Examples are: CXCL-8, CCL2, CCL3, CCL4, CCL5, CCL11, CXCL10. The main function of chemokines is to manage the migration of ... C4-CC chemokines), but a small number of CC chemokines possess six cysteines (C6-CC chemokines). C6-CC chemokines include CCL1 ... The third group of chemokines is known as the C chemokines (or γ chemokines), and is unlike all other chemokines in that it has ... CCL1 for the ligand 1 of the CC-family of chemokines, and CCR1 for its respective receptor. The CC chemokine (or β-chemokine) ...

The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. CXCL10 is secreted by ... C-X-C motif chemokine ligand 10 (CXCL10) also known as Interferon gamma-induced protein 10 (IP-10) or small-inducible cytokine ... Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD (August 2002). "The CXCR3 binding chemokine IP-10/CXCL10: structure ... CXCL10 in plasma is mirrored by intrahepatic CXCL10 mRNA, and both strikingly predict the first days of elimination of HCV RNA ...

Booth V, Keizer DW, Kamphuis MB, Clark-Lewis I, Sykes BD (August 2002). "The CXCR3 binding chemokine IP-10/CXCL10: structure ... CXC chemokine receptors are integral membrane proteins that specifically bind and respond to cytokines of the CXC chemokine ... However, CXCR6 is more closely related in structure to CC chemokine receptors than to other CXC chemokine receptors. ACKR3 was ... within the chemokine receptor cluster on human chromosome 3p21) and its similarity to other chemokine receptors in its gene ...

It is closely related to two other CXC chemokines called CXCL10 and CXCL11, whose genes are located near the gene for CXCL9 on ... Chemokine (C-X-C motif) ligand 9 (CXCL9) is a small cytokine belonging to the CXC chemokine family that is also known as ... Campbell JD, Stinson MJ, Simons FE, Rector ES, HayGlass KT (July 2001). "In vivo stability of human chemokine and chemokine ... Shields PL, Morland CM, Salmon M, Qin S, Hubscher SG, Adams DH (December 1999). "Chemokine and chemokine receptor interactions ...

... -A binds to the CXC chemokines CXCL9 (MIG), CXCL10 (IP-10), and CXCL11 (I-TAC) whereas CXCR3-B can also bind to CXCL4 in ... Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G ... Chemokine receptors Chemokine Cluster of differentiation GRCh38: Ensembl release 89: ENSG00000186810 - Ensembl, May 2017 GRCm38 ... "Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria". ...

2005). "Identification of genes differentially expressed in T cells following stimulation with the chemokines CXCL12 and CXCL10 ...

... host-derived pro-inflammatory chemokines (e.g. CXCL8, CCL2, CCL3, CCL4, CCL5, CCL11, CXCL10), platelet-activating factor, and ... stimulates their expression the chemokine receptor, CCR5, to inhibit chemokine signaling, enhances their phagocyte activity, ... chemokine receptor-like 1), also termed the ChemR23 or E series resolvin receptor (ERV), is expressed on inflammation- ...

"Human osteoblasts express functional CXC chemokine receptors 3 and 5: activation by their ligands, CXCL10 and CXCL13, ... is a G protein-coupled seven transmembrane receptor for chemokine CXCL13 (also known as BLC) and belongs to the CXC chemokine ... that could lead to decreased autoimmune response While chemokines and chemokine receptors have been thought to be involved in ... C-X-C chemokine receptor type 5 (CXC-R5) also known as CD185 (cluster of differentiation 185) or Burkitt lymphoma receptor 1 ( ...

It does this by increasing production of interferon gamma, which in turn increases the production of a chemokine called ... inducible protein-10 (IP-10 or CXCL10). IP-10 then mediates this anti-angiogenic effect. Because of its ability to induce ...

The main chemokine receptors on these cells are CXCR3A and CCR5. Epithelial cells and keratinocytes are able to recruit TH1 ... cells to sites of infection by releasing the chemokines CXCL9, CXCL10 and CXCL11 in response to interferon gamma. Additionally ... CCR5 and CXCR3 are the main chemokine receptors for this cell. Group 1 ILCs Groups 1 ILCs are defined to include ILCs ... TH1 cells are also characterized by the expression of chemokine receptors which allow their movement to sites of inflammation. ...

... as well as promoting the production of chemokines CXCL10, CXCL9 and CXCL11. These chemokines play an important role in ... The recruitment of more immune cells also occurs and is mediated by the chemokines produced during the inflammatory process. In ...

... might play a role in the pathogenesis of tuberculosis via cleavage of the chemokine C-X-C motif chemokine ligand 10 (CXCL10). ... The cleaved substrates lose their biological activity in the majority of cases, but in the case of the chemokine RANTES and ... DPP-4 is known to cleave a broad range of substrates including growth factors, chemokines, neuropeptides, and vasoactive ... "The Mycobacterium tuberculosis prolyl dipeptidyl peptidase cleaves the N-terminal peptide of the immunoprotein CXCL-10". Biol ...

Flares are accompanied by increased serum levels of activated T lymphocyte chemokines (IP-10/CXCL10, MIG/CXCL9), G-CSF and ... Activated CD4(+)/CD25(+) T-lymphocyte counts correlated negatively with serum concentrations of IP-10/CXCL10, whereas CD4(+)/ ... IP-10/CXCL10) genes. T cell associated genes (CD3, CD8B) are down regulated. ...

C-X-C motif chemokine 11 (CXCL11) is a protein that in humans is encoded by the CXCL11 gene. C-X-C motif chemokine 11 is a ... CXCL9 and CXCL10. CXCL11 is chemotactic for activated T cells. Its gene is located on human chromosome 4 along with many other ... This chemokine elicits its effects on its target cells by interacting with the cell surface chemokine receptor CXCR3, with a ... "Entrez Gene: CXCL11 chemokine (C-X-C motif) ligand 11". Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin ...

Over the past three decades, Luster has been intimately associated with the birth, growth and development of the chemokine ... of this important family of immunoregulatory chemotactic cytokines in health and diseases since his initial discovery of CXCL10 ... His laboratory is interested in defining the roles of chemokines and lipid chemoattractant molecules in autoimmune, allergic, ... According to Google Scholar, Luster's most cited paper, the review "Chemokines-chemotactic cytokines that mediate inflammation ...

... and secretion proteins of the chemokine family such as CXCL9, CXCL10, and CXCL11 which present direct antimicrobial activity. ... Examples of genes whose DNA virus-triggered expression is stimulated by SNX8 are IFNB1, ISG56, CXCL10 and IL6 (being IFNB1 and ...

In addition, SeV triggers the expression of the chemokine interferon-γ inducible protein 10 kDa (CXCL10), which is involved in ... chemokine (C-C motif) ligand 5, and chemokine (C-X-C motif) ligand 10. These molecules activate both CD8+ T cells as well as ... chemokine (C-C motif) ligand 5, and chemokine (C-X-C motif) ligand 10. These molecules activate both CD8+ T cells as well as ... Among the ten most virus-induced mRNAs are IFNα8, IFNα13, IFNβ, IFNλ: (L28α, IL28β, IL29), OASL, CXCL10, CXCL11 and HERC5. ...

The brominated form of noscapine has been shown to inhibit the secretion of the cytokine TNF-α and the chemokine IP-10/CXCL10 ...

Chemokine ligands CXCL9, CXCL10, and CCL5 that bind to chemokine receptors such as CXCR3 and CCR5, Immune suppressive or ... These initiate the following cascade: CXCR3 ligand chemokines (CXCL-9, -10 and -11) are produced in response to activated B ... To illustrate, growth factors and chemokines activated in response to injury are recruited by tumour cells, sustaining chronic ... immunity broadens in the target organ by producing chemokines of the CXCL family that recruit the receptor CXCR3-bearing ...

... particularly chemokines such as CXCL10 and CCL2 (MCP-1) which attract monocytes, natural killer cells, T-lymphocytes, and ... Keratinocytes also modulate the immune system: apart from the above-mentioned antimicrobial peptides and chemokines they are ...

"Anti-CXCL10 Therapeutic Antibody (eldelumab) - Creative Biolabs". www.creativebiolabs.net. Retrieved 2017-03-24. Statement On A ... Eldelumab (alternative identifier BMS-936557) is a fully human monoclonal antibody (type IgG1 kappa) that targets chemokine (C- ... X-C motif) ligand 10 (CXCL10)/Interferon-γ-inducible protein-10 (IP-10) designed for the treatment of Crohn's disease and ...

"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". ... CXCL10 release by TNF-alpha and IFN-gamma in HaCaT cell line". Cytokine. 20 (1): 1-6. doi:10.1006/cyto.2002.1965. PMID 12441140 ... CCL17 is one of the few chemokines that are not stored in the body, except in the thymus; these chemokines are made when needed ... CCL17 as well as its partner chemokine CCL22 induce chemotaxis in T-helper cells. They do this by binding to CCR4, a chemokine ...

CroFab Cross-presentation Cross-reactivity Cryptic self epitopes Cryptotope CX3CL1 CX3CR1 CXC chemokine receptors CXCL1 CXCL10 ... Breakthrough infection Broadly neutralizing HIV-1 antibodies Bursa of Fabricius C-C chemokine receptor type 6 C-C chemokine ... CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated immunity CELSR1 Central tolerance Chemokine Chemokine ... 7 Calreticulin Cancer immunology Cancer immunoprevention Cancer immunotherapy Cantuzumab ravtansine Cathelicidin CC chemokine ...

NG-641: This vector contains four transgenes expressing secreted Interferon alpha, the chemokines CXCL9, CXCL10 and an anti-FAP ...

... and T cells through chemokines such as CCL2, CCL4, CCL5, CXCL8, CXCL9, CXCL10, and CXCL11. Along with dendritic cells, ... Macrophages secrete many chemokines such as CXCL1, CXCL2, and CXCL8 (IL-8) that attract neutrophils to the site of infection. ... HIV can enter the macrophage through binding of gp120 to CD4 and second membrane receptor, CCR5 (a chemokine receptor). Both ... Some of the T cell chemoattractants secreted by macrophages include CCL5, CXCL9, CXCL10, and CXCL11. Macrophages are ...

... chemokine (C-X-C motif) ligand 9, scyb9 CXCL10: chemokine (C-X-C motif) ligand 10, scyb10 CXCL11: chemokine (C-X-C motif) ... chemokine (C-X-C motif) ligand 1, scyb1 CXCL2: chemokine (C-X-C motif) ligand 2, scyb2 CXCL3: chemokine (C-X-C motif) ligand 3 ... chemokine (C-X-C motif) ligand 5, scyb5 CXCL6: chemokine (C-X-C motif) ligand 6, scyb6 CXCL7: chemokine (C-X-C motif) ligand 7 ... scyb3 CXCL4: chemokine (C-X-C motif) ligand 4, Platelet factor-4, PF-4, scyb4 CXCL5: ...

Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis. Klein RS, Lin E, Zhang B, Luster ... In Klein's first author paper in development in 2001, she reported that the chemokine CXC12 and its receptor CXCR4 are ... In 2002, Klein helped discover that deficiency in Chemokine Receptor 2 (CCR2) decreased monocyte recruitment to the CNS which ... Her lab has extensively explored how cytokines and chemokines affect blood brain barrier permeability and her lab has ...

A study has shown that it modulates secretion of CXCL10. The cyclic thiourea derivative thiamazole is a white to matte brown ... October 2007). "Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes". The Journal of Endocrinology. 195 ...