"Functional link between BLM defective in Bloom's syndrome and the ataxia-telangiectasia-mutated protein, ATM". J. Biol. Chem. ... Bloom syndrome protein is a protein that in humans is encoded by the BLM gene and is not expressed in Bloom syndrome. The Bloom ... "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. ... "Replication protein A physically interacts with the Bloom's syndrome protein and stimulates its helicase activity". J. Biol. ...

... the ataxia telangiectasia mutated ATM kinase, and 53BP1. Because Artemis can remove damaged ends from DNA, it has been proposed ... "Protein Knowledgebase: Gene DCLRE1C - DNA cross-link repair 1C protein (Protein artemis)". Retrieved June 2, 2011. de Villartay ... "Endogenously induced DNA double strand breaks arise in heterochromatic DNA regions and require ataxia telangiectasia mutated ... Artemis is a protein that in humans is encoded by the DCLRE1C (DNA cross-link repair 1C) gene. Artemis is a nuclear protein ...

Alpha-synuclein activates ATM (ataxia-telangiectasia mutated), a major DNA damage repair signaling kinase. Alpha-synuclein ... the genes coding PINK1 and Parkin are thought to be mutated so as to impair the ability of these proteins to breakdown ... that heat-shock proteins, which assist in refolding proteins susceptible to aggregation, beneficially affect PD when ... The protein alpha-synuclein has increased presence in the brains of Parkinson's Disease patients and, as α-synuclein is ...

At a DSB, MRE11-RAD50-NBS1 (MRN) protein complex recruits ataxia telangiectasia mutated (ATM) kinase which phosphorylates ... HMGA2 protein specifically targets the promoter of ERCC1, thus reducing expression of this DNA repair gene. ERCC1 protein ... HGMA proteins are polypeptides of ~100 amino acid residues characterized by a modular sequence organization. These proteins ... April 2003). "Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in ...

Alpha-synuclein activates ataxia telangiectasia mutated, a major DNA damage-repair signaling kinase. In addition, alpha- ... At the same time, regimens for PD restrict proteins during breakfast and lunch, allowing protein intake in the evening. PD ... Alpha-synuclein, a protein encoded by SNCA gene mutations, is the main component of the Lewy bodies that accumulate in the ... Levodopa and proteins use the same transportation system in the intestine and the blood-brain barrier, thereby competing for ...

... protein and the ATM (ataxia telangiectasia mutated) protein. ATM is thought to be a master controller of cell cycle checkpoint ... BRCA1-associated ATM activator 1 is a protein in humans that is encoded by the BRAT1 gene. The protein encoded by this ... The protein encoded by this gene is thought to play a role in the DNA damage pathway regulated by BRCA1 and ATM. GRCh38: ... Human proteins, All stub articles, Human chromosome 7 gene stubs). ...

It is composed of ataxia telangiectasia mutated (ATM), ataxia telangiectasia and Rad3 related (ATR), DNA-dependent protein ... Many of these functions relate to the ability of class I PI3Ks to activate protein kinase B (PKB, aka Akt) as in the PI3K/AKT/ ... The class IA PI3K p110α is mutated in many cancers. Many of these mutations cause the kinase to be more active. It is the ... Many other proteins have been identified that are regulated by PtdIns(3,4,5)P3, including Bruton's tyrosine kinase (BTK), ...

Ataxia telangiectasia mutated, BARD1, BRCA1, BRCA2, BRCC3, BRE, Bloom syndrome protein, DMC1, RAD54, P53 RAD52, RAD54B, and ... DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the ... This protein can interact with the ssDNA-binding protein RPA, BRCA2, PALB2 and RAD52. The structural basis for Rad51 filament ... Seitz EM, Brockman JP, Sandler SJ, Clark AJ, Kowalczykowski SC (May 1998). "RadA protein is an archaeal RecA protein homolog ...

... protein and ATM (ataxia-telangiectasia mutated) serine/threonine kinase weakens with age in oocytes of numerous species ...

Ataxia telangiectasia mutated) and ATR (Ataxia- and Rad-related) kinases, whose sequence and functions have been well conserved ... In E. coli , the proteins involved are the Mut class proteins: MutS, MutL, and MutH. In most Eukaryotes, the analog for MutS is ... These proteins seem to be required for transmitting the checkpoint activation signal to downstream proteins. DNA damage ... Checkpoint Proteins can be separated into four groups: phosphatidylinositol 3-kinase (PI3K)-like protein kinase, proliferating ...

Ataxia telangiectasia mutated) and ATR (Ataxia telangiectasia and Rad3 related), and the microtubule-binding protein XMAP215/ ... a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in ... DNA-dependent protein kinase) Fanconi anemia responsible protein FANCF (FANCF) Damaged DNA-binding protein AlkD (Alkylpurin DNA ... The nuclear transport protein importin beta contains 19 HEAT repeats. Representative examples of HEAT repeat proteins include ...

Ataxia telangiectasia mutated (ATM) Ataxia telangiectasia and Rad3 related (ATR) 5' AMP-activated protein kinase (AMPK) RAF ... 5' adenosine-monophosphate-activated protein kinase (AMPK) has also been found to be an effector for RHEB. AMPK is a protein ... The protein is a lipid-anchored, cell-membrane protein with five repeats of the RAS-related GTP-binding region. Also present ... encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)". The ...

... encoding protein Adp-ribosyltransferase 5 ASRGL1: encoding enzyme L-asparaginase ATM: ataxia telangiectasia mutated (includes ... encoding protein Uncharacterized protein C11orf16 C11orf49: encoding protein UPF0705 protein C11orf49 C11orf52 encoding protein ... encoding protein Acrosomal protein SP-10 AKIP1: A kinase interacting protein 1 ALKBH3 encoding protein AlkB homolog 3, alpha- ... encoding protein C1q and tumor necrosis factor related protein 5 CAPRIN1: encoding protein, cell cycle associated protein 1 ...

... and ataxia telangiectasia-mutated (ATM) most involved in repairing DSBs to the more versatile Rad3-related (ATR). ATR is ... Proteins such as "damage-up" proteins (DDPs) can promote endogenous DNA lesions by either increasing the amount of reactive ... Next, further protein-protein interactions and posttranslational modifications (PTMs) complete the kinase activation, and a ... These three DDR kinases all recognize damage via protein-protein interactions which localize the kinases to the areas of damage ...

... protein kinase C (PKC), ataxia telangiectasia mutated kinase (ATM), cyclin-dependent kinase 5 (CDK5), and casein kinase 1 (CK1 ... "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2017-05-07. "Human BLAT ... "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2017-05-06. (All articles ... The relatively fast rate of change in LENG9 compared to that of other proteins suggests that the gene is adaptive for vital ...

A similar mechanism involves the ataxia telangiectasia mutated (ATM) serine/threonine kinase which is an enzyme involved in the ... The NF- κB proteins interact with IκB inhibitory proteins, but during oxidative stress IκB proteins are degraded in the cell. ... The loss of IκB proteins for NF- κB proteins to bind to results in NF- κB proteins entering the nucleus to bind to specific ... The production of ROS in high quantity in cells results in the degradation of biomolecules such as proteins, DNA, and RNA. In ...

Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK (May 2001). "Ataxia telangiectasia mutated (ATM) kinase and ATM and ... Chen J (September 2000). "Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following ... A mutated BRCA1 gene usually makes a protein that does not function properly. Researchers believe that the defective BRCA1 ... A protein called valosin-containing protein (VCP, also known as p97) plays a role to recruit BRCA1 to the damaged DNA sites. ...

Serine/threonine-protein kinase ATR, also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein ... Gatei M, Zhou BB, Hobson K, Scott S, Young D, Khanna KK (May 2001). "Ataxia telangiectasia mutated (ATM) kinase and ATM and ... Ataxia telangiectasia and Rad3-related protein has been shown to interact with: BRCA1, CHD4, HDAC2, MSH2, P53 RAD17, and RHEB. ... Chen J (September 2000). "Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following ...

... has been shown to interact with Mdm2 and Ataxia telangiectasia mutated. Abnormalities in this gene are one of the causes ... "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in ... "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". ... The gene encoding the RRM2B protein is located on chromosome 8, at position 8q23.1. The gene and its products are also known by ...

... a protein), MAPRE2 (Microtubule-associated protein RP/EB, a protein), ATM (Ataxia telangiectasia mutated, a protein kinase), ... TERF1 has been shown to interact with: Abl gene, Ataxia telangiectasia mutated, MAPRE1, NME1, PINX1 SALL1, TINF2, TNKS2, and ... the protein has other functions. These functions include the binding of the protein, facilitation in the activity of protein ... The protein has the ultimate use of functioning as an inhibitor of telomerase, a protein enzyme that assists in the elongation ...

In the presence of ionizing radiation (IR), the Smc1 subunit of cohesin is phosphorylated by the ataxia telangiectasia mutated ... This alternative form is composed of core RFC proteins RFC2, RFC3, RFC4, and RFC5, but replaces the RFC1 protein with cohesion ... SMC1ß, REC8 and STAG3 are meiosis specific cohesin proteins. The STAG3 protein is essential for female meiosis and fertility. ... The cohesin ring is composed of two SMC (structural maintenance of chromosomes) proteins and two additional Scc proteins. ...

... has been shown to interact with: Ataxia telangiectasia mutated, BRCA1, H2AFX, MRE11A, Rad50, and TERF2 GRCh38: Ensembl ... Nibrin, also known as NBN or NBS1, is a protein which in humans is encoded by the NBN gene. Nibrin is a protein associated with ... The central role is carried out by ataxia telangiectasia mutated (ATM) by activating the DSB signaling cascade, phosphorylating ... ICP8, which is a viral single-strand binding protein, is known to interact with several DNA repair proteins, such as Rad50, ...

December 1999). "The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like ... By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 ... In this organism the Mre11 protein interacts with the Rad50 protein and appears to have an active role in the repair of DNA ... Double-strand break repair protein MRE11 is an enzyme that in humans is encoded by the MRE11 gene. The gene has been designated ...

Ataxia telangiectasia mutated (ATM) is a kinase that (similar to mTOR) can phosphorylate KAP1 resulting in the switch from ... KRAB-associated protein-1), is a protein that in humans is encoded by the TRIM28 gene. The protein encoded by this gene ... The protein localizes to the nucleus and is thought to associate with specific chromatin regions. The protein is a member of ... "KAP-1 corepressor protein interacts and colocalizes with heterochromatic and euchromatic HP1 proteins: a potential role for ...

... has been shown to interact with: Ataxia telangiectasia and Rad3 related, Ataxia telangiectasia mutated, HUS1, NHP2L1, ... Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene. The protein encoded by this gene ... This protein binds to chromatin prior to DNA damage and is phosphorylated by ATR after the damage. This protein recruits the ... March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human ...

Ataxia telangiectasia mutated (ATM) activates after a larger amount of DSBs is detected at later stages of DNA re-replication. ... Once bound to chromatin the ORC recruits the AAA+ ATPase Cdc6 and the coiled-coil domain protein Cdt1. Cdt1 binding and the ... Ataxia telangiectasia and Rad3 related (ATR) is activated earlier when it detects ssDNA in the earlier phases of DNA re- ... Replication initiation proteins are overexpressed in tissue samples from several types of human cancers and experimental ...

DNA damage repair Ataxia-telangiectasia mutated and RAD3-related (ATR) BRCA1 DNA replication Chromatin bridges Topoisomerase II ... Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using ... DNA damage repair is initiated and maintained by two kinases, ataxia-telangiectasia mutated (ATM) and ATR, with ATR proving to ... ataxia-telangiectasia mutated and RAD3-related (ATR). It also plays a critical role in DNA replication initiation and ...

... increased phosphorylation of ataxia telangiectasia mutated (ATM), checkpoint kinase 1 (Chk 1), Chk 2; and reduced cell division ... causing oxidized protein levels to increase. This led researchers to conclude that oxidation of cellular proteins is ... as well as inhibiting pore-destabilizing proteins (Bcl-2-associated X protein, Bcl-2 homologous antagonist/killer). The ... The altered protein expression in neurons, controlled in part by ROS-dependent demethylation of CpG sites in gene promoters ...

April 2000). "Caffeine abolishes the mammalian G(2)/M DNA damage checkpoint by inhibiting ataxia-telangiectasia-mutated kinase ... The CHEK2 protein encoded by the CHEK2 gene is a serine threonine kinase. The protein consists of 543 amino acids and the ... Furthermore, the CHK2 protein interacts with several other proteins including p53 (p53). Stabilization of p53 by CHK2 leads to ... ataxia-telangiectasia and Rad3 related) kinase that responds primarily to single-strand breaks. In mice, CHEK2 is essential for ...

The presence of DNA damage triggers the ATM (Ataxia telangiectasia mutated) or ATR (Ataxia Telangiectasia and Rad3 related) ... The cell cycle is driven by proteins called cyclin dependent kinases that associate with cyclin regulatory proteins at ... One such protein is rad18 that is required for G2 arrest even when Chk1 is phosphorylated and active. Thus, rad18 is required ... Proteins that localize to sites of DNA damage in the G2 phase initiate a signaling cascade that regulates important components ...