... is a phenazine dye and is believed to work by interfering with DNA. Clofazimine was discovered in the 1950s at ... Clofazimine is also a FIASMA (functional inhibitor of acid sphingomyelinase). Clofazimine has a biological half life of about ... Macrophages were first reported to be inhibited due to the stabilization of lysosomal membrane by clofazimine. Clofazimine also ... Clofazimine, sold under the brand name Lamprene, is a medication used together with rifampicin and dapsone to treat leprosy. It ...

... progesterone and the anti-lepromatous drug clofazimine). The Kv1.3 blocker clofazimine has been reported to be effective in the ... Furthermore, clofazimine in combination with the antibiotics clarithromycin and rifabutin induced remission for about 2 years ... Arbiser JL, Moschella SL (February 1995). "Clofazimine: a review of its medical uses and mechanisms of action". Journal of the ... Mackey JP, Barnes J (July 1974). "Clofazimine in the treatment of discoid lupus erythematosus". The British Journal of ...

Clofazimine broadly inhibits coronaviruses including SARS-CoV-2. Nature. 2021 593(7859):418-423. PMID 33727703 Martin-Sancho L ...

When it is not possible to find five drugs from the lists above; the drugs imipenem,co-amoxiclav,clofazimine,prochlorperazine, ... Jagannath, C; Reddy, M V; Kailasam, S; O'Sullivan, J F; Gangadharam, P R (1995). "Chemotherapeutic activity of clofazimine and ... Janulionis, E.; Sofer, C.; Song, H.-Y.; Wallis, R. S. (2004). "Lack of Activity of Orally Administered Clofazimine against ... Clofazimine, cycloserine/terizidone Group C: Other core second-line agents (ethambutol, delamanid, pyrazinamide, imipenem- ...

Clofazimine is a weakly bactericidal dye that has some activity against M. leprae. Its precise mechanism of action is unknown ... Clofazimine is given to treat sulfone-resistant leprosy or to patients who are intolerant to sulfones. It also exerts an ... Clofazimine achieves significant concentrations in tissues, including the phagocytic cells; it has a plasma half-life of 70 ... The most disturbing adverse reaction to clofazimine is a red-brown discoloration of the skin, especially in light-skinned ...

Other alternatives to corticosteroid treatment include dapsone, doxycycline, clofazimine, and cyclosporine. All of these drugs ...

While in Nigeria, he pioneered the use of anti-leprosy drug, clofazimine. Browne returned to England 1965 and used his vast ...

Rifabutin, clarithromycin and clofazimine are antibiotics designed to attack mycobacterium avium subsp. paratuberculosis, which ...

... and clofazimine for Crohn's disease". Gastroenterology. 132 (7): 2313-2319. doi:10.1053/j.gastro.2007.03.031. PMID 17570206. ...

Today, the drugs of choice for treating leprosy are dapsone, rifampicin and clofazimine. Slater LB (2009). War and disease: ...

Other medications for tuberculosis that can prolong the QT interval include fluoroquinolones and clofazimine.[citation needed] ...

He is known for leading the team which developed the anti-leprosy drug clofazimine. Barry was born in Sunday's Well, Cork. He ... He led a team of scientists at Trinity College, Dublin to discover the anti-leprosy drug clofazimine. In 1969 he was awarded ...

Dapsone, low-dose prednisolone, clofazimine, and isotretinoin have all been tried in some cases. The 1450-nm diode laser has ...

The binding of clofazimine to mycobacterial DNA can has been proven as weakly bactericidal against Mycobacterium leprae in mice ... Clofazimine's mechanisms are not fully understood regarding Mycobacterium leprae, but the drug's binding appear to occur at ... Out of the three main drugs rifampin is more bactericidal than either dapsone or clofazimine. It is important to find new ... WHO recommends patients with multibacillary leprosy use a combination of Rifampicin, Clofazimine, and Dapsone for 12 months. ...

... is commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is also used to both ... is an antibiotic commonly used in combination with rifampicin and clofazimine for the treatment of leprosy. It is a second-line ...

Clofazimine, Clomipramine, Cyancobalamin, Gold, Methyldopa, Psoralens, Streptomycin, Sulfasalazine and Tetracycline. A ...

... clarithromycin and clofazimine. The combination is envisaged as a new treatment for Crohn's disease. Myoconda was first devised ...

The search for further effective antileprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s. Later, ... A three-drug regimen of rifampicin, dapsone and clofazimine is recommended for all people with leprosy, for six months for ... Treatment of paucibacillary leprosy is with the medications dapsone, rifampicin, and clofazimine for six months. Treatment for ...

It is also one of the only companies in the world to manufacture clofazimine[citation needed]. SCC ready mix concrete ( ...

While there yet appears no optional medical therapy, clofazimine has been effective in some cases with lobomycosis. It is a ...

... in rare cases clofazimine, cystine, silica, or Charcot-Leyden crystals may be found in the histiocytes instead. Non- ...

In the twenty-first century, effective, free treatment of dapsone, rifampicin, and clofazimine was available through WHO. ...

The most common drugs to treat leprosy include rifampicin and clofazimine in combination with dapsone for multibacillary ...

1954: Clofazimine first synthesized by a medical research team led by Cork man Vincent Barry at Trinity College, Dublin. 1965: ...

The search for more effective anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s. Later, ... The search for additional anti-leprosy drugs led to the use of clofazimine and rifampicin in the 1960s and 1970s. Later, Indian ...

... is treated by anti-leprosy therapy (dapsone, rifampin, and clofazimine), optimal wound care, and treatment ...

Lucio's phenomenon is treated by anti-leprosy therapy (dapsone, rifampin, and clofazimine), optimal wound care, and treatment ...

In 1961 BELRA helped to develop Clofazimine (B663), which to this day remains a part of the multi drug therapy used for multi ... Clofazimine is added to the MDT and the treatment period is lengthened to 12 months. Lepra also recognises the importance of ...

... the trypanocidal effects of benidipine and clofazimine have been discovered. These drugs showed the ability to inhibit ...

According to a 2009 meta-analysis, there is some evidence of benefit for both thalidomide and clofazimine in the treatment of ...