... proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone ... The latter DNA sequences have been recognized as antioxidant/electrophile response elements or NF-E2-binding motifs to which ... Nguyen T, Huang HC, Pickett CB (May 2000). "Transcriptional regulation of the antioxidant response element. Activation by Nrf2 ... "An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements ...

Role of AP1 binding site contained within human antioxidant response element". J. Biol. Chem. 267 (21): 15097-104. doi:10.1016/ ... Furthermore, reduced forms of ubiquinone and vitamin E quinone have been shown to possess antioxidant properties that are ... External (via chemicals) and internal (stress response or caloric restriction) induction of NQO1 is mediated solely through the ... Dinkova-Kostova AT, Talalay P (2010). "NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme ...

... proteins negatively regulate antioxidant response element-mediated expression and antioxidant induction of the NAD(P)H:Quinone ... Mouse Mafg gene is induced by Nrf2-sMaf heterodimers through an antioxidant response element (ARE) at the promoter proximal ... The latter DNA sequences have been recognized as antioxidant/electrophile response elements or NF-E2-binding motifs to which ... "An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements ...

3). The latter DNA sequences have been recognized as antioxidant/electrophile response elements or NF-E2-binding motifs, to ... Katsuoka, F (2005). "Genetic evidence that small maf proteins are essential for the activation of antioxidant response element- ... Katsuoka, F (2005). "Nrf2 transcriptionally activates the mafG gene through an antioxidant response element". J. Biol. Chem. ... "An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements ...

Nguyen T, Nioi P, Pickett CB (May 2009). "The Nrf2-antioxidant response element signaling pathway and its activation by ... The 3′-UTR often contains microRNA response elements (MREs). MREs are sequences to which miRNAs bind. These are prevalent ... Los M, Maddika S, Erb B, Schulze-Osthoff K (May 2009). "Switching Akt: from survival signaling to deadly response". BioEssays. ... Gene expression in mammals is regulated by many cis-regulatory elements, including core promoters and promoter-proximal ...

Venugopal R, Jaiswal AK (Dec 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element- ... "Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes". The Journal of Biological ... bounce-back response) in response to proteasome inhibition. This compensatory up-regulation of proteasome genes in response to ... NFE2L1 is a key regulator of cellular functions including oxidative stress response, differentiation, inflammatory response, ...

... around 10 kb upstream and 1 kb downstream of Klf9 transcription start site contain conserved antioxidant response elements ( ... Nrf2 is a major regulator of the antioxidant response to ROS within the cell. Klf9 is upregulated by Nrf2; when oxidative ... The protein encoded by this gene is a transcription factor that binds to GC box elements located in the promoter. Binding of ... Previously known as Basic Transcription Element Binding Protein 1 (BTEB Protein 1), Klf9 is part of the Sp1 C2H2-type zinc ...

"In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens". Endocrinology. 145 (1 ... Colon cells with reduced ability to undergo apoptosis in response to DNA damage would tend to accumulate mutations, and such ...

"In vitro and in vivo regulation of antioxidant response element-dependent gene expression by estrogens". Endocrinology. 145 (1 ... Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response. Nature. 2021 Dec;600(7887):158-163. doi: ... it is based on the alterations in the induction of the SOS response due to DNA damage. The benefits of this technique are that ...

A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated ... "Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene". Drug Metabolism ... ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane ... induction in response to oxidative stress. Click on genes, proteins and metabolites below to link to respective articles. [[ ...

"An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements ... "Genetic evidence that small maf proteins are essential for the activation of antioxidant response element-dependent genes". ... mafG and mafK expression by electrophile-response-element activators". The Biochemical Journal. 361 (Pt 2): 371-7. doi:10.1042/ ... Nrf2-sMaf heterodimer regulates a battery of cytoprotective genes, such as antioxidant/xenobiotic metabolizing enzyme genes. ...

In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins ... Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element- ... and binds to the antioxidant response element (ARE) in the upstream promoter region of many antioxidative genes, and initiates ... "Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of ...

"Nrf3 negatively regulates antioxidant-response element-mediated expression and antioxidant induction of NAD(P)H:quinone ... Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element- ... factors to bind antioxidant response elements in target genes. RNA microarray data has shown NRF3's involvement in various ... Hayes JD, McMahon M (December 2001). "Molecular basis for the contribution of the antioxidant responsive element to cancer ...

Some lines of investigation are focused on the application of D. radiodurans antioxidant systems in human cells to prevent ROS ... Journal of Trace Elements in Medicine and Biology. 50: 465-473. doi:10.1016/j.jtemb.2018.02.001. PMID 29449107. S2CID 46779191 ... "A Model for Manganese interaction with Deinococcus radiodurans proteome network involved in ROS response and defense". ... Michael Daly has suggested the bacterium uses manganese complexes as antioxidants to protect itself against radiation damage. ...

Natsch, Andreas; Emter, Roger (2007). "Skin Sensitizers Induce Antioxidant Response Element Dependent Genes: Application to the ...

Mulcahy RT, Gipp JJ (Apr 1995). "Identification of a putative antioxidant response element in the 5'-flanking region of the ... "Human glutamate cysteine ligase gene regulation through the electrophile response element". Free Radical Biology & Medicine. 37 ...

"Nitric oxide-induced transcriptional up-regulation of protective genes by Nrf2 via the antioxidant response element counteracts ... "Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain ... "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element ...

A carbohydrate-response element (ChoRE) is responsible for regulating glycolytic enzyme gene expression in response to changing ... Lactate, as an antioxidant, may act to scrub down the levels of reactive oxygen species thus enhancing resistance to radiation ... A lactate-sensitive response element for genes in fibroblasts involved in hyaluronan metabolism has been identified. Finally, ... GLUT1 levels, in response to hypoxic conditions, have been shown to increase with changes at both the mRNA and protein levels. ...

"Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of ... Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the ... Bloom DA, Jaiswal AK (November 2003). "Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads ... not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element- ...

Venugopal R, Jaiswal AK (1999). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated ... factor jun-B is a transcription factor involved in regulating gene activity following the primary growth factor response. It ...

Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element- ... This includes the cAMP response element binding protein (CREB), the phosphorylation of which induces its association with the ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... This is known to occur on many genes including fosB and c-fos in response to psychostimulant exposure. ΔFosB is also ...

Venugopal R, Jaiswal AK (1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated ...

Venugopal R, Jaiswal AK (December 1998). "Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element- ... Kara CJ, Liou HC, Ivashkiv LB, Glimcher LH (April 1990). "A cDNA for a human cyclic AMP response element-binding protein which ... "Isolation and characterization of a novel member of the gene family encoding the cAMP response element-binding protein CRE-BP1 ... c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the ...

"Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of ...

IFN-stimulated response elements (ISREs) Calcium-response element CaRE1 Antioxidant response element (ARE) p53 response element ... Retinoic acid response elements (RAREs) ROR-response element Thyroid hormone response element Growth hormone response element ( ... androgen response elements (AREs) glucocorticoid response elements (GREs) cAMP response element (CRE) B recognition element AhR ... Examples of HREs include estrogen response elements and androgen response elements. Examples of response elements include: ...

... elements and the allergic-response ("false alarm") elements within the immune system. Some studies also suggest that the ... suggesting that consumption of antioxidants, certain lipids, and/or a Mediterranean diet may help to prevent atopic diseases. A ... In addition, several studies have documented that an IgE-mediated response to S. aureus is present in people with atopic eczema ... Atopy is the tendency to produce an exaggerated immunoglobulin E (IgE) immune response to otherwise harmless substances in the ...

... factor that is able to regulate the expression of electrophilic response elements as well as antioxidants in response to ... mTORC1 interacts at the Ragulator-Rag complex on the surface of the lysosome in response to amino acid levels in the cell. Even ... December 2004). "Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex". Genes ... Śledź KM, Moore SF, Durrant TN, Blair TA, Hunter RW, Hers I (July 2020). "Rapamycin restrains platelet procoagulant responses ...

2000). "Increased binding activity at an antioxidant-responsive element in the metallothionein-1 promoter and rapid induction ... of metallothionein-1 and -2 in response to cerebral ischemia and reperfusion". The Journal of Neuroscience. 20 (14): 5200-7. ... Richarz AN, Brätter P (2002). "Speciation analysis of trace elements in the brains of individuals with Alzheimer's disease with ...

Iodine is an essential trace element in biological systems. It has the distinction of being the heaviest element commonly ... It has been shown to act as an antioxidant and antiproliferant in various tissues that can uptake iodine. Molecular iodine (I2 ... Eskin, Bernard A.; Grotkowski, Carolyn E.; Connolly, Christopher P.; Ghent, William R. (1995). "Different tissue responses for ... Biology and pharmacology of chemical elements Calcium in biology - Use of calcium by organisms Magnesium in biology - Use of ...

This causes the nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated response pathway to induce antioxidant responses. ... which stimulates transcription directed by xenobiotic response elements. AhR ligands can induce formation of an AhR-estrogen ... Due to the influence of the compound on the central nervous system, its responses and change in response are compared. It is ...