Vesicular transport adaptor proteins are proteins involved in forming complexes that function in the trafficking of molecules ... Protein complexes, Protein families, Molecular evolution, Vesicular transport proteins). ... Epsin and AP180 in the ANTH domain are other adaptor proteins that have been reviewed. An important transport complex, COPII, ... Most of the adaptor proteins are heterotetramers. In the AP complexes, there are two large proteins (~100 kD) and two smaller ...
Clathrin adaptor proteins, also known as adaptins, are vesicular transport adaptor proteins associated with clathrin. These ... The two major types of clathrin adaptor complexes are the heterotetrameric vesicular transport adaptor proteins (AP1-5), and ... Touz MC, Kulakova L, Nash TE (July 2004). "Adaptor protein complex 1 mediates the transport of lysosomal proteins from a Golgi- ... adaptors. Adaptins are distantly related to the other main type of vesicular transport proteins, the coatomer subunits, sharing ...
Peripheral membrane proteins, Vesicular transport proteins). ... The AP2 adaptor complex is a multimeric protein that works on ... A family of proteins called muniscins are thought to be the primary allosteric activators of the AP2 adaptor complex, due to ... Henne WM, Boucrot E, Meinecke M, Evergren E, Vallis Y, Mittal R, McMahon HT (June 2010). "FCHo proteins are nucleators of ... Tian Y, Chang JC, Fan EY, Flajolet M, Greengard P (October 2013). "Adaptor complex AP2/PICALM, through interaction with LC3, ...
The adaptor proteins investigated work in vesicular transport in eukaryotes, particularly in cargo-selection and coat-protein ... The study found that F. alba had all five adaptor protein complexes present in its genome, whereas the kingdom Fungi only ... in 2014 traced the evolution of the five adaptor protein (AP) complexed in fungi, but also provided some insight onto Fonticula ... contained a complete set of all five adaptor protein complexes. An amoeboid trophic phase alternating with an aggregating ...
AP2 adaptor complex Vesicular transport adaptor protein Umasankar PK, Ma L, Thieman JR, Jha A, Doray B, Watkins SC, Traub LM ( ... Peripheral membrane proteins, Protein complexes, Protein families, Molecular evolution, Vesicular transport proteins). ... The μ homology domain of muniscins has been reported to have evolved from part of an ancient cargo adaptor protein complex ... The muniscin protein family was initially defined in 2009 as proteins having 2 homologous domains that are involved in clathrin ...
... a mammalian master molecule in vesicular transport and protein sorting, suppresses the degradation of ESCRT proteins signal ... Signal transducing adapter molecule 1 is a protein that in humans is encoded by the STAM gene. This gene was identified by the ... The encoded protein contains an SH3 domain and the immunoreceptor tyrosine-based activation motif (ITAM). This protein ... Mizuno E, Kawahata K, Kato M, Kitamura N, Komada M (September 2003). "STAM proteins bind ubiquitinated proteins on the early ...
... such as the EHD protein family Rab proteins SNAREs Vesicular transport adaptor proteins e.g. Sorting nexins Synaptotagmin TRAPP ... Membrane transport protein Wikipedia:MeSH D12.776#MeSH D12.776.543.990 --- vesicular transport proteins Vesicular+Transport+ ... A vesicular transport protein, or vesicular transporter, is a membrane protein that regulates or facilitates the movement of ... v t e (Vesicular transport proteins, Peripheral membrane proteins, All stub articles, Membrane protein stubs). ...
... tied to kinesin-dependent vesicular transport. In this context, JIP1/2 act as cargo adaptors, binding to a motor protein and a ... This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different ... In addition to their "normal" cargoes (C-termini of transmembrane proteins), they also transport MAP2K and MAP3K enzymes, ... Several mammalian scaffold proteins have been identified. These include the JNK-interacting protein (JIP) 1 and its closerly- ...
... are a family of cytosolic adaptor proteins involved in vesicular fusion at membranes during intracellular transport and ... Rice LM, Brunger AT (July 1999). "Crystal structure of the vesicular transport protein Sec17: implications for SNAP function in ... Figure 1 shows interactions of the vesicular and membrane SNARE proteins with NSF and SNAP in the assembly, fusion, and ... Abnormal levels of multiple vesicular trafficking proteins are often observed in conjunction and a compound effect may lead to ...
... may refer to: Signal transducing adaptor protein Vesicular transport adaptor protein Clathrin adaptor protein, ... also known as adaptin This disambiguation page lists articles associated with the title Adaptor protein. If an internal link ...
... adaptor proteins.2C vesicular transport "Role of Signal Transducing Adaptor Protein (STAP) Family in Chronic Myelogenous ... phosphoinositide-3-kinase adaptor protein 1 SH2B1 - SH2B adaptor protein 1 SH2B2 - SH2B adaptor protein 2 SH2B3 - SH2B adaptor ... NCK adaptor protein 1 NCK2 - NCK adaptor protein 2 NOS1AP - nitric oxide synthase 1 (neuronal) adaptor protein PIK3AP1 - ... GRB2-associated binding protein 2 GRAP - GRB2-related adaptor protein GRAP2 - GRB2-related adaptor protein 2 GRB2 - Growth ...
"Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation". ... Zinc finger, FYVE domain containing 27 is a protein that in humans is encoded by the ZFYVE27 gene. This gene encodes a protein ... The encoded protein appears to promote Neurite formation. A mutation in this gene has been reported to be associated with ... of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein". The ...
Additionally, reticulons may be used to shape coated protein vesicles by interacting with a component of the adaptor protein ... In one example, it was shown that increasing expression of RTN3 keeps transport of proteins from retrograding from the Golgi ... Reticulons have been found to interact with proteins that are involved with vesicular formation and morphogenesis of the ER. ... The family of vertebrate proteins are called reticulons, and all other located eukaryotes are called reticulon-like proteins. ...
RIAM (Rap1-GTP-interacting adapter molecule) is a broadly expressed adaptor protein that contains an RA (Ras association)-like ... PKD-dependent regulation of vesicular transport requires PKD kinase activity, while PKD-dependent regulation of TCR signaling ... These proteins are divided into families depending on their protein structure, and the most well studied is the Ras superfamily ... Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular ...
2001). "Novel adapter protein AP162 connects a sialyl-Le(x)-positive mucin with an apoptotic signal transduction pathway". ... PLEKHM1 may have critical function in vesicular transport in osteoclasts. PLEKHM1 contains a C-terminal Rubicon Homology (RH) ... 2007). "Involvement of PLEKHM1 in osteoclastic vesicular transport and osteopetrosis in incisors absent rats and humans". J. ... 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957-68. doi: ...
... vesicular transport, apoptosis, membrane dynamics and receptor signaling. This protein family is of great clinical importance ... protein-protein interactions, vesicle trafficking, membrane dynamics, receptor signaling, apoptosis, adaptor/regulatory modules ... "neurobeachin-like protein 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-02-24. "Pfam: Family: ... Protein pages needing a picture, Genes on human chromosome 2, Human gene pages with Wikidata item, Genes, Human proteins). ...
These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate ... Secretory carrier-associated membrane protein 1 is a protein that in humans is encoded by the SCAMP1 gene. This gene product ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library ... Liu L, Guo Z, Tieu Q, Castle A, Castle D (December 2002). "Role of secretory carrier membrane protein SCAMP2 in granule ...
... which is involved in vesicular transport. These 3 complexes are identical and have been termed the conserved oligomeric Golgi ( ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... 1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107-13. doi:10.1006/abio. ... 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and ...
... complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): ... Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065-8. doi:10.1074/jbc.273.46.30065. PMID ... Double C2-like domain-containing protein alpha is a protein that in humans is encoded by the DOC2A gene. There are at least two ... "Protein unc-13 homolog A". UniProt. Sakaguchi G, Orita S, Maeda M, Igarashi H, Takai Y (December 1995). "Molecular cloning of ...
... , like most other Rab11FIP proteins, interacts with Rab11 by serving as an adaptor protein. This leads to downstream ... Rab11FIP5 aids in this sorting process by binding to kinesin II and forming a protein complex to regulate vesicular trafficking ... This process involves the transport of cargo proteins, like endocytosed receptors, to endosome recycling complexes and ... Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene. RAB11FIP5 has been shown to ...
The active form, ARF*GTP, binds to vesicle coat proteins and adaptors, including coat protein I (COPI) and various ... Activators of cholera toxin and critical components of intracellular vesicular transport processes". The Journal of Biological ... ARF requires assistance from other proteins in order to switch between binding to GTP and GDP. GTPase activating proteins (GAPs ... Arp and Sar proteins: A family of GTP-binding proteins with a structural device for 'front-back' communication". EMBO Reports. ...
... complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): ... Implication in dynein-dependent vesicle transport". J. Biol. Chem. 273 (46): 30065-8. doi:10.1074/jbc.273.46.30065. PMID ... Double C2-like domain-containing protein beta is a protein that in humans is encoded by the DOC2B gene. There are at least two ... protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and ...
Transferring to the GSL synthesis site is done with the help of a transport protein known as four phosphate adaptor protein 2 ( ... C1P also has known roles in vesicular trafficking, cell survival, phagocytosis ("cell eating") and macrophage degranulation. ... 2007). "Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein". J. ... Sph is also known to interact with protein targets such as the protein kinase H homologue (PKH) and the yeast protein kinase ( ...
... and other cytolytic effector proteins. Once these proteins are delivered to the target cell, they induce its apoptosis. The ... Finetti, Francesca; Baldari, Cosima T. (2013-01-01). "Compartmentalization of signaling by vesicular trafficking: a shared ... "Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse". Nature Cell Biology ... of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin ...
The following step of transporting the pIgR across the cell (through tubulo-vesicular compartments to apical recycling endosome ... pIgR belongs to the family of type I transmembrane proteins. The extracellular portion of the protein contains 6 domains: 5 ... TLR4, like the majority of TLRs, transduce the signal though MyD88 adaptor and execute the function via NF-kB, which stimulates ... as secretory component is a soluble protein, whereas plasma membrane receptors are transmembrane proteins. Numerous models were ...
Transport of insoluble protein contributes to the fast movement while the slow transport is transporting up to 40% - 50% ... LIS1 encodes an adaptor protein Lis1 that is responsible for stabilization of neurotubule during neuronal migration by ... The process repeats itself as cycles so that kinesins move along the neurotubules together with the organelles and vesicular ... soluble protein. The speed of transport depends on the types of cargo to be transported. Neurotrophins, a family of proteins ...
The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively ... a family of ADP ribosylation factor-binding proteins related to adaptors and associated with the Golgi complex". J. Cell Biol. ... nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular ... including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized ...
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene ... uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation". The Journal of Biological Chemistry ... is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It ... Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene. ...
"Divergent retroviral late-budding domains recruit vacuolar protein sorting factors by using alternative adaptor proteins". Proc ... The encoded protein is one of the three subunits of the ESCRT-I complex (endosomal complexes required for transport) involved ... Tanzi GO, Piefer AJ, Bates P (2003). "Equine Infectious Anemia Virus Utilizes Host Vesicular Protein Sorting Machinery during ... Vacuolar protein sorting-associated protein 28 homolog is a protein that in humans is encoded by the VPS28 gene. This gene ...
... membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein". Molecular ... Hanada K, Kumagai K, Yasuda S, Miura Y, Kawano M, Fukasawa M, Nishijima M (Dec 2003). "Molecular machinery for non-vesicular ... "Phosphatidylinositol 4 phosphate regulates targeting of clathrin adaptor AP-1 complexes to the Golgi". Cell. 114 (3): 299-310. ... Collagen type IV alpha-3-binding protein, also known as ceramide transfer protein (CERT) or StAR-related lipid transfer protein ...