoter in the human ALOX5 gene commonly possess five GGGCCGG repeats which bind the Sp1 transcription factor and ...

WRKY transcription factors have been a significant area of plant research for the past 20 years. The WRKY DNA-binding domain ... Eighteen amino acids are highly conserved in the WRKY protein domain, including the core motif, zinc-finger binding cysteines ... The WRKY domain is found in the WRKY transcription factor family, a class of transcription factors. The WRKY domain is found ... the evolutionary conserved DNA-binding specificities of WRKY transcription factors by molecular dynamics and in vitro binding ...

The degree to which the ETS1 transcription factor can bind to its binding sites on the PARP1 promoter depends on the ... helix DNA binding motif known as the Ets domain that specifically recognizes DNA sequences that contain a GGAA/T core element. ... Bi FF, Li D, Yang Q (2013). "Hypomethylation of ETS transcription factor binding sites and upregulation of PARP1 expression in ... The later suggests that several other transcription factors may facilitate Ets1 binding to unfavorable DNA sequences. ChIP-Seq ...

The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The ... The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the ... Eukaryotic translation initiation factor 3 subunit C like is a protein that in humans is encoded by the EIF3CL gene. ... "Entrez Gene: Eukaryotic translation initiation factor 3 subunit C like". Retrieved 2020-04-15. v t e This article incorporates ...

The core recommendations of this group took account of all psychological theory and spiritual factors in the human condition. " ... Service users who feel rejected are bound to escalate their behaviour in order to be heard and in order to "hit back" at those ... "Psychological mindedness" was the concept and the phrase that seemed to bind everything together. This work has led to the ... Conte HR, Ratto R, Karusa T (1996). "The Psychological Mindedness Scale: Factor structure and relationship to outcome of ...

... recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding ... RAG2 plays a role of an accessory factor. Its primary function seems to be to interact with RAG1 protein and activate its ... Its N-terminal part is thought to form a six-bladed propeller in the active core. RAG2 is conserved among all species that ... RAG2 is one of the two core components of the RAG complex. RAG complex is a multiprotein complex that mediates the DNA cleavage ...