Chromogranin A
In humans, chromogranin A protein is encoded by the CHGA gene. Examples of cells producing chromogranin A (ChgA) are chromaffin ... Chromogranin A is cleaved by an endogenous prohormone convertase to produce several peptide fragments. See chromogranin A ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Chromogranin A or parathyroid secretory protein 1 (gene name CHGA) is a member of the granin family of neuroendocrine secretory ...
SCG5
Taupenot L, Harper KL, O'Connor DT (March 2003). "The chromogranin-secretogranin family". The New England Journal of Medicine. ... Lloyd RV, Jin L (March 1994). "Analysis of chromogranin/secretogranin messenger RNAs in human pituitary adenomas". Diagnostic ...
SCG3
Hosaka M, Watanabe T, Sakai Y, Uchiyama Y, Takeuchi T (October 2002). "Identification of a chromogranin A domain that mediates ... The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. ... "Entrez Gene: SCG3 secretogranin III". Huttner WB, Gerdes HH, Rosa P (January 1991). "The granin (chromogranin/secretogranin) ... "Secretogranin III binds to cholesterol in the secretory granule membrane as an adapter for chromogranin A". The Journal of ...
Granin
Chromogranins and secretogranins together share a C-terminal motif, whereas chromogranins A and B share a region of high ... chromogranin A (CgA) chromogranin B (CgB) secretogranin II (SgII) (see also secretoneurin) secretogranin III (SgIII) ... Stridsberg M, Angeletti RH, Helle KB (June 2000). "Characterisation of N-terminal chromogranin A and chromogranin B in mammals ... Granins (chromogranins or secretogranins) are acidic proteins and are present in the secretory granules of a wide variety of ...
SCG2
2000). "Co-distribution patterns of chromogranin B-like immunoreactivity with chromogranin A and secretoneurin within the human ... Chromogranin Kirchmair R, Gander R, Egger M, et al. (2004). "The neuropeptide secretoneurin acts as a direct angiogenic ... SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene. The protein ... 2009). "Chromogranin peptides in amyotrophic lateral sclerosis". Regul. Pept. 152 (1-3): 13-21. doi:10.1016/j.regpep.2008.07. ...
Pheochromocytoma
If metanephrine values are equivocal, chromogranin A can be used as an adjunct marker to predict the presence of a tumor.[ ... Other additional biomarkers can be helpful to aid in the diagnosis of pheochromocytoma as well, most notable is Chromogranin A ... d'Herbomez M, Do Cao C, Vezzosi D, Borzon-Chasot F, Baudin E (September 2010). "Chromogranin A assay in clinical practice". ... However, a 2006 report from Italy found that over 90% of studied pheochromocytoma patients demonstrated elevated chromogranin A ...
Homeostasis
Koeslag, Johan H.; Saunders, Peter T.; Wessels, Jabus A. (1999). "The chromogranins and counter-regulatory hormones: do they ...
Neuroendocrine tumor
Aside from the hormones of secretory tumors, the most important markers are: chromogranin A (CgA), present in 99% of metastatic ... Neuroendocrine secretory protein-55, a member of the chromogranin family, is seen in pancreatic endocrine tumors but not ... Widely used neuroendocrine tissue markers are various chromogranins, synaptophysin and PGP9.5. Neuron-specific enolase (NSE) is ... chromogranin A, and neurotensin do not cause a clinical syndrome, although blood levels may be elevated. Functional tumors are ...
Solid pseudopapillary tumour
... they are negative for chromogranin and pancreatic enzymes. The gold standard for diagnosing solid pseudopapillary tumour of the ...
Secretoneurin
Stridsberg M, Oberg K, Li Q, Engström U, Lundqvist G (January 1995). "Measurements of chromogranin A, chromogranin B ( ... Secretoneurin, is a 33-amino acid neuropeptide derived from secretogranin II (chromogranin C, CHGC). It is cleaved into the ... Tasiemski A, Hammad H, Vandenbulcke F, Breton C, Bilfinger TJ, Pestel J, Salzet M (July 2002). "Presence of chromogranin- ... Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (June 1997). "Complex co-localization of chromogranins and ...
Ceruminous adenoma
The cells are negative with chromogranin, synaptophysin and CK20. The major diagnosis from which to separate ceruminous adenoma ...
Carcinoid syndrome
Nobels FR, Kwekkeboom DJ, Bouillon R, Lamberts SW (June 1998). "Chromogranin A: its clinical value as marker of neuroendocrine ... Markers of the condition such as chromogranin-A are imperfect indicators of disease progression. The incidence of ...
Saliva testing
Soell M, Feki A, Hannig M, Sano H, Pinget M, Selimovic D (February 2010). "Chromogranin A detection in saliva of type 2 ... chromogranin A) was over-expressed in 100% of diabetic patients when compared to controls. In 2010 Qvarnstrom, et al., ...
Thyroid neoplasm
Intrathyroidal parathyroid adenoma expressing chromogranin A (f) and PTH (g). Calcitonin-negative medullary thyroid carcinoma ( ...
Lung cancer
SCLCs bear the markers of neuroendocrine cells, such as chromogranin, synaptophysin, and CD56. Adenocarcinomas tend to express ...
Peptide YY
July 1989). "Developmental profile of chromogranin, hormonal peptides, and 5-hydroxytryptamine in gastrointestinal endocrine ...
Insulinoma
Pancreatic insulinoma Pancreatic insulinoma Chromogranin A Insulin immuostain Causes of hypoglycemia Metastatic Insulinoma ...
Secretogranin-1
... , also known as Chromogranin B, is a protein that in humans is encoded by the CHGB gene. It is a member of the ...
Synaptophysin
Diagnostically, it is often used in combination with chromogranin A. Synaptophysin has been shown to interact with AP1G1 and ...
B3GAT1
Jirásek T, Hozák P, Mandys V (2003). "Different patterns of chromogranin A and Leu-7 (CD57) expression in gastrointestinal ... conditions that it is of less use in distinguishing these tumours from others than more specific markers such as chromogranin ...
MIA PaCa-2
... chromogranin A, synaptophysin, SSTR2, and NTR1, but not CD56. The cells have a round, epithelial morphology, and are adherent ...
Mepartricin
Fan S, Hao ZY, Zhang L, Chen XG, Zhou J, Zang YF, Tai S, Liang CZ (2014). "Increased chromogranin A and neuron-specific enolase ...
Pancreatic neuroendocrine tumor
... chromogranin A, and neurotensin, do not cause a clinical syndrome although blood levels may be elevated. In total, 85% of ... immunohistochemistry is generally positive for chromogranin and synaptophysin. Genetic testing thereof typically shows altered ...
Molecular diagnostics
"Selective localization of the parathyroid secretory protein-I/adrenal medulla chromogranin A protein family in a wide variety ...
Zollinger-Ellison syndrome
An increased level of chromogranin A is a common marker of neuroendocrine tumors. In addition, the source of the increased ...
Neuroendocrine differentiation
Chromogranin A, which is the most abundant product of prostatic neuroendocrine cells and neuroendocrine tumor cells, is widely ... chromogranin A (CgA), synaptophysin and neuron-specific enolase (NSE) (three proteins that are used as markers for ... chromogranin A, synaptophysin, neuron-specific enolase, calcitonin and bombesin/gastrin-releasing peptide, while lacking, or ...
Paraganglioma
... the chief cells located in the cell balls are positive for chromogranin, synaptophysin, neuron specific enolase, serotonin, ...
Nerve tissue protein
Agrin Chimerin Proteins Chromogranins Dopamine and cAMP-Regulated Phosphoprotein 32 Fragile X Mental Retardation Protein GAP-43 ...
Atrial fibrillation
Cortisol and other stress biomarkers (including vasopressin, chromogranin A, and heat shock proteins), as well as emotional ...
Neuroendocrine cell
... chromogranin A, gastrin-releasing peptide (GRP), and cholecystokinin. These cells can be the source of several types of lung ...