... pathway induced by the CD27 antigen, a member of the tumor necrosis factor receptor (TFNR) superfamily. The CD27 antigen ... Prasad KV, Ao Z, Yoon Y, Wu MX, Rizk M, Jacquot S, Schlossman SF (Jul 1997). "CD27, a member of the tumor necrosis factor ... Held-Feindt J, Mentlein R (2002). "CD70/CD27 ligand, a member of the TNF family, is expressed in human brain tumors". Int. J. ... SIVA1 has been shown to interact with CD27. Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that ...

... naïve B cells are CD27−, memory B-cells are CD27+ and plasma cells are CD27++. The surface antigen CD138 (syndecan-1) is ... Another important surface antigen is CD319 (SLAMF7). This antigen is expressed at high levels on normal human plasma cells. It ... After leaving the bone marrow, the B cell acts as an antigen-presenting cell (APC) and internalizes offending antigens, which ... The absence of antigens and the depletion of B cells does not appear to have an effect on the production of high-affinity ...

However, they are able to promote the secretion of immunoglobulins though CD27/CD70 interactions. B cells begin expressing CD27 ... Centroblasts do not express immunoglobulins and are unable to respond to the follicular dendritic cell antigens present in the ... CD27 is an important marker for germinal center formation in the lymphoid follicle and is produced by centroblasts interacting ... Xiao, Yanling; Hendriks, Jenny; Langerak, Petra; Jacobs, Heinz; Borst, Jannie (2004-06-15). "CD27 Is Acquired by Primed B Cells ...

CD27: This molecule supports antigen-specific expansion of naïve T cells and is vital for the generation of T cell memory. CD27 ... CD27's activity is governed by the transient availability of its ligand, CD70, on lymphocytes and dendritic cells. CD27 ... October 2013). "Agonist anti-human CD27 monoclonal antibody induces T cell activation and tumor immunity in human CD27- ... Like CD27, OX40 promotes the expansion of effector and memory T cells, however it is also noted for its ability to suppress the ...

... on activated antigen presenting cells (APC) including dendritic cells and B cells binds to CD27 on T lymphocytes and ... The interaction between CD27 and CD70 leads to the recruitment of intracellular adaptor proteins, such as TRAF2 and TRAF5, ... CD27 signaling stimulates naïve CD4+ T lymphocytes to differentiate into Th1 cells by activation the transcription factor T-bet ... CD70 is also known as a ligand for CD27. In physiological condition the expression of CD70 on immune cells is transient and ...

... +Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD27 genome location and CD27 gene ... "Entrez Gene: CD27 CD27 molecule". Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, et al. (April 2009). "CD27 ... CD27 has been shown to interact with SIVA1, TRAF2 and TRAF3. Some mutations can decrease the expression of CD27. Three such ... Furthermore, CD27 is expressed on both naïve and activated effector T cells as well as NK cells and activated B cells. It is a ...

... is required in addition to the antigen-specific signal from their antigen receptors. T cells require two signals ... Also, CD27 is a receptor constitutively expressed on TN (its expression is downregulated upon TCR stimulation) and enhances T ... B cell binds antigens with its BCR (a membrane-bound antibody), which transfers intracellular signals to the B cell as well as ... In contrast, CD27 and HVEM promote TH1 polarization. OX40 and ICOS expression was linked to T folicular helper (TFH) ...

... antigens, cd24 MeSH D23.050.301.264.035.126 - antigens, cd26 MeSH D23.050.301.264.035.127 - antigens, cd27 MeSH D23.050.301.264 ... antigens, cd18 MeSH D23.050.301.264.894.126 - antigens, cd26 MeSH D23.050.301.264.894.127 - antigens, cd27 MeSH D23.050.301.264 ... antigens, cd24 MeSH D23.101.100.110.126 - antigens, cd26 MeSH D23.101.100.110.127 - antigens, cd27 MeSH D23.101.100.110.128 - ... antigens, cd18 MeSH D23.101.100.894.126 - antigens, cd26 MeSH D23.101.100.894.127 - antigens, cd27 MeSH D23.101.100.894.128 - ...

MZ B cells shuttle between the blood-filled marginal zone for antigen collection and the follicle for antigen delivery to ... They are furthermore distinguished by the expression of CD9 and CD27 (in humans). In mice, MZ B cells characteristically ... MZ B cells respond to a wide spectrum of T-independent, but also T-dependent antigens. It is believed that MZ B cells are ... Moreover, MZ B cells are potent antigen-presenting cells, that are able to activate CD4+ T cells more effectively than FO B ...

Among them, it is associated with a particular genetic variant of the human leukocyte antigen called HLA-DR7. This variant is ... Immunologically, peripheral B-cells show more functional IgD+ positive CD27 cells than usual.[citation needed] In the followup ...

B1b cells seem to recognize more types of antigens including intracellular antigens. Previously, B1b cell antigen recognition ... Human B1 cells have been found to have marker profile of CD20+CD27+CD43+CD70- and could either be CD5+ or CD5-, which has been ... making antibodies against antigens and acting as antigen-presenting cells. These B1 cells are commonly found in peripheral ... Hence, there appears to be a role for self or foreign antigen in shaping the repertoire of the B-1 B cell compartment. B1 cells ...

GITR interacts with its ligand (GITRL) that is expressed on antigen-presenting cells (APC) and endothelial cells. Human ... OX40 or CD27. GITR is constitutively expressed on CD25+CD4+ regulatory T cells and its expression is upregulated on all T cell ...

... and malignant cells that express activation-induced cytidine deaminase but not CD27, CCL20, MAdCAM-1, or C-C chemokine receptor ... develops as a consequence of chronic inflammation and specific antigen stimulation. In support of this possibility, there have ... and associations with chronic inflammatory diseases and chronic antigen stimulation; Mantle cell lymphoma differs from DFL by ...

Borst, Jannie; Hendriks, Jenny; Xiao, Yanling (June 2005). "CD27 and CD70 in T cell and B cell activation". Current Opinion in ... that recognizes a common epitope on the human T cell receptor for antigen". Journal of Immunology. 135 (3): 1922-1928. doi: ... The identification of TNF receptor CD27 and CD70 ligand as important costimulatory system on T cells LUMC. "Prof. Jannie Borst ... Church, J. A. (2004-08-01). "Lethal T Cell Immunodeficiency Induced by Chronic Costimulation via CD27-CD70 Interactions". ...

Gene Signature : CCL5, CD27, CD274 (PD-L1), CD276 (B7-H3), CD8A, CMKLR1, CXCL9, CXCR6, HLA-DQA1, HLA-DRB1, HLA-E, IDO1, LAG3, ... Antigen-activated T cells secrete CCR5 ligands (CCL2 and CCL3) to recruit natural killer (NK) cells and other innate immune ... They are found to express conformational epitopes, such as MHC molecules, as nonself antigens, which activates both B and T ... by antigen-presenting cells (APCs). CXCR3 expressing Th1-polarized CD4 T cells and cytotoxic T cells are recruited to the site ...

And there was an increase in the expression of co-stimulatory molecules CD27 and CD28 (CD27+CD28+, p=0.016; and CD27-CD28+, p= ... The investigators for this work used influenza matrix protein antigen and the tumor antigens Melan-A/MART-1 and survivin to ... In the absence of antigen presentation via MHC class II molecules, efti reactivates dormant antigen-experienced memory T cells ... circulating tumor antigen), and efti increases activation of antigen-presenting cells (APCs) as they take up that debris. This ...

... antigen is a protein that in humans is encoded by the CD160 gene. CD160 is a 27 kDa glycoprotein which was initially ... CD28-CD27-cells. In tissues, CD160 is expressed on all intestinal intraepithelial lymphocytes. CD160 shows a broad specificity ... CD160+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CD160 genome location and CD160 ...

... chimeric antigen receptor T cell therapy using CD19-directed CAR-T cells; and lenalidomide, a drug with multiple anti-tumor ... a monoclonal antibody that binds to the CD27 protein expressed by cells and thereby promotes the anti-tumor activity of T cells ...

In a secondary response, the memory B cells specific to the antigen or similar antigens will respond. When memory B cells ... Memory B cells are typically distinguished by the cell surface marker CD27, although some subsets do not express CD27. Memory B ... where they can be activated by a floating foreign peptide brought in through the lymph or by antigen presented by antigen ... When reintroduced to antigen, some of these B1 cells can differentiate into memory B cells without interacting with a T cell. ...

"PLCE1 is a poor prognostic marker and may promote immune escape from osteosarcoma by the CD70-CD27 signaling pathway". Bosnian ... "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor ...

CD27 plays a role in lymphoid proliferation, differentiation, and apoptosis. The acquisition of CD27 and Flt3 by the HSC ... Here is the parade of killers and how they work: Cytotoxic T cells (also called Tc or antigen-specific cyto -lytic or -toxic T ... It can be expressed as a set (Lin2, Sca1high, c-kit high, CD44+, Thy1.1low, CD27 2, and IL-7Ra2). This set is a 'barcode' for ... Once in a secondary lymphoid organ the B cell can be introduced to an antigen that it is able to recognize.[citation needed] ...

After primary antigen exposure and elimination, antigen-specific TSCM preferentially survive among memory T cells and stably ... high levels of CD27, CD28, IL-7Rα (CD127), CD62L, and C-C chemokine receptor 7 (CCR7), as well as markers of memory T cells, ... Multiparametric flow cytometry and TCR sequencing studies showed that more than 30% of naïve T cells primed by antigen directly ... Flow cytometry analysis of tumor-infiltrating antigen-presenting cell (APC) populations in human kidney, prostate and bladder ...

Identification of good antigens has been challenging: such antigens must be highly expressed on the majority of cancer cells, ... Signaling domains from a wide variety of co-stimulatory molecules have been successfully tested, including CD28, CD27, CD134 ( ... After an antigen is bound to the external antigen recognition domain, CAR receptors cluster together and transmit an activation ... T cells are genetically engineered to express chimeric antigen receptors specifically directed toward antigens on a patient's ...

CD25 deficiency CD27 deficiency STAT5b deficiency ITK deficiency SH2D1A deficiency (XLP1) MAGT1 deficiency DOCK2 deficiency ... selective immunoglobulin A deficiency Specific antibody deficiency to specific antigens with normal B cell and normal Ig ...

... antigens, cd27 MeSH D12.776.543.750.705.852.760.072 - antigens, cd30 MeSH D12.776.543.750.705.852.760.097 - antigens, cd40 MeSH ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 - antigens, cd79 MeSH D12.776.543.750.705.816.824 - receptors, antigen, t- ... antigens, cd22 MeSH D12.776.543.550.200.124 - antigens, cd24 MeSH D12.776.543.550.200.131 - antigens, cd31 MeSH D12.776.543.550 ... antigens, cd11a MeSH D12.776.543.750.705.408.100.150 - antigens, cd11b MeSH D12.776.543.750.705.408.100.200 - antigens, cd11c ...

Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... Maurer D, Holter W, Majdic O, Fischer GF, Knapp W (1991). "CD27 expression by a distinct subpopulation of human B lymphocytes ... CD11a+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH) ITGAL Info with links in the Cell ... CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ...

CD27-/IgD- memory B cells are associated with increased disease activity and renal lupus. T cells, which regulate B-cell ... That leads to the maturation of DCs and also to the presentation of intracellular antigens of late apoptotic or secondary ... Close to TBM, follicular dendritic cells (FDC) are localised in GC, which attach antigen material to their surface and, in ... When apoptotic material is not removed correctly by phagocytes, they are captured instead by antigen-presenting cells, which ...

B-cells that have not encountered an antigen are called naive B cells. When naïve B-cells encounter an antigen, one of the ... In normal lymphoid tissues CD27 and its ligand CD70 have a restricted expression pattern, but a 1999 study found CD70 on 71% of ... that bind to a specific antigen. Once activated by an antigen, B-cells proliferate and further differentiate into plasma cells ... Follicular dendritic cells and T cells help to select the B-cells that have a high affinity to the antigen for further ...

Dong HY, Shahsafaei A, Dorfman DM (2003). "CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve ... Tissue Antigens. 54 (5): 485-98. doi:10.1034/j.1399-0039.1999.540506.x. PMID 10599888. Billard C, Delaire S, Raffoux E, ...

However, peripheral blood Bregs were mostly CD24 and CD27 positive after cultivation with anti-CD40 antibody and CpG bacterial ... After the response to antigen or different stimuli such as lipopolysaccharide (LPS) pro- and anti-inflammatory cytokines TNFα, ... "IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses". The ...