"Detection of phosphotyrosine-containing proteins in polyomavirus middle tumor antigen-transformed cells after treatment with a ... Brugge, Joan S.; Erikson, E.; Erikson, R.L. (1981). "The specific interaction of the Rous sarcoma virus transforming protein, ... Brugge, Joan S.; Erikson, R. L. (1977). "Identification of a transformation-specific antigen induced by an avian sarcoma virus ... "The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins." Cell 25.2 (1981 ...

SV40 large TAg, other polyomavirus large T antigens, adenovirus E1a proteins, and oncogenic human papillomavirus E7 proteins ... The transforming activity of TAg is due in large part to its perturbation of the retinoblastoma (pRb) and p53 tumor suppressor ... SV40 DNA replication is initiated by binding of large T-antigen to the origin region of the genome. The function of T-antigen ... T-antigen also binds and inactivates tumor suppressor proteins (p53, p105-Rb). This causes the cells to leave G1 phase and ...

Unlike for other polyomaviruses, MCV sT antigen transforms cells in vitro by activating cap-dependent translation. MCV also ... MCV T antigen has similar features to the T antigens of other polyomaviruses, which are known oncoproteins, and is expressed in ... genome and encodes characteristic polyomavirus genes from opposite strands including a large T antigen, a small T antigen (LT ... Shuda M, Kwun HJ, Feng H, Chang Y, Moore PS (September 2011). "Human Merkel cell polyomavirus small T antigen is an oncoprotein ...

Courtneidge, Sara A.; Smith, Alan E. (2 June 1983). "Polyoma virus transforming protein associates with the product of the c- ... The genes for the small tumor antigen (STag), middle tumor antigen (MTag), and large tumor antigen (LTag) are encoded in the " ... the small tumor antigen and large tumor antigen. MTag occurs only in a few known polyomaviruses, while STag and LTag are ... The middle tumor antigen (also called the middle T-antigen and abbreviated MTag or MT) is a protein encoded in the genomes of ...

... antigens, polyomavirus transforming MeSH D12.776.624.664.520.420 - papillomavirus e7 proteins MeSH D12.776.624.664.520.750 - ... antigen, b-cell MeSH D12.776.377.715.548.950.500 - antigens, cd79 MeSH D12.776.377.715.647.100 - alpha-macroglobulins See List ... transforming growth factor beta MeSH D12.776.467.374.440.890 - interferon type i MeSH D12.776.467.374.440.890.125 - interferon ... antigen-antibody complex MeSH D12.776.377.715.548.114.301 - antitoxins MeSH D12.776.377.715.548.114.301.138 - antivenins MeSH ...

... antigens, polyomavirus transforming MeSH D23.050.327.150 - deltaretrovirus antigens MeSH D23.050.327.150.500 - htlv-i antigens ... antigens, polyomavirus transforming MeSH D23.050.285.329 - carcinoembryonic antigen MeSH D23.050.285.550 - neprilysin MeSH ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ... forssman antigen MeSH D23.050.285.018 - antigens, cd24 MeSH D23.050.285.025 - antigens, cd30 MeSH D23.050.285.040 - antigens, ...

... polyomavirus transforming antigen - polypeptide - polysaccharide - porphyrin - Posttranslational modification - potassium - ... transforming growth factor - transforming growth factor alpha - transforming growth factor beta - transforming growth factor ... CD4 antigen - CD45 antigen - CD95 antigen - CDC28 protein kinase - cell - cell adhesion molecule - cell biology - cell cycle ... T-cell antigen receptors - tachykinin - tachykinin receptor - talin protein - tandem repeat sequence - taste bud - TATA box - ...

... but its presence may increase the transforming efficiency of LTag. In other polyomaviruses, such as Merkel cell polyomavirus, ... and sometimes other tumor antigens as well, such as the murine polyomavirus middle tumor antigen). Polyomavirus STag proteins ... The genes for both the small and the large tumor antigen are encoded in the "early region" of the polyomavirus genome, so named ... In oncogenic polyomaviruses, the tumor antigens are responsible for the transformation activity, although the exact molecular ...

Unlike for SV40, the MCV small T antigen directly transforms rodent cells in vitro. The middle tumor antigen is used in model ... Lyon IARC polyomavirus is related to raccoon polyomavirus.[citation needed] The following 14 polyomaviruses with human hosts ... These include the sea otter polyomavirus 1 and Alpaca polyomavirus Another virus is the giant panda polyomavirus 1. Another ... "Discovery of STL polyomavirus, a polyomavirus of ancestral recombinant origin that encodes a unique T antigen by alternative ...

... which is primarily responsible for the virus's transforming activity. Merkel cell polyomavirus (MCPyV), also known as Human ... Some polyomavirus LTag proteins - most notably the well-studied SV40 large tumor antigen from the SV40 virus - are oncoproteins ... In oncogenic polyomaviruses, the tumor antigens are responsible for the transformation activity, although the exact molecular ... Lane, D. P.; Crawford, L. V. (1979-03-15). "T antigen is bound to a host protein in SY40-transformed cells". Nature. 278 (5701 ...

When these cells are transformed by the polyoma virus, higher tyrosine activity is observed in the cellular matrix, which is ... For example, the T-cell antigen receptor leads to intracellular signalling by activation of Lck and Fyn, two proteins that are ... that have been transformed by the polyomavirus possess higher tyrosine activity in the cellular matrix. Furthermore, tyrosine ... The polyoma virus affects tyrosine kinase activity inside the nuclear matrix. Fibroblasts are cells involved in wound healing ...

"Similar cell surface antigens on hamster cells transformed by different papovaviruses". Journal of Immunology. 118 (6): 2295- ... The papovaviruses have since been split into two categories: papillomaviruses and polyomaviruses.) In his first faculty ... Wright, P. J.; Bernhardt, G.; Major, E. O.; Di Mayorca, G. (1976). "Comparison of the serology, transforming ability, and ... "Comparison of wild-type BK virus DNA and BK virion DNA rescued from virus-transformed BHK cells". Virology. 103 (1): 1-10. doi: ...

... the cause of infectious laryngotracheitis in poultry SV40 large T antigen, a proto-oncogene derived from polyomavirus SV40 Heat ... an extension for many web browsers Laplace transform Less than Logic Theorist, a computer program written in 1955-56 to prove ...

Brugge, Joan S.; Erikson, E.; Erikson, R.L. (1981). "The specific interaction of the Rous sarcoma virus transforming protein, ... "Identification of a transformation-specific antigen induced by an avian sarcoma virus". Nature. Springer Science and Business ... "Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and ...

The transformed cells often express permanently some viral genes. This leads to the presentation of viral antigenic peptides ... Kaposi sarcoma virus and Merkel cell polyoma virus cause skin cancers. Human T-lymphotropic virus (HTLV) causes T cell ... In some patients, the majority of the tumor-specific T cells recognize mutated antigens. The contribution of these antigens to ... The carcinoma cells still harbour the viral genes and antigens. As expected T cell responses against antigens encoded by genes ...

... acutely transforming or slowly transforming. In acutely transforming viruses, the viral particles carry a gene that encodes for ... Merkel cell polyomavirus - a polyoma virus - is associated with the development of Merkel cell carcinoma Not all oncoviruses ... In SV40, the large T antigen (LT) is an analogue; LT also binds to several other cellular proteins, such as p107 and p130, on ... slowly transforming viruses have very long tumor latency compared to acutely transforming viruses, which already carry the ...

... in which MMTV-LTR is used to drive the expression of mammary gland specific polyomavirus middle T-antigen, leading to a rapid ... Siegel, P. M.; Shu, W; Cardiff, R. D.; Muller, W. J.; Massagué, J (2003). "Transforming growth factor beta signaling impairs ... Guy, C. T.; Cardiff, R. D.; Muller, W. J. (1992). "Induction of mammary tumors by expression of polyomavirus middle T oncogene ... The role of autocrine transforming growth factor beta 1(TGF-β1) signaling on motility and survival in PymT cells derived from ...

"Simian virus 40 large T antigen and p53 are microtubule-associated proteins in transformed cells". Cell Growth & ... Butel has studied polyomavirus SV40 infection in humans and animals for most of her career. She has published studies on the ... Her area of expertise is on polyomavirus pathogenesis of infections and disease. She has more than 120 publications on PubMed. ... "Viral microRNA effects on pathogenesis of polyomavirus SV40 infections in syrian golden hamsters". PLOS Pathogens. 10 (2): ...

"T antigen mutations are a human tumor-specific signature for Merkel cell polyomavirus". Proceedings of the National Academy of ... an obsolete term originally used for acutely transforming retroviruses). The development of cancer is determined by a variety ... Merkel cell polyomavirus closely related to SV40 and mouse polyomaviruses that have been used as animal models for cancer ... The most recently discovered human cancer virus is a polyomavirus (Merkel cell polyomavirus) that causes most cases of a rare ...

An P, Sáenz Robles MT, Pipas JM (13 October 2012). "Large T antigens of polyomaviruses: amazing molecular machines". Annual ... interacts with viral transforming proteins and cellular transcription factor E2F1". The Journal of Biological Chemistry. 273 (2 ... and a molecule called proliferating cell nuclear antigen, or PCNA, which speeds DNA replication and repair by helping to attach ... E4F1 EID1 ENC1 FRK HBP1 HDAC1 HDAC3 Histone deacetylase 2 Insulin JARID1A Large tumor antigen LIN9 MCM7 MORF4L1 MRFAP1, MyoD ...

... of a CHO cell line transfected with the polyomavirus large T antigen gene and a DNA expression vector encoding polyomavirus ... Methodology varies depending on the organism to transform. While plants can be transformed with a construct introduced into ... which is carried apart from the EBNA-1 gene and the mouse polyomavirus large T antigen EpiCHO system, which consists ... Graham FL, Smiley J, Russell WC, Nairn R (July 1977). "Characteristics of a human cell line transformed by DNA from human ...

In the summer of 1979, studies of polyomavirus middle T and v-Src associated kinase activities led to the discovery of tyrosine ... Protein phosphorylation Eckhart W, Hutchinson MA, Hunter T (1979). "An activity phosphorylating tyrosine in polyoma T antigen ... 2012). "N-terminal tyrosine phosphorylation of caveolin-2 negates anti-proliferative effect of transforming growth factor beta ... that negatively regulates the anti-proliferative function of transforming growth factor beta (TGF-beta) in endothelial cells. ...

Molecular mimicry refers to an overlap in structural similarity between a viral antigen and a self-antigen. The bystander ... An example would be the JC polyomavirus, in which its tropism is limited to glial cells since its enhancer is only active in ... Persistent viruses can sometimes transform host cells into cancer cells. Viruses such as the human papillomavirus (HPV), human ... Nevertheless, induction of apoptosis in major immune cells or antigen-presenting cells may also act as a mechanism of ...

"Differential tumorigenicity of 3T3 cells transformed in vitro with polyoma virus and in vivo selection for high tumorigenicity ... One such antigen was MAGE-A1. The coexistence of a progressing melanoma with melanoma-specific T cells implicitly does not ... CAFs can also secrete transforming growth factor beta (TGF-β), which is associated with EMT, a process by which cancer cells ... As many fibroblasts are transformed into CAFs during carcinogenesis, this reduces the amount of ECM produced and the ECM that ...

... is a novel broadly expressed tumor antigen recognized by antigen-specific T cells". Clin. Cancer Res. 14 (17): 5503-11. doi: ... The promoter of the human MMP7 contains a TATA box, an activator protein 1 (AP-1) site, and two inverted polyomavirus enhancer ... However, the opposite effects of TGF-β on MMP7 were observed among transformed cells. In human glioma cell lines and human ...

April 2019). "Antibodies reacting to mimotopes of Simian virus 40 large T antigen, the viral oncoprotein, in sera from children ... 2017). "Detection of Merkel Cell Polyomavirus DNA in Serum Samples of Healthy Blood Donors". Frontiers in Oncology. 7: 294. doi ... Dressman D, Yan H, Traverso G, Kinzler KW, Vogelstein B (July 2003). "Transforming single DNA molecules into fluorescent ... March 2020). "Droplet-digital PCR assay to detect Merkel cell polyomavirus sequences in chorionic villi from spontaneous ...