... n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular ... "Entrez Gene: CFL1 cofilin 1 (non-muscle)". Chai X, Förster E, Zhao S, Bock HH, Frotscher M (January 2009). "Reelin stabilizes ... Lee K, Jung J, Kim M, Guidotti G (2001). "Interaction of the alpha subunit of Na,K-ATPase with cofilin". Biochem. J. 353 (Pt 2 ... Cofilin 1 has been shown to interact with HSPH1 and LIMK1. GRCh38: Ensembl release 89: ENSG00000172757 - Ensembl, May 2017 ...
Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene. Cofilin is a widely distributed ... Cofilin-2 is a member of the AC group of proteins that also includes cofilin-1 (CFL1) and destrin (DSTN), all of which regulate ... "Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14". Ann. Hum ... 2006). "Cofilin cross-bridges adjacent actin protomers and replaces part of the longitudinal F-actin interface". J. Mol. Biol. ...
... has been shown to interact with Cofilin 1. GRCh38: Ensembl release 89: ENSG00000120694 - Ensembl, May 2017 GRCm38: ... 869 (1-2): 49-55. doi:10.1016/S0006-8993(00)02346-5. PMID 10865058. S2CID 7179171. Strausberg RL, Feingold EA, Grouse LH, et al ... 1444 (1): 138-42. doi:10.1016/s0167-4781(98)00254-1. PMID 9931472. "Entrez Gene: HSPH1 heat shock 105kDa/110kDa protein 1". ... The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA ...
... signaling leads to phosphorylation of actin-interacting protein cofilin 1 at ser3; this may stabilize the actin ... "Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3". The Journal ... 112 (1-2): 33-45. doi:10.1016/S0169-328X(03)00032-9. PMID 12670700. Hack I, Hellwig S, Junghans D, Brunne B, Bock HH, Zhao S, ... 1 (2): 72-73. doi:10.1046/j.1535-7597.2001.00017.x. PMC 320825. PMID 15309195. Zaki M, Shehab M, El-Aleem AA, Abdel-Salam G, ...
In both yeast and mammals, CAPs appear to be involved in recycling G-actin monomers from ADF/cofilins for subsequent rounds of ... Moriyama K, Yahara I (April 2002). "Human CAP1 is a key factor in the recycling of cofilin and actin for rapid actin turnover ... A second unique function of CAP in regulating actin dynamics is its ability to specifically bind to pointed ends of cofilin- ... Shekhar S, Chung J, Kondev J, Gelles J, Goode BL (22 November 2019). "Synergy between Cyclase-associated protein and Cofilin ...
ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play ... The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin ... 2005). "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". EMBO J. 24 (3): ... 2007). "The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and ...
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998). "Cofilin phosphorylation by LIM-kinase 1 ... Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel ... Nebl G, Meuer SC, Samstag Y (1996). "Dephosphorylation of serine 3 regulates nuclear translocation of cofilin". J. Biol. Chem. ... Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of ...
Vallenius, T; Luukko K; Mäkelä T P (Apr 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha- ... Otey CA, Pavalko FM, Burridge K (1990). "An interaction between alpha-actinin and the beta 1 integrin subunit in vitro". J. ... Vallenius T, Luukko K, Mäkelä TP (2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4 ... An actin interface distinct from that of gelsolin domain 1 and from ADF/cofilin". Eur. J. Biochem. 268 (23): 6165-75. doi: ...
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (Jun 1998). "Cofilin phosphorylation by LIM- ... Sumi T, Matsumoto K, Takai Y, Nakamura T (27 Dec 1999). "Cofilin phosphorylation and actin cytoskeletal dynamics regulated by ... Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (Aug 2001). "Cofilin phosphorylation and actin reorganization activities of ... Vardouli L, Moustakas A, Stournaras C (Mar 2005). "LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton ...
ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play ... The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin ... a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233-46. doi:10.1016/S0092-8674(01)00638-9. PMID ... "Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin". The EMBO Journal. 24 (3): ...
2004). "A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia". J. Cell Biol ... ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play ... 2007). "Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge". Cell. 128 (5): 915-29. doi:10.1016/j ... The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin ...
"Prion-like protein aggregates exploit the RHO GTPase to cofilin-1 signaling pathway to enter cells". The EMBO Journal. 37 (6). ... One of the inhibitors discovered in Bertolotti's lab, Sephin1, has passed through favourable Phase 1 clinical trials in 2019 ... Münch, Christian; O'Brien, John; Bertolotti, Anne (2011-03-01). "Prion-like propagation of mutant superoxide dismutase-1 ... "Exposure of hydrophobic surfaces initiates aggregation of diverse ALS-causing superoxide dismutase-1 mutants". Journal of ...
Spratley SJ, Bastea LI, Döppler H, Mizuno K, Storz P (September 2011). "Protein kinase D regulates cofilin activity through p21 ... 349 (1): 45-50. doi:10.1016/j.canlet.2014.03.024. PMID 24704155. Park JK, Kim S, Han YJ, Kim SH, Kang NS, Lee H, Park S (June ... 317 (1): 24-32. doi:10.1016/j.canlet.2011.11.007. PMID 22085492. Yeo D, Huynh N, Beutler JA, Christophi C, Shulkes A, Baldwin ... 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. Dan C, Nath N, Liberto M, Minden A (January 2002). "PAK5, a new ...
Birkenfeld J, Betz H, Roth D (January 2003). "Identification of cofilin and LIM-domain-containing protein kinase 1 as novel ... 9 (1): 143-54. doi:10.1089/jam.1996.9.143. PMID 10160204. Filoche M, Tai CF, Grotberg JB (July 2015). "Three-dimensional model ... 369 (Pt 1): 45-54. doi:10.1042/BJ20021152. PMC 1223062. PMID 12323073. Waterman MJ, Stavridi ES, Waterman JL, Halazonetis TD ( ... Koyama S, Williams LT, Kikuchi A (July 1995). "Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in ...
Enhanced docetaxel-mediated cytotoxicity in human prostate cancer cells through knockdown of cofilin-1 by carbon nanohorn ... 1 July 2016). "Design of Assembled Systems Based on Conjugated Polyphenylene Derivatives and Carbon Nanohorns". Chemistry - A ...
"Caspase-11 regulates cell migration by promoting Aip1-Cofilin-mediated actin depolymerization". Nature Cell Biology. 9 (3): 276 ... Production of IL-1β downstream of caspase-11 requires another canonical inflammasome, called the NLRP3 inflammasome, that ... The CARD domain of caspase-11 has been shown to associate with AIP-1 and cofilin to facilitate actin depolymerization. In ... This mechanism contrasts to that of the canonical inflammasome, in which a bacterial ligand activates caspase-1 through an ...
Toshima J, Toshima JY, Amano T, Yang N, Narumiya S, Mizuno K (2001). "Cofilin phosphorylation by protein kinase testicular ... Toshima J, Toshima JY, Takeuchi K, Mori R, Mizuno K (2001). "Cofilin phosphorylation and actin reorganization activities of ... Dual specificity testis-specific protein kinase 1 is an enzyme that in humans is encoded by the TESK1 gene. This gene product ... "Entrez Gene: TESK1 testis-specific kinase 1". Toshima JY, Toshima J, Watanabe T, Mizuno K (November 2001). "Binding of 14-3- ...
... cofilin 1 MeSH D12.776.220.525.212.750 - cofilin 2 MeSH D12.776.220.525.212.875 - destrin MeSH D12.776.220.525.246.500 - actin- ... neuregulin-1 See List of MeSH codes (D12.776.476). MeSH D12.776.503.280.249.500 - mannose-binding lectin MeSH D12.776.503.280. ... hiv-1 reverse transcriptase MeSH D12.776.964.970.880.325 - gene products, env MeSH D12.776.964.970.880.325.330 - hiv envelope ... neurofibromin 1 MeSH D12.776.402.150.500.500 - p120 gtpase activating protein MeSH D12.776.402.300.700.500 - ras-GRF1 MeSH ...
... cofilin 2 MeSH D05.750.078.730.212.875 - destrin MeSH D05.750.078.730.246 - actin-related protein 2-3 complex MeSH D05.750. ...
The product of this gene belongs to the actin-binding proteins ADF (Actin-Depolymerizing Factor)/cofilin family. This family of ... Furthermore, the binding of actin by destrin and cofilin is regulated negatively by phosphorylation. Destrin can also sever ... Destrin binds actin and is thought to connect it as gelsolin segment-1 does. ...
... like UNC-60A and cofilin like UNC-60B proteins of Caenorhabditis elegans". Biomolecular NMR Assignments. 9 (2): 261-265. doi: ... Shukla, Vaibhav Kumar; Kabra, Ashish; Yadav, Rahul; Ono, Shoichiro; Kumar, Dinesh; Arora, Ashish (1 October 2015). "NMR ... 1 February 2017). "Unraveling the stereochemical and dynamic aspects of the catalytic site of bacterial peptidyl-tRNA hydrolase ...
In accordance with their proposed rule, proteins like ADF, cofilin and LIMK1 are slingshot substrates. Phosphatases of ... Regenerating Liver (PRLs): Three PRL genes were described in mammals (PRL-1, PRL-2 and PRL-3). They share a high sequence ...
The latter is the enzyme that uses ATP to phosphorylate and inactivate the actin-depolymerizing factor cofilin. When cofilin is ... In the presence of Pyr1, LIMK1 is inhibited, which means that the phosphorylation of cofilin decreases, which results in the ... Pyr 1 is a cell permeable competitive inhibitor of Lim Kinase (especially LIMK1). ...
ADF/cofilin are the only substrates yet identified for the LIM kinases. LIM kinases directly phosphorylate and inactivate ... are actin-binding kinases that phosphorylate members of the ADF/cofilin family of actin binding and filament severing proteins ... LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal ... members of the cofilin family, resulting in stabilization of filamentous (F)-actin. Lim kinases are activated by signaling ...
Meanwhile, phosphorylation of PI3K by SRC activates RhoA which leads to activation of cofilin-P and disruption of filamentous ... When the WAVE-1 gene was disrupted in mice, it resulted in cognitive defects such as losses in learning and memory implicating ... 51 (1): 43-56. doi:10.1016/j.neuron.2006.05.018. PMC 2587166. PMID 16815331. Ohkubo, T; Ozawa, M. (1999). "p120ctn Binds to the ... 28 (1): 245-259. doi:10.1016/S0896-6273(00)00100-8. PMID 11086998. S2CID 17810792. Tanaka, H; Shan, W; Phillips, GR; Arndt, K; ...
... which then stimulates cofilin, which effectively reorganizes the actin cytoskeleton of the cell. In the case of neurons, ... The LINGO-1 structure has been shown to be highly stable both in its crystal form and in solution, thanks to its leucine-rich ... LINGO-1 is coded by the LINGO-1 gene, which is located on the human chromosome 15, more precisely on the locus 15q24-26, which ... LINGO-1 is expressed almost exclusively in the central nervous system (CNS). It can be found in the brain and in neurons and ...
2005). "Ribosomal protein S18 identified as a cofilin-binding protein by using phage display library". Mol. Cell. Biochem. 262 ... 239 (1): 144-9. doi:10.1111/j.1432-1033.1996.0144u.x. PMID 8706699. Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed ... 12 (1): 1-11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033. Mishra-Gorur K, Singer HA, Castellot JJ (2002 ... 1-2): 187-93. doi:10.1023/B:MCBI.0000038234.35936.1c. PMID 15532723. S2CID 30534195. Andersen JS, Lam YW, Leung AK, et al. ( ...
1999). "Aip1p interacts with cofilin to disassemble actin filaments". J. Cell Biol. 145 (6): 1251-64. doi:10.1083/jcb.145.6. ... 327 (1): 268-75. doi:10.1016/j.bbrc.2004.11.156. PMID 15629458. Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a ... 56 (1): 59-69. doi:10.1006/geno.1998.5672. PMID 10036186. "Entrez Gene: WDR1 WD repeat domain 1". Dawson SJ, White LA (1992). " ... 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157. Fujibuchi T, Abe Y, Takeuchi T, et al. (2005). "AIP1/WDR1 ...
Existing strands can be interrupted by filament cleaving proteins, such as cofilin and gelsolin. Cofilin binds along two actin- ... They possess a number of accessory proteins including ADF/cofilin, which has a molecular weight of 16kDa and is coded for by a ... The import of actin into the nucleus (probably in a complex with cofilin) is facilitated by the import protein importin 9. Low ... Some proteins, such as cofilin appear to increase the angle of turn, but again this could be interpreted as the establishment ...
"Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining ... 78 (1-2): 46-54. doi:10.1006/geno.2001.6640. PMID 11707072. Qiu C, Lienhard S, Hynes NE, Badache A, Leahy DJ (February 2008). " ... "Entrez Gene: Mediator of cell motility 1". Meira M, Masson R, Stagljar I, Lienhard S, Maurer F, Boulay A, Hynes NE (March 2009 ... Mediator of cell motility 1 is a protein that in humans is encoded by the MEMO1 gene. GRCh38: Ensembl release 89: ...