... deficiency typically refers to decreased function of arginase I, the liver isoform of arginase. This deficiency is ... Arginase belongs to the ureohydrolase family of enzymes. Arginase catalyzes the fifth and final step in the urea cycle, a ... Arginase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) GeneReviews/NIH/NCBI/UW entry on Arginase ... Specifically, arginase converts L-arginine into L-ornithine and urea. Mammalian arginase is active as a trimer, but some ...

... urea Arginase Nadai Y (1958). "Arginase. II. Distribution and properties of D-arginase". J. Biochem. 45: 1011-1020. doi:10.1093 ... D-arginase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t e (EC 3.5.3, All stub ... D-arginase (EC 3.5.3.10) is an enzyme with systematic name D-arginine amidinohydrolase. This enzyme catalyses the following ...

... arginase; several phosphatases and phosphoesterases-that includes two bridging carboxylate ligands and a bridging water or ...

In people with arginase deficiency, arginase is missing, and arginine is not broken down properly. consequently, urea cannot be ... "Arginase Deficiency". GeneReviews. PMID 20301338. Retrieved 20 November 2016.update 2014 "Arginase Deficiency: Background, ... The ARG1 gene provides instructions for making an enzyme called arginase, this enzyme controls the last steps of the urea cycle ... Argininemia is an autosomal recessive urea cycle disorder where a deficiency of the enzyme arginase causes a buildup of ...

Waddington SN (2002). "Arginase in glomerulonephritis". Kidney Int. 61 (3): 876-81. doi:10.1046/j.1523-1755.2002.00236.x. PMID ...

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I ... Jiang M, Ding Y, Su Y, Hu X, Li J, Zhang Z (December 2006). "Arginase-flotillin interaction brings arginase to red blood cell ... "Androgen-regulated expression of arginase 1, arginase 2 and interleukin-8 in human prostate cancer". PLOS ONE. 5 (8): e12107. ... "Entrez Gene: Arginase, liver". [provided by RefSeq, Sep 2011] Human ARG1 genome location and ARG1 gene details page in the UCSC ...

Arginase and urea synthesis". The Journal of Biological Chemistry. 184 (2): 479-484. doi:10.1016/S0021-9258(19)50977-2. PMID ...

"Arginase formulations and methods". Wipo (PCT). WO (8495A2). 2011. Ryan, Sinéad M; Mantovani, Giuseppe; Wang, Xuexuan; ...

Arginase, type II is an arginase protein that in humans is encoded by the ARG2 gene. Arginase catalyzes the hydrolysis of ... "Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide ... "Species differences in expression pattern of arginase isoenzymes and differential effects of arginase inhibition on collagen ... "Entrez Gene: Arginase, type II". Human ARG2 genome location and ARG2 gene details page in the UCSC Genome Browser. ...

Genetic disruption of arginase-2 in mouse attenuates the onset of senescence and extends lifespan. Arginase inhibitors have ... Xiong Y, Yepuri G, Montani JP, Ming XF, Yang Z (2017). "Arginase-II Deficiency Extends Lifespan in Mice". Front Physiol. 8: 682 ...

It can also inhibit arginase, an enzyme that competes with NO synthase for arginine. The resulting increase in the ... Huynh, Ngan Ngoc; Chin-Dusting, Jaye (2006). "Amino Acids, Arginase and Nitric Oxide in Vascular Health". Clinical and ...

Cleavage by arginase also produces canaline, a potent insecticide. The toxicity of canavanine may be enhanced under conditions ...

"Enhancer-mediated control of macrophage-specific arginase I expression". Journal of Immunology. 172 (12): 7565-73. doi:10.4049/ ...

Evidence of boronic acid mimics as transition state analogue inhibitors of human arginase I was elucidated by x-ray crystal ... Among the synthesized analogues, R = L-Leu possesses the most potent inhibitory activity (Ki = 9.1 nM). Arginase is a binuclear ... Maarsingh H, Zaagsma J, Meurs H (October 2009). "Arginase: a key enzyme in the pathophysiology of allergic asthma opening novel ... "Design of amino acid sulfonamides as transition-state analogue inhibitors of arginase". Journal of the American Chemical ...

Arginine is cleaved by arginase to form urea and ornithine. The ornithine is then transported back to the mitochondria to begin ... Deficiency of arginase) Hyperornithinemia, hyperammonemia, homocitrullinuria (HHH) syndrome (Deficiency of the mitochondrial ... synthetase I OTC Ornithine transcarbamoylase ASS argininosuccinate synthetase ASL argininosuccinate lyase ARG1 arginase 1 ...

"Pirfenidone inhibits lung allograft fibrosis through L-arginine-arginase pathway". Am. J. Transplant. 5 (6): 1256-63. doi: ...

2007). "Arginase-flotillin interaction brings arginase to red blood cell membrane". FEBS Lett. 580 (28-29): 6561-4. doi:10.1016 ...

Arginase, which catalyses the conversion of arginine to urea and ornithine, is one of the five members of the urea cycle ... There are several arginase isozymes that differ in catalytic, molecular and immunological properties. Deficiency in the liver ... Baker BS, Tata JR, Xu Q (1993). "Developmental and hormonal regulation of the Xenopus liver-type arginase gene". Eur. J. ... The ureohydrolase superfamily includes arginase (EC 3.5.3.1), agmatinase (EC 3.5.3.11), formiminoglutamase (EC 3.5.3.8) and ...

They also promote extracellular matrix synthesis via production of ornithine, via arginase; this is used as a precursor for ...

EDTA also acts as a selective inhibitor against dNTP hydrolyzing enzymes (Taq polymerase, dUTPase, MutT), liver arginase and ... "Non-chelating inhibition of the H101N variant of human liver arginase by EDTA". Journal of Inorganic Biochemistry. 98 (8): 1465 ...

Other enzymes containing manganese are arginase and Mn-containing superoxide dismutase (Mn-SOD). Also the enzyme class of ...

Leopoldini M, Russo N, Toscano M (August 2009). "Determination of the catalytic pathway of a manganese arginase enzyme through ...

Other enzymes containing manganese are arginase and a Mn-containing superoxide dismutase (Mn-SOD). Some reverse transcriptases ...

The Effect of Variation in Dietary Protein upon the Hepatic Arginase of the Rat". Biochemical Journal. 51 (5): 681-686. doi: ...

M2 macrophages express arginase-1, an enzyme that converts arginine to ornithine and urea. Ornithine help increase smooth ...

... arginase, a bimetallic enzyme binuclear Mn2-metalloenzyme arginase, crucial for pathogenesis of the ... Arginase of H. pylori also plays a role in evasion of the pathogen from the host immune system mainly by various proposed ... George G, Kombrabail M, Raninga N, Sau AK (March 2017). "Arginase of Helicobacter Gastric Pathogens Uses a Unique Set of Non- ... mechanisms, arginase competes with host-inducible nitric oxide (NO) synthase for the common substrate L-arginine, and thus ...

M2 macrophages activate arginase 1 (Arg1) that blocks iNOS activity and therefore inhibits nitric oxide production. They also ...

Mregs do not contribute to the production of extracellular matrix because they express low levels of arginase. Mregs show up- ... Mregs also differ from alternatively activated macrophages by producing high levels of nitric oxide and low arginase activity. ... Mregs can also inhibit the arginase activity of alternatively activated macrophages, the proliferation of fibroblasts, and can ...

Arginase deficiency Citrullinemia N-acetylglutamate synthetase deficiency Ornithine translocase deficiency Carbamoyl phosphate ...

L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a ...