An alkylating antineoplastic agent is an alkylating agent used in cancer treatment that attaches an alkyl group (CnH2n+1) to ... University of Nebraska page on alkylating agent drugs Alkylating+antineoplastic+agents at the U.S. National Library of Medicine ... alkylating agents are classified under L01A. Many of the agents are known as "classical alkylating agents". These include true ... The platinum agents are also sometimes described as nonclassical. Alkylating antineoplastic agents have limitations. Their ...

... an alkylating antineoplastic agent; Hydroxydaunorubicin, also known as doxorubicin: an anthracycline antibiotic that is able to ...

It has potential anti-inflammatory and anti-neoplastic properties. It is an alkylating antineoplastic agent. Dibrospidium ... Alkylating antineoplastic agents, Quaternary ammonium compounds, Spiro compounds, Nitrogen heterocycles, Organobromides, ... 1983). "New antitumor agent - Spirobromin". Pharmaceutical Chemistry Journal. 17 (5): 375-377. doi:10.1007/BF00765650. S2CID ... Chlorides, Amides, All stub articles, Antineoplastic and immunomodulating drug stubs). ...

... an alkylating antineoplastic agent from oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue (anthraquinone ...

Alkylating antineoplastic agent and anthracyclins are two examples. "Chemotherapy: The Basics". OncoLink. Archived from the ... Cell-cycle nonspecific antineoplastic agents (CCNS) refer to a class of pharmaceuticals that act as antitumor agents at all or ... "Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration--time product". Cancer ...

... a platinum-based alkylating antineoplastic agent. GEMOX-R regimen is a highly effective salvage regimen in patients with ...

... an alkylating antineoplastic agent from the oxazafosforine group; Mitoxantrone - a synthetic anthracycline analogue ( ...

... an alkylating antineoplastic agent of the oxazafosforine group; Carboplatin - a platinum-based antineoplastic drug, also an ... alkylating antineoplastic agent; Etoposide - a topoisomerase inhibitor. Cycles are repeated every 14 days for 3 cycles, then ...

Derivates from distamycin are used as alkylating antineoplastic agents to combat tumours. Derivates with fluorophores are used ... "Minor groove binders as anti-infective agents". Pharmacology & Therapeutics. 139 (1): 12-23. doi:10.1016/j.pharmthera.2013.03. ... "Hybrid molecules between distamycin a and active moieties of antitumor agents". Bioorganic & Medicinal Chemistry. 15 (1): 17-35 ...

... is accomplished with the class of drugs called alkylating antineoplastic agents. Nucleophilic alkylating agents ... Electrophilic alkylating agents deliver the equivalent of an alkyl cation. Alkyl halides are typical alkylating agents. ... Alkylating agents Category:Ethylating agents Category:Methylating agents March Jerry; (1985). Advanced Organic Chemistry ... This mechanism of toxicity is relevant to the function of anti-cancer drugs in the form of alkylating antineoplastic agents. ...

... a platinum-based antineoplastic, also an alkylating antineoplastic agent. Effective salvage therapy for lymphoma with cisplatin ...

Alkylating antineoplastic agents are a class of compounds that are used to treat cancer. In such case, the term alkyl is used ... For example, nitrogen mustards are well-known alkylating agents, but they are not simple hydrocarbons. In chemistry, alkyl is a ...

It is a cell cycle non-specific alkylating antineoplastic agent, in the class of alkyl sulfonates. Its chemical designation is ... Alkylating antineoplastic agents, IARC Group 1 carcinogens, Orphan drugs, Specialty drugs, Mesylate esters, 1,4-Butanediyl ... It is an alkylating agent that forms DNA-DNA interstrand crosslinks between the DNA bases guanine and adenine and between ... Both IV and oral formulations require prophylactic antiemetic agents administered prior to the busulfan dose and scheduled ...

... in particular alkylating antineoplastic agents, can increase the risk of subsequently developing AML. Other chemotherapy agents ...

As an antineoplastic agent, it is under investigation for the treatment of cancer, particularly head and neck cancer. ... Porfiromycin works by generating oxygen radicals and alkylating DNA, resulting in interstrand cross-links and single-strand ... Porfiromycin is an N-methyl derivative of the antineoplastic antibiotic, mitomycin C, which is isolated from various ... Antineoplastic drugs, Heterocyclic compounds with 4 rings, Indolequinones, Quinones, Indoles, Carbamates, Amines). ...

Alkylating antineoplastic agents, for example, cause DNA damage, which is more harmful to cancer cells than regular cells. ...

G-CSF is still included, even though the "G" is taken out of the acronym.) Amsacrine is an alkylating antineoplastic agent that ... There are several intensified versions of the FLAG regimen in which a third chemotherapeutic agent is added. In the FLAG-IDA ... In this setting, it is often combined with other agents, such as: Cyclophosphamide (FLAMSA-CYC), and/or Busulfan or treosulfan ...

Various chemotherapeutic regimens have been used for this including combinations of alkylating antineoplastic agents, ... rituximab combined with the chemotherapeutic alkylating agent bendamustine; 2) rituximab combined with the chemotherapeutic ... However, recent advancements in the treatment of t-FL (e.g. the addition to standard chemotherapy of agents such as rituximab) ... The use of an immunotherapeutic agent such as Rituximab alone or in combination with a chemotherapeutic regimen such as CVP (i. ...

... is a nitrogen mustard and alkylating antineoplastic agent (i.e., chemotherapy agent). It is a metabolite of a number of ... Alkylating antineoplastic agents, Carbamates, Human drug metabolites, Nitrogen mustards, Organochlorides, Chloroethyl compounds ... antineoplastic agents that have been developed for the treatment of tumors, including estramustine phosphate, alestramustine, ... All stub articles, Antineoplastic and immunomodulating drug stubs). ...

... which are divided into broad categories such as alkylating agents and antimetabolites. Traditional chemotherapeutic agents act ... Chemotherapy is the treatment of cancer with one or more cytotoxic anti-neoplastic drugs (chemotherapeutic agents) as part of a ... Hormones are important agents in sex-related cancers, such as cancer of the breast, endometrium, prostate, ovary and testis and ... Radiation is a more potent source of cancer when combined with other cancer-causing agents, such as radon plus tobacco smoke. ...

The mechanism of antineoplastic activity of mannomustine, like for all other alkylating agents, lies in its ability to alkylate ... Mannomustine (INN), also known as mannitol nitrogen mustard, tradename Degranol is an old alkylating antineoplastic agent from ... Alkylating antineoplastic agents, Nitrogen mustards, Chloroethyl compounds). ...

In the treatment of malignancies, radiation therapy, alkylating antineoplastic agents, and epipodophyllotoxins are not used, ...

... which altretamine exerts its anti-cancer effect is unknown but it is classified by MeSH as an alkylating antineoplastic agent. ... is an antineoplastic agent. It was approved by the U.S. FDA in 1990. It is indicated for use as a single agent in the ... of patients with persistent or recurrent ovarian cancer following first-line therapy with cisplatin and/or alkylating agent- ... This unique structure is believed to damage tumor cells through the production of the weakly alkylating species formaldehyde, a ...

Alkylating antineoplastic agents, Alkaloids, Antineoplastic drugs, Biotechnology, Chemotherapeutic adjuvants, Antibiotics). ... As small-molecule, synthetic, DNA minor groove binding alkylating agents, duocarmycins are suitable to target solid tumors. ... Analogues of naturally occurring antitumour agents, such as duocarmycins, represent a new class of highly potent antineoplastic ... Boger, Dale L. (1991). "Duocarmycins: a new class of sequence selective DNA minor groove alkylating agents". Chemtracts: ...

... agents are sometimes described as "alkylating-like" due to similar effects as alkylating ... Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. Their active ... As studied mainly on cisplatin, but presumably for other members as well, platinum-based antineoplastic agents cause ... Articles with short description, Short description matches Wikidata, Platinum-based antineoplastic agents, Medicinal inorganic ...

It is an antineoplastic agent. It exerts its effect by acting as a suicide inhibitor of the enzyme O6-alkylguanine-DNA ... O6-BG was used clinically in combination with the alkylating agent temozolomide for glioblastoma, however the combination was ... Antineoplastic drugs, Experimental cancer drugs, Benzyl compounds). ...

... and hence was thought to be an alkylating antineoplastic agent. However, subsequent research has found that EMP is devoid of ... developed as a dual ester prodrug of an estrogen and normustine as a nitrogen mustard alkylating antineoplastic agent which, ... Antineoplastic agents related to EMP, although none of them were marketed, include alestramustine, atrimustine, cytestrol ... EMP is described as relatively well tolerated among cytostatic antineoplastic and nitrogen-mustard agents, rarely or not at all ...

brands, Prodrugs, Schering-Plough brands, Teratogens, Explosive chemicals, Alkylating antineoplastic agents, Methylating agents ... Mirroring its medicinal use as an alkylating antineoplastic agent, temozolomide has been reported to be a comparatively safe ... Temozolomide is an alkylating agent used to treat serious brain cancers; most commonly as second-line treatments for ... The agent was discovered at Aston University in Birmingham, England. Its preclinical activity was reported in 1987. It was ...

... or streptozocin (INN, USP) (STZ) is a naturally occurring alkylating antineoplastic agent that is particularly ... Alkylating antineoplastic agents, IARC Group 2B carcinogens, Monosaccharide derivatives, Nitrosamines, Nitrosoureas, Ureas). ... As with other alkylating agents in the nitrosourea class, it is toxic to cells by causing damage to the DNA, though other ...

Alkylating antineoplastic agents, 1,4-Benzoquinones, All stub articles, Antineoplastic and immunomodulating drug stubs). ... It is aziridinylbenzoquinone-based, and may have potential antineoplastic activity. It is an alkylating agent. It can react ...