Pearse, BM (1987). "Clathrin and coated vesicles". EMBO J. 6 (9): 2507-2512. doi:10.1002/j.1460-2075.1987.tb02536.x. PMC 553666 ... Clathrin coated pits in the plasma membrane bud a segment of the surface into the cell; this membrane is processed through ... Anderson, RG; Brown, MS; Goldstein, JL (1977). "Role of the coated endocytic vesicle in the uptake of receptor-bound low ...

Pearse first purified coated vesicles; she also discovered the clathrin coat molecule in 1975. Coated pits and vesicles were ... Subscription or UK public library membership required.) Pearse, B. M. (1987). "Clathrin and coated vesicles". The EMBO Journal ... Pearse, B. M. F.; Bretscher, M. S. (1981). "Membrane Recycling by Coated Vesicles". Annual Review of Biochemistry. 50: 85-101. ... Pearse, B. M. F. (1975). "Coated vesicles from pig brain: Purification and biochemical characterization". Journal of Molecular ...

Robinson MS (2015). "Forty Years of Clathrin-coated Vesicles". Traffic. 16 (12): 1210-38. doi:10.1111/tra.12335. PMID 26403691 ... Cocucci E, Aguet F, Boulant S, Kirchhausen T (2012). "The first five seconds in the life of a clathrin-coated pit". Cell. 150 ( ... "A clathrin coat assembly role for the muniscin protein central linker revealed by TALEN-mediated gene editing". eLife. 3. doi: ... is thought to help curve the membrane as the clathrin coated pit forms. The muniscins are early arriving proteins involved in ...

The best characterized type of vesicle is the clathrin coated vesicle (CCV). The formation of a COPII vesicle at the ... Robinson MS (2015). "Forty Years of Clathrin-coated Vesicles" (PDF). Traffic. 16 (12): 1210-38. doi:10.1111/tra.12335. PMID ... COPII and clathrin vesicles structure of COPI coat from this publication, free with free registration Video description of the ... but the coat of COPI is not closely related to the coats of either CCVs or COPII vesicles. AP-5 is associated with 2 proteins, ...

VSIV enters the cell through partially clathrin-coated vesicles; virus-containing vesicles contain more clathrin and clathrin ... the molecules accumulate in both the ER and a subcellular vesicle fraction of low density called the lipid-rich vesicle ... VSIV G does not follow the same path as most vesicles because transport of the G protein from the ER to the plasma membrane is ... The main sign in animals is oral disease appearing as mucosal vesicles and ulcers in the mouth, but also on the udder and ...

Another function of Hsc70 is as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane ... It works with auxilin to remove clathrin from coated vesicles. In neurons, synaptojanin is also an important protein involved ... binds a conformationally labile domain of clathrin light chain LCa to stimulate ATP hydrolysis". Cell. 62 (5): 875-87. doi: ... in vesicle uncoating. Hsc70 is a key component of chaperone-mediated autophagy wherein it imparts selectivity to the proteins ...

Bovine bocaviruses utilise endocytosis in clathrin-coated vesicles to enter cells; they are dependent upon acidification, and ... Dudleenamjil, E; Lin, C.-Y; Dredge, D; Murray, B. K; Robison, R. A; Johnson, F. B (2010). "Bovine parvovirus uses clathrin- ... Entry into the host cell is achieved by attachment to host receptors, which mediates clathrin-mediated endocytosis. Replication ...

The best-characterized coated vesicles are the clathrin-coated vesicles (CCVs). The coats on CCVs are primarily of clathrin, ... Her interest was in clathrin-coated vesicles that binds to cargo. She eventually succeeded in purifying components of the coat ... She also discovered different combinations of adapting, when together with clathrin, form a coat around vesicles that bud from ... Continuing, Margaret discovered that there were two different populations of clathrin-coated vesicles, one that uses AP-2 at ...

In non-dividing cells, the formation of clathrin-coated vesicles occurs continuously. Formation of clathrin-coated vesicles is ... Clathrin is a protein that plays a major role in the formation of coated vesicles. Clathrin was first isolated and named by ... After a vesicle buds into the cytoplasm, the coat rapidly disassembles, allowing the clathrin to recycle while the vesicle gets ... Clathrin performs critical roles in shaping rounded vesicles in the cytoplasm for intracellular trafficking. Clathrin-coated ...

Clathrin coated vesicles enable neurotransmitter receptors and other proteins to be endocytosed or taken up across neuronal ... Phonphok Y, Rosenthal KS (April 1991). "Stabilization of clathrin coated vesicles by amantadine, tromantadine and other ... The CLINT1 protein binds to the terminal domain of the clathrin heavy chain and stimulates clathrin cage vesicle assembly. ... in four studies It is known that the antipsychotic drugs chlorpromazine and clozapine stabilise clathrin coated vesicles and ...

Korolchuk VI, Banting G (Jun 2002). "CK2 and GAK/auxilin2 are major protein kinases in clathrin-coated vesicles". Traffic. 3 (6 ... Umeda A, Meyerholz A, Ungewickell E (May 2000). "Identification of the universal cofactor (auxilin 2) in clathrin coat ... Fölsch H, Pypaert M, Schu P, Mellman I (Feb 2001). "Distribution and function of AP-1 clathrin adaptor complexes in polarized ... Fölsch H, Ohno H, Bonifacino JS, Mellman I (Oct 1999). "A novel clathrin adaptor complex mediates basolateral targeting in ...

In general, reelin binds VLDLR and undergoes endocytosis via clathrin-coated vesicles. Meanwhile, an intracellular protein, ... In general, lipoprotein receptors undergo a process by which they are endocytosed with their ligand into clathrin-coated pits. ... Endocytosis is mediated through NPxY sequences known to signal for receptor internalization through clathrin-coated pits. The ... The NPxY motif functions in signal transduction and the targeting of receptors to coated pits and consists of the sequence ...

1999). "Clathrin-coated vesicles bearing GAIP possess GTPase-activating protein activity in vitro". Proc. Natl. Acad. Sci. U.S. ... 1998). "RGS-GAIP, a GTPase-activating protein for Galphai heterotrimeric G proteins, is located on clathrin-coated vesicles". ... 2000). "Membrane-associated GAIP is a phosphoprotein and can be phosphorylated by clathrin-coated vesicles". Proc. Natl. Acad. ...

... complexes are found in coated vesicles and clathrin-coated pits. AP complexes connect cargo proteins and lipids to clathrin at ... Clathrin coats contain both clathrin (acts as a scaffold) and adaptor complexes that link clathrin to receptors in coated ... These vesicles have specific coat proteins (such as clathrin or coatomer) that are important for cargo selection and direction ... This is an adaptor protein which helps the formation of a clathrin coat around a vesicle. This entry represents a subdomain of ...

There are three types of vesicle coats: clathrin, COPI and COPII. The various types of coat proteins help with sorting of ... COPI coated vesicles are responsible for retrograde transport from the Golgi to the ER, while COPII coated vesicles are ... Clathrin coats are found on vesicles trafficking between the Golgi and plasma membrane, the Golgi and endosomes and the plasma ... The clathrin coat is thought to assemble in response to regulatory G protein. A protein coat assembles and disassembles due to ...

1991). "Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta- ... a component of non-clathrin-coated vesicles essential for membrane traffic". J Biol Chem. 269 (48): 30073-6. doi:10.1016/S0021- ... a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles". Nature. 349 (6306): 248-51. ... Orcl L, Palmer DJ, Amherdt M, Rothman JE (1993). "Coated vesicle assembly in the Golgi requires only coatomer and ARF proteins ...

... a cytosolic protein complex containing subunits of non-clathrin-coated Golgi transport vesicles". Nature. 349 (6306): 248-51. ... Lowe M, Kreis TE (1997). "In vivo assembly of coatomer, the COP-I coat precursor". J. Biol. Chem. 271 (48): 30725-30. doi: ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ... "Similar subunit interactions contribute to assembly of clathrin adaptor complexes and COPI complex: analysis using yeast three- ...

Forgac M (January 1999). "The vacuolar H+-ATPase of clathrin-coated vesicles is reversibly inhibited by S-nitrosoglutathione". ... In synaptic transmission in neuronal cells, V-ATPase acidifies synaptic vesicles. Norepinephrine enters vesicles by V-ATPase[ ... Vma21p coordinates assembly of the Vo subunits as well as escorting the Vo domain into vesicles for transport to the Golgi. The ... V-ATPases are found within the membranes of many organelles, such as endosomes, lysosomes, and secretory vesicles, where they ...

Clathrin-coated vesicles bud from immature Weibel-Palade bodies, reducing their volumes, condensing their contents, and ... The Golgi then buds off clathrin-coated vesicles which consist almost exclusively of vWF. Immature Weibel-Palade bodies remain ... Weibel-Palade bodies may also coalesce into larger vesicles called secretory pods for multigranular exocytosis. Secretory pod ...

"Extraction of Cholesterol with Methyl-β-Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles". Molecular ...

Le Borgne R, Hoflack B (1997). "Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN". J ... in a COPII-coated vesicle. This targeting away from the secretory pathway is achieved by the presence of a specific sorting ...

Two further studies confirmed this hypothesis using V-ATPase from bovine clathrin coated vesicles. They showed that application ... inhibited proton flow through Vo and that this inhibition could be overcome by adding back the Vo domain to the coated vesicles ... Isoforms a1 and a2 target V-ATPase intracellularly, to synaptic vesicles and endosomes respectively. Subunits a3 and a4, ... As it promotes the acidification of lysosomes, endosomes, and secretory vesicles, V-ATPase contributes to processes including:[ ...

Drake MT, Zhu Y, Kornfeld S (2001). "The assembly of AP-3 adaptor complex-containing clathrin-coated vesicles on synthetic ... Odorizzi G, Cowles CR, Emr SD (1998). "The AP-3 complex: a coat of many colours". Trends Cell Biol. 8 (7): 282-8. doi:10.1016/ ... AP-3 facilitates the budding of vesicles from the Golgi membrane and may be directly involved in protein sorting to the ... and surface expression of the AQP4 water channel are coordinated by serial and regulated interactions with different clathrin- ...

Endocytosis usually involves clathrin-coated vesicles, though non-clathrin-coated vesicles may also be used. After the ... endocytic vesicles lose their clathrin coat, however, they usually do not fuse with larger, low pH endosomes, as they do during ... decreasing synaptic vesicle exocytosis and modulating the mechanisms governing synaptic vesicle recovery and endocytosis. These ... This release in vesicles, regardless of which pool they are released from, is considered a form of short term synaptic ...

... which is a molecular chaperone responsible for the uncoating of clathrin-coated vesicles during endocytosis. The clathrin- ... At pH 7 GAK allows Hsc70 to uncoat clathrin baskets and at pH 6 Hsc70 binds clathrin baskets without uncoating clathrin. ... "Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells". The Journal of Biological ... The domain of interest is the C-terminal domain which consists of three subdomains such as a C-terminal J domain, a clathrin- ...

"The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles". Cellular ...

They were able to see the difference between clathrin-coated and non-clathrin-coated vesicles. The buds help molecules in the ... There are also many vesicles that surround the Golgi, most of which are not coated with clathrin. In 2002, McIntosh's team ... For transport within the Golgi, McIntosh's team proposed evidence that it can be done by vesicles in the cell that fuse with ... Kinesin, a motor protein found to move around vesicles in the cell, was recently discovered on another paper published the same ...

"Myosin VI isoform localized to clathrin-coated vesicles with a role in clathrin-mediated endocytosis". The EMBO Journal. 20 (14 ... October 2019). "Clathrin light chain A drives selective myosin VI recruitment to clathrin-coated pits under membrane tension". ... Myosin-VI's Met-Ile-Sec bonding interactions are limited to the myosin-VI long isoform but interact with clathrin in ... MYO6 has been shown to interact with GIPC1, DAB2., ubiquitin, and clathrin. Myosin VI, being a motor protein, focuses its ...

It is then stored in clathrin-coated vesicles within the cytosol and ultimately protected from proteolysis. This ensures that ... Paing MM, Johnston CA, Siderovski DP, Trejo J (April 2006). "Clathrin adaptor AP2 regulates thrombin receptor constitutive ...

This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in ... Foti M, Mangasarian A, Piguet V, Lew DP, Krause KH, Trono D, Carpentier JL (Oct 1997). "Nef-mediated clathrin-coated pit ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ... Page LJ, Robinson MS (Nov 1995). "Targeting signals and subunit interactions in coated vesicle adaptor complexes". The Journal ...