... as done by cardiac glycosides. Nevertheless, due to questions of toxicity and dosage, cardiac glycosides have been replaced ... Cardiac glycosides have long served as the main medical treatment to congestive heart failure and cardiac arrhythmia, due to ... hellebore) Cardiac glycosides affect the sodium-potassium ATPase pump in cardiac muscle cells to alter their function. Normally ... "Cardiac Glycosides". www.people.vcu.edu. Retrieved 2017-05-25. Cheeke PR (1989-07-31). Toxicants of Plant Origin: Glycosides. ...

... are relatively sensitive to the effects of cardiac glycosides and the clinical manifestations of "glycoside intoxication". In ... Cardiac glycosides. Desai, Umesh R. Virginia Commonwealth University. School of Pharmacy. Retrieved on 2009-07-27. Legend of ... both of which contain (like oleander) potent cardiac glycosides that have led to their use as arrow poisons in Africa. The ... Newman, R. A; Yang, P; Pawlus, A. D; Block, K. I (2008). "Cardiac Glycosides as Novel Cancer Therapeutic Agents". Molecular ...

... is a cardiac glycoside, a type of drug that can be used in the treatment of congestive heart failure and cardiac arrhythmia ( ... Desai UR (2005). "Cardiac Glycosides". VCU School of Pharmacy. (CS1 Polish-language sources (pl), CS1 Italian-language sources ...

Cardiac glycosides: Part VI. Moraceae: The genus Antiaris Lesch. Planta Medica, 10: 143-151. Boer, E. & Sosef, M.S.M., 1998. ... Glykoside und Aglycone, 150 [Glycosides of Antiaris toxicaria Lesch. Glycoside and aglycones, 150]. Helvetica Chimica Acta, 38( ... in particular a cardiac glycoside named antiarin. It is used as a toxin for arrows, darts, and blowdarts in Island Southeast ...

Foxglove contains cardiac glycosides. Poisonous hemlock (conium) has medicinal uses.[citation needed] Prions, resulting in ...

Naturally Occurring Cardiac Glycosides'; The Medical Journal of Australia; issue 144, pp. 540-543 R. E. McFadyen, J. J. ...

... s are cardiac glycoside poisons produced by the upas tree (Antiaris toxicaria). There are two forms, α-antiarin and β- ... β-Antiarin, a cardiac glycoside steroid, can be isolated from upas tree latex (Antiaris toxicaria). Its use ranges from medical ... If the dosage of cardiac glycoside (i.e. beta-antiarin) doubles, then the substance becomes a poison. The earliest known use of ... National Institutes of Health.[dead link] Manunta, Paolo; Ferrandi, Mara (2006). "Cardiac Glycosides and Cardiomyopathy". ...

The direct effect of cardiac glycosides on heart muscle cells is to increase contraction of the cells, both in force and ... The use of D. purpurea extract containing cardiac glycosides for the treatment of heart conditions was first described in the ... "Cardiac Glycoside Plant Poisoning: Medscape reference". Retrieved 3 July 2012. Anon. "Notes on poisoning:Digitalis purpura". ... The term digitalis is also used for drug preparations that contain cardiac glycosides, particularly one called digoxin, ...

Cardiac glycosides, particularly digoxin, have been conventionally used for treatment of common cardiac problems, mainly heart ... Digoxin, as a cardiac glycoside, has a chemical structure basically similar to that of estradiol. Digoxin has the ability to ... Digoxin is in the cardiac glycoside family of medications. It was first isolated in 1930 from the foxglove plant, Digitalis ... December 2008). "Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth". Proceedings of the ...

Mutated isolates of E. cheiranthoides with altered cardiac glycoside content have been identified. Cardiac glycosides, which ... In contrast, another cardiac glycoside, erycordin, was inactive in this oviposition assay. Pieris rapae tarsal sensilla respond ... Lei, Zhen-Huan; Yahara, Shoji; Nohara, Toshihiro; Tai, Bao-Shan; Xiong, Jin-Zhe; Ma, Ying-Li (2000). "Cardiac Glycosides form ... Lei, Zhen-Huan; Nakayama, Hitoshi; Kuniyasu, Akihiko; Tai, Bao-Shan; Nohara, Toshihiro (2002). "Cardiac Glycosides from ...

There is a rather large homology in structure between arenobufagin and cardiac glycosides. Cardiac glycosides are natural ... Arenobufagin works like Cardiac glycosides. It inhibits the sodium-potassium pump because it stabilises the E2-P transition ... Structure of arenobufagin Structure of a cardiac glycoside, proscillaridin Although a low dosis of arenobufagin can be used as ... K+ pump current in cardiac myocytes. European Journal of Pharmacology. 1993 Aug 3;239(1-3):223-6. PMID 8223897 Li, Manmei; Wu, ...

Like most members of the genus Erysimum, E. crepidifolium contains both cardiac glycosides (cardenolides), and glucosinolates. ... "Cardiac glycosides of Erysimum crepidifolium". Chemistry of Natural Compounds. 10 (5): 619-622. doi:10.1007/bf00567853. ISSN ...

... a cardiac glycoside. The plant was used on heart conditions long before the glycoside was identified. Digoxin is used to treat ... The cardiac glycosides are powerful drugs from medicinal plants including foxglove and lily of the valley. They include digoxin ... Cardiac Glycoside". Texas A&M University. Archived from the original on 2 July 2018. Retrieved 26 February 2017. The man ... Anthraquinone glycosides are found in medicinal plants such as rhubarb, cascara, and Alexandrian senna. Plant-based laxatives ...

Anthraquinone glycosides are found in senna, rhubarb, and Aloe. The cardiac glycosides are phytochemicals from plants including ... a cardiac glycoside. The plant was used to treat heart conditions long before the glycoside was identified. Digoxin is used to ... Cardiac Glycoside". Texas A&M University. Retrieved 26 February 2017. The man credited with the introduction of digitalis into ... Senna alexandrina, containing anthraquinone glycosides, has been used as a laxative for millennia. The foxglove, Digitalis ...

November 2019). "Cardiac glycosides are broad-spectrum senolytics". Nature Metabolism. 1 (11): 1074-1088. doi:10.1038/s42255- ... October 2019). "Identification and characterization of Cardiac Glycosides as senolytic compounds". Nature Communications. 10 (1 ...

Elderfield, Robert C. (1 October 1935). "The Chemistry of the Cardiac Glycosides". Chemical Reviews. 17 (2): 187-249. doi: ... Cardiac glycosides, Glucosides, All stub articles, Organic compound stubs). ...

... those who are poisoned by ingesting cardiac glycosides experience, within an hour, a variety of gastrointestinal and cardiac ... Cerberin, as a cardiac glycoside, is seen as binding to and inhibiting the cellular Na+/K+ -ATPase, because it binds to the ... Cerberin, like all cardiac glycosides, has as its core a steroid-type set of four carbocycles (all-carbon rings). In cerberin, ... Cardiac glycosides, such as cerberin, alter the transport of ions against their gradient. Cerberin is able to bind to the ...

... is a glycoside extracted from Convallaria majalis. Convallatoxin is a natural cardiac glycoside that can be found ... Convallatoxin is a digitalis like compound (DLC), which is mainly used as a cardiac glycoside since it can inhibit the Na+,K+- ... Welsh, K J; Huang, R S P; Actor, J K; Dasgupta, A (2019-03-05). "Rapid Detection of the Active Cardiac Glycoside Convallatoxin ... Anderson, SE; Barton, CE (2017). "The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53- ...

... is a cardiac glycoside used for the treatment of heart failure and certain kinds of heart arrhythmia. It is a ... February 2013). "Trial watch: Cardiac glycosides and cancer therapy". Oncoimmunology. 2 (2): e23082. doi:10.4161/onci.23082. ... "Cytotoxicity of digitoxin and related cardiac glycosides in human tumor cells". Anti-Cancer Drugs. 12 (5): 475-83. doi:10.1097/ ... "Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization". Proceedings of the National Academy of ...

Cardiac glycosides of Maquira and Naucleopsis species". Journal of Ethnopharmacology. 37 (2): 129-143. doi:10.1016/0378-8741(92 ...

Toxic cardiac glycosides occur in the roots. High levels of ranunculin and protoanemonin, especially in the leaves and sap, ... collapse and death from cardiac arrest. Although Helleborus niger (black hellebore) contains protoanemonin or ranunculin, which ...

Cardiac glycosides, which affect heart function, are a ready example. Genera studied and known to contain such glycosides ... Genera containing cardiac glycosides- Cerbera, Nerium, Asclepias, Cascabela, Strophanthus, Acokanthera, Apocynum, Thevetia, etc ... Kohls, S.; Scholz-Böttcher, B.M.; Teske, J.; Zark, Patrick; Rullkötter, J. (2012). "Cardiac glycosides from Yellow Oleander ( ... the family being rich in genera containing alkaloids and cardiac glycosides, those containing the latter often finding use as ...

All parts of the C. thevetia plant are toxic to most vertebrates as they contain cardiac glycosides. Many cases of intentional ... Kohls S, Scholz-Böttcher BM, Teske J, Zark P, Rullkötter J (2012). "Cardiac glycosides from Yellow Oleander (Thevetia peruviana ...

... s are a group of poisonous cardiac glycosides. They are obtained especially from the seeds of a West Indian shrub or ... v t e (Cardiac glycosides, All stub articles, Biochemistry stubs). ...

... is a cardiac glycoside. It is an acetyl derivative of digitoxin, found in the leaves of Digitalis species. It ... is used to treat cardiac failure, particularly that associated with tachycardia. Kemertelidze ÉP, Gvazava LN (1979-11-01). " ...

"Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization". Proceedings of the National Academy of ... Initially developed as a facile method to manipulate carbohydrate substitutions of naturally occurring glycosides to afford the ... glycorandomization has led to the discovery of new glycoside analogs which display improvements in potency, selectivity and/or ... "Identification of neuroprotective spoxazomicin and oxachelin glycosides via chemoenzymatic glycosyl-scanning". Journal of ...

Chen, K. K.; Henderson, F. G.; Anderson, R. C. (August 1950). "The cardiac action of Helleborus glycosides and their aglycones ...

They are aglycone constituents of cardiac glycosides and must have at least one double bond in the molecule. The class includes ... Cardenolides are a class of steroids (or aglycones if viewed as cardiac glycoside constituents), and cardenolides are a subtype ... Naudé, T. W. (1977). "The occurrence and significance of South African cardiac glycosides". Journal of the South African ... Many plants contain derivatives, collectively known as cardenolides, including many in the form of cardenolide glycosides ( ...

In addition to its low levels of cardiac glycosides, A. tuberosa has rough leaves, which are also unattractive to egg-laying ... Unlike other milkweeds, this plant has a clear sap, and the level of toxic cardiac glycosides is consistently low (although ... A. tuberosa) is the least favored by monarch caterpillars .... because it has very little toxin (cardiac glycosides) in its ... Many species of milkweed contain toxic cardiac glycosides (cardenolides). Monarch caterpillars deter predators by incorporating ...

Roughly 38 different cardiac glycosides (cardenolides) - which are highly toxic if consumed by humans or animals - occur in the ... Due to the concentration of cardiac glycosides (cardenolides), it is highly poisonous if consumed by humans or other animals. ... "Pharmacological treatment of cardiac glycoside poisoning". British Journal of Clinical Pharmacology. 81 (3): 488-495. doi: ...