Disorders of calcium metabolism
... occur when the body has too little or too much calcium. The serum level of calcium is closely ... Disorders in calcium metabolism can lead to hypocalcemia, decreased plasma levels of calcium or hypercalcemia, elevated plasma ... and therefore levels of ionized calcium are better measures than a total calcium; however, one can correct a total calcium if ... A normal ionized calcium is 1.12-1.45 mmol/L (4.54-5.61 mg/dL). A normal total calcium is 2.2-2.6 mmol/L (9-10.5 mg/dl). Total ...
Harold E. Harrison and Helen C. Harrison
They were jointly the authors of Disorders of Calcium and Phosphate Metabolism in Childhood and Adolescence, a comprehensive ... Harrison, Harold E.; Harrison, Helen C. (1979). "Disorders of Calcium and Phosphate Metabolism in Childhood and Adolescence". ... and jointly published more than 175 research papers and one textbook on topics including pediatric metabolic disorders, ...
Osteitis fibrosa cystica
"Association of Level Oo GFR with Bone Disease And Disorders of Calcium And Phosphorus Metabolism". NKF K/DOQI Guidelines. ... PTH causes the release of calcium from the bones into the blood, and the reabsorption of calcium in the kidney. Thus, excess ... The symptoms of the disease are the consequences of both the general softening of the bones and the excess calcium in the blood ... ESRD occurs when the kidneys fail to produce calcitriol, a form of vitamin D, which assists in the absorption of calcium into ...
Phosphonate
... s are also increasingly used in medicine to treat disorders associated with bone formation and calcium metabolism. ... Wiemer, AJ; Hohl, RJ; Wiemer, DF (June 2009). "The intermediate enzymes of isoprenoid metabolism as anticancer targets". Anti- ...
Milk fever
"Parturient Paresis in Cows: Disorders of Calcium Metabolism: Merck Veterinary Manual". www.merckvetmanual.com. Retrieved 2015- ... In normal calcium regulation, a decrease in plasma calcium levels causes the parathyroid glands to secrete parathyroid hormone ... Intravenous calcium, though indicated in many cases, is potentially fatal through "heart blockade", or transient high calcium ... Treatment generally involves calcium injection by intravenous, intramuscular or subcutaneous routes. Before calcium injection ...
Charles Enrique Dent
His research interests broadened to include the study of clinical disorders of calcium and phosphorus metabolism, vitamin D ... In 1956 he was appointed Professor of Human Metabolism at UCH. In 1954 he was elected a Fellow of the Royal College of ... From 1946, his career focused on several inborn errors of metabolism. He was appointed a Commander of the Order of the British ... Charles Enrique Dent, CBE, FRCP, FRS (25 August 1911 - 19 September 1976) was a British professor of human metabolism at ...
Mitral annular calcification
... stenosis or hypertrophic cardiomyopathy abnormal calcium-phosphorus metabolism Chronic kidney disease/ESRD genetic disorders ... Mitral annular calcification (MAC) is a multifactorial chronic degenerative process in which calcium with lipid is deposited ( ...
Calcium-sensing receptor
Molecular Genetics and Metabolism. 64 (3): 198-204. doi:10.1006/mgme.1998.2716. PMID 9719629. "Entrez Gene: CaSR calcium- ... Nemeth EF, Shoback D (Jun 2013). "Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders". Best ... Calcium cations bind to the first Calcium binding site in the inactive conformation. In the second binding site, Calcium ... The order of Calcium binding affinity to four of the bindings sites is as follows: 1 = 2 > 3 > 4. The lower affinity of Calcium ...
Metabolic disorder
Disorders of calcium metabolism DNA repair-deficiency disorders Glucose metabolism disorders Hyperlactatemia Iron metabolism ... disorders Lipid metabolism disorders Malabsorption syndromes Metabolic syndrome X Inborn error of metabolism Mitochondrial ... Hur, Kyu Yeon; Lee, Myung-Shik (2015-06-01). "Gut Microbiota and Metabolic Disorders". Diabetes & Metabolism Journal. 39 (3): ... Metabolic disorder screening can be done in newborns via blood, skin, or hearing tests. Metabolic disorders can be treatable by ...
D. Sudhaker Rao
His main research interests are the role of vitamin D and calcium nutrition in parathyroid disorders and bone health. He has ... He specializes in bone and mineral metabolism and endocrinology, specifically in hyperparathyroidism, osteomalacia, and bone ... Rao has contributed extensively to the broad field of bone & mineral metabolism. ...
Porcine stress syndrome
It is an inherited, autosomal recessive disorder due to a defective ryanodine receptor leading to huge calcium influx, muscle ... contracture and increase in metabolism. PSS can manifest itself in the abattoir as the production of Pale, Soft and Exudative ... Psychologist Melanie Joy has likened PSS to post-traumatic stress disorder in humans. Wendt M, Bickhardt K, Herzog A, Fischer A ...
Fuller Albright
... especially to the area of calcium metabolism. Albright made great strides and contributions to the understanding of disorders ... mainly into calcium metabolism and lead poisoning. He was subsequently assistant resident to Warfield Longcope at Johns Hopkins ... specifically the study of metabolism. After his internship at Massachusetts General Hospital he embarked on a one-year ... "extraordinarily original and monumental contributions to the understanding of metabolism of bone and other tissues." (1949) The ...
HFE H63D gene mutation
The homozygous H63D variant is an indicator of the iron metabolism disorder hemochromatosis, which may increase the risk of ... and disturbances in the calcium channels in particular. ... Disorders of adrenal and other endocrine organ function due to ... If thought disorders are in the foreground, a timely diagnosis is therefore often delayed. Tic disorders: variable Tourette's- ... Diseases and disorders, Single-nucleotide polymorphism associated disease, Genetic diseases and disorders). ...
Klotho (biology)
Regulation of calcium and phosphate metabolism by FGF23/Klotho]". Clinical Calcium. 19 (4): 523-528. PMID 19329831. Nabeshima Y ... Torbus-Paluszczak M, Bartman W, Adamczyk-Sowa M (October 2018). "Klotho protein in neurodegenerative disorders". Neurological ... van Goor MK, Hoenderop JG, van der Wijst J (June 2017). "TRP channels in calcium homeostasis: from hormonal control to ... Wolf MT, An SW, Nie M, Bal MS, Huang CL (December 2014). "Klotho up-regulates renal calcium channel transient receptor ...
Renal osteodystrophy
Lui S, Chu H (1943). "Studies in calcium and phosphorus metabolism with special reference to pathogenesis and effects of ... CKD-MBD is defined as a systemic disorder of mineral and bone metabolism due to CKD manifested by either one or a combination ... It is one measure of the skeletal component of the systemic disorder of chronic kidney disease-mineral and bone disorder (CKD- ... phosphate binders such as calcium carbonate, calcium acetate, sevelamer hydrochloride or carbonate, lanthanum carbonate, ...
Chronic kidney disease
Changes in mineral and bone metabolism that may cause 1) abnormalities of calcium, phosphorus (phosphate), parathyroid hormone ... CKD-mineral and bone disorders have been associated with poor outcomes. Metabolic acidosis may result from decreased capacity ... or vitamin D metabolism; 2) abnormalities in bone turnover, mineralization, volume, linear growth, or strength (kidney ...
Stanozolol
... gastrointestinal disorders resulting in alterations of normal metabolism; use during pre-operative and postoperative periods in ... Equal or greater consideration should be given to diet, calcium balance, physiotherapy, and good general health promoting ... Because of the presence of its 17α-methyl group, the metabolism of stanozolol is sterically hindered, resulting in it being ... 1455-. ISBN 978-0-08-053960-7. Androgenic compounds rendered resistant to gastrointestinal and liver metabolism by containing ...
Parathyroid hormone
Additional screens performed: - In-depth immunological phenotyping Disorders of calcium metabolism Parathyroid hormone family ... Hormonal Control of Calcium & Phosphate Metabolism & the Physiology of Bone". In Barrett KE, Barman SM, Boitano S, Brooks H ( ... PTH, Intact and Calcium Test Detail. Quest Diagnostics Lab. Accessed 2019-06-29. Parathyroid Hormone (PTH) Plus Calcium. ... The main determinant of the amount of calcium excreted into the urine per day is the plasma ionized calcium concentration ...
Hypercalcaemia
Calcium metabolism Dent's disease Electrolyte disturbance Disorders of calcium metabolism Minisola, S; Pepe, J; Piemonte, S; ... controversy around the usefulness of corrected calcium as it may be no better than total calcium. Once calcium is confirmed to ... glucocorticoids increase urinary calcium excretion and decrease intestinal calcium absorption no effect on calcium level in ... Calcium deposits known as limbus sign may be visible in the eyes. Symptoms are more common at high calcium blood values (12.0 ...
Hillel Abbe Shapiro
But his initial research was into amphibian metabolism, with his Ph.D. awarded in 1933 for 'Studies in the calcium metabolism ... 1981). Rehabilitation: including the role of disease, disorder and disability : the College of Medicine of South Africa Third ... Shapiro, H. A (1933). Studies in the calcium metabolism of the amphibian (Thesis). Place of publication not identified: [ ... guide 1 for Mju 400-K Studies in the calcium metabolism of the amphibian Symposium on enavid The frog pregnancy test : the ...
Calcilytic
Clinical Endocrinology & Metabolism. 27 (3): 373-84. doi:10.1016/j.beem.2013.02.008. PMID 23856266. Kim JY, Ho H, Kim N, Liu J ... However, long term use of these causes resorption, degrading the bone to raise blood calcium. Consequently, these drugs have ... Nemeth EF, Shoback D (June 2013). "Calcimimetic and calcilytic drugs for treating bone and mineral-related disorders". Best ... April 2015). "Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma". ...
Zoledronic acid
Monitoring for other mineral metabolism disorders and the avoidance of invasive dental procedures for those who develop ... These include osteoporosis, high blood calcium due to cancer, bone breakdown due to cancer, Paget's disease of bone and ... Serious side effects may include kidney problems, low blood calcium, and osteonecrosis of the jaw. Use during pregnancy may ... Appropriate hydration is important before administration, as is adequate calcium and vitamin D intake before Aclasta therapy in ...
Osteoporosis
In addition to estrogen, calcium metabolism plays a significant role in bone turnover, and deficiency of calcium and vitamin D ... due to decreased absorption of calcium in the stomach. Many diseases and disorders have been associated with osteoporosis. For ... In Parkinson's disease there may be a link between the loss of dopaminergic neurons and altered calcium metabolism (and iron ... Those with an otherwise adequate calcium intake can develop osteoporosis due to the inability to absorb calcium and/or vitamin ...
Chief cell
PTH plays an important role in regulating blood calcium levels by raising the amount of calcium in the blood. Parathyroid ... BMC Endocrine Disorders. 7: 8. doi:10.1186/1472-6823-7-8. PMC 2099428. PMID 17916247. Khan, AR; James, MN (Apr 1998). " ... Clinical Cases in Mineral and Bone Metabolism. 7 (3): 207-240. PMC 3213842. Costa-Guda, J; Tokura, T; Roth, SI; Arnold, A (Oct ... 2010). "P12 - PTHC1: A Continuing Cell Line Expressing PTH and Genes Involved in Calcium Homeostasis". ...
Phosphate diabetes
... leading to a deficiency of phosphate in the body and disrupting the full calcium-phosphate metabolism process. A common symptom ... Thus, this disorder most often occurs in females. While phosphate diabetes is typically inherited through X-linked dominant ... In addition, increased levels of FGF23 would affect vitamin D metabolism and inhibit the action of vitamin D. Vitamin D needs ... Phosphate diabetes that results from mutations in the PHEX gene is an X-linked dominant disorder, where the mutated gene is ...
Colony collapse disorder
"The authors recommended a diet containing 1000 ppm potassium, 500 ppm calcium, 300 ppm magnesium and 50 ppm each of sodium, ... found that bees fed high-fructose corn syrup or sugar shows downregulation in several genes related to protein metabolism and ... "Colony Collapse Disorder Action Plan" (PDF). USDA. 20 June 2007. "CCD Steering Committee, Colony Collapse Disorder Progress ... US EPA (29 August 2013). "Colony Collapse Disorder". US EPA. Retrieved 10 December 2018. "Colony Collapse Disorder". sfyl.ifas. ...
Agouti-signaling protein
The increase in appetite is coupled to alterations in nutrient metabolism due to the paracrine actions of agouti on adipose ... Hyperinsulinemia is caused by mutations to agouti, as the agouti protein functions in a calcium dependent manner to increase ... while certain polymorphisms of AgRP have been linked to eating disorders like anorexia nervosa. The mechanism underlying ... AgRP acts as an appetite stimulator and increases appetite while decreasing metabolism. Because of these mechanisms, AgRP may ...
Calcitonin
Disorders of the Parathyroid Gland and Calcium Homeostasis". In Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser SL, Loscalzo ... The hormone participates in calcium (Ca2+) metabolism. In many ways, calcitonin counteracts parathyroid hormone (PTH) and ... In its skeleton-preserving actions, calcitonin protects against calcium loss from the skeleton during periods of calcium ... Calcitonin lowers blood calcium and phosphorus mainly through its inhibition of osteoclasts. Osteoblasts do not have calcitonin ...
Sestamibi parathyroid scan
Rosen, Clifford J. (2008-11-18). Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism. John Wiley and Sons ... especially because of the internal biofeedback loop within the body with calcium inherently feeding back to calcium-receptors ... The remaining three glands are able to properly regulate serum calcium levels appropriately after the resolution of the ... hypercalcemia, as the calcium receptors lead to stimulation of parathyroid hormone secretion.[citation needed] "Parathyroid ...
Clevidipine
... rare genetic disorders characterized by abnormal triglyceride metabolism), lipoid nephrosis, or acute pancreatitis if it is ... Dihydropyridine calcium channel blockers can produce negative inotropic effects and exacerbate heart failure. Heart failure ... Clevidipine (INN, trade name Cleviprex) is a dihydropyridine calcium channel blocker indicated for the reduction of blood ... Clevidipine is a dihydropyridine L-type calcium channel blocker, highly selective for vascular, as opposed to myocardial, ...