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Antibacterial therapeutic agents". Feigin & Cherry's textbook of pediatric infectious diseases (6th ed.). Philadelphia, PA: ... and prevents the synthesis of bacterial proteins. Chloramphenicol has also been used to treat neonates born before 37 weeks of ... Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents". In Brunton EL, Lazo JS, Parker K (eds.). Goodman & ... Deveci A, Coban AY (September 2014). "Optimum management of Citrobacter koseri infection". Expert Review of Anti-Infective ...
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ISBN 978-0-12-526451-8. Bryskier A. "Antibacterial Agents; Structure Activity Relationships" (PDF). p. 143. Archived from the ... The primary means of bacterial resistance to macrolides occurs by post-transcriptional methylation of the 23S bacterial ... Classification of agents Pharmamotion. Author: Gary Kaiser. The Community College of Baltimore County. Retrieved on July 31, ... Macrolide antibiotics bind reversibly to the P site on the 50S subunit of the bacterial ribosome. This action is considered to ...
"Targeting antibacterial agents by using drug-carrying filamentous bacteriophages". Antimicrobial Agents and Chemotherapy. 50 (6 ... Bacteriophages are bacterial viruses, evolved to infect bacterial cells. To do that, phages must use characteristic structures ... Purified recombinant phage enzymes can be used as separate antibacterial agents in their own right. Phage therapy also has the ... Borysowski J, Weber-Dabrowska B, Górski A (April 2006). "Bacteriophage endolysins as a novel class of antibacterial agents". ...
A potent antibacterial agent". Journal of Medicinal Chemistry. 13 (4): 616-619. doi:10.1021/jm00298a007. PMID 4916317. Duncan ... Lincomycin is used to treat severe bacterial infections in patients who cannot use penicillin antibiotics. Lincomycin shows ... Although similar in antibacterial spectrum and mechanism of action to macrolides, lincomycin is also effective against other ...
"Narrow-Spectrum Antibacterial Agents". MedChemComm. 9: 12-21. doi:10.1039/C7MD00528H. ISSN 2040-2503. PMC 5839511. PMID ... Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome ( ... Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. ISSN 1098-6596. PMC 6325184. PMID 30397052. (Articles ... indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the ...
Li, Qun; Mitscher, Lester A.; Shen, Linus L. (2000). "The 2-pyridone antibacterial agents: bacterial topoisomerase inhibitors ... Mitscher, Lester A. (2005-06-14). "Bacterial Topoisomerase Inhibitors: Quinolone and Pyridone Antibacterial Agents". ChemInform ... Anti-Cancer Agents. 4 (5): 429-34. doi:10.2174/1568011043352777. PMID 15379698. S2CID 1468756. Song Y, Shao Z, Dexheimer TS, ... Studies have shown that teniposide is an active anti-tumor agent and have been used in clinical settings to evaluate the ...
Hiraki, J. (1995). "Basic and applied studies on ε-polylysine". Journal of Antibacterial Antifungal Agents. 23: 349-354. Mazia ... This eventually leads to the abnormal distribution of the cytoplasm causing damage to the bacterial cell that is produced by ... s as delivery agents for antisense oligonucleotides". Pharmaceutical Research. 24 (8): 1581-1589. doi:10.1007/s11095-006-9231-y ... which offers a new way to deliver therapeutic agents specifically to the sites of injury after vascular damage. In 2010, ...
Agents with anti-pseudomonal activity, including doripenem, imipenem, and meropenem, are not recommended in this population. ... Carbapenems are a class of very effective antibiotic agents most commonly used for the treatment of severe bacterial infections ... Structure Activity Relationships "Antibacterial Agents; Structure Activity Relationships," André Bryskier MD; beginning at ... thus inhibiting bacterial cell wall synthesis. However, these agents individually exhibit a broader spectrum of activity ...
Gardnerella at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Mahajan GB (2012). "Antibacterial agents ... Actinomycetota is one of the dominant bacterial phyla and contains one of the largest of bacterial genera, Streptomyces. ... Although some of the largest and most complex bacterial cells belong to the Actinomycetota, the group of marine Actinomarinales ... Pandey B, Ghimire P, Agrawal VP (January 12-15, 2004). Studies on the antibacterial activity of the Actinomycetes isolated from ...
Gratia called the antibacterial agent "mycolysate". The next year they found another killer mould that could inhibit B. ... She found that in 1946, seven out of eight bacterial infections were susceptible to penicillin, but two years later only three ... But these findings received little attention as the antibacterial agent and its medical value were not fully understood, and ... The foaming problem was solved by the introduction of an anti-foaming agent, glyceryl monoricinoleate. The technique also ...
host DHFR have found application as antibacterial agents. An extensive review of the chemical space of small-molecules that ... Bacteria also need DHFR to grow and multiply and hence inhibitors selective for bacterial vs. ... Hawser S, Lociuro S, Islam K (March 2006). "Dihydrofolate reductase inhibitors as antibacterial agents". Biochemical ... the experimental antimalarial and anti-toxoplasmosis compound JPC-2056 Oral piritrexim, a treatment for metastatic urothelial ...
"New Family Of Antibacterial Agents Uncovered". Science News. ScienceDaily. 2009-01-17. Retrieved 2009-01-17. Jung S, Dingley AJ ... Functionally, the protein causes bacterial cells to clump together and aggregate, changing the morphology of the bacterial ... This potent antibacterial activity extended to known multi-resistant strains of pathogenic bacteria, such as those of ... This results in a disruption of the structure of the bacterial membrane. Hydramacin-1 was first isolated from epithelial cells ...
Risks of antibacterial agents in pregnancy]". Le Infezioni in Medicina. 10 (1): 8-15. PMID 12700435. Bar-Oz B, Moretti ME, ... Bacterial cytotoxicity could arise from incomplete repair of closely spaced 8-oxo-2'-deoxyguanosine in the DNA resulting in ... "Antibacterial Agents; Structure Activity Relationships," André Bryskier MD (CS1: long volume value, CS1 maint: DOI inactive as ... Anti-Infective Agents in Medicinal Chemistry. 6 (1): 49-56. doi:10.2174/187152107779314179. Archived from the original (PDF) on ...
Risks of antibacterial agents in pregnancy]". Le Infezioni in Medicina. 10 (1): 8-15. PMID 12700435. "Levaquin- levofloxacin ... Ofloxacin is used in the treatment of bacterial infections such as: Acute bacterial exacerbations of chronic obstructive ... An eye drop may be used for a superficial bacterial infection of the eye and an ear drop may be used for otitis media when a ... Ofloxacin is a quinolone antibiotic useful for the treatment of a number of bacterial infections. When taken by mouth or ...
... need DHFR to grow and multiply and hence inhibitors selective for bacterial DHFR have found application as antibacterial agents ... Pyrimethamine is a widely used antiprotozoal agent. Other classes of compounds that target DHFR in general, and bacterial DHFRs ... Regardless, trimethoprim and sulfamethoxazole in combination has been used as an antibacterial agent for decades. ... Trimethoprim, an antibiotic, inhibits bacterial DHFR while methotrexate, a chemotherapy agent, inhibits mammalian DHFR. However ...
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Pongs, O. (1979). "Chapter 3: Chloramphenicol". In Hahn, eFred E. (ed.). Mechanism of Action of Antibacterial Agents. ... and other infectious bacterial diseases. Since its discovery, chloromycetin has been linked to an increased risk of fatal ... Wright, Peter M.; Seiple, Ian B.; Myers, Andrew G. (2014). "The Evolving Role of Chemical Synthesis in Antibacterial Drug ... the remainder of her career and spent the latter part of it researching fertility drugs and the synthesis of blood-lipid agents ...
Pongs O (1979). "Chapter 3: Chloramphenicol". In Hahn FE (ed.). Mechanism of Action of Antibacterial Agents. Antibiotics Volume ... "Chloramphenicol spectrum of bacterial susceptibility and Resistance" (PDF). Product Data Safety Sheet. TOKU-E. December 2010. ... Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ... During the last decade chloramphenicol has been re-evaluated as an old agent with potential against systemic infections due to ...
Breijyeh Z, Jubeh B, Karaman R (March 2020). "Resistance of Gram-Negative Bacteria to Current Antibacterial Agents and ... "Morphological and ultrastructural changes in bacterial cells as an indicator of antibacterial mechanism of action". Cellular ... Levison ME, Levison JH (December 2009). "Pharmacokinetics and pharmacodynamics of antibacterial agents". Infectious Disease ... The bacterial strain developed after introduction of methicillin in 1959. In MRSA, mutations in the genes (mec system) for PBP ...
"Long-circulating bacteriophage as antibacterial agents". Proceedings of the National Academy of Sciences. 93 (8): 3188-3192. ... He is best known for his work on bacterial transcription and the biology of bacteriophage lambda. He has made important ... the organization of the bacterial nucleoid, and phage therapy. Adhya was born in Kolkata, India and studied chemistry at the ...
Long-circulating bacteriophage as antibacterial agents. Proc. Natl. Acad. Sci. USA 93:3188-3192. Gupta, K., Y. Lee and J. Yin. ... Phage ecology and bacterial pathogenesis, p. 66-91. In M. K. Waldor, D. I. Friedman, and S. L. Adhya (eds.), Phages: Their Role ... More than one phage can coinfect the same bacterial cell. When this happens, the phage can exchange genes, which is equivalent ... Phage-bacterial coevolution is typically studied within the context of phage community ecology. This article incorporates ...
He then cleaved the double helix of another virus; an antibacterial agent known as bacteriophage lambda. In the third step, he ... Such biological barriers included fastidious bacterial hosts that were unable to survive in natural environments. Other ... In experiments designed to introduce or propagate DNA from non-viral or other low risk agents in animal cells, only low risk ... The moderate risk level of containment was intended for experiments in which there was a probability of generating an agent ...
Zhang L, He J, Bai L, Ruan S, Yang T, Luo Y (July 2021). "Ribosome-targeting antibacterial agents: Advances, challenges, and ... Buynak JD (September 2007). "Cutting and stitching: the cross-linking of peptidoglycan in the assembly of the bacterial cell ... Dalhoff A (February 2021). "Selective toxicity of antibacterial agents-still a valid concept or do we miss chances and ignore ... Since anti-pathogen inhibitors generally target only one enzyme, such drugs are highly specific and generally produce few side ...
... a Novel Fluorocycline Antibacterial Agent". Drugs. 76 (5): 567-588. doi:10.1007/s40265-016-0545-8. ISSN 1179-1950. PMID ... "Eravacycline is active against bacterial isolates expressing the polymyxin resistance gene mcr-1" (PDF). Antimicrobial Agents ... Sutcliffe, J. A.; O'Brien, W.; Fyfe, C.; Grossman, T. H. (2013-11-01). "Antibacterial activity of eravacycline (TP-434), a ... Antimicrobial Agents and Chemotherapy. 58 (4): 1847-1854. doi:10.1128/AAC.01614-13. ISSN 1098-6596. PMC 4023720. PMID 24342651 ...
"Looking for the new preparations for antibacterial therapy. V. New antimicrobial agents from the oxazolidinones groups in ... An additional global Phase 3 study is planned for acute bacterial skin and skin structure infections (ABSSSI) for the ... "Mechanism of action of the oxazolidinone antibacterial agents". Expert Opinion on Investigational Drugs. 8 (8): 1195-1202. doi: ... The antibacterial effect of oxazolidinones is by working as protein synthesis inhibitors, targeting an early step involving the ...
April 2016). "Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent". Drugs. 76 (5): 567-88. doi:10.1007/s40265-016 ... They also bind to some extent the bacterial 50S ribosomal subunit and may alter the cytoplasmic membrane causing intracellular ... and structural bases for antibacterial activity of tigecycline". Antimicrobial Agents and Chemotherapy. 50 (6): 2156-66. doi: ... Also, because the molecules are soluble in water it can worsen kidney failure (this is not true of the lipid-soluble agents ...
This makes the cell much less affected by stressors such as antibacterial agents, starvation, hypoxia, and acidity. Some ... Various bacterial mechanisms recognize different environmental changes and mount an appropriate response. A bacterial cell can ... bacterial cells can secrete extracellular polymeric substances to form a film that can provide support to the bacterial colony ... In most bacterial strains, sigma factor-32 (32) is responsible for regulating the heat-shock response. Sigma factor-32 is ...