Angiopoietin 1
... increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. This suggests that ... Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar ... may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a ... Angiopoietin 1 has been shown to interact with TEK tyrosine kinase. Recently, studies in malaria-endemic areas suggest that ...
Angiopoietin-related protein 1
2005). "Biological characterization of angiopoietin-3 and angiopoietin-4". FASEB J. 18 (11): 1200-8. doi:10.1096/fj.03-1466com ... 1999). "Molecular cloning, expression, and characterization of angiopoietin-related protein. angiopoietin-related protein ... angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. The protein encoded by this gene is another ... "Molecular cloning and characterization of a novel angiopoietin family protein, angiopoietin-3". FEBS Lett. 443 (3): 353-6. doi: ...
Angiopoietin
To be specific, angiopoietin levels provide an indication for sepsis. Research on angiopoietin-2 has shown that it is involved ... Angiopoietin-2 has been proposed as a biomarker in different cancer types. Angiopoietin-2 expression levels are proportional to ... Angiopoietin-2 is elevated in patients with angiosarcoma. Research has shown angiopoietin signaling to be relevant in treating ... Angiopoietins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) "angiopoietin.de: endothelia activation ...
Angiopoietin-related protein 2
... also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 ... angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPTL2 protein is a secreted glycoprotein ... and characterization of angiopoietin-related protein. angiopoietin-related protein induces endothelial cell sprouting". J Biol ... Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific ...
TEK tyrosine kinase
Angiopoietin-1 receptor also known as CD202B (cluster of differentiation 202B) is a protein that in humans is encoded by the ... January 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig- ... Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (November 2001). "Dok-R plays a pivotal role in angiopoietin-1- ... The ligand for the receptor is angiopoietin-1. TEK has also been suggested as a marker for nucleus pulposus progenitor cells, ...
Epithelial-mesenchymal transition
Li JJ, Huang YQ, Basch R, Karpatkin S (February 2001). "Thrombin induces the release of angiopoietin-1 from platelets". ... Angiopoietin-1) and cytokines including the EMT inducer TGF-β. The release of TGF-β by platelets in blood vessels near primary ... 201 (1): 27-36. doi:10.1677/joe-08-0497. PMID 19171567. Jolly MK, Boareto M, Huang B, Jia D, Lu M, Ben-Jacob E, et al. (1 ... 270 (1-2): 87-93. doi:10.1016/j.mce.2007.02.005. PMC 1987709. PMID 17363142. Russ HA, Bar Y, Ravassard P, et al. (2008). "In ...
Pericyte
Angiopoietin 2 can act as an antagonist to Tie-2, destabilizing the endothelial cells, which results in less endothelial cell ... Angiopoietin 1 and Tie-2 signaling is essential for maturation and stabilization of endothelial cells. Platelet-derived growth ... Similar to the inhibition of the PDGF pathway, angiopoietin 2 reduces levels of pericytes, leading to diabetic retinopathy. ... "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ...
GRLF1
Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP (Aug 2007). "Angiopoietin-1 ... 257 (1): 23-31. doi:10.1016/S0378-1119(00)00387-5. PMID 11054565. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O ( ... 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157. Barberis D, Casazza A, Sordella R, Corso S, Artigiani S, ... Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene. The human glucocorticoid ...
Vascular endothelial growth factor
Makinde T, Murphy RF, Agrawal DK (2007). "Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in ... The expression of angiopoietin-2 in the absence of VEGF leads to endothelial cell death and vascular regression. Conversely, a ... doi:10.1007/978-1-4419-8871-3_13. ISBN 978-1-4613-4699-9. PMID 15015562. Eremina V, Quaggin SE (2004). "The role of VEGF-A in ... In 1998, neuropilin 1 and neuropilin 2 were shown to act as VEGF receptors. In mammals, the VEGF family comprises five members ...
Thomas N. Sato
... and angiopoietins, that play the key roles in the blood vessel formation. National Science Contest for Elementary School ... "Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis". Cell. 87 (7): 1171-1180. doi: ... "Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis". Science. 277 (5322): 55-60. doi:10.1126/ ... October 1993). "Tie-1 and tie-2 define another class of putative receptor tyrosine kinase genes expressed in early embryonic ...
Hedgehog signaling pathway
Activation of the Hedgehog pathway leads to an increase in Angiogenic Factors (angiopoietin-1 and angiopoietin-2), Cyclins ( ... Lee SW, Moskowitz MA, Sims JR (March 2007). "Sonic hedgehog inversely regulates the expression of angiopoietin-1 and ... 23 (1): 23-34. doi:10.1016/j.ccr.2012.11.017. PMC 3548977. PMID 23291299. Nakamura M, Kubo M, Yanai K, Mikami Y, Ikebe M, Nagai ... 121 (1): 148-160. doi:10.1172/JCI42874. PMC 3007144. PMID 21183792. Kim J, Lee JJ, Kim J, Gardner D, Beachy PA (July 2010). " ...
Angiopoietin-related protein 7
... is a protein that in humans is encoded by the ANGPTL7 gene. It is one of the 8 angiopoietin-like ... "Entrez Gene: ANGPTL7 angiopoietin-like 7". Angiopoietin-like proteins: a comprehensive look Tanigawa, Yosuke; Wainberg, Michael ... Peek R, Kammerer RA, Frank S, Otte-Holler I, Westphal JR (Jan 2002). "The angiopoietin-like factor cornea-derived transcript 6 ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 1, All stub articles, ...
Milica Radisic
"Hydrogels With Integrin-Binding Angiopoietin-1-Derived Peptide, QHREDGS, for Treatment of Acute Myocardial Infarction". ...
George Yancopoulos
Yancopoulos has cloned novel families of growth factors, including ephrins/Ephs and angiopoietins, and elucidated the basis of ... December 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 ( ... 1 (1): 25-34. doi:10.1016/S1097-2765(00)80004-0. PMID 9659900. DeChiara TM, Kimble RB, Poueymirou WT, et al. (March 2000). " ... 247 (4949 Pt 1): 1446-51. Bibcode:1990Sci...247.1446M. doi:10.1126/science.2321006. PMID 2321006. Boulton TG, Nye SH, Robbins ...
E74 like ets transcription factor 3
Prescott JD, Koto KS, Singh M, Gutierrez-Hartmann A (June 2004). "The ETS transcription factor ESE-1 transforms MCF-12A human ... Kwon JH, Keates S, Simeonidis S, Grall F, Libermann TA, Keates AC (January 2003). "ESE-1, an enterocyte-specific Ets ... Cabral A, Fischer DF, Vermeij WP, Backendorf C (May 2003). "Distinct functional interactions of human Skn-1 isoforms with Ese-1 ... v t e (Articles with short description, Short description matches Wikidata, Genes on human chromosome 1, All stub articles, ...
TNIP2
"ABIN-2 protects endothelial cells from death and has a role in the antiapoptotic effect of angiopoietin-1". Blood. 102 (13): ... 543 (1-3): 55-60. doi:10.1016/S0014-5793(03)00401-0. PMID 12753905. S2CID 31400521. Liu WK, Yen PF, Chien CY, et al. (2004). " ... 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional ... 342 (1): 300-9. doi:10.1016/j.bbrc.2006.01.114. PMID 16480954. Greenberg H, Ye X, Wilson D, et al. (2006). "Chronic ...
ANGPT2
"Genomic structures of the human angiopoietins show polymorphism in angiopoietin-2". Cytogenetics and Cell Genetics. 94 (3-4): ... "Entrez Gene: ANGPT2 angiopoietin 2". Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, Martiny-Baron G, Marmé D, ... Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. Naturally occurring antagonist for both ANGPT1 and ... Huang YQ, Li JJ, Hu L, Lee M, Karpatkin S (March 2002). "Thrombin induces increased expression and secretion of angiopoietin-2 ...
DOK2
Master Z, Jones N, Tran J, Jones J, Kerbel RS, Dumont DJ (2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell ... 2001). "Dok-R plays a pivotal role in angiopoietin-1-dependent cell migration through recruitment and activation of Pak". EMBO ... 23 (1): 94-101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157. Van Slyke P, Coll ML, Master Z, et al. (2005). "Dok-R ... 105 (6 Pt 1): 1063-70. doi:10.1067/mai.2000.107604. PMID 10856136. Jones N, Dumont DJ (1998). "The Tek/Tie2 receptor signals ...
MEF2C
... transcription factor MEF2C-null mouse exhibits complex vascular malformations and reduced cardiac expression of angiopoietin 1 ... 19 (1): 21-30. doi:10.1128/mcb.19.1.21. PMC 83862. PMID 9858528. Wilson-Rawls J, Molkentin JD, Black BL, Olson EN (Apr 1999). " ... 180 (1): 227-41. doi:10.1006/dbio.1996.0297. PMID 8948587. Sartorelli V, Huang J, Hamamori Y, Kedes L (Feb 1997). "Molecular ... Maeda T, Gupta MP, Stewart AF (Jun 2002). "TEF-1 and MEF2 transcription factors interact to regulate muscle-specific promoters ...
NADPH oxidase
... and mitochondrial-derived reactive oxygen species contribute to angiopoietin-1 signaling and angiogenic responses in ... Ang-1 triggers NOX2, NOX4, and the mitochondria to release ROS and that ROS derived from these sources play distinct roles in ... 2012: 1-26. doi:10.1155/2012/217037. ISSN 2090-0120. Herb M, Gluschko A, Wiegmann K, Farid A, Wolf A, Utermöhlen O, et al. ( ... 7 (1): 109. doi:10.1186/1471-2148-7-109. PMC 1940245. PMID 17612411. Ha EM, Oh CT, Bae YS, Lee WJ (November 2005). "A direct ...
Michele De Palma
He later showed that inhibition of the Tie2-ligand Angiopoietin 2 induces tumor regression and inhibits metastasis by ... He also identified expression of Angiopoietin 2 as an adaptive resistance mechanism upon anti-angiogenic treatment by VEGF ... "Role of Angiopoietin-2 in Adaptive Tumor Resistance to VEGF Signaling Blockade". Cell Reports. 8 (3): 696-706. doi:10.1016/j. ... "Dual angiopoietin-2 and VEGFA inhibition elicits antitumor immunity that is enhanced by PD-1 checkpoint blockade". Science ...
Schlemm's canal
... and episcleral lymphatic vasculature completely failed to develop in the combined absence of angiopoietin 1 and ... In the combined absence of angiopoietin 1 and angiopoietin 2, Schlemm's canal and episcleral lymphatic vasculature completely ... angiopoietin 2. This causes buphthalmos and glaucoma. Glaucoma may be related to drainage of aqueous humor from the eye. This ...
Angiopoietin receptor
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind ... The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis). The angiopoietins are ... In humans, three angiopoietins have been identified: Ang1, Ang2, and Ang4 (Ang 3 is the mouse ortholog of human Ang4). Ang1 and ... But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.[citation ...
GAB2
A paracrine factor, NRG1 β, utilizes GAB2 to activate the ERK and AKT pathways in the heart to produce angiopoietin 1. The C- ... 5 (1): 31-9. doi:10.1093/dnares/5.1.31. PMID 9628581. Wickrema A, Uddin S, Sharma A, Chen F, Alsayed Y, Ahmad S, Sawyer ST, ... 21 (1-2): 72-82. doi:10.1093/emboj/21.1.72. PMC 125816. PMID 11782427. Pan XL, Ren RJ, Wang G, Tang HD, Chen SD (June 2010). " ... 1 (2): 130-134. PMC 3232456. PMID 22163099. Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (September 2003). "GC-GAP ...
Proteases in angiogenesis
... while the angiopoietin receptor Tie-1 facilitates embryonic blood vessel formation. Upon binding of their ligands, Notch-1 and ... ErbB-4 and the angiopoietin receptor Tie-1. Notch-1 signaling is essential for endothelial differentiation, and tumor ... 86 (1): 124-129. doi:10.1055/s-0037-1616208. PMID 11486997. Bajou, K; Noël, A; Gerard, RD; Masson, V; Brunner, N; Holst-Hansen ... Unexpectedly, when PAI-1 deficient mice were challenged with cancer cells on a collagenous matrix, angiogenesis and vascular ...
Gregg L. Semenza
HIF-1α was further found essential to the EPO production process, as test subjects modified to be deficient in HIF-1α were ... Semenza's work showed that the HIF proteins consisted of two parts; HIF-1β, a stable base to most conditions, and HIF-1α that ... He is known for his discovery of HIF-1, which allows cancer cells to adapt to oxygen-poor environments. He shared the 2019 ... Semenza further found that HIF-1α overproduction could lead to cancer in other subjects. Semenza's research overlapped with ...
Hereditary angioedema
HAE with a angiopoietin 1 (ANGPT1) mutation]; myoferlin [HAE with a myoferlin (MYOF) mutation]; kininogen 1 [HAE with a ... angiopoietin 1, plasminogen or kininogen 1. The pathophysiologic mechanisms contributing to bradykinin mediated angioedema in ... 100 (1 Suppl 2): S41-6. doi:10.1016/S1081-1206(10)60585-6. PMID 18220151. Reuters: UPDATE 1-US clears Lev Pharma drug for rare ... HAE affects approximately 1 in 50,000 people. The condition is typically first noticed in childhood. Type I and II affected ...
TIE1
Angiopoietin § Tie pathway GRCh38: Ensembl release 89: ENSG00000066056 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Receptor,+TIE-1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Genes on human ... Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans ... TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. ...
ELF2
2002). "NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a ... 11 (1): 86-96. doi:10.1038/sj.leu.2400516. PMID 9001422. Mao S, Frank RC, Zhang J, et al. (1999). "Functional and physical ... a novel transcription factor related to the Ets factor ELF-1". Mol. Cell. Biol. 16 (9): 5091-106. doi:10.1128/MCB.16.9.5091. ...
Weibel-Palade body
... angiopoietin-2, osteoprotegerin, the P-selectin cofactor CD63/lamp3, and α-1,3-fucosyltransferase VI. Multimeric vWF is ... 84 (1): 92-9. doi:10.1172/JCI114175. PMC 303957. PMID 2472431. Doyle EL, Ridger V, Ferraro F, Turmaine M, Saftig P, Cutler DF ( ... 95 (1): 355-60. doi:10.1083/jcb.95.1.355. PMC 2112360. PMID 6754744. Tuma RF, Durán WN, Ley K, eds. (2008). Microcirculation ( ... 23 (1): 101-12. doi:10.1083/jcb.23.1.101. PMC 2106503. PMID 14228505. Wagner DD, Olmsted JB, Marder VJ (October 1982). " ...