Betaine-homocysteine S-methyltransferase
In the field of enzymology, a betaine-homocysteine S-methyltransferase also known as betaine-homocysteine methyltransferase ( ... "Betaine-homocysteine S-methyltransferase-2 is an S-methylmethionine-homocysteine methyltransferase". J. Biol. Chem. 283 (14): ... Pajares MA, Pérez-Sala D (December 2006). "Betaine homocysteine S-methyltransferase: just a regulator of homocysteine ... Betaine+Homocysteine+Methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) EC 2.1.1.5 ...
Autophagy
The degradation of betaine homocysteine methyltransferase (BHMT), a metabolic enzyme, could be used to assess autophagy flux in ...
Methionine
... this step is performed by homocysteine methyltransferase or betaine-homocysteine S-methyltransferase.) Although mammals cannot ... Homocysteine can also be remethylated using glycine betaine (N,N,N-trimethylglycine, TMG) to methionine via the enzyme betaine- ... homocysteine methyltransferase (E.C.2.1.1.5, BHMT). BHMT makes up to 1.5% of all the soluble protein of the liver, and recent ... If homocysteine is produced, the thiol group is methylated, yielding methionine. Two methionine synthases are known; one is ...
Methylenetetrahydrofolate reductase
... that homocysteine can also be converted to methionine by the folate-independent enzyme betaine-homocysteine methyltransferase ( ... 677TT (but not 677CC/CT) individuals with lower plasma folate levels are at risk for elevated plasma homocysteine levels. In ... It does not result in thermolabile MTHFR and does not appear to affect homocysteine levels. It does, however, affect the ... 5-Methyltetrahydrofolate is used to convert homocysteine (a potentially toxic amino acid) to methionine by the enzyme ...
ATR-X syndrome
... and 2-BHMT2 encodes for betaine-homocysteine methyltransferase, which catalyzes the methylation of homocysteine. ATR ...
List of EC numbers (EC 2)
... betaine-homocysteine S-methyltransferase EC 2.1.1.6: catechol O-methyltransferase EC 2.1.1.7: nicotinate N-methyltransferase EC ... EC 2.1.1.1: nicotinamide N-methyltransferase EC 2.1.1.2: guanidinoacetate N-methyltransferase EC 2.1.1.3: thetin-homocysteine S ... 2.1.1.8: histamine N-methyltransferase EC 2.1.1.9: thiol S-methyltransferase EC 2.1.1.10: homocysteine S-methyltransferase EC ... NNS virus cap methyltransferase EC 2.1.1.376: glycine betaine-corrinoid protein Co-methyltransferase EC 2.1.1.377: [methyl-Co( ...
List of MeSH codes (D08)
... betaine-homocysteine S-methyltransferase MeSH D08.811.913.555.500.250 - catechol O-methyltransferase MeSH D08.811.913.555. ... homocysteine S-methyltransferase MeSH D08.811.913.555.500.645 - 5-methyltetrahydrofolate-homocysteine s-methyltransferase MeSH ... histone-lysine n-methyltransferase MeSH D08.811.913.555.500.800.650 - o-6-methylguanine-DNA methyltransferase MeSH D08.811. ... protein o-methyltransferase MeSH D08.811.913.555.500.800.800.700 - protein d-aspartate-l-isoaspartate methyltransferase MeSH ...
Amino acid synthesis
... this step is performed by homocysteine methyltransferase or betaine-homocysteine S-methyltransferase.) Methionine biosynthesis ... Homocysteine is a coactivator of glyA and must act in concert with MetR. On the other hand, PurR, a protein which plays a role ... Plamann MD, Stauffer GV (1989). "Regulation of the Escherichia coli glyA gene by the metR gene product and homocysteine". J. ... The methionine gene product MetR and the methionine intermediate homocysteine are known to positively regulate glyA. ...
Methionine synthase
Methyltransferase Arakawa's syndrome II Betaine-homocysteine S-methyltransferase GRCh38: Ensembl release 89: ENSG00000116984 - ... "MTR 5-methyltetrahydrofolate-homocysteine methyltransferase (Homo sapiens)". Entrez. 19 May 2009. Retrieved 24 May 2009. Li YN ... In humans it is encoded by the MTR gene (5-methyltetrahydrofolate-homocysteine methyltransferase). Methionine synthase forms ... EC 2.1.1.13 5-Methyltetrahydrofolate-Homocysteine+S-Methyltransferase at the U.S. National Library of Medicine Medical Subject ...
Trimethylglycine
The second pathway (restricted to liver and kidney in most mammals) involves betaine-homocysteine methyltransferase (BHMT) and ... Trimethylglycine is also used as the hydrochloride salt (marketed as betaine hydrochloride or betaine HCl). Betaine ... Betaine aldehyde is further oxidised in the mitochondria in mice to betaine by the enzyme betaine-aldehyde dehydrogenase (EC ... When insufficient betaine is available, elevated homocysteine levels and decreased SAM levels in blood occur. Supplementation ...
Dimethylglycine N-methyltransferase
S-adenosyl-L-homocysteine + betaine This enzyme is purified from the marine cyanobacterium Synechococcus sp. WH8102. Lu WD, Chi ... WH8102 and characterization of its N-methyltransferase genes involved in betaine synthesis". Archives of Microbiology. 186 (6 ... N-dimethylglycine N-methyltransferase (betaine-forming). This enzyme catalyses the following chemical reaction S-adenosyl-L- ... Dimethylglycine N-methyltransferase (EC 2.1.1.161, BsmB, DMT) is an enzyme with systematic name S-adenosyl-L-methionine:N, ...
Diet and cancer
SAM is the substrate for methylation reactions catalyzed by DNA, RNA and protein methyltransferases. The products of these ... choline and betaine found in beef, eggs and some vegetables). Assimilated methionine is transformed in S-adenosyl methionine ( ... and homocysteine: correlations with diet". Cancer Epidemiology, Biomarkers & Prevention. 10 (6): 649-655. PMID 11401915. Prinz- ... SAH has a negative feedback on its own production as an inhibitor of methyltransferase enzymes. Therefore, SAM:SAH ratio ...
S-Methylmethionine
McNeil SD (1999). "Betaines and related osmoprotectants. Targets for metabolic engineering of stress resistance". Plant ... It is biosynthesized from L-methionine and S-adenosylmethionine by the enzyme methionine S-methyltransferase. S- ... The coproduct is S-adenosyl homocysteine. The biological roles of S-methylmethionine are not well understood. Speculated roles ... "S-methylmethionine plays a major role in phloem sulfur transport and is synthesized by a novel type of methyltransferase". The ...
Glycocyamine
The simultaneous intake of methyl providing substances such as betaine appears advisable because of the risk of homocysteine ... glycocyamine is methylated to creatine with S-adenosyl methionine by the enzyme guanidinoacetate N-methyltransferase (GAMT). ... Betaine can provide a methyl group to glycocyamine, via methionine, for the formation of creatine. In overall, such treatment ... This causes homocysteine levels to rise, which has been shown to produce cardiovascular and skeletal problems.[citation needed ...
Choline
... synthesis of choline and glycine betaine in transgenic tobacco plants that overexpress phosphoethanolamine N-methyltransferase ... The source of the methyl group is S-adenosyl-L-methionine and S-adenosyl-L-homocysteine is generated as a side product. In ... Choline and folate, interacting with vitamin B12, act as methyl donors to homocysteine to form methionine, which can then go on ... It also works as a substrate for the BHMT-enzyme, which methylates homocysteine to methionine. This is a S-adenosylmethionine ( ...