... or aspartokinase (AK) is an enzyme that catalyzes the phosphorylation of the amino acid aspartate. This ... Viola RE (May 2001). "The central enzymes of the aspartate family of amino acid biosynthesis". Accounts of Chemical Research. ... "aspartate family". Aspartokinases are present only in microorganisms and plants, but not in animals, which must obtain ... aspartate-family amino acids from their diet. Consequently, methionine, lysine and threonine are essential amino acids in ...

... allosterically inhibits aspartate kinase and glutamate dehydrogenase. Glutamate dehydrogenase reversibly converts ... Threonine acts as another allosteric inhibitor of aspartate kinase and homoserine dehydrogenase, but it is a competitive ... Homoserine is produced from aspartate via aspartate-4-semialdehyde, which is produced from β-phosphoaspartate. By the action of ... and the aspartate metabolic pathway. It forms by two reductions of aspartic acid via the intermediacy of aspartate semialdehyde ...

It is found in protein kinases with various specificities, including the aspartate, glutamate and uridylate kinase families. In ... The lysine-sensitive isoenzyme of aspartate kinase from spinach leaves has a subunit composition of 4 large and 4 small ... The conversion of aspartate into either the storage amino acid asparagine or aspartate family amino acids may be subject to a ... Kochhar S, Kochhar VK, Sane PV (April 1998). "Subunit structure of lysine sensitive aspartate kinase from spinach leaves". ...

The alanine aminotransferase, aspartate aminotransferase and creatine kinase levels may be raised. The gamma- ...

At night, aspartate is converted to asparagine for storage. Additionally, the aspartate kinase-homoserine dehydrogenase gene is ... Homoserine dehydrogenase and aspartate kinase are both subject to significant regulation (refer to figure 3). HSD is inhibited ... The AK-HSD gene codes for aspartate kinase, an intermediate domain (coding for the linker region between the two enzymes in the ... Threonine acts as a competitive inhibitor for both HSD and aspartate kinase. In AK-HSD expressing organisms, one of the ...

The ACT domain is named after three of the proteins that contain it: aspartate kinase, chorismate mutase and TyrA. The ...

Dardick C, Schwessinger B, Ronald P (August 2012). "Non-arginine-aspartate (non-RD) kinases are associated with innate immune ... NODs transduce signals in the pathway of NF-κB and MAP kinases via the serine-threonine kinase called RIP2. NODs signal via N- ... Some IRAK and RIP family kinases fall into a small functional class of kinases termed non-RD, many of which do not ... revealed that despite the small number of non-RD kinases in these genomes (9%-29%), 12 of 15 kinases known or predicted to ...

... aspartokinase β-aspartate semialdehyde dehydrogenase homoserine dehydrogenase homoserine kinase threonine synthase. Threonine ... Threonine is synthesized from aspartate in bacteria such as E. coli. It is encoded by all the codons starting AC (ACU, ACC, ACA ... In many organisms it is O-phosphorylated by a kinase preparatory to further metabolism. This is especially important in ... In addition, threonine residues undergo phosphorylation through the action of a threonine kinase. In its phosphorylated form, ...

"Evidence for direct protein kinase-C mediated modulation of N-methyl-D-aspartate receptor current". Mol. Pharmacol. 59 (5): 960 ... The enzyme belongs to the serine/threonine protein kinase family and to the Ca2+/calmodulin-dependent protein kinase subfamily ... "Entrez Gene: CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta". Walikonis RS, Oguni A, Khorosheva EM, ... of a phosphorylation site for calcium/calmodulindependent protein kinase II in the NR2B subunit of the N-methyl-D-aspartate ...

Kobashi N, Nishiyama M, Tanokura M (March 1999). "Aspartate kinase-independent lysine synthesis in an extremely thermophilic ... catalysed condensation reaction between the aspartate derived, L-aspartate semialdehyde, and pyruvate to form (4S)-4-hydroxy-2, ... The DAP pathway is regulated at multiple levels, including upstream at the enzymes involved in aspartate processing as well as ... The diaminopimelate (DAP) pathway belongs to the aspartate derived biosynthetic family, which is also involved in the synthesis ...

Signs of overdose include panting, trembling, vomiting, and diarrhea, as well as increased blood levels of creatinine kinase, ... aspartate transaminase, and alanine transaminase. Dogs who received atipamezole without first receiving dexmedetomidine have ...

The activities of the enzymes creatine kinase (CK) and aspartate aminotransferase (AST) are elevated due to the death of muscle ...

Blood tests such as Creatine Kinase Concentration (CK), Aspartate Transaminase Levels (AST), and/or Lactate Dehydrogenase (LDH ...

fraD encodes the sugar kinase FraD that phosphorylates F-Asp into 6-phosphofuctose-aspartate (6-P-F-Asp). It is unusual in that ... fraB functions as a deglycase that cleaves 6-P-F-Asp into glucose-6-phosphate (G-6-P) and aspartate. Mutants lacking fraD or ... This fra locus has five genes: fraR (a regulator), fraB a fructose-asparagine deglycase, fraD a sugar kinase, fraA a fructose- ... Notably, mutations in fraB cause the buildup of the toxic intermediate 6-phosphofuctose-aspartate (6-P-F-Asp). The buildup of 6 ...

... generally on an aspartate residue, by a transmembrane kinase. Some proteins that belong to this category are: Rhizobiaceae fixJ ...

... the relative levels of creatine kinase, aldolase, aspartate aminotransferase, alanine aminotransferase, and lactate ...

... aspartate kinase, work carried out during a period in the laboratory of Georges Cohen in France and, most notably, glutamine ...

In phosphorelays, the "hybrid" histidine kinase contains an internal aspartate-containing receiver domain to which the ... to an aspartate on a final response regulator. In orthodox two-component signaling, a histidine kinase protein ... In some cases, a phosphorelay system is constructed from four separate proteins rather than a hybrid histidine kinase with an ... In bacteria, where two-component signaling is extremely common, about 25% of known histidine kinases are of the hybrid type. ...

... the phosphotransfer from the kinase to an aspartate of the response regulator, and (with bifunctional enzymes) the ... The kinase core has a unique fold, distinct from that of the Ser/Thr/Tyr kinase superfamily. HKs can be roughly divided into ... Histidine kinases usually have an N-terminal ligand-binding domain and a C-terminal kinase domain, but other domains may also ... Not all orthodox kinases are membrane bound, e.g., the nitrogen regulatory kinase NtrB (GlnL) is a soluble cytoplasmic HK. ...

Aspartate kinase becomes downregulated by the presence of threonine or lysine. Lysine is synthesized from aspartate via the ... The formation of aspartate kinase (AK), which catalyzes the phosphorylation of aspartate and initiates its conversion into ... The synthesis of aspartate kinase (AK), which catalyzes the phosphorylation of aspartate and initiates its conversion into ... The aspartate pathway uses L-aspartic acid as the precursor for the biosynthesis of one fourth of the building block amino ...

... methyl-d-aspartate/extracellular signal-regulated kinase/mitogen- and stress-activated kinase signalling pathway". European ...

The cytoplasmic domain has a juxtamembrane domain and tyrosine kinase domain that is interrupted by a kinase insert domain. At ... aspartate aminotransferase, alanine transaminase), edema, nausea, lacrimation, and reduced appetite, but no signs of liver ... CSF1R, the protein encoded by the CSF1R gene is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor ... Courtneidge SA, Dhand R, Pilat D, Twamley GM, Waterfield MD, Roussel MF (March 1993). "Activation of Src family kinases by ...

Aspartate 145 also changes position. Together these structural changes allow ATP phosphates to bind correctly. When CAK ... Lolli G, Johnson LN (April 2005). "CAK-Cyclin-dependent Activating Kinase: a key kinase in cell cycle control and a target for ... The active site of Cdk2 lies in a cleft between the two lobes of the kinase. ATP binds deep within the cleft and its phosphate ... CDK-activating kinase (CAK) activates the cyclin-CDK complex by phosphorylating threonine residue 160 in the CDK activation ...

"Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... DLG3 is a member of the membrane-associated guanylate kinase (MAGUK) superfamily of proteins. DLG3 has been shown to interact ... 1996). "Interaction of the N-methyl-D-aspartate receptor complex with a novel synapse-associated protein, SAP102". J. Biol. ... 1999). "Interaction of NE-dlg/SAP102, a neuronal and endocrine tissue-specific membrane-associated guanylate kinase protein, ...

"Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... "Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions". Nature. 376 (6543 ... Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene. This gene encodes a cytoplasmic ... "Entrez Gene: PTK2B PTK2B protein tyrosine kinase 2 beta". Soni D, Regmi SC, Wang DM, DebRoy A, Zhao YY, Vogel SM, Malik AB, ...

"Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... Choi J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E (April 2002). "Phosphorylation of stargazin by protein kinase A regulates ... PSD-95 is a member of the membrane-associated guanylate kinase (MAGUK) family. With PSD-93 it is recruited into the same NMDA ... The GUK domain that they have is structurally very similar to that of the guanylate kinases, however it is known to be ...

"Interaction of the tyrosine kinase Pyk2 with the N-methyl-D-aspartate receptor complex via the Src homology 3 domains of PSD-95 ... N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved ... June 1997). "DAP-1, a novel protein that interacts with the guanylate kinase-like domains of hDLG and PSD-95". Genes to Cells. ... "Entrez Gene: GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A". Hamza TH, Chen H, Hill-Burns EM, Rhodes SL, ...

"Protein kinase C activation modulates alpha-calmodulin kinase II binding to NR2A subunit of N-methyl-D-aspartate receptor ...

"Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate ... Ripellino JA, Neve RL, Howe JR (1998). "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor ... Barria A, Derkach V, Soderling T (1998). "Identification of the Ca2+/calmodulin-dependent protein kinase II regulatory ...

"Identification of a Ca2+/calmodulin-dependent protein kinase II regulatory phosphorylation site in non-N-methyl-D-aspartate ... "Entrez Gene: CAMK2G calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma". Moyers JS, Bilan PJ, Zhu J, Kahn CR ( ... "Phosphorylation of smooth myosin light chain kinase by smooth muscle Ca2+/calmodulin-dependent multifunctional protein kinase ... Calcium/calmodulin-dependent protein kinase type II gamma chain is an enzyme that in humans is encoded by the CAMK2G gene. The ...