As the first calpain whose three-dimensional structure was determined, m-calpain is the type-protease for the C2 (calpain) ... calpain and m-calpain (or calpain I and II), that differed primarily in their calcium requirements in vitro. Their names ... Calpain for Modulatory Proteolysis Database The Calpain Family of Proteases. (2001). University of Arizona. Calpain Info with ... Calpains constitute the C2 family of protease clan CA in the MEROPS database. The calpain proteolytic system includes the ...

... (also known as calpamodulin) is a protein in humans that is encoded by the CAPN6 gene. Calpains are a ubiquitous, ... "Entrez Gene: Calpain 6". National Center for Biotechnology Information. U.S. National Library of Medicine. Archived from the ... Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and ... Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks a critical ...

... (EC 3.4.22.53, calcium-activated neutral protease II, m-calpain, milli-calpain) is an intracellular heterodimeric ... "Structure and nomenclature / Calpain Research Portal: Calpain Structure and Nomenclature". calpain.net. Retrieved 2021-01-17. ... Calpain Research Portal CAPN2 Crystal Structure of Human Calpain-2 Strobl S, Fernandez-Catalan C, Braun M, Huber R, Masumoto H ... Calpain-2 heterodimer is highly homologous to calpain-1, which is formed by a catalytic CAPN1 and a regulatory CAPNS1 subunits ...

... (EC 3.4.22.52, mu-calpain, calcium-activated neutral protease I) is an enzyme. This enzyme catalyses the following ... and m-calpain". The Biochemical Journal. 367 (Pt 1): 263-9. doi:10.1042/bj20020485. PMC 1222847. PMID 12014988. Calpain-1 at ...

... is a protein that in humans is encoded by the CAPN9 gene. Calpains are ubiquitous, well-conserved family of calcium- ... "Entrez Gene: CAPN9 calpain 9". Huang Y, Wang KK (2001). "The calpain family and human disease". Trends in Molecular Medicine. 7 ... The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit ... Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and ...

... is a protein that in humans is encoded by the CAPN3 gene. Calpain, a heterodimer consisting of a large and a small ... "Entrez Gene: CAPN3 calpain 3, (p94)". Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir ... Huang Y, de Morrée A, van Remoortere A, Bushby K, Frants RR, den Dunnen JT, van der Maarel SM (2008). "Calpain 3 is a modulator ... Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K (1990). "Four genes for the calpain ...

"CAPN8 - Calpain-8 - Homo sapiens (Human) - CAPN8 gene & protein". www.uniprot.org. Retrieved 18 May 2022. "Entrez Gene: Calpain ... Calpain-8 is a protein in humans that is encoded by the CAPN8 gene. GRCh38: Ensembl release 89: ENSG00000203697 - Ensembl, May ...

... (CANP 1) is a protein that in humans is encoded by the CAPN1 gene. The calpains, calcium-activated ... "Entrez Gene: CAPN1 calpain 1, (mu/I) large subunit". Shinozaki K, Maruyama K, Kume H, Tomita T, Saido TC, Iwatsubo T, Obata K ( ... The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of ... This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. CAPN1 has been shown to interact with PSEN2. GRCh38: ...

... (CSS1), is a protein that in humans is encoded by the CAPNS1 gene. Calpains are a ubiquitous, well- ... "Entrez Gene: CAPNS1 calpain, small subunit 1". Lin GD, Chattopadhyay D, Maki M, Wang KK, Carson M, Jin L, Yuen PW, Takano E, ... Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded ... Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi-Imajoh S, Shimizu N, Suzuki K (1990). "Four genes for the calpain ...

... is a protein that in humans is encoded by the CAPN2 gene. The calpains, calcium-activated neutral ... m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells". J. Cell. Biochem. 66 (2): 197-209. doi: ... "Entrez Gene: CAPN2 calpain 2, (m/II) large subunit". Gil-Parrado S, Fernández-Montalván A, Assfalg-Machleidt I, Popp O, ... Potential role of calpain, protein tyrosine phosphatase 1b, and p130Cas in integrin-mediated signaling events". J. Biol. Chem. ...

Calpain. "Kiki Memorial and Art Gathering". Equestria Daily. Retrieved February 15, 2015. Sporeman, Sean (May 6, 2015). "Follow ...

Lokuta, M. A., Nuzzi, P. A., & Huttenlocher, A. (2003). Calpain regulates neutrophil chemotaxis. Proceedings of the National ... involving intracellular proteolysis by the calcium-dependent protease calpain. Her laboratory was also the first to document ... Calpain-mediated proteolysis of talin regulates adhesion dynamics. Nature cell biology, 6(10), 977-983. https://doi.org/10.1038 ...

Calpain (February 16, 2015). "Season 5 Concept Art at PonyCon Appears! New Characters and More Revealed!". Equestria Daily. ... Calpain (January 19, 2015). "PonyCon 2015 To Premiere New Season 5 Trailer With MLP Directors!". Equestria Daily. Retrieved ...

Calpain (September 20, 2017). "America's Got Talent Special MLP Movie Sneak Peak". Equestria Daily. Retrieved September 27, ...

Calpain (September 29, 2015). "Ratings For The 'Friendship Games' Are In". Equestria Daily. Archived from the original on ...

Calpain 3 is unique from other calpain proteases in that it is relatively specific to muscle. Calpain 3 is both a protease and ... Research is being done to identify the proteins cleaved by calpain-3. Gene therapy is being studied to replace the function of ... Mutation in the gene CAPN3, which encodes the protein calpain-3 (CAPN3), is the cause of calpainopathy. As of 2019, more than ... The structural role of calpain 3 is stabilization of the triad protein complexes. A triad protein complex plays a role ...

"Ionomycin-activated calpain triggers apoptosis. A probable role for Bcl-2 family members". The Journal of Biological Chemistry ...

Löfvenberg L, Backman L (1999). "Calpain-induced proteolysis of beta-spectrins". FEBS Lett. 443 (2): 89-92. doi:10.1016/S0014- ...

1997). "Identification of mu-, m-calpains and calpastatin and capture of mu-calpain activation in endothelial cells". J. Cell. ... 1989). "Inhibition of calpain by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene". J. Biol. ... It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the ... 1990). "Cloning and expression of the genes for calpains and calpastatins". Biochem. Soc. Symp. 55: 29-44. PMID 2559735. Asada ...

This protein is a substrate of calpain II. A second transcript from this gene has been described, but its full length nature ...

The protease calpain has also been shown to be involved in this type of cell destruction; just as the use of calpain inhibitors ... Wang KK (Jan 2000). "Calpain and caspase: can you tell the difference?". Trends in Neurosciences. 23 (1): 20-26. doi:10.1016/ ... Villa PG, Henzel WJ, Sensenbrenner M, Henderson CE, Pettmann B (Mar 1998). "Calpain inhibitors, but not caspase inhibitors, ...

These cysteine proteases include calpain, caspase, and cathepsin. These three proteins are examples of detectable signs of ...

This group includes the calpains. Basic proteases (or alkaline proteases) Proteases are involved in digesting long protein ...

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene. Calpains are calcium-dependent cysteine proteases involved ... "Entrez Gene: CAPN5 calpain 5". Vanderklish PW, Bahr BA (2001). "The pathogenic activation of calpain: a marker and mediator of ... A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the ... 2007). "Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels". BMC Med. Genet. 8: 1. doi ...

... interacts with many sarcomeric proteins including: Z line region: telethonin and alpha-actinin I band region: calpain-3 ... July 1998). "Functional defects of a muscle-specific calpain, p94, caused by mutations associated with limb-girdle muscular ... Kinbara K, Sorimachi H, Ishiura S, Suzuki K (August 1998). "Skeletal muscle-specific calpain, p49: structure and physiological ... Sorimachi H, Ono Y, Suzuki K (2000). "Skeletal Muscle-Specific Calpain, p94, and Connectin/Titin: Their Physiological Functions ...

This may be mediated via the proteasome or calpain. Rogers S, Wells R, Rechsteiner M (1986). "Amino acid sequences common to ... "The PEST Domain of IκBα is necessary and sufficient for in vitro degradation by mu-calpain". J. Biol. Chem. 274 (43): 30874-81 ...

Weber, Jonasz J.; Ortiz Rios, Midea M.; Riess, Olaf; Clemens, Laura E.; Nguyen, Huu P. (2016-01-01). "The calpain-suppressing ... "Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat". Brain. 138 (12): 3632-3653. doi: ... effects of olesoxime were attributed to modulating the activity of calcium-dependent proteases called calpains. A 2009-2011 ...

May 2002). "Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain". Molecular and Cellular Biology. 22 (10 ...

This includes a binding site for SA1 or SA2, recognition motifs for separase, caspase, and calpain to cleave, as well as a ... Panigrahi AK, Zhang N, Mao Q, Pati D (November 2011). "Calpain-1 cleaves Rad21 to promote sister chromatid separation". ... RAD21 is cleaved by several proteases including Separase and Calcium-dependent cysteine endopeptidase Calpain-1 during mitosis ...

Calpain-10 is a protein that in humans is encoded by the CAPN10 gene. Calpains are ubiquitous, well-conserved family of calcium ... "Entrez Gene: CAPN10 calpain 10". Sorimachi H, Ishiura S, Suzuki K (1998). "Structure and physiological function of calpains". ... 2001). "Characterization and expression of calpain 10. A novel ubiquitous calpain with nuclear localization". J. Biol. Chem. ... Horikawa Y (2007). "Calpain-10 (NIDDM1) as a Susceptibility Gene for Common Type 2 Diabetes". Endocr. J. 53 (5): 567-76. doi: ...