... armadillo (ARM) GUK and LIM domains, which mediate specific protein-protein binding. The literature-based adhesome contains ... Protein domains enriched in the adhesome include: Pleckstrin homology (PH) and FERM domains, which target proteins to the ... examined the effect of inhibition of myosin contractility on the integrin adhesome composition and found LIM domain proteins ... The adhesome contains multi domain proteins with various functions, some of which are specifically enriched in the adhesome ...

Plakophilin proteins contain nine central, conserved armadillo repeat domains flanked by N-terminal and C-terminal domains. ... "Protein sequence of human PKP2 (Uniprot ID: Q99959-2)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 11 ... Plakophilin-2 is a member of the armadillo repeat and plakophilin protein family. ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ...

The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo repeats. Other proteins containing ... Armadillo repeat-containing X-linked protein 1 is a protein that in humans is encoded by the ARMCX1 gene. This gene encodes a ... Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed ... "Entrez Gene: ARMCX1 armadillo repeat containing, X-linked 1". Human ARMCX1 genome location and ARMCX1 gene details page in the ...

But, the armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important ... 4 Armadillo+Domain+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Armadillo/plakoglobin ARM ... Proteins that contain armadillo repeats typically contain several tandemly repeated copies. Each armadillo repeat is composed ... Examples of proteins that contain armadillo repeats include β-catenin, Sarm1 (SARM1), α-importin, plakoglobin, adenomatous ...

The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins ... Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene. This gene encodes a ... Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed ... Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally ...

... rho GTPase activating protein 21 ARID5B: encoding protein AT-rich interactive domain-containing protein 5B ARMH3: Armadillo ... encoding protein Transmembrane protein 26 TMEM72: encoding protein Transmembrane protein 72 TYSND1: encoding protein Trypsin ... WW domain binding protein 1-like ZNF37A: zinc finger protein 37A ZNF438: zinc finger protein 438 ZRANB1: Zinc finger ranbp2- ... plexin domain-containing protein 2 PRAP1: encoding protein Proline rich acidic protein 1 PROSER2: proline and serine rich 2 or ...

... rigid protein domain with an elongated shape - called armadillo (ARM) domain. An average armadillo repeat is composed of three ... DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as ... The first helices of the ARM domain form an additional, special protein-protein interaction pocket: This can accommodate a ...

A fifth TIR-domain-containing adaptor protein called Sterile α and HEAT (Armadillo motif) (SARM) is a TLR4 signaling pathway ... This TRIF-dependent pathway involves the recruitment of the adaptor proteins TIR-domain-containing adaptor inducing interferon- ... Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the ... Morphine causes inflammation by binding to the protein lymphocyte antigen 96, which, in turn, causes the protein to bind to ...

... encoding protein Ankyrin repeat domain-containing protein 24 ARMC6: encoding protein Armadillo repeat-containing protein 6 ... encoding protein Transmembrane Protein 205 UBXN6: encoding protein UBX domain protein 6 UCA1: a long non-coding RNA Urothelial ... encoding protein Transmembrane emp24 domain-containing protein 1 TMEM160: encoding protein Transmembrane protein 160 TMEM205: ... encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger ...

Several protein domains also form tandem repeats within their amino acid primary structure, such as armadillo repeats. However ... in proteins, perfect tandem repeats are unlikely in most in vivo proteins, and most known repeats are in proteins which have ... "Protein tandem repeats - the more perfect, the less structured". The FEBS Journal. 277 (12): 2673-82. doi:10.1111/j.1742- ... A combined method for the identification of tandem repeats in protein structures Tandem Repeats Finder Mreps STAR Splinter TRED ...

Armadillo repeats: named after the β-catenin-like Armadillo protein of the fruit fly Drosophila melanogaster. Basic leucine ... a biological database covering protein domains Pfam: database of protein domains Protein Protein structure Protein structure ... Protein domains, connected by intrinsically disordered flexible linker domains, induce long-range allostery via protein domain ... multi-domain proteins. Many domains in eukaryotic multidomain proteins can be found as independent proteins in prokaryotes, ...

... armadillo repeats, tetratricopeptide repeats, etc. Whenever a linear solenoid domain structure participates in protein-protein ... Solenoid protein domains are a highly modular type of protein domain. They consist of a chain of nearly identical folds, often ... While individual BRCT domains are found in certain proteins (e.g. some DNA ligases) binding DNA, these tandem BRCT domains ... Proteins that contain tandem repeats of ordinary domains are very common in eukaryotes. Even if these domains are perfectly ...

Evidence of two reserved ARM superfamily domains are shown in the TMCO6 protein. The ARM domain, Armadillo/ beta-catenin-like- ... "Transmembrane And Coiled-Coil Domain 6". GeneCards. "transmembrane and coiled-coil domain-containing protein 6 isoform 1 H - ... Function of the conserved ARM domain and SRP1 domains are known. The ARM domains play a role in mediating the interaction of ... Transmembrane and coiled-coil domain-containing protein". Protein - NCBI. Behnke J, Eskelinen EL, Saftig P, Schröder B (Mar ...

... or Armadillo Like Helical Domain Containing 3, also known as UPF0668 and c10orf76, is a protein that in humans is encoded ... These domains have been shown to participate in protein-protein binding interactions, specifically via the SH3 protein binding ... NCBI identifies a protein domain of unknown function between amino acids Asp435 and Leu671, known as DUF1741 (Domain of Unknown ... The locus is alternatively spliced and predicted to yield five protein variants, three of which contain a protein domain of ...

... gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence ... Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ARVCF gene. ... Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In ... Binding to PDZ-Domain Proteins and Cell-Cell Adhesion Regulate Plasma Membrane and Nuclear Localization of ARVCF". Mol Biol ...

... is a small protein consisting of three functionally distinct domains: the IBB domain, ARM domain, and exportin CAS ... and the targeted protein. The majority of the importin α protein is made up of a series of ten tandem armadillo, or ARM, ... The N-terminal region of the proteins consists of an importin-β-binding, or IBB, domain. This region of the protein is ... NLS binding to the ARM domain, and thereby the formation of the import complex, is regulated by the IBB domain of importin α. ...

... of the luminal domain and the transmembrane domain near the C-terminus. This effectively abrogates its function as a protein ... A similar variant is also reported in armadillo. So this is not a random mutation. The function of this truncated protein is ... The protein contains two hydrophobic transmembrane domains that help anchoring the molecule on the ER membrane, such that its ... It encodes a protein of 377 amino acid residues. ERGIC2 protein is also known as PTX1, CDA14 or Erv41. The biological function ...

Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ ... Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. This gene is a ... 1996). "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic ... Zinc finger and BTB domain-containing protein 16 has been shown to interact with: Angiotensin II receptor type 1, BCL6, BMI1, ...

... domain, a kinase domain, a RAS domain, a GTPase domain, and a WD40 domain. The protein is present largely in the cytoplasm but ... The LRRK2 gene encodes a protein with an armadillo repeats (ARM) region, an ankyrin repeat (ANK) region, a leucine-rich repeat ... Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA (May 2006). "LRRK2 in Parkinson's disease: protein domains and functional ... LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. ...

"Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793-7. Bibcode: ... Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger ... Epsin-1 is a protein that in humans is encoded by the EPN1 gene. EPN1 is an endocytic accessory protein that interacts with ... Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 ...

In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein ... 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple ... Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene ... Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess ...

The SARM1 protein has a mitochondrial localization signal, an auto-inhibitory N-terminus region consisting of armadillo (ARM)/ ... Essuman K, Summers DW, Sasaki Y, Mao X, Yim AK, DiAntonio A, Milbrandt J (February 2018). "TIR Domain Proteins Are an Ancient ... that bind to SARM1's allosteric ARM domain region and activate its TIR domain NADase activity. When NAD+ levels are low, ... SARM1's TIR domain is a multi-functional NAD(P)ase enzyme capable of hydrolyzing NAD+ or NADP, cyclizing NAD+ or NADP to form ...

The SARM1 protein has four domains, a mitochondrial localization signal, an auto-inhibitory N-terminus region consisting of ... armadillo/HEAT motifs, two sterile alpha motifs responsible for multimerization, and a C-terminus Toll/Interleukin-1 receptor ... Although the protein created localizes within the nucleus and is barely detectable in axons, studies suggest that its ... The protective effect of the WldS protein has been shown to be due to the NMNAT1 region's NAD+ synthesizing active site. ...

The protein contains the following three domains: N-terminal Armadillo domain (residues 82-262) central ELMO (Engulfment and ... The structure of the pleckstrin homology domain of ELMO1 has been determine by X-ray crystallography. The protein encoded by ... 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP ... Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome ...

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene. Proteins containing PDZ domains have ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a ...

Like other NBPF proteins, the NBPF1 protein product contains a repeated domain called DUF1220, a domain of unknown function ... Additionally, it contains amino acid repeats that are present in humans, other primates, and even armadillos. Another feature ... The two most important domain types in the NBPF1 protein are the coiled coil domains and DUF1220 domains. NBPF1 contains three ... This protein is member of the neuroblastoma breakpoint family of proteins, a group of proteins that are thought to be involved ...

Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR (October 2001). "The C. elegans PH domain protein CED-12 regulates cytoskeletal ... All isoforms contain a series of armadillo repeats, which begin at the N-terminus and extend around two thirds of the way along ... the protein, as well as a C-terminal proline-rich motif and a central PH domain. They function as part of a protein complex ... In humans there are three paralogous isoforms: ELMO1 ELMO2 ELMO3 The ELMO domain was first characterized in the CED-12 proteins ...

... including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The actin ... Another commonly found domain is an armadillo repeat region (ARR) located in the FH3 domain. The FH2 domain, has been shown by ... Protein pages needing a picture, Genes on human chromosome 15, Protein domains, Cell biology, Proteins, Cellular processes). ... The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each ...

... encoding protein FERM and PDZ domain containing 4 FUNDC1: encoding protein FUN14 domain containing 1 FUNDC2: FUN14 domain- ... encoding protein Armadillo repeat containing X-linked 6 BEX1: encoding protein Brain-expressed X-linked protein 1 BEX2: ... encoding protein V-set and immunoglobulin domain containing 1 YIPF6: encoding protein Protein YIPF6 ZC3H12B: encoding protein ... encoding protein Coiled coil domain containing protein 120 CCDC22: encoding protein Coiled-coil domain containing 22 CD99L2: ...

Armadillo proteins are involved in mediating attachment to intracellular filaments and cell membrane proteins. Armadillo ... which are in the cadherin family of cell adhesion proteins. Both have five extracellular domains, and have calcium-binding ... and the armadillo family of mediatory proteins plakoglobin and plakophilin. ... Desmoplakin has two isoforms that differ in the length of their middle rod domain. All desmoplakins have an N-terminal head, a ...