Anthranilate synthase
... anthranilate + pyruvate + L-glutamate Anthranilate synthase creates anthranilate, an important intermediate in the biosynthesis ... Anthranilate synthase catalyzes the change from chorismate to anthranilate. As its other substrate, it can use either glutamine ... The subunits of anthranilate synthase are encoded by the trpE and trpD genes in E. coli, both of which appear in the trp operon ... The enzyme anthranilate synthase (EC 4.1.3.27) catalyzes the chemical reaction chorismate + L-glutamine ⇌ {\displaystyle \ ...
Amino acid synthesis
Tryptophan biosynthesis involves conversion of chorismate to anthranilate using anthranilate synthase. This enzyme requires ... Anthranilate synthase is regulated by the gene products of trpE and trpG. trpE encodes the first subunit, which binds to ... Anthranilate synthase is also regulated by feedback inhibition: tryptophan is a co-repressor to the TrpR repressor. The ... Enzymes involved in this biosynthesis include acetolactate synthase (also known as acetohydroxy acid synthase), acetohydroxy ...
Trp operon
The roles of their products are: TrpE (P00895): Anthranilate synthase produces anthranilate. TrpD (P00904): Cooperates with ... The Indole-3-glycerol-phosphate synthase on the same protein then turns the product into (1S,2R)-1-C-(indol-3-yl)glycerol 3- ... TrpC (P00909): Phosphoribosylanthranilate isomerase domain first turns N-(5-phospho-β-D-ribosyl)anthranilate into 1-(2- ...
Anthranilic acid
... is biosynthesized from chorismic acid by the action of anthranilate synthase. In organisms capable of ... Anthranilate-based insect repellents have been proposed as replacements for DEET. Fenamic acid is a derivative of anthranilic ... The anion [C6H4(NH2)(CO2)]−, obtained by the deprotonation of anthranilic acid, is called anthranilate. Anthranilic acid was ... Kynureninase 3-Aminobenzoic acid 4-Aminobenzoic acid Methyl anthranilate "Front Matter". Nomenclature of Organic Chemistry : ...
Camptothecin
First, chorismate is converted to anthranilate by the alpha-subunit of anthranilate synthase (ASA). Anthranilate reacts with 5- ... synthase to yield indole. The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with serine, leading ... Condensation of IPP and dimethylallyl diphosphate (DMAPP) yields geranyl diphosphate (GPP). The geraniol synthase (GS) then ... from MVA or MEP pathway are converted to strictosidine through a condensation reaction catalyzed by strictosidine synthase. ...
Li Jiayang
Li, J; Last, R. L. (1996). "The Arabidopsis thaliana trp5 mutant has a feedback-resistant anthranilate synthase and elevated ... "Isolation of cDNAs encoding the tryptophan pathway enzyme indole-3-glycerol phosphate synthase from Arabidopsis thaliana". ...
Phosphoribosylanthranilate isomerase
"Indoleglycerol phosphate synthase-phosphoribosyl anthranilate isomerase: comparison of the bifunctional enzyme from Escherichia ... anthranilate contains inhibitors, but not if it is generated by anthranilate phosphoribosyltransferase) 26300 (Bacillus ... component lib of the anthranilate synthetase complex has N-(5'-phosphoribosyl)anthranilate isomerase and indole-3-glycerol ... The systematic name of this enzyme class is N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase. Other names in ...
Farinamycin
... made from shikimate and is then attacked by nascent ammonia to produce the ortho aminobenzoate isomer by anthranilate synthase ... Enaminomycin C is formed from anthranilate, which is made via the shikimate pathway as well. Subsequent oxidation is followed ... Farinamycin is made of three different components: 3-OH-anthranilate (3-HAA), 3,4-aminohydroxybenzamide (3,4-AHBAm) and the ... natural product Enaminomycin C. 3-OH anthranilate is derived from the central shikimate pathway metabolite chorismate. ...
TRPE
... may refer to: Time-resolved photon emission Anthranilate synthase, an enzyme This disambiguation page lists articles ...
N-Feruloylserotonin
In plants, the enzyme anthranilate synthase (AS) is composed of two subunits that modulate the production or suppression of ...
Aminodeoxychorismate synthase
Enzymes with similar structures to aminodeoxychorismate synthase are: Anthranilate synthase (TrpE) Isochorismate synthase (MenF ... It is believed that aminodeoxychorismate synthase may have evolved from anthranilate synthase (TrpE) - an enzyme that catalyses ... Aminodeoxychorismate synthase ADC synthase 4-amino-4-deoxychorismate synthase PabB In certain microbial species such as ... Formerly aminodeoxychorismate synthase was referred to as PABA synthase; however this name is no longer recommended as it is ...
Glutamine amidotransferase
... the second component of anthranilate synthase and 4-amino-4-deoxychorismate (ADC) synthase; CTP synthase; GMP synthase; ... This activity is found in a range of biosynthetic enzymes, including glutamine amidotransferase, anthranilate synthase ... glutamine-dependent carbamoyl-phosphate synthase; phosphoribosylformylglycinamidine synthase II; and the histidine ... or as domains in a much larger multifunctional synthase protein, such as CPSase. On the basis of sequence similarities two ...
Pesticide research
... a virtual library of potential herbicidal inhibitors of the enzyme anthranilate synthase was generated by keeping the core ...
Xuong Nguyen-Huu
The Structures of Anthranilate Synthase of Serratia Marcescens Crystallized in the Presence of (i) its substrates, Chorismate ...
List of EC numbers (EC 4)
... anthranilate synthase EC 4.1.3.28: Now EC 2.3.3.3, citrate (Re)-synthase EC 4.1.3.29: Now EC 2.3.3.4, decylhomocitrate synthase ... 11-diene synthase EC 4.2.3.25: S-linalool synthase EC 4.2.3.26: R-linalool synthase EC 4.2.3.27: isoprene synthase EC 4.2.3.28 ... α-santalene synthase EC 4.2.3.83: β-santalene synthase EC 4.2.3.84: 10-epi-γ-eudesmol synthase EC 4.2.3.85: α-eudesmol synthase ... cubebol synthase EC 4.2.3.92: (+)-γ-cadinene synthase EC 4.2.3.93: δ-guaiene synthase EC 4.2.3.94: γ-curcumene synthase EC 4.2. ...
Benzoyl-CoA
... anthranilate N-benzoyltransferase, biphenyl synthase, glycine N-benzoyltransferase, ornithine N-benzoyltransferase and ... It is a substrate in the formation of xanthonoids in Hypericum androsaemum by benzophenone synthase, condensing a molecule of ...
List of MeSH codes (D08)
... anthranilate phosphoribosyltransferase MeSH D08.811.600.085 - anthranilate synthase MeSH D08.811.600.116 - aspartate ... riboflavin synthase MeSH D08.811.913.225.825 - spermidine synthase MeSH D08.811.913.225.912 - spermine synthase MeSH D08.811. ... anthranilate synthase MeSH D08.811.520.224.600.700 - isocitrate lyase MeSH D08.811.520.224.800 - tryptophanase MeSH D08.811. ... nitric oxide synthase type i MeSH D08.811.682.664.500.772.500 - nitric oxide synthase type ii MeSH D08.811.682.664.500.772.750 ...
Indole-3-glycerol-phosphate synthase
Creighton TE; Yanofsky C (1970). "Chorismate to tryptophan (Escherichia coli) - Anthranilate synthetase, PR transferase, PRA ... indoleglycerol phosphate synthase, indole-3-glycerophosphate synthase, 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate ... The enzyme indole-3-glycerol-phosphate synthase (IGPS) (EC 4.1.1.48) catalyzes the chemical reaction 1-(2-carboxyphenylamino)-1 ... anthranilate isomerase (EC 5.3.1.24) (PRAI) activity, the third step of tryptophan biosynthesis. In fungi, IGPS is the central ...
List of EC numbers (EC 2)
... mycocerosate synthase EC 2.3.1.112: D-tryptophan N-malonyltransferase EC 2.3.1.113: anthranilate N-malonyltransferase EC 2.3. ... 2-ethylmalate synthase EC 2.3.3.7: 3-ethylmalate synthase EC 2.3.3.8: ATP citrate synthase EC 2.3.3.9: malate synthase EC 2.3. ... synthase EC 2.3.3.2: decylcitrate synthase EC 2.3.3.3: citrate (Re)-synthase EC 2.3.3.4: decylhomocitrate synthase EC 2.3.3.5: ... synthase EC 2.4.1.12: cellulose synthase (UDP-forming) EC 2.4.1.13: sucrose synthase EC 2.4.1.14: sucrose-phosphate synthase EC ...
Indole
It is an intermediate in the biosynthesis of tryptophan, where it stays inside the tryptophan synthase molecule between the ... Indole is biosynthesized in the shikimate pathway via anthranilate. ...
List of EC numbers (EC 6)
... anthranilate-CoA ligase EC 6.2.1.33: 4-chlorobenzoate-CoA ligase EC 6.2.1.34: trans-feruloyl-CoA synthase EC 6.2.1.35: acetate ... c-diamide synthase EC 6.3.5.12: Ni-sirohydrochlorin a,c-diamide synthase * EC 6.3.5.13: lipid II isoglutaminyl synthase ( ... thioglycine synthase * EC 6.2.2.2: oxazoline synthase * EC 6.2.2.3: thiazoline synthase * * No Wikipedia article EC 6.3.1.1: ... 2-hydroxypropanoate synthase * EC 6.3.2.56: staphyloferrin B synthase * EC 6.3.2.57: staphyloferrin A synthase * EC 6.3.2.58: D ...
List of enzymes
Anthranilate-CoA ligase EC 6.2.1.33: 4-chlorobenzoate-CoA ligase EC 6.2.1.34: Trans-feruloyl-CoA synthase EC 6.2.1.35: ACP-SH: ... Thiazole synthase EC 2.8.1.11: Molybdopterin synthase sulfurtransferase EC 2.8.1.12: Molybdopterin synthase EC 2.8.1.13: tRNA- ... Biotin synthase EC 2.8.1.7: Cysteine desulfurase EC 2.8.1.8: Lipoyl synthase EC 2.8.1.9: Molybdenum cofactor sulfurtransferase ... EC 1.21.3 Isopenicillin N synthase EC 1.21.3.1 Tetrahydrocannabinolic acid synthase EC 1.21.3.7 Category:EC 1.21.4 Category:EC ...
Tryptophan
Plants and microorganisms commonly synthesize tryptophan from shikimic acid or anthranilate: anthranilate condenses with ... In the last step, tryptophan synthase catalyzes the formation of tryptophan from indole and the amino acid serine. The ... The conversion is catalyzed by the enzyme tryptophan synthase. There was a large outbreak of eosinophilia-myalgia syndrome (EMS ...
Antimycin
2. N-formyl-L-kynurenine is converted to anthranilate by the pathway-specific kynureninase, AntP. 3. Anthranilate is activated ... Antimycins are produced by a non-ribosomal peptide synthetase (NRPS)/polyketide synthase (PKS) assembly complex which acts as ... 4. Anthranilate is converted to 3-aminosalicylate by a multicomponent oxygenase, AntHIJKL. 5. 3-Aminosalicylate is presented to ...
Index of molecular biology articles
2-oxobutyrate synthase - (2,3-dihydroxybenzoyl)adenylate synthase - 2,4-Dihydroxy-1,4-benzoxazin-3-one-glucoside dioxygenase - ... anthranilate adenylyltransferase - anti-sense strand - antibiotic resistance - antibody - antisense - antisense strand - AP-1 ... licodione synthase - ligase - linear epitope - linkage - linker protein - linoleate diol synthase - lipofectin - ... vanillin synthase - VanY protein domain - Var1 protein domain - vax2os1 - vector - VEK-30 protein domain - vinorine hydroxylase ...
Phosphoribosyl pyrophosphate
... with the first step being N-alkylation of anthranilic acid catalysed by the enzyme anthranilate phosphoribosyltransferase. ... Mechanistic Analysis of the Bacterial Hydroxymethylpyrimidine Phosphate Synthase". Angewandte Chemie International Edition. 49 ...
TIM barrel
In another study involving the S. solfataricus indole-3-glycerol phosphate synthase TIM barrel protein, a conserved βαβαβ ... anthranilate (PRA) to 1-(O-carboxyphenylamino)- 1'-deoxyribulose-5'-phosphate (CdRP). PriA is a TIM barrel enzyme that ... These clamps (or hydrophobic side chain bridge analogs) are conserved in 3 indole-3-glycerolphosphate synthase TIM barrel ... indole-3-glycerol phosphate synthase, by hydrogen exchange mass spectrometry and Gō model simulation". Journal of Molecular ...
List of EC numbers (EC 1)
... pyruvate synthase EC 1.2.7.2: Now included with EC 1.2.7.1, pyruvate synthase. EC 1.2.7.3: 2-oxoglutarate synthase EC 1.2.7.4: ... anthranilate 1,2-dioxygenase (deaminating, decarboxylating) EC 1.14.12.2: Now EC 1.14.13.35 anthranilate 3-monooxygenase ( ... berbamunine synthase EC 1.1.3.35: Now EC 1.14.21.4, salutaridine synthase EC 1.1.3.36: Now EC 1.14.21.5, (S)-canadine synthase ... clavaminate synthase EC 1.14.11.22: Now EC 1.14.20.5, flavone synthase EC 1.14.11.23: Now EC 1.14.20.6, flavonol synthase EC ...