C3-convertase
C5 convertase formation and cell lysis. C3 convertase can be used to refer to the form produced in the alternative pathway ( ... Hourcade D (2006). "The Role of Properdin in the Assembly of the Alternative Pathway C3 Convertases of Complement". J Biol Chem ... Since C3 convertases cleave C3 to produce C3b which can then form an additional C3 convertase through the alternative pathway, ... C3 convertase formation can occur in three different pathways: the classical, lectin, and alternative pathways. Cleavage of ...
Genome-wide association study
... a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway-mediated diseases". Blood ... A suggested alternative to linkage studies was the genetic association study. This study type asks if the allele of a genetic ... A common alternative to case-control GWA studies is the analysis of quantitative phenotypic data, e.g. height or biomarker ... An alternative application is therefore the potential for GWA studies to elucidate pathophysiology. One such success is related ...
C3 convertase
The term C3 convertase may refer to: C3-convertase, an enzyme Alternative-complement-pathway C3/C5 convertase, an enzyme This ...
Alternative complement pathway
This complex is also known as a fluid-phase C3-convertase. This convertase, the alternative pathway C3-convertase, although ... a stable compound which can bind an additional C3b to form alternative pathway C5-convertase. The C5-convertase of the ... The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the ... After the creation of C5 convertase (either as (C3b)2BbP or C4b2b3b from the classical pathway), the complement system follows ...
M. Amin Arnaout
C3 nephritic factor is an autoantibody to the complement C3bBb convertase that activates the alternative complement pathway, a ... finding that suggested the potential of B cell or complement C5 depletion as adjunct therapies in certain forms of kidney ...
Complement system
... the alternative complement pathway is one element of innate immunity.[citation needed] Once the alternative C3 convertase ... C3b later joins with C4b2b to make C5 convertase (C4b2b3b complex). The alternative pathway is continuously activated at a low ... the classical complement pathway, the alternative complement pathway, and the lectin pathway. The alternative pathway accounts ... July 2009). "Structural and functional implications of the alternative complement pathway C3 convertase stabilized by a ...
Outline of immunology
... iC3b C5 - C5a C3-convertase C5-convertase Late stage Membrane attack complex (MAC) C6 C7 C8 C9 Complement pathway inhibitors C1 ... MASP2 Mannan-binding lectin Alternative complement pathway Factor B Factor D Factor P (Properdin) Middle stage C3 - C3a / C3b ... system Complement system Classical complement pathway Mannan-binding lectin pathway Alternate complement pathway Complement ... divided by pathway) Classical complement pathway C1Q complex - C1R / C1S C4 - C4a C2 Mannan-binding lectin pathway MASP1 / ...
List of EC numbers (EC 3)
... complement factor I EC 3.4.21.46: complement factor D EC 3.4.21.47: alternative-complement-pathway C3/C5 convertase EC 3.4. ... classical-complement-pathway C3/C5 convertase EC 3.4.21.44: Now EC 3.4.21.43, classical-complement-pathway C3/C5 convertase EC ... proprotein convertase 1 EC 3.4.21.94: proprotein convertase 2 EC 3.4.21.95: snake venom factor V activator EC 3.4.21.96: ... Complement subcomponent C1r EC 3.4.21.42: complement subcomponent C1s EC 3.4.21.43: ...
Properdin
Hourcade D (2006). "The Role of Properdin in the Assembly of the Alternative Pathway C3 Convertases of Complement". J Biol Chem ... This protein binds to bacterial cell walls and dying human cells to stabilize the C3 and C5-convertase enzyme complexes to form ... It binds to preformed alternative pathway C3-convertases. Properdin also inhibits the Factor H - mediated cleavage of C3b by ... The alternative pathway is not dependent on antibodies. This branch of the complement system is activated by IgA immune ...
Complement factor B
... components of the alternative-pathway C3 convertase of complement". The Biochemical Journal. 253 (3): 667-75. doi:10.1042/ ... Rawal N, Pangburn MK (March 2001). "Structure/function of C5 convertases of complement". International Immunopharmacology. 1 (3 ... The active subunit Bb is a serine protease that associates with C3b to form the alternative pathway C3 convertase. Bb is ... This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in ...
C5-convertase
"Alternative pathway of complement: Recruitment of precursor properdin by the labile C3/C5 convertase and the potentiation of ... The target of C5 convertase is complement protein C5. C5 is a two-chain (α, β) plasma glycoprotein (Mr = 196,000). C5 and C3 ... C3 and C5 convertase activity is generated upon addition of Factors B and D. The classical pathway C5 convertase is composed of ... Cell-bound C3 and C5 convertase differ in their C3b requirement. C3-convertase (C3bBb) need only one molecule of C3b to form, ...
Classical complement pathway
C3b binds to the C3 convertase (C4b2b), to form C5 convertase (C4b2b3b). C5 convertase then cleaves C5 into C5a and C5b. Like ... Alternative complement pathway - another complement system pathway Lectin pathway - another complement system pathway Noris, ... The C3b component of the cleaved C3 binds to C3 convertase (C4b2b) to generate C5 convertase (C4b2b3b), which cleaves the C5 ... Activation of the complement pathway through the classical, lectin or alternative complement pathway is followed by a cascade ...
C3b
... alternative pathway and lectin pathway) that ultimately lead to the formation of a C3 convertase. Formation of a C3 convertase ... In such cases treatment with the complement-inhibitory anti-C5 monoclonal antibody, eculizumab, is found to be highly effective ... Additionally, C3b plays a role in forming a C3 convertase when bound to Factor B (C3bBb complex), or a C5 convertase when bound ... Incorporation of an additional C3b into the C3bBb C3 convertase leads to the formation of C3Bb3b C5 convertase. Once cleaved ...
List of MeSH codes (D12.776.124)
... complement c3-c5 convertases MeSH D12.776.124.486.274.860.387.500 - complement c3-c5 convertases, alternative pathway MeSH ... complement c5 convertase, alternative pathway MeSH D12.776.124.486.274.860.387.750 - complement c3-c5 convertases, classical ... complement c3 convertase, classical pathway MeSH D12.776.124.486.274.860.387.750.750 - complement c5 convertase, classical ... complement c3 convertase, alternative pathway MeSH D12.776.124.486.274.860.387.500.750 - ...
Complement component 4
... participates in all three of the complement pathways (classical, alternative, and lectin); the alternative pathway is " ... the C4b-C2a complex with protease activity has been termed the C3 convertase. Protein 4b can be further cleaved into 4c and 4d ... C5 binding sites, 4) private allelic residues. Additionally, the same study identified the expression of human complement C4 ... All three pathways converge at a step in which complement protein C3 is cleaved into proteins C3a and C3b, which results in a ...
Factor H
... and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on ... January 2011). "The development of atypical hemolytic uremic syndrome depends on complement C5". Journal of the American ... amongst other complement proteins and factors, leading to regulation of the alternative pathway of complement in particular. ... Its principal function is to regulate the alternative pathway of the complement system, ensuring that the complement system is ...