... , or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene ... mRNAs undergoing alternative splicing and alternative splicing events or to study the functional impact of alternative splicing ... Research Group dealing with alternative Splicing issues and mis-splicing in human diseases Alternative Splicing of ion channels ... Wikimedia Commons has media related to Alternative splicing. A General Definition and Nomenclature for Alternative Splicing ...

... (ASAP) in computational biology was a database for alternative splicing data maintained ... Lee, Christopher; Atanelov, Levan; Modrek, Barmak; Xing, Yi (2003-01-01). "ASAP: the Alternative Splicing Annotation Project". ... analysis and comparative genomics of alternative splicing in 15 animal species". Nucleic Acids Res. England. 35 (Database issue ... AspicDB ECgene RNA splicing Kim, Namshin; Alekseyenko Alexander V; Roy Meenakshi; Lee Christopher (Jan 2007). "The ASAP II ...

Alternative Splicing Annotation Project AspicDB RNA splicing Koscielny, Gautier; Le Texier, Vincent; Gopalakrishnan, Chellappa ... "Alternative Splicing Database Project , EBI". www.ebi.ac.uk. Archived from the original on 2011-12-27. Retrieved 2020-03-04. ... The Alternative Splicing and Transcript Diversity database (ASTD) was a database of transcript variants maintained by the ... The Alternative Splicing and Transcript Diversity database". Genomics. United States. 93 (3): 213-20. doi:10.1016/j.ygeno. ...

The Human-transcriptome DataBase for Alternative Splicing (H-DBAS) is a database of alternatively spliced human transcripts ... Alternative splicing Takeda, Jun-ichi; Suzuki Yutaka; Nakao Mitsuteru; Kuroda Tsuyoshi; Sugano Sumio; Gojobori Takashi; ... alternative splicing database of completely sequenced and manually annotated full-length cDNAs based on H-Invitational". ... RNA splicing, All stub articles, Biological database stubs). ...

This phenomenon is then called alternative splicing. Alternative splicing can occur in many ways. Exons can be extended or ... DNA damage also has an impact on the splicing and alternative splicing of genes intimately associated with DNA repair. For ... The major spliceosome splices introns containing GU at the 5' splice site and AG at the 3' splice site. It is composed of the ... This type of splicing is termed canonical splicing or termed the lariat pathway, which accounts for more than 99% of splicing. ...

... (abbreviated sQTLs or splicing QTLs) are quantitative trait loci that regulate alternative ... Ongen H, Dermitzakis ET (October 2015). "Alternative Splicing QTLs in European and African Populations". American Journal of ... April 2016). "RNA splicing is a primary link between genetic variation and disease". Science. 352 (6285): 600-4. Bibcode: ... Takata A, Matsumoto N, Kato T (February 2017). "Genome-wide identification of splicing QTLs in the human brain and their ...

Alternative trans-splicing includes intragenic trans-splicing and intergenic trans-splicing. Intragenic trans-splicing involves ... Trans-splicing differs from cis-splicing in that there is no 5' splice site on the pre-mRNA. Instead the 5' splice site is ... splice site upstream. When the 5' outron in spliced, the 5' splice site of the spliced leader RNA is branched to the outron and ... trans-splicing can also be the mechanism behind certain oncogenic fusion transcripts. Spliced leader (SL) trans-splicing is ...

... splice site usage regulating alternative 3' splice site usage Myotonic dystrophy (MD) is most noticeably caused by inheriting ... "Alternative splicing and genetic diversity: silencers are more frequently modified by SNVs associated with alternative exon/ ... ESSs silence splice sites adjacent to them by interfering with the components of the core splicing complex, such as the snRNP's ... Exonic splicing silencers work by inhibiting the splicing of pre-mRNA strands or promoting exon skipping. The single stranded ...

Alternative splicing differs from RNA editing in that alternative splicing does not change the mRNA sequence like RNA editing ... Alternative splicing is a mechanism by which different proteins can be produced from a single gene by means of using ... This includes alternative splicing during transcription, whether the viral genome is segmented, the host range of viruses, ... Viruses may make use of alternative splicing solely to produce multiple proteins from a single pre-mRNA strand or for other ...

"Alternative Splicing". Genome.gov. Retrieved 2023-04-23. Modzelewski AJ, Gan Chong J, Wang T, He L (September 2022). "Mammalian ... leading up to the formation of a stem-loop structure and an alternative splicing event that fundamentally influences ...

The identification of alternative splice variants, and possibly the relative quantities, containing a trans-spliced leader ... Pecci A, Viegas LR, Baranao JL, Beato M (June 2001). "Promoter choice influences alternative splicing and determines the ... Spliced leaders have been seen in trypanosomatids, Euglena, flatworms, Caenorhabditis. Some species contain only one spliced ... end of the messenger RNA require the presence of a trans-spliced leader sequence. Spliced leader sequences are short sequences ...

Alternative splicing produces ∆Elk1. This variant lacks part of the DNA-binding domain that allows interaction with SRF. On the ... Elk1 also interacts with BRCA1 splice variants, namely BRCA1a and BRCA1b. This interaction enhances BRCA1-mediated growth ... "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth ...

Evidence for alternative splicing". J. Mol. Biol. 207 (3): 491-503. doi:10.1016/0022-2836(89)90459-2. PMID 2760922. Buvoli M, ... Buvoli M, Cobianchi F, Bestagno MG, Mangiarotti A, Bassi MT, Biamonti G, Riva S (1990). "Alternative splicing in the human gene ... and may modulate splice site selection. Multiple alternatively spliced transcript variants have been found for this gene but ... These variants have multiple alternative transcription initiation sites and multiple polyA sites. Post translational ...

Kelemen O, Convertini P, Zhang Z, Wen Y, Shen M, Falaleeva M, Stamm S (February 2013). "Function of alternative splicing". Gene ... Another mechanism for the correct regulation of gene expression is achieved through alternative splicing. This is a co- ... Latorre E, Mesonero JE, Harries LW (November 2019). "Alternative splicing in serotonergic system: Implications in ... including utilization of alternative splice acceptor sites, exon skipping, rare exon usage, and intron retention. There are a ...

Alternative splicing, polyadenylation, and isoforms". The Journal of Biological Chemistry. 270 (34): 20112-22. doi:10.1074/jbc. ... Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. Cluster of differentiation ...

Alternative splicing of transcription products". The Journal of Biological Chemistry. 272 (28): 17843-50. doi:10.1074/jbc. ... Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional ... "Multi-forms of human MTH1 polypeptides produced by alternative translation initiation and single nucleotide polymorphism". ...

Alternative splicing, polyadenylation, and isoforms". J. Biol. Chem. 270 (34): 20112-22. doi:10.1074/jbc.270.34.20112. PMID ... 2004). "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis". Glycobiology ... large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55-65. ...

Teplova M, Patel DJ (December 2008). "Structural insights into RNA recognition by the alternative-splicing regulator ... Muscleblind Like Splicing Regulator 1 (MBNL1) is an RNA splicing protein that in humans is encoded by the MBNL1 gene. It has a ... The repressive function of Human MBNL1 by sequestering at normal splice sites has been shown to lead to RNA-splicing defects ... autoregulate alternative splicing of the MBNL1 pre-mRNA transcript. The founding member of the human MBNL family of proteins ...

Alternative splicing, polyadenylation, and isoforms". The Journal of Biological Chemistry. 270 (34): 20112-22. doi:10.1074/jbc. ...

Kim N; Lee C (2008). "Bioinformatics Detection of Alternative Splicing". Bioinformatics. Methods in Molecular Biology. Vol. 452 ... can be aligned to a sequenced genome to find where there are genes and get information about alternative splicing and RNA ... BLAST was developed to provide a faster alternative to FASTA without sacrificing much accuracy; like FASTA, BLAST uses a word ... Optical computing approaches have been suggested as promising alternatives to the current electrical implementations, yet their ...

"Medical Definition of ALTERNATIVE SPLICING". Merriam-webster.com. Retrieved 20 December 2021. "UniProtKB - Q5SQI0 (ATAT_HUMAN ... ATAT1 presents seven different isoforms due to alternative splicing, a process which consists in the combination of exons ...

Lareau LF, Green RE, Bhatnagar RS, Brenner SE (June 2004). "The evolving roles of alternative splicing". Current Opinion in ... In 2022, it was discovered that aminoacyl-trna synthetases may incorporate alternative amino acids during shortages of their ...

Woodley L, Valcárcel J (Oct 2002). "Regulation of alternative pre-mRNA splicing". Briefings in Functional Genomics & Proteomics ... the mutant pre-mRNA and the therapeutic pre-trans-splicing molecule carrying the wild-type sequence are spliced together to ... masking exonic splicing enhancer sequences and therefore preventing binding of the splicing machinery and therefore resulting ... Wally V, Murauer EM, Bauer JW (Aug 2012). "Spliceosome-mediated trans-splicing: the therapeutic cut and paste". The Journal of ...

Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been ...

... others may be expressed in soluble form through alternative splicing. Like the similar KIR family, LILR genes are found in the ... "Extensive Alternative Splicing of KIR Transcripts". Frontiers in Immunology. 9: 2846. doi:10.3389/fimmu.2018.02846. PMC 6288254 ... as well as in alternative splicing. This family has undergone significant diversification in primate lineages. The leukocyte ...

Alternative splicing results in multiple variants. [provided by RefSeq, Jul 2017]. GRCh38: Ensembl release 89: ENSG00000186487 ...

This gene undergoes extensive alternative splicing; although ten transcript variants have been described, the full length ... Functional diversity of GIT2 through alternative splicing". The Journal of Biological Chemistry. 275 (29): 22373-80. doi: ...

Alternative splicing Alternative Splicing Annotation Project AspicDB ChimerDB TassDB Kim, Pora; Kim Namshin; Lee Younghee; Kim ... ECgene in computational biology is a database of genomic annotations taking alternative splicing events into consideration. ... genome annotation for alternative splicing". Nucleic Acids Res. England. 33 (Database issue): D75-9. doi:10.1093/nar/gki118. ... RNA splicing, Gene expression, All stub articles, Biological database stubs). ...

Alternative splicing results in transcript variants. The LRRs and NTF2-like domains are required for export activity. The ... "Multipotent genetic suppression of retrotransposon-induced mutations by Nxf1 through fine-tuning of alternative splicing". PLOS ... is a component of the splicing-dependent exon-exon junction complex". The EMBO Journal. 20 (22): 6424-33. doi:10.1093/emboj/ ...

Alternative splicing occurs for this gene; however, the full-length nature of all transcript variants has not yet been ...